{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T20:09:18Z","timestamp":1776197358080,"version":"3.50.1"},"reference-count":69,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Stem cell therapy is a current world-wide topic in medical science. Various therapies have been approved based on their effectiveness and put into practical use. In Japan, research and development-related stem cell therapy, generally referred to as regenerative medicine, has been led by the government. The national scheme started in 2002, and support for the transition to clinical trials has been accelerating since 2011. Of the initial 18 projects that were accepted in the budget for preclinical research, 15 projects have begun clinical trials so far. These include the transplantation of retinal, cardiac, and dopamine-producing cells differentiated from human induced pluripotent stem (iPS) cells and hepatocyte-like cells differentiated from human embryonic stem (ES) cells. The distinctive feature of the stem cell research in Japan is the use of iPS cells. A national framework was also been set-up to attain the final goal: health insurance coverage. Now, insurance covers cell transplantation therapies for the repair and recovery of damaged skin, articular cartilage, and stroke as well as therapies introduced from abroad, such as allogeneic mesenchymal stem cells for graft-versus-host disease and chimeric antigen receptor-T (CAR-T) cell therapy. To prepare this review, original information was sought from Japanese authentic websites, which are reliable but a little hard to access due to the fact of multiple less-organized databases and the language barrier. Then, each fact was corroborated by citing its English version or publication in international journals as much as possible. This review provides a summary of progress over the past decade under the national program and a state-of-the-art factual view of research activities, government policy, and regulation in Japan for the realization of stem cell therapy.<\/jats:p>","DOI":"10.3390\/jcm11237030","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T06:04:36Z","timestamp":1669615476000},"page":"7030","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical Trials of Stem Cell Therapy in Japan: The Decade of Progress under the National Program"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-8998","authenticated-orcid":false,"given":"Shin","family":"Enosawa","sequence":"first","affiliation":[{"name":"Division for Advanced Medical Sciences, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0167-7799(99)01394-3","article-title":"Biotechnology in the 21st century","volume":"18","author":"Cantor","year":"2000","journal-title":"Trends Biotechnol."},{"key":"ref_2","unstructured":"(2022, October 17). Submission of Final Report by the Biotechnology Strategy Council. Friday, Available online: https:\/\/japan.kantei.go.jp\/koizumiphoto\/2002\/12\/06bt_e.html."},{"key":"ref_3","unstructured":"(2022, October 17). Priority Strategies for Science and Technology, Available online: https:\/\/www.mext.go.jp\/en\/publication\/whitepaper\/title03\/detail03\/sdetail03\/sdetail03\/1372929.htm."},{"key":"ref_4","unstructured":"(2022, October 17). Strategies for the Development of Biotechnology, (In Japanese)."},{"key":"ref_5","unstructured":"(2022, October 17). Research Center Network for Realization of Regenerative Medicine, Available online: https:\/\/www.jst.go.jp\/saisei-nw\/en\/document\/saisei-nw_2015_en.pdf."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1002\/art.21212","article-title":"Comparison of human stem cells derived from various mesenchymal tissues: Superiority of synovium as a cell source","volume":"52","author":"Sakaguchi","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1634\/stemcells.2006-0281","article-title":"Synovial stem cells are regionally specified according to local microenvironments after implantation for cartilage regeneration","volume":"25","author":"Koga","year":"2007","journal-title":"Stem Cells"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1097\/ICO.0b013e31817f2298","article-title":"Cultivated corneal endothelial transplantation in a primate: Possible future clinical application in corneal endothelial regenerative medicine","volume":"S1","author":"Koizumi","year":"2008","journal-title":"Cornea"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ajpath.2012.03.033","article-title":"ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue","volume":"181","author":"Okumura","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1634\/stemcells.2005-0542","article-title":"Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy","volume":"24","author":"Terai","year":"2006","journal-title":"Stem Cells"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00535-012-0580-5","article-title":"Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy","volume":"47","author":"Terai","year":"2012","journal-title":"J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/jor.21267","article-title":"Articular cartilage repair using an intra-articular magnet and synovium-derived cells","volume":"29","author":"Hori","year":"2011","journal-title":"J. Orthop. