{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:53:22Z","timestamp":1762077202111,"version":"build-2065373602"},"reference-count":62,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","award":["413635475"],"award-info":[{"award-number":["413635475"]}]},{"name":"Munich Clinician Scientist Program (MCSP) of the Ludwig Maximilians University Munich","award":["413635475"],"award-info":[{"award-number":["413635475"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Subjects conceived through assisted reproductive technologies (ART) potentially suffer from impaired left ventricular (LV) function due to premature vascular aging. This study aimed to evaluate whether subtle differences in LV diastolic function can be observed echocardiographically between young ART subjects and their spontaneously conceived peers. The echocardiographic assessment included the measurement of LV dimensions, mitral inflow velocities, and myocardial velocity at early diastole (E\u2019, cm\/s) at the LV wall and the interventricular septum (IVS). An average from E\/E\u2019LV and E\/E\u2019IVS (E\/E\u2019AVG) was derived. In total, 66 ART subjects and 83 controls (12.85 \u00b1 5.80 years vs. 13.25 \u00b1 5.89 years, p = 0.677) were included. The ART subjects demonstrated a significantly lower E\u2019LV (19.29 \u00b1 3.29 cm\/s vs. 20.67 \u00b1 3.78 cm\/s, p = 0.020) compared to their spontaneously conceived peers. Study participants of \u2265 10 years of age displayed a significantly higher E\/E\u2019AVG (6.50 \u00b1 0.97 vs. 6.05 \u00b1 0.99, p = 0.035) within the ART cohort. The results of this study demonstrate a significantly lower LV diastolic function in the ART subjects. However, no significant changes in LV diastolic function were observed between the two groups when the results were adjusted for age, birth weight percentile, and gestational age. Those ART subjects born preterm might have an elevated risk of developing LV diastolic alterations and could therefore profit from close echocardiographic monitoring.<\/jats:p>","DOI":"10.3390\/jcm11237128","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T02:24:46Z","timestamp":1669861486000},"page":"7128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies"],"prefix":"10.3390","volume":"11","author":[{"given":"Franziska","family":"Sciuk","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0452-1148","authenticated-orcid":false,"given":"Theresa","family":"Vilsmaier","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Kramer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Langer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Kolbinger","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"},{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengzhu","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3580-2268","authenticated-orcid":false,"given":"Andr\u00e9","family":"Jakob","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Rogenhofer","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Dalla-Pozza","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Thaler","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus Alexander","family":"Haas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix Sebastian","family":"Oberhoffer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Marchioninistra\u00dfe 15, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/humupd\/dmv016","article-title":"Infertility around the globe: New thinking on gender, reproductive technologies and global movements in the 21st century","volume":"21","author":"Inhorn","year":"2015","journal-title":"Hum. 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