{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:06:45Z","timestamp":1762078005631,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800983","BMU2020MX022","BYSYZD2019035","KF2020-18","PKUSSNCT-21A13"],"award-info":[{"award-number":["81800983","BMU2020MX022","BYSYZD2019035","KF2020-18","PKUSSNCT-21A13"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University Medicine Seed Fund for Interdisciplinary Research","award":["81800983","BMU2020MX022","BYSYZD2019035","KF2020-18","PKUSSNCT-21A13"],"award-info":[{"award-number":["81800983","BMU2020MX022","BYSYZD2019035","KF2020-18","PKUSSNCT-21A13"]}]},{"name":"Key Clinical Projects of Peking University Third Hospital","award":["81800983","BMU2020MX022","BYSYZD2019035","KF2020-18","PKUSSNCT-21A13"],"award-info":[{"award-number":["81800983","BMU2020MX022","BYSYZD2019035","KF2020-18","PKUSSNCT-21A13"]}]},{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences","award":["81800983","BMU2020MX022","BYSYZD2019035","KF2020-18","PKUSSNCT-21A13"],"award-info":[{"award-number":["81800983","BMU2020MX022","BYSYZD2019035","KF2020-18","PKUSSNCT-21A13"]}]},{"name":"Program for New Clinical Techniques and Therapies of Peking University School and Hospital of Stomatology 21A13","award":["81800983","BMU2020MX022","BYSYZD2019035","KF2020-18","PKUSSNCT-21A13"],"award-info":[{"award-number":["81800983","BMU2020MX022","BYSYZD2019035","KF2020-18","PKUSSNCT-21A13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa and considered a potential malignant disease, for which a method for complete cure is lacking. The dexamethasone and gentamicin mouthwash, combined with total glucosides of paeony (TGP), was tested in the treatment of OLP patients without fungal infection, with a view to provide evidence that may assist in resolving the dilemma. Methods: A randomized and single-blind clinical trial of 48 non-erosive and erosive OLP patients was conducted, with the patients divided into two groups. Group A was treated with dexamethasone plus gentamycin mouthwash and Group B received an additional TGP capsule together with the aforementioned mouthwash. All the patients were followed up with four times, at 2 weeks, 1 month, 3 months, and 6 months. The clinical manifestations, sign score, and VAS scale were recorded. The total effective rate (%) was defined as (cases of complete resolution + cases of partial resolution)\/total cases observed \u00d7 100%. Results: A total of 43 patients completed all follow-up appointments. Among the 21 patients in Group A, the total effective rate was 61.9%. Of the 22 patients in Group B, the total effective rate was 89.66%. The clinical manifestation, sign score, and VAS of the two groups all indicated improvements, and there were significant differences between the two groups (p &lt; 0.05). Conclusions: Dexamethasone plus gentamycin mouthwash combined with TGP treatment for OLP patients is a safe and effective treatment of OLP.<\/jats:p>","DOI":"10.3390\/jcm11237004","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T06:04:36Z","timestamp":1669615476000},"page":"7004","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Evaluation of Dexamethasone Plus Gentamycin Mouthwash Use in Combination with Total Glucosides of Paeony for Treatment of Oral Lichen Planus without Fungal Infection: A Comparative Study with Long-Term Follow-Up"],"prefix":"10.3390","volume":"11","author":[{"given":"Zhihui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Stomatology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Tao","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.oooo.2016.05.004","article-title":"Diagnosis of oral lichen planus: A position paper of the American Academy of Oral and Maxillofacial Pathology","volume":"122","author":"Cheng","year":"2016","journal-title":"Oral Surg. 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