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nm.2695","article-title":"Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5\u207a stem cell","volume":"18","author":"Yui","year":"2012","journal-title":"Nat. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"11331","DOI":"10.1073\/pnas.0500010102","article-title":"Generation of Rx+\/Pax6+ neural retinal precursors from embryonic stem cells","volume":"102","author":"Ikeda","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1242\/jcs.050393","article-title":"In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction","volume":"122","author":"Osakada","year":"2009","journal-title":"J. Cell Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Hayashi, R., Ishikawa, Y., Ito, M., Kageyama, T., Takashiba, K., Fujioka, T., Tsujikawa, M., Miyoshi, H., Yamato, M., and Nakamura, Y. (2012). Generation of corneal epithelial cells from induced pluripotent stem cells derived from human dermal fibroblast and corneal limbal epithelium. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045435"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nprot.2017.007","article-title":"Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells","volume":"12","author":"Hayashi","year":"2017","journal-title":"Nat. Protoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.stem.2012.09.013","article-title":"Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes","volume":"12","author":"Tohyama","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/stem.1060","article-title":"Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson\u2019s disease","volume":"30","author":"Doi","year":"2012","journal-title":"Stem Cells"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/lt.23800","article-title":"Hepatocyte transplantation using a living donor reduced graft in a baby with ornithine transcarbamylase deficiency: A novel source of hepatocytes","volume":"20","author":"Enosawa","year":"2014","journal-title":"Liver Transpl."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.reth.2016.06.003","article-title":"In vivo maturation of human embryonic stem cell-derived teratoma over time","volume":"5","author":"Akutsu","year":"2016","journal-title":"Regen. Ther."},{"key":"ref_24","first-page":"287","article-title":"Research and Development Strategy for Future Embryonic Stem Cell-Based Therapy in Japan","volume":"3","author":"Umezawa","year":"2020","journal-title":"JMA J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.stem.2014.01.011","article-title":"Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells","volume":"14","author":"Nakamura","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"12704","DOI":"10.1073\/pnas.0910106107","article-title":"Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury","volume":"107","author":"Tsuji","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nbt1384","article-title":"Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells","volume":"26","author":"Osakada","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1161\/CIRCULATIONAHA.111.084343","article-title":"Feasibility, safety, and therapeutic efficacy of human induced pluripotent stem cell-derived cardiomyocyte sheets in a porcine ischemic cardiomyopathy model","volume":"126","author":"Kawamura","year":"2012","journal-title":"Circulation"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature12271","article-title":"Vascularized and functional human liver from an iPSC-derived organ bud transplant","volume":"499","author":"Takebe","year":"2013","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1002\/stem.2465","article-title":"Efficient Regeneration of Human V\u03b124+ Invariant Natural Killer T Cells and Their Anti-Tumor Activity In Vivo","volume":"34","author":"Yamada","year":"2016","journal-title":"Stem Cells"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"12794","DOI":"10.1038\/s41598-020-69641-4","article-title":"Quality assessment tests for tumorigenicity of human iPS cell-derived cartilage","volume":"10","author":"Takei","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Saito, H., Takeuchi, M., Chida, K., and Miyajima, A. (2011). Generation of glucose-responsive functional islets with a three-dimensional structure from mouse fetal pancreatic cells and iPS cells in vitro. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028209"},{"key":"ref_33","unstructured":"CiRA Foundation (2022, October 17). iPS Cell Stock Project. Available online: https:\/\/www.cira-foundation.or.jp\/e\/research-institution\/ips-stock-project\/."