{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:58:08Z","timestamp":1773309488557,"version":"3.50.1"},"reference-count":64,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T00:00:00Z","timestamp":1669420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Cardiac involvement of chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) is recognized extremely rarely. In addition, most CLL\/SLL patients with heart infiltration are asymptomatic. In this review, we present the results of a literature search for English language articles concerning CLL\/SLL or Richter transformation with symptomatic cardiac involvement. In total, 18 well-described cases with CLL\/SLL and heart infiltration were identified. Only three patients were not diagnosed with CLL\/SLL before the cardiac manifestation. In other patients, cardiac CLL\/SLL was diagnosed between 5 months and 20 years from CLL\/SLL diagnosis. All patients in these series had a diagnosis of secondary cardiac CLL\/SLL. In addition, we identified four reported cases with Richter transformation in the heart. The treatment of patients with CLL\/SLL and cardiac infiltration is variable and depends on the previous history and clinical characteristics of heart infiltration. In addition, no recommendations exist on how to treat patients with CLL\/SLL and cardiac involvement.<\/jats:p>","DOI":"10.3390\/jcm11236983","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T06:04:36Z","timestamp":1669615476000},"page":"6983","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiac Involvement in Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3411-6357","authenticated-orcid":false,"given":"Tadeusz","family":"Robak","sequence":"first","affiliation":[{"name":"Department of Hematology, Medical University of Lodz, 93-510 Lodz, Poland"},{"name":"Department of General Hematology, Copernicus Memorial Hospital, 93-510 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-8187","authenticated-orcid":false,"given":"Jaros\u0142aw","family":"Kasprzak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Lodz, 92-213 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Jesionek-Kupnicka","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chair of Oncology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cezary","family":"Chudobi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Radiology, Copernicus Memorial Hospital, 93-510 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6078-5415","authenticated-orcid":false,"given":"Pawe\u0142","family":"Robak","sequence":"additional","affiliation":[{"name":"Department of Oncohematology, Copernicus Memorial Hospital, 93-510 Lodz, Poland"},{"name":"Department of Experimental Hematology, Medical University of Lodz, 93-510 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.annonc.2020.09.019","article-title":"Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"32","author":"Eichhorst","year":"2021","journal-title":"Ann. 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