{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:14:05Z","timestamp":1774584845708,"version":"3.50.1"},"reference-count":80,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education and Science (Poland)","award":["SKN\/SP\/496681\/2021"],"award-info":[{"award-number":["SKN\/SP\/496681\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Obstructive sleep apnea (OSA) is a disorder that, apart from somatic sequelae, increases the risk of developing psychiatric conditions. Brain-derived neurotrophic factor (BDNF) signaling pathway is involved in the pathophysiology of depression and insomnia. Therefore, the study aimed to investigate differences in concentrations of BDNF and proBDNF in patients with OSA and healthy individuals, to evaluate diurnal changes of these proteins, and to assess the correlations with psychiatric symptoms. Methods: Sixty individuals following polysomnography (PSG) were divided into two groups based on the apnea-hypopnea index (AHI): OSA patients (AHI \u2265 30; n = 30) and control group (AHI &lt; 5; n = 30). Participants filled out questionnaires: Beck Depression Inventory (BDI), Athens Insomnia Scale (AIS), and Pittsburgh Sleep Quality Index (PSQI). Peripheral blood was collected before and after PSG. Protein concentrations were measured using ELISA. OSA group was divided into subgroups: AIS (\u2212)\/AIS (+) (AIS &gt; 5), PSQI (\u2212)\/PSQI (+) (PSQI &gt; 5), and BDI (\u2212)\/BDI (+) (BDI &gt; 19). Results: No differences in BDNF and proBDNF protein levels were observed between OSA and the control groups. However, BDNF and proBDNF evening protein concentrations were higher in the AIS (+) and PSQI (+) groups (p &lt; 0.001 for all). The BDI (+) group was characterized by lower morning levels of both proteins (p = 0.047 and p = 0.003, respectively). Conclusions: BDNF signaling pathway might be involved in the pathophysiology of depression and insomnia in patients with OSA. BDNF and proBDNF protein levels might be useful in defining OSA phenotypes.<\/jats:p>","DOI":"10.3390\/jcm11237135","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T02:24:46Z","timestamp":1669861486000},"page":"7135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["BDNF and proBDNF Serum Protein Levels in Obstructive Sleep Apnea Patients and Their Involvement in Insomnia and Depression Symptoms"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-6488","authenticated-orcid":false,"given":"Agata","family":"Gabryelska","sequence":"first","affiliation":[{"name":"Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-8742","authenticated-orcid":false,"given":"Szymon","family":"Turkiewicz","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ditmer","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-6804","authenticated-orcid":false,"given":"Filip Franciszek","family":"Karuga","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8559-1078","authenticated-orcid":false,"given":"Dominik","family":"Strzelecki","sequence":"additional","affiliation":[{"name":"Department of Affective and Psychotic Disorders, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Bia\u0142asiewicz","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2122-0304","authenticated-orcid":false,"given":"Marcin","family":"Sochal","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1001\/jama.2020.3514","article-title":"Diagnosis and Management of Obstructive Sleep Apnea: A Review","volume":"323","author":"Gottlieb","year":"2020","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hosseini, H., Homayouni-Tabrizi, M., Amiri, H., Safari-Faramani, R., Moradi, M.-T., Fadaei, R., and Khazaie, H. (2022). The effect of continuous positive airway pressure on total antioxidant capacity in obstructive sleep apnea: A systematic review and meta-analysis. Sleep Breath.","DOI":"10.1007\/s11325-022-02733-9"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Gabryelska, A., Chrzanowski, J., Sochal, M., Kaczmarski, P., Turkiewicz, S., Ditmer, M., Karuga, F.F., Czupryniak, L., and Bia\u0142asiewicz, P. (2021). Nocturnal Oxygen Saturation Parameters as Independent Risk Factors for Type 2 Diabetes Mellitus among Obstructive Sleep Apnea Patients. J. Clin. Med., 10.","DOI":"10.1183\/23120541.sleepandbreathing-2021.66"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: THE HypnoLaus study","volume":"3","author":"Heinzer","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e010440","DOI":"10.1161\/JAHA.118.010440","article-title":"Obstructive Sleep Apnea in Cardiovascular Disease: A Review of the Literature and Proposed Multidisciplinary Clinical Management Strategy","volume":"8","author":"Tietjens","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000988","article-title":"Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association","volume":"144","author":"Yeghiazarians","year":"2021","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.chest.2017.05.009","article-title":"Obstructive Sleep Apnea and Diabetes: A State of the Art Review","volume":"152","author":"Reutrakul","year":"2017","journal-title":"Chest"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.11622\/smedj.2017027","article-title":"Obstructive sleep apnoea and Type 2 diabetes mellitus: Are they connected?","volume":"58","author":"Mok","year":"2017","journal-title":"Singap. Med. J."