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"102033","DOI":"10.1016\/j.scr.2020.102033","article-title":"CiRA iPSC seed stocks (CiRA\u2019s iPSC Stock Project)","volume":"50","author":"Hanatani","year":"2020","journal-title":"Stem Cell Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Tsujimoto, H., and Osafune, K. (2021). Current status and future directions of clinical applications using iPS cells-focus on Japan. FEBS J.","DOI":"10.1111\/febs.16162"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1067\/mpa.2002.122363","article-title":"Strabismus surgery for large-angle cyclotorsion after macular translocation surgery","volume":"6","author":"Freedman","year":"2002","journal-title":"J. Am. Assoc. Pediatr. Ophthalmol. Strabismus"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.trim.2003.12.012","article-title":"The cellular repair of the brain in Parkinson\u2019s disease\u2014Past, present and future","volume":"12","author":"Sayles","year":"2004","journal-title":"Transpl. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tins.2004.12.006","article-title":"Cell transplantation in Parkinson\u2019s disease: How can we make it work?","volume":"28","author":"Winkler","year":"2005","journal-title":"Trends Neurosci."},{"key":"ref_39","unstructured":"Zimmer Biomet (2022, November 12). DeNovo\u00ae NT Natural Tissue Graft. Available online: https:\/\/www.zimmerbiomet.com\/en\/products-and-solutions\/specialties\/biologics\/denovo-nt-natural-tissue.html."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1177\/0363546510361950","article-title":"The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage","volume":"38","author":"Adkisson","year":"2010","journal-title":"Am. J. Sports Med."},{"key":"ref_41","unstructured":"(2022, October 17). Japanese Law Translation. Act on Securing Quality, Efficacy and Safety of Products Including Pharmaceuticals and Medical Devices, Available online: https:\/\/www.japaneselawtranslation.go.jp\/ja\/laws\/view\/3213."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.reth.2016.04.001","article-title":"Japan\u2019s challenges of translational regenerative medicine: Act on the safety of regenerative medicine","volume":"4","author":"Tobita","year":"2016","journal-title":"Regen. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Noguchi, H. (2022). Clinical Islet Transplantation Covered by Health Insurance in Japan. J. Clin. Med., 11.","DOI":"10.3390\/jcm11143977"},{"key":"ref_44","unstructured":"(2022, October 17). Japan Agency for Medical Research and Development, Available online: https:\/\/www.amed.go.jp\/en\/index.html."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1002\/sctm.20-0491","article-title":"Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow-up","volume":"10","author":"Mizuno","year":"2021","journal-title":"Stem Cells Transl. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"13832","DOI":"10.1038\/s41598-021-93462-8","article-title":"Alterations in cartilage quantification before and after injections of mesenchymal stem cells into osteoarthritic knees","volume":"11","author":"Sekiya","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Sekiya, I., Katano, H., and Ozeki, N. (2021). Characteristics of MSCs in Synovial Fluid and Mode of Action of Intra-Articular Injections of Synovial MSCs in Knee Osteoarthritis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22062838"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ajo.2021.11.012","article-title":"Superiority of Mature Differentiated Cultured Human Corneal Endothelial Cell Injection Therapy for Corneal Endothelial Failure","volume":"237","author":"Ueno","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ophtha.2020.09.002","article-title":"Five-Year Follow-up of First 11 Patients Undergoing Injection of Cultured Corneal Endothelial Cells for Corneal Endothelial Failure","volume":"128","author":"Numa","year":"2021","journal-title":"Ophthalmology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJMoa1608368","article-title":"Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration","volume":"376","author":"Mandai","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Sugita, S., Mandai, M., Hirami, Y., Takagi, S., Maeda, T., Fujihara, M., Matsuzaki, M., Yamamoto, M., Iseki, K., and Hayashi, N. (2020). HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration. J. Clin. Med., 9.","DOI":"10.3390\/jcm9072217"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Sugimoto, N., Kanda, J., Nakamura, S., Kitano, T., Hishizawa, M., Kondo, T., Shimizu, S., Shigemasa, A., Hirai, H., and Arai, Y. (2022). iPLAT1: The first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study. Blood.","DOI":"10.1182\/blood.2022017296"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1161\/CIRCRESAHA.117.309697","article-title":"Cell Therapy Trials in Congenital Heart Disease","volume":"120","author":"Oh","year":"2017","journal-title":"Circ. