{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:11:44Z","timestamp":1784013104237,"version":"3.55.0"},"reference-count":30,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Lublin"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Preeclampsia and hypertension complicate several pregnancies. Identifying women at risk of developing these conditions is essential to establish potential treatment modalities. Biomarkers such as C19MC microRNA in pregnant patients wopuld assist in defining pregnancy surveillance and implementing interventions. This study sought to analyze circulating C19MC microRNA as an early marker of hypertension and preeclampsia in pregnant patients. A systematic review was undertaken using the following registers: disease registries, pregnancy registries, and pregnancy exposure registries, and the following databases: PubMed, CINAHL, Web of Science, Scopus, and EMBASE. The risk of bias was assessed using the Cochrane technique. From the 45 publications retrieved from the registers and databases, only 21 were included in the review after the removal of duplicates, screening, and eligibility evaluation. All 210 publications had a low risk of bias and illuminated the potential use of circulating C19MC microRNA as an early marker of hypertension and preeclampsia in pregnant patients. Therefore, it was concluded that C19MC microRNA can be used as an early marker of gestational preeclampsia and hypertension.<\/jats:p>","DOI":"10.3390\/jcm11237051","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T02:53:29Z","timestamp":1669690409000},"page":"7051","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Analysis of Circulating C19MC MicroRNA as an Early Marker of Hypertension and Preeclampsia in Pregnant Patients: A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"given":"Adrianna","family":"Kondracka","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Jaszczuk","sequence":"additional","affiliation":[{"name":"Department of Cancer Genetics with Cytogenetic Laboratory, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2254-053X","authenticated-orcid":false,"given":"Dorota","family":"Koczkodaj","sequence":"additional","affiliation":[{"name":"Department of Cancer Genetics with Cytogenetic Laboratory, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-4300","authenticated-orcid":false,"given":"Bartosz","family":"Kondracki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Fr\u0105szczak","sequence":"additional","affiliation":[{"name":"Department of Oncological Gynecology and Gynecology, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-3302","authenticated-orcid":false,"given":"Anna","family":"Oniszczuk","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-8078","authenticated-orcid":false,"given":"Magda","family":"Rybak-Krzyszkowska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Perinatology, University Hospital, 31-501 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-7167","authenticated-orcid":false,"given":"Jakub","family":"Staniczek","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Gynecologic Oncology, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7591-5887","authenticated-orcid":false,"given":"Agata","family":"Filip","sequence":"additional","affiliation":[{"name":"Department of Cancer Genetics with Cytogenetic Laboratory, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kwa\u015bniewska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e186041","DOI":"10.1155\/2013\/186041","article-title":"Circulating C19MC MicroRNAs in Preeclampsia, Gestational Hypertension, and Fetal Growth Restriction","volume":"2013","author":"Hromadnikova","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_2","unstructured":"\u0160pa\u010dkov\u00e1, K. (2019). First-Trimester Screening of Pregnancy-Related Complications Using Plasma Exosomal C19MC MicroRNAs. [Ph.D. Thesis, Department of Anthropology and Human Genetics, Faculty of Science, Charles University]."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ali, A., Hadlich, F., Abbas, M.W., Iqbal, M.A., Tesfaye, D., Bouma, G.J., Winger, Q.A., and Ponsuksili, S. (2021). MicroRNA\u2013MRNA Networks in Pregnancy Complications: A Comprehensive Downstream Analysis of Potential Biomarkers. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052313"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1038\/s41598-017-04468-0","article-title":"Syncytiotrophoblast Derived Extracellular Vesicles Transfer Functional Placental MiRNAs to Primary Human Endothelial Cells","volume":"7","author":"Cronqvist","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.preghy.2019.11.003","article-title":"Expression Profiles of Candidate MicroRNAs in the Peripheral Blood Leukocytes of Patients with Early- and Late-Onset Preeclampsia versus Normal Pregnancies","volume":"19","author":"Demirer","year":"2020","journal-title":"Pregnancy Hypertens."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"He, X., and Ding, D.-N. (2022). Expression and Clinical Significance of MiR-204 in Patients with Hypertensive Disorder Complicating Pregnancy. BMC Pregnancy Childbirth, 22.","DOI":"10.1186\/s12884-022-04501-9"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.clinbiochem.2020.02.012","article-title":"Placenta-Specific Plasma MiR518b Is a Potential Biomarker for Preeclampsia","volume":"79","author":"Jelena","year":"2020","journal-title":"Clin. Biochem."