{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:35:18Z","timestamp":1762076118915,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Perforation of the ileum in the antepartum period resulting in meconial peritonitis is a condition that, although rare, is burdened by several complications. In 80\u201390% of cases, meconial ileus is the first manifestation of a disease, cystic fibrosis. In the remaining 10\u201320% of cases, it is caused by other situations, such as prematurity. In most cases, the diagnosis of meconial ileus occurs after birth, although in some cases it can be suspected prenatally, with the finding of a hyperechoic intestine on second trimester ultrasound. The prognosis depends on the gestational age, the location of the obstruction and the presence of fetal abnormalities. Mortality is very high and the recovery of intestinal function in the postoperative course is very high risk. In this case series, we describe two meconial peritonitis and our experience at the center.<\/jats:p>","DOI":"10.3390\/jcm11237127","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T09:18:36Z","timestamp":1669799916000},"page":"7127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Series of Acute Meconium Peritonitis Secondary to Perforation of the Ileum in the Antepartum Period"],"prefix":"10.3390","volume":"11","author":[{"given":"Maria","family":"Piccioni","sequence":"first","affiliation":[{"name":"Department of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico, 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-8308","authenticated-orcid":false,"given":"Lucia","family":"Merlino","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico, 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"D\u2019Ovidio","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico, 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-4073","authenticated-orcid":false,"given":"Federica","family":"Del Prete","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico, 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico, 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2042-7971","authenticated-orcid":false,"given":"Lucia","family":"Petrivelli","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico, 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8187-3580","authenticated-orcid":false,"given":"Flaminia","family":"Vena","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico, 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"D\u2019Ambrosio","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico, 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Giancotti","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico, 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Brunelli","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico, 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1148\/radiology.165.3.3317498","article-title":"Meconium peritonitis: Prenatal sonographic findings and their clinical significance","volume":"165","author":"Foster","year":"1987","journal-title":"Radiology"},{"key":"ref_2","first-page":"89","article-title":"Meconium peritonitis; changes in fetal C-reactive protein and CA 125 levels in relation to stage of disease","volume":"162","author":"Ohmichi","year":"1997","journal-title":"J. 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