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10047-006-0371-y","article-title":"Current issues regarding skin substitutes using living cells as industrial materials","volume":"10","author":"Hata","year":"2007","journal-title":"J. Artif. Organs"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1302\/0301-620X.84B4.0840571","article-title":"Transplantation of cartilage-like tissue made by tissue engineering in the treatment of cartilage defects of the knee","volume":"84","author":"Ochi","year":"2002","journal-title":"J. Bone Jt. Surg. Br. Vol."},{"key":"ref_56","unstructured":"Pharmaceuticals and Medical Devices Agency (2022, October 17). List of Approved Products, Regenerative Medical Products, Available online: https:\/\/www.pmda.go.jp\/english\/review-services\/reviews\/approved-information\/0002.html."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Mizutani-Akimoto, A., Hasuike-Niitsu, E., Nagase, K., Okano, T., Kanazawa, H., and Yoshida, R. (2018). Mesenchylmal Stem Cell Culture on Poly(Nisopropylacrylamide) Hydrogel with Repeated Thermo-Stimulation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19041253"},{"key":"ref_58","unstructured":"(2018). Editorials. Racing hearts. Japan must show that a promising therapy damaged hearts works as claimed. Nature, 557, 611\u2013612."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1016\/j.stemcr.2021.09.006","article-title":"LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS\/PC transplantation for contusive spinal cord injury","volume":"16","author":"Ito","year":"2021","journal-title":"Stem Cell Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"110019","DOI":"10.1016\/j.celrep.2021.110019","article-title":"Long-term selective stimulation of transplanted neural stem\/progenitor cells for spinal cord injury improves locomotor function","volume":"37","author":"Kawai","year":"2021","journal-title":"Cell Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"12034","DOI":"10.1038\/s41598-020-68745-1","article-title":"Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration","volume":"10","author":"Mitsuzawa","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"110933","DOI":"10.1016\/j.celrep.2022.110933","article-title":"Generation of functional chimeric kidney containing exogenous progenitor-derived stroma and nephron via a conditional empty niche","volume":"39","author":"Saito","year":"2022","journal-title":"Cell Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"101484","DOI":"10.1016\/j.xpro.2022.101484","article-title":"Protocol for the generation and expansion of human iPS cell-derived ureteric bud organoids","volume":"3","author":"Ryosaka","year":"2022","journal-title":"STAR Protoc."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"121031","DOI":"10.1016\/j.biomaterials.2021.121031","article-title":"Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo","volume":"276","author":"Ikeo","year":"2021","journal-title":"Biomaterials"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1038\/s41467-020-17968-x","article-title":"Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis","volume":"11","author":"Han","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1038\/s41467-020-17969-w","article-title":"Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells","volume":"11","author":"Kishimoto","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Tamura, R., Miyoshi, H., Imaizumi, K., Yo, M., Kase, Y., Sato, T., Sato, M., Morimoto, Y., Sampetrean, O., and Kohyama, J. (2022). Gene therapy using genome-edited iPS cells for targeting malignant glioma. Bioeng. Transl. Med., e10406.","DOI":"10.1002\/btm2.10406"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Noguchi, H., Miyagi-Shiohira, C., and Nakashima, Y. (2018). Induced Tissue-Specific Stem Cells and Epigenetic Memory in Induced Pluripotent Stem Cells. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19040930"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Ibano, N., Inada, E., Otake, S., Kiyokawa, Y., Sakata, K., Sato, M., Kubota, N., Noguchi, H., Iwase, Y., and Murakami, T. (2022). The Role of Genetically Modified Human Feeder Cells in Maintaining the Integrity of Primary Cultured Human Deciduous Dental Pulp Cells. J. Clin. Med., 11.","DOI":"10.3390\/jcm11206087"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/23\/7030\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:28:23Z","timestamp":1760146103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/23\/7030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,28]]},"references-count":69,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["jcm11237030"],"URL":"https:\/\/doi.org\/10.3390\/jcm11237030","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,28]]}}}