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ditmer, M., Gabryelska, A., Turkiewicz, S., Bia\u0142asiewicz, P., Ma\u0142ecka-Wojciesko, E., and Sochal, M. (2021). Sleep Problems in Chronic Inflammatory Diseases: Prevalence, Treatment, and New Perspectives: A Narrative Review. J. Clin. Med., 11.","DOI":"10.3390\/jcm11010067"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.5664\/jcsm.6908","article-title":"Patients With Obstructive Sleep Apnea Are Over Four Times More Likely to Suffer From Psoriasis Than the General Population","volume":"14","author":"Gabryelska","year":"2018","journal-title":"J. Clin. Sleep Med."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kuna, K., Szewczyk, K., Gabryelska, A., Bia\u0142asiewicz, P., Ditmer, M., Strzelecki, D., and Sochal, M. (2022). Potential Role of Sleep Deficiency in Inducing Immune Dysfunction. Biomedicines, 10.","DOI":"10.3390\/biomedicines10092159"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.sleep.2012.03.002","article-title":"Obstructive sleep apnea and the risk of autoimmune diseases: A longitudinal population-based study","volume":"13","author":"Kang","year":"2012","journal-title":"Sleep Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1378\/chest.12-1219","article-title":"Genetic and immunologic aspects of sleep and sleep disorders","volume":"143","author":"Parish","year":"2013","journal-title":"Chest"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/MCP.0000000000000915","article-title":"More than sleepiness: Prevalence and relevance of nonclassical symptoms of obstructive sleep apnea","volume":"28","author":"Verbraecken","year":"2022","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Gabryelska, A., Sochal, M., Wasik, B., Szczepanowski, P., and Bia\u0142asiewicz, P. (2021). Factors Affecting Long-Term Compliance of CPAP Treatment\u2014A Single Centre Experience. J. Clin. Med., 11.","DOI":"10.3390\/jcm11010139"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"196","DOI":"10.5664\/jcsm.27772","article-title":"Comorbid insomnia and obstructive sleep apnea: Challenges for clinical practice and research","volume":"6","author":"Luyster","year":"2010","journal-title":"J. Clin. sleep Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.sleep.2019.01.004","article-title":"Short-term CPAP adherence in obstructive sleep apnea: A big data analysis using real world data","volume":"59","author":"Cistulli","year":"2019","journal-title":"Sleep Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2101958","DOI":"10.1183\/13993003.01958-2021","article-title":"Comorbid insomnia and sleep apnoea is associated with all-cause mortality","volume":"60","author":"Lechat","year":"2022","journal-title":"Eur. Respir. J."},{"key":"ref_19","first-page":"00012","article-title":"Depression, Obstructive Sleep Apnea and Psychosocial Health","volume":"1","author":"Jehan","year":"2017","journal-title":"Sleep Med. Disord. Int. J."},{"key":"ref_20","first-page":"46","article-title":"Increased Suicidality and Worse Outcomes in MDD Patients With OSA: A Nationwide Inpatient Analysis of 11 Years From 2006 to 2017","volume":"63","author":"Reddy","year":"2022","journal-title":"J. Acad. Consult. Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sochal, M., Ditmer, M., Gabryelska, A., and Bia\u0142asiewicz, P. (2022). The Role of Brain-Derived Neurotrophic Factor in Immune-Related Diseases: A Narrative Review. J. Clin. Med., 11.","DOI":"10.3390\/jcm11206023"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jpsychires.2022.10.022","article-title":"Effects of brain-derived neurotrophic factor (BDNF) on the Schizophrenia model of animals","volume":"156","author":"Shi","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"114857","DOI":"10.1016\/j.psychres.2022.114857","article-title":"Brain-Derived Neurotrophic Factor (BDNF) as a biomarker of treatment response in patients with Treatment Resistant Depression (TRD): A systematic review & meta-analysis","volume":"317","author":"Meshkat","year":"2022","journal-title":"Psychiatry Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"136805","DOI":"10.1016\/j.neulet.2022.136805","article-title":"Impact of sleep disorders and disease duration on neurotrophins levels in cocaine use disorder","volume":"786","author":"Miuli","year":"2022","journal-title":"Neurosci. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"103318","DOI":"10.1016\/j.drudis.2022.07.003","article-title":"Neurotrophin-targeted therapeutics: A gateway to cognition and more?","volume":"27","author":"Nordvall","year":"2022","journal-title":"Drug Discov. Today"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/aps.2011.184","article-title":"Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: A role for brain-derived neurotrophic factor","volume":"33","author":"Xie","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"R199","DOI":"10.1152\/ajpregu.00422.2014","article-title":"The truncated TrkB receptor influences mammalian sleep","volume":"308","author":"Watson","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biopsych.2021.05.008","article-title":"Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action","volume":"90","author":"Monteggia","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e13978","DOI":"10.1111\/nmo.13978","article-title":"Brain-derived neurotrophic factor is elevated in the blood serum of Crohn\u2019s disease patients, but is not influenced by anti-TNF-\u03b1 treatment\u2014A pilot study","volume":"33","author":"Sochal","year":"2021","journal-title":"Neurogastroenterol. Motil. Off. J. Eur. Gastrointest. Motil. Soc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s11325-010-0415-7","article-title":"Effects of obstructive sleep apnea on serum brain-derived neurotrophic factor protein, cortisol, and lipid levels","volume":"15","author":"Panaree","year":"2011","journal-title":"Sleep Breath."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"zsz145","DOI":"10.1093\/sleep\/zsz145","article-title":"Effect of continuous positive airway pressure on inflammatory, antioxidant, and depression biomarkers in women with obstructive sleep apnea: A randomized controlled trial","volume":"42","author":"Troncoso","year":"2019","journal-title":"Sleep"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.sleep.2021.11.018","article-title":"Inflammatory markers and BDNF in obstructive sleep apnea (OSA) in Parkinson\u2019s disease (PD)","volume":"90","author":"Kaminska","year":"2022","journal-title":"Sleep Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Flores, K.R., Viccaro, F., Aquilini, M., Scarpino, S., Ronchetti, F., Mancini, R., Di Napoli, A., Scozzi, D., and Ricci, A. (2020). Protective role of brain derived neurotrophic factor (BDNF) in obstructive sleep apnea syndrome (OSAS) patients. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0227834"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"479","DOI":"10.5664\/jcsm.6506","article-title":"Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: An American academy of sleep medicine clinical practice guideline","volume":"13","author":"Kapur","year":"2017","journal-title":"J. Clin. Sleep Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s41105-021-00324-x","article-title":"Sleep quality according to the Pittsburgh Sleep Quality Index in over 7000 pregnant women in Poland","volume":"19","author":"Smyka","year":"2021","journal-title":"Sleep Biol. Rhythm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0022-3999(02)00330-6","article-title":"Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia","volume":"53","author":"Backhaus","year":"2002","journal-title":"J. Psychosom. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/5584_2019_345","article-title":"Sleep disorders and adherence to inhalation therapy in patients with chronic obstructive pulmonary disease","volume":"1160","author":"Chabowski","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.smrv.2015.01.009","article-title":"The Pittsburgh sleep quality index as a screening tool for sleep dysfunction in clinical and non-clinical samples: A systematic review and meta-analysis","volume":"25","author":"Mollayeva","year":"2016","journal-title":"Sleep Med. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.2147\/NDT.S136868","article-title":"Sleep disturbances among patients with epilepsy","volume":"13","author":"Staniszewska","year":"2017","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S454","DOI":"10.1002\/acr.20556","article-title":"Measures of depression and depressive symptoms: Beck Depression Inventory-II (BDI-II), Center for Epidemiologic Studies Depression Scale (CES-D), Geriatric Depression Scale (GDS), Hospital Anxiety and Depression Scale (HADS), and Patient Health Questionn","volume":"63","author":"Smarr","year":"2011","journal-title":"Arthritis Care Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1007\/s10597-017-0188-6","article-title":"Predictors of Depression in Iranian Women with Polycystic Ovarian Syndrome","volume":"54","author":"Mirghafourvand","year":"2018","journal-title":"Community Ment. Health J."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Beck, A.T., Steer, R.A., and Brown, G. (1996). Beck depression inventory\u2013II. Psychol. Assess., Available online: http:\/\/www.nctsn.org\/content\/beck-depression-inventory-second-edition-bdi-ii.","DOI":"10.1037\/t00742-000"},{"key":"ref_43","first-page":"e2344","article-title":"Psychometric characteristics of Beck depression inventory\u2013II in patients with major depressive disorder","volume":"11","author":"Dabson","year":"2007","journal-title":"Brain Behav."