{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:09:06Z","timestamp":1791090546244,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81773322"],"award-info":[{"award-number":["81773322"]}]},{"name":"National Natural Science Foundation of China","award":["82173420"],"award-info":[{"award-number":["82173420"]}]},{"name":"National Natural Science Foundation of China","award":["81673054"],"award-info":[{"award-number":["81673054"]}]},{"name":"National Natural Science Foundation of China","award":["81673073"],"award-info":[{"award-number":["81673073"]}]},{"name":"National Natural Science Foundation of China","award":["81974471"],"award-info":[{"award-number":["81974471"]}]},{"name":"National Natural Science Foundation of China","award":["13JC1402300"],"award-info":[{"award-number":["13JC1402300"]}]},{"name":"National Natural Science Foundation of China","award":["SHDC2020CR6022"],"award-info":[{"award-number":["SHDC2020CR6022"]}]},{"name":"National Natural Science Foundation of China","award":["SHDC2020CR1014B"],"award-info":[{"award-number":["SHDC2020CR1014B"]}]},{"name":"National Natural Science Foundation of China","award":["SHDC22022302"],"award-info":[{"award-number":["SHDC22022302"]}]},{"name":"Key Project in Basic Research Advocated by the Shanghai Science and Technology Commission","award":["81773322"],"award-info":[{"award-number":["81773322"]}]},{"name":"Key Project in Basic Research Advocated by the Shanghai Science and Technology Commission","award":["82173420"],"award-info":[{"award-number":["82173420"]}]},{"name":"Key Project in Basic Research Advocated by the Shanghai Science and Technology Commission","award":["81673054"],"award-info":[{"award-number":["81673054"]}]},{"name":"Key Project in Basic Research Advocated by the Shanghai Science and Technology Commission","award":["81673073"],"award-info":[{"award-number":["81673073"]}]},{"name":"Key Project in Basic Research Advocated by the Shanghai Science and Technology Commission","award":["81974471"],"award-info":[{"award-number":["81974471"]}]},{"name":"Key Project in Basic Research Advocated by the Shanghai Science and Technology Commission","award":["13JC1402300"],"award-info":[{"award-number":["13JC1402300"]}]},{"name":"Key Project in Basic Research Advocated by the Shanghai Science and Technology Commission","award":["SHDC2020CR6022"],"award-info":[{"award-number":["SHDC2020CR6022"]}]},{"name":"Key Project in Basic Research Advocated by the Shanghai Science and Technology Commission","award":["SHDC2020CR1014B"],"award-info":[{"award-number":["SHDC2020CR1014B"]}]},{"name":"Key Project in Basic Research Advocated by the Shanghai Science and Technology Commission","award":["SHDC22022302"],"award-info":[{"award-number":["SHDC22022302"]}]},{"name":"Clinical Research Plan of SHDC","award":["81773322"],"award-info":[{"award-number":["81773322"]}]},{"name":"Clinical Research Plan of SHDC","award":["82173420"],"award-info":[{"award-number":["82173420"]}]},{"name":"Clinical Research Plan of SHDC","award":["81673054"],"award-info":[{"award-number":["81673054"]}]},{"name":"Clinical Research Plan of SHDC","award":["81673073"],"award-info":[{"award-number":["81673073"]}]},{"name":"Clinical Research Plan of SHDC","award":["81974471"],"award-info":[{"award-number":["81974471"]}]},{"name":"Clinical Research Plan of SHDC","award":["13JC1402300"],"award-info":[{"award-number":["13JC1402300"]}]},{"name":"Clinical Research Plan of SHDC","award":["SHDC2020CR6022"],"award-info":[{"award-number":["SHDC2020CR6022"]}]},{"name":"Clinical Research Plan of SHDC","award":["SHDC2020CR1014B"],"award-info":[{"award-number":["SHDC2020CR1014B"]}]},{"name":"Clinical Research Plan of SHDC","award":["SHDC22022302"],"award-info":[{"award-number":["SHDC22022302"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Annexin A6 (AnxA6) is a lipid-binding protein that regulates cholesterol homeostasis and secretory pathways. However, the correlation of AnxA6 polymorphism with lipometabolism has never been studied in psoriasis. Objectives: To investigate the impact of AnxA6 polymorphism on lipid profiles and the expression of AnxA6 protein in both peripheral blood mononuclear cells (PBMCs) and lipometabolism in psoriasis. Methods: A total of 265 psoriatic patients received methotrexate (MTX) treatment for 12 weeks, after which their lipid profiles were determined by measuring total cholesterol (TC), triglycerides (TGs), lipoprotein (a) [LP(a)], high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL), apolipoprotein (a)1 (ApoA1), and apolipoprotein B (ApoB). In addition, AnxA6 (rs11960458) was genotyped in 262 patients and the expression of AnxA6 in PBMCs was measured by Western blotting at baseline and week 8 post-MTX treatment. Results: The CC genotype carriers of rs11960458 had a lower expression of AnxA6 and lower levels of the pro-atherogenic lipids TC, LDL, and ApoB compared to TC genotype carriers. MTX significantly downregulated the levels of the anti-atherogenic lipids HDL-C and ApoA1 and the level of AnxA6 in TC genotype carriers, as well as the level of TGs in CC genotype carriers. Conclusions: The polymorphism of AnxA6, rs11960458, was statistically associated with the levels of pro-atherogenic lipids and with the downregulation of MTX on the levels of anti-atherogenic lipids and TGs in psoriasis.<\/jats:p>","DOI":"10.3390\/jcm11237059","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T07:10:27Z","timestamp":1669792227000},"page":"7059","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Annexin A6 Polymorphism Is Associated with Pro-atherogenic Lipid Profiles and with the Downregulation of Methotrexate on Anti-Atherogenic Lipid Profiles in Psoriasis"],"prefix":"10.3390","volume":"11","author":[{"given":"Fuxin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0024-338X","authenticated-orcid":false,"given":"Nikhil","family":"Yawalkar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, CH-3000 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-7022","authenticated-orcid":false,"given":"Zhenghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1295-2626","authenticated-orcid":false,"given":"Kexiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jdv.13854","article-title":"A systematic review of worldwide epidemiology of psoriasis","volume":"31","author":"Michalek","year":"2017","journal-title":"J. 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