},{"key":"ref_8","first-page":"7288","article-title":"The Predictive Value of MicroRNA in Early Hypertensive Disorder Complicating Pregnancy (HDCP)","volume":"13","author":"Jin","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12986-020-00475-7","article-title":"Maternal Obesity Alters C19MC MicroRNAs Expression Profile in Fetal Umbilical Cord Blood","volume":"17","author":"Jing","year":"2020","journal-title":"Nutr. Metab."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e002703","DOI":"10.1136\/bmjdrc-2021-002703","article-title":"First Trimester Plasma MicroRNAs Levels Predict Matsuda Index-Estimated Insulin Sensitivity between 24th and 29th Week of Pregnancy","volume":"10","author":"Poirier","year":"2022","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1161\/HYPERTENSIONAHA.119.14081","article-title":"Unique MicroRNA Signals in Plasma Exosomes from Pregnancies Complicated by Preeclampsia","volume":"75","author":"Li","year":"2020","journal-title":"Hypertension"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/jcp.27291","article-title":"Roles of MicroRNAs in Preeclampsia","volume":"234","author":"Lv","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/jog.12749","article-title":"Circulating Chromosome 19 MiRNA Cluster MicroRNAs in Pregnant Women with Severe Pre-Eclampsia","volume":"41","author":"Miura","year":"2015","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Munjas, J., Sopi\u0107, M., Stefanovi\u0107, A., Ko\u0161ir, R., Nini\u0107, A., Joksi\u0107, I., Antoni\u0107, T., Spasojevi\u0107-Kalimanovska, V., and Prosenc Zmrzljak, U. (2021). Non-Coding RNAs in Preeclampsia\u2014Molecular Mechanisms and Diagnostic Potential. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910652"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/jog.13610","article-title":"Reference Values for Circulating Pregnancy-Associated MicroRNAs in Maternal Plasma and Their Clinical Usefulness in Uncomplicated Pregnancy and Hypertensive Disorder of Pregnancy","volume":"44","author":"Murakami","year":"2018","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3892\/ijmm.2020.4626","article-title":"Placental Exosomes Isolated from Urine of Patients with Gestational Diabetes Exhibit a Differential Profile Expression of MicroRNAs across Gestation","volume":"46","author":"Noyola","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1007\/s43032-021-00799-6","article-title":"The Value of Circulating MicroRNAs for Diagnosis and Prediction of Preeclampsia: A Meta-Analysis and Systematic Review","volume":"29","author":"Qin","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100013","DOI":"10.1016\/j.xcrm.2020.100013","article-title":"Discovery and Verification of Extracellular MiRNA Biomarkers for Non-Invasive Prediction of Pre-Eclampsia in Asymptomatic Women","volume":"1","author":"Srinivasan","year":"2020","journal-title":"Cell Rep. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.tjog.2014.03.001","article-title":"Potential Role of Circulating MicroRNAs as Early Markers of Preeclampsia","volume":"53","author":"Ura","year":"2014","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"18077","DOI":"10.1038\/s41598-020-73783-w","article-title":"MicroRNAs 363 and 149 Are Differentially Expressed in the Maternal Circulation Preceding a Diagnosis of Preeclampsia","volume":"10","author":"Whigham","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Wommack, J.C., Trzeciakowski, J.P., Miranda, R.C., Stowe, R.P., and Ruiz, R.J. (2018). Micro RNA Clusters in Maternal Plasma Are Associated with Preterm Birth and Infant Outcomes. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0199029"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1101\/sqb.2016.81.030932","article-title":"Discovery of Double-Stranded Genomic DNA in Circulating Exosomes","volume":"81","author":"Kalluri","year":"2016","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by Extracellular Vesicles: Where We Are and Where We Need to Go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8009","DOI":"10.2147\/IJN.S142732","article-title":"Placenta-Derived Exosomes: Potential Biomarkers of Preeclampsia","volume":"12","author":"Pillay","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.1038\/emm.2016.153","article-title":"Exosome-Derived MicroRNAs in Cancer Metabolism: Possible Implications in Cancer Diagnostics and Therapy","volume":"49","author":"Tomasetti","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/14737159.2018.1480939","article-title":"MiRNAs in Pregnancy-Related Complications: An Update","volume":"18","author":"Mavreli","year":"2018","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12964-022-00853-z","article-title":"The Implications of Exosomes in Pregnancy: Emerging as New Diagnostic Markers and Therapeutics Targets","volume":"20","author":"Ghafourian","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"103780","DOI":"10.1016\/j.ebiom.2021.103780","article-title":"Clinical Tools and Biomarkers to Predict Preeclampsia","volume":"75","author":"MacDonald","year":"2022","journal-title":"eBioMedicine"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Czernek, L., and D\u00fcchler, M. (2020). Exosomes as Messengers between Mother and Fetus in Pregnancy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124264"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1089\/gtmb.2019.0264","article-title":"Diagnostic Potential of MicroRNAs as Biomarkers in the Detection of Preeclampsia","volume":"24","author":"Hornakova","year":"2020","journal-title":"Genet. Test. Mol. 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