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.yebeh.2017.09.023","article-title":"Validation of the Polish version of the Beck Depression Inventory in patients with epilepsy","volume":"77","author":"Wiglusz","year":"2017","journal-title":"Epilepsy Behav."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.pcd.2020.05.015","article-title":"Cut-off points for Polish-language versions of depression screening tools among patients with Type 2 diabetes","volume":"14","author":"Kokoszka","year":"2020","journal-title":"Prim. Care Diabetes"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0022-3999(00)00095-7","article-title":"Athens Insomnia Scale: Validation of an instrument based on ICD-10 criteria","volume":"48","author":"Soldatos","year":"2000","journal-title":"J. Psychosom. Res."},{"key":"ref_47","first-page":"211","article-title":"Validation of the Polish version of the Athens Insomnia Scale","volume":"45","author":"Szelenberger","year":"2011","journal-title":"Psychiatr. Pol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s11325-021-02400-5","article-title":"7,8-Dihydroxyflavone protects retinal ganglion cells against chronic intermittent hypoxia-induced oxidative stress damage via activation of the BDNF\/TrkB signaling pathway","volume":"26","author":"Fang","year":"2022","journal-title":"Sleep Breath."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"117573","DOI":"10.1016\/j.lfs.2020.117573","article-title":"Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia","volume":"250","author":"An","year":"2020","journal-title":"Life Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41401-019-0323-8","article-title":"Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea","volume":"41","author":"Yang","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_51","first-page":"546","article-title":"Chronic intermittent hypoxia affects endogenous serotonergic inputs and expression of synaptic proteins in rat hypoglossal nucleus","volume":"9","author":"Wu","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3760\/cma.j.issn.0366-6999.20131683","article-title":"Intermittent hypoxia with or without hypercapnia is associated with tumorigenesis by decreasing the expression of brain derived neurotrophic factor and miR-34a in rats","volume":"127","author":"Zhang","year":"2014","journal-title":"Chin. Med. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.nbd.2010.05.020","article-title":"Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity","volume":"40","author":"Xie","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1080\/00207454.2020.1766460","article-title":"mTOR\/NF-\u03baB signaling pathway protects hippocampal neurons from injury induced by intermittent hypoxia in rats","volume":"131","author":"Zhang","year":"2021","journal-title":"Int. J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Turkiewicz, S., Ditmer, M., Sochal, M., Bia\u0142asiewicz, P., Strzelecki, D., and Gabryelska, A. (2021). Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212536"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.brainres.2008.07.039","article-title":"Brain-derived neurotrophic factor (BDNF) and TrkB in the piglet brainstem after post-natal nicotine and intermittent hypercapnic hypoxia","volume":"1232","author":"Tang","year":"2008","journal-title":"Brain Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"835515","DOI":"10.3389\/fmed.2021.835515","article-title":"The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity","volume":"8","author":"Makhout","year":"2022","journal-title":"Front. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e13035","DOI":"10.1111\/jsr.13035","article-title":"Interleukin 6 as a marker of depression in women with sleep apnea","volume":"30","author":"Gozal","year":"2021","journal-title":"J. Sleep Res."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Gabryelska, A., and Sochal, M. (2022). Evaluation of HIF-1 Involvement in the BDNF and ProBDNF Signaling Pathways among Obstructive Sleep Apnea Patients. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314876"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/lio2.225","article-title":"Neurotrophic factor BDNF is upregulated in soft palate muscles of snorers and sleep apnea patients","volume":"4","author":"Shah","year":"2019","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1164\/ajrccm.164.2.2105010c","article-title":"Upper airway nerve lesions in obstructive sleep apnea","volume":"164","author":"Svanborg","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.chest.2018.06.017","article-title":"Axon and Schwann Cell Degeneration in Nerves of Upper Airway Relates to Pharyngeal Dysfunction in Snorers and Patients With Sleep Apnea","volume":"154","author":"Shah","year":"2018","journal-title":"Chest"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/lio2.683","article-title":"The evaluation of serum brain-derived neurotrophic factor and neurofilament light chain levels in