{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:59:57Z","timestamp":1774976397770,"version":"3.50.1"},"reference-count":20,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Post-transplant lymphoproliferative disorders (PTLD) are rare immunosuppression complications affecting 5% of transplant patients. Isolated central nervous system (CNS)-PTLD without nodal or extra-nodal organ involvement is rarely reported and is difficult to diagnose due to the non-specific clinical manifestations and imaging features overlapping with other common CNS lesions. Case presentation: We present a case of a 72-year-old female subjected to a renal transplant 11 years ago with progressively worsening headaches and confusion. Imaging revealed vasogenic edema in the left frontal and bilateral temporal lobes. She was subjected to a craniotomy and excisional biopsy to obtain tissue for diagnostic and therapeutic interventions. Pathology examination showed atypical EBV-positive lymphoplasmacytic infiltrate, consistent with Polymorphic type PTLD. Conclusions: Patients diagnosed with PTLD need to have close monitoring of immunosuppressive medications while in the hospital. Early diagnosis is essential for patient survival with PTLD, as their health can deteriorate fast.<\/jats:p>","DOI":"10.3390\/jcm11237058","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T07:10:27Z","timestamp":1669792227000},"page":"7058","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant"],"prefix":"10.3390","volume":"11","author":[{"given":"Austin","family":"Feindt","sequence":"first","affiliation":[{"name":"School of Medicine, University of South Florida School of Medicine, 12901 Bruce B Downs Blvd., Tampa, FL 33612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Lara-Velazquez","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Florida College of Medicine, 653-1 8th St. W, Jacksonville, FL 32209, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Alkhasawneh","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Florida College of Medicine, 8th St. W, Jacksonville, FL 32209, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Florida College of Medicine, 8th St. W, Jacksonville, FL 32209, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8560-035X","authenticated-orcid":false,"given":"Raafat","family":"Makary","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Florida College of Medicine, 8th St. W, Jacksonville, FL 32209, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Dombrowski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brain Repair, USF Health, 2 Tampa General Cir, Tampa, FL 33606, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daryoush","family":"Tavanaiepour","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Florida College of Medicine, 653-1 8th St. W, Jacksonville, FL 32209, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gazanfar","family":"Rahmathulla","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Florida College of Medicine, 653-1 8th St. W, Jacksonville, FL 32209, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/modpathol.3880218","article-title":"Microsatellite analysis in post-transplantation lymphoproliferative disorder to determine donor\/recipient origin","volume":"13","author":"Ng","year":"2000","journal-title":"Mod. 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