patients with obstructive sleep apnea syndrome","volume":"6","author":"Arslan","year":"2021","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"zsaa147","DOI":"10.1093\/sleep\/zsaa147","article-title":"Decrease in sleep depth is associated with higher cerebrospinal fluid neurofilament light levels in patients with Alzheimer\u2019s disease","volume":"44","author":"Targa","year":"2021","journal-title":"Sleep"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"158","DOI":"10.20452\/pamw.15220","article-title":"Serum hypoxia-inducible factor-1\u03b1 protein level as a diagnostic marker of obstructive sleep apnea","volume":"130","author":"Gabryelska","year":"2020","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.5664\/jcsm.8682","article-title":"Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1\u03b1 protein","volume":"16","author":"Gabryelska","year":"2020","journal-title":"J. Clin. sleep Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e12995","DOI":"10.1111\/jsr.12995","article-title":"Influence of one-night CPAP therapy on the changes of HIF-1\u03b1 protein in OSA patients\u2014A pilot study","volume":"29","author":"Gabryelska","year":"2020","journal-title":"J. Sleep Res."},{"key":"ref_68","first-page":"47","article-title":"Potential inflammatory markers in obstructive sleep apnea-hypopnea syndrome","volume":"17","author":"Lu","year":"2017","journal-title":"Bosn. J. basic Med. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1080\/00207454.2020.1746308","article-title":"The role of mTOR signalling pathway in hypoxia-induced cognitive impairment","volume":"131","author":"Qaid","year":"2021","journal-title":"Int. J. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12931-019-1033-y","article-title":"Altered irisin\/BDNF axis parallels excessive daytime sleepiness in obstructive sleep apnea patients","volume":"20","author":"More","year":"2019","journal-title":"Respir. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"zsy192","DOI":"10.1093\/sleep\/zsy192","article-title":"Objective sleep duration is associated with cognitive deficits in primary insomnia: BDNF may play a role","volume":"42","author":"Fan","year":"2019","journal-title":"Sleep"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jpsychires.2018.12.020","article-title":"Brain-derived neurotrophic factor is a biomarker for subjective insomnia but not objectively assessable poor sleep continuity","volume":"110","author":"Mikoteit","year":"2019","journal-title":"J. Psychiatr. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/mp.2013.10","article-title":"BDNF: An indicator of insomnia?","volume":"19","author":"Giese","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.psyneuen.2004.01.010","article-title":"Sleep disturbances are correlated with decreased morning awakening salivary cortisol","volume":"29","author":"Backhaus","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0165-1781(02)00249-4","article-title":"Nocturnal cortisol and melatonin secretion in primary insomnia","volume":"113","author":"Riemann","year":"2002","journal-title":"Psychiatry Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.5498\/wjp.v12.i9.1264","article-title":"Why do we not reverse the path? Stress can cause depression, reduction of brain-derived neurotrophic factor and increased inflammation","volume":"12","author":"Claro","year":"2022","journal-title":"World J. Psychiatry"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Gabryelska, A., Turkiewicz, S., Karuga, F.F., Sochal, M., Strzelecki, D., and Bia\u0142asiewicz, P. (2022). Disruption of Circadian Rhythm Genes in Obstructive Sleep Apnea Patients\u2014Possible Mechanisms Involved and Clinical Implication. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020709"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Gabryelska, A., Sochal, M., Turkiewicz, S., and Bia\u0142asiewicz, P. (2020). Relationship between HIF-1 and Circadian Clock Proteins in Obstructive Sleep Apnea Patients\u2014Preliminary Study. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051599"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/0748730417693124","article-title":"Circadian Rhythms in Plasma Brain-derived Neurotrophic Factor Differ in Men and Women","volume":"32","author":"Cain","year":"2017","journal-title":"J. Biol. Rhythm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.nbd.2013.08.016","article-title":"Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus","volume":"62","author":"Wall","year":"2014","journal-title":"Neurobiol. Dis."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/23\/7135\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:30:50Z","timestamp":1760146250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/23\/7135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":80,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["jcm11237135"],"URL":"https:\/\/doi.org\/10.3390\/jcm11237135","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,30]]}}}