{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:17:38Z","timestamp":1790536658315,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Tooth germ autotransplantation of open apices of the teeth exhibits high pulpal healing rates, whereas that of mature permanent teeth normally causes irreversible pulpal necrosis. Extraoral root-end resection (EORER) during transplantation may promote pulpal revascularization (PRV) in transplanted mature teeth and reduce endodontic treatment requirement. This study compared the primary outcomes of survival rates, PRV, and root resorption and determined relevant confounders in autotransplanted mature and immature teeth. The medical charts of consecutive patients who underwent tooth autotransplantation between January 2017 and March 2021 were evaluated. Teeth with a documented follow-up of at least 1 year were included. During the study period, 59 teeth were transplanted in 44 patients. Overall, 2 teeth were excluded owing to missing data; 57 teeth were analyzed, including 25 mature teeth additionally treated with EORER. After a mean follow-up of 21.2 \u00b1 16.1 months, no significant differences in primary outcomes were detected. Fifty-five teeth remained in situ (96.5%), and radiological signs of root resorption were detected in 9\/57 teeth (15.8%). PRV was positive in 54\/57 teeth (94.7%). Surgical duration and PRV failure were significantly associated with high incidences of root resorption. Mature teeth autotransplantation with EORER yielded similar results to immature teeth autotransplantation and is a feasible treatment option. Long surgery and failed revascularization increased root resorption rates. More factors should be evaluated in larger trials with longer observation periods.<\/jats:p>","DOI":"10.3390\/jcm11237199","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T06:29:09Z","timestamp":1670221749000},"page":"7199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Extraoral Root-End Resection May Promote Pulpal Revascularization in Autotransplanted Mature Teeth\u2014A Retrospective Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8031-7865","authenticated-orcid":false,"given":"Petra","family":"Rugani","sequence":"first","affiliation":[{"name":"Department of Dental Medicine and Oral Health, Division of Oral Surgery and Orthodontics, Medical University of Graz, Billrothgasse 4, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8944-3160","authenticated-orcid":false,"given":"Barbara","family":"Kirnbauer","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine and Oral Health, Division of Oral Surgery and Orthodontics, Medical University of Graz, Billrothgasse 4, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Mischak","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine and Oral Health, Division of Oral Surgery and Orthodontics, Medical University of Graz, Billrothgasse 4, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Ebeleseder","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine and Oral Health, Division of Oral Surgery and Orthodontics, Medical University of Graz, Billrothgasse 4, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Jakse","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine and Oral Health, Division of Oral Surgery and Orthodontics, Medical University of Graz, Billrothgasse 4, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.joms.2016.09.010","article-title":"Success rate of autotransplantation of teeth with an open apex: Systematic review and meta-analysis","volume":"75","author":"Abarca","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.surge.2012.10.003","article-title":"Developments in autotransplantation of teeth","volume":"11","author":"Cross","year":"2013","journal-title":"Surgeon"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.joen.2012.04.001","article-title":"Autotransplantation of a premolar: A long-term follow-up report of a clinical case","volume":"38","author":"Cardona","year":"2012","journal-title":"J. Endod."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.joen.2014.07.008","article-title":"Autogenous premolar transplantation into artificial socket in maxillary lateral incisor site","volume":"40","author":"Intra","year":"2014","journal-title":"J. Endod."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0266-4356(96)90374-5","article-title":"A clinical follow-up study of 278 autotransplanted teeth","volume":"34","author":"Lundberg","year":"1996","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1034\/j.1600-9657.2002.00118.x","article-title":"Autotransplantation of teeth: Requirements for predictable success","volume":"18","author":"Tsukiboshi","year":"2002","journal-title":"Dent. Traumatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ijom.2016.12.007","article-title":"Autotransplantation of third molars with completely formed roots into surgically created sockets and fresh extraction sockets: A 10-year comparative study","volume":"46","author":"Yu","year":"2017","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/ejo\/12.1.25","article-title":"A long-term study of 370 autotransplanted premolars. Part III. Periodontal healing subsequent to transplantation","volume":"12","author":"Andreasen","year":"1990","journal-title":"Eur. J. Orthod."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/edt.12353","article-title":"Outcomes and prognostic factors that influence the success of tooth autotransplantation in children and adolescents","volume":"33","author":"Kafourou","year":"2017","journal-title":"Dent. Traumatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/adj.12420","article-title":"Autotransplantation: A viable treatment option for adolescent patients with significantly compromised teeth","volume":"61","author":"Ong","year":"2016","journal-title":"Aust. Dent. J"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1089\/ten.tea.2010.0181","article-title":"Regeneration of dental-pulp-like tissue by chemotaxis-induced cell homing","volume":"16","author":"Kim","year":"2010","journal-title":"Tissue Eng. A"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.joen.2017.10.007","article-title":"Influence of apical diameter on the outcome of regenerative endodontic treatment in teeth with pulp necrosis: A review","volume":"44","author":"Fang","year":"2018","journal-title":"J. Endod."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.joen.2020.03.002","article-title":"3-Dimensional analysis and systematic review of root canal morphology and physiological foramen geometry of 109 mandibular first premolars by micro-computed tomography in a mixed Swiss-German population","volume":"46","author":"Wolf","year":"2020","journal-title":"J. Endod."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.ajodo.2015.06.018","article-title":"Retrospective study of 100 autotransplanted teeth with complete root formation and subsequent orthodontic treatment","volume":"148","author":"Kokai","year":"2015","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0099-2399(81)80097-0","article-title":"Pulpal changes in replanted and autotransplanted immature teeth of dogs","volume":"7","author":"Skoglund","year":"1981","journal-title":"J. Endod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.joen.2018.04.016","article-title":"Influence of extraoral apicoectomy on revascularization of an autotransplanted tooth: A case report","volume":"44","author":"Jakse","year":"2018","journal-title":"J. Endod."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/iej.13230","article-title":"Successful pulp revascularization of an autotransplantated mature premolar with fragile fracture apicoectomy and plasma rich in growth factors: A 3-year follow-up","volume":"53","author":"Dominguez","year":"2020","journal-title":"Int. Endod. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1007\/s00784-020-03673-y","article-title":"A retrospective analysis of autotransplanted teeth including an evaluation of a novel surgical technique","volume":"25","author":"Raabe","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0300-9785(81)80020-8","article-title":"Pulpal changes in replanted and autotransplanted apicoectomized mature teeth of dogs","volume":"10","author":"Skoglund","year":"1981","journal-title":"Int. J. Oral Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0300-9785(81)80019-1","article-title":"Vascular changes in replanted and autotransplanted apicoectomized mature teeth of dogs","volume":"10","author":"Skoglund","year":"1981","journal-title":"Int. J. Oral Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/ejo\/12.1.38","article-title":"A long-term study of 370 autotransplanted premolars. Part IV. Root development subsequent to transplantation","volume":"12","author":"Andreasen","year":"1990","journal-title":"Eur. J. Orthod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0889-5406(95)70009-9","article-title":"Pulp and periodontal healing, root development and root resorption subsequent to transplantation and orthodontic rotation: A long-term study of autotransplanted premolars","volume":"108","author":"Paulsen","year":"1995","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_23","first-page":"497","article-title":"[Tooth transplantation] German","volume":"59","author":"Filippi","year":"2008","journal-title":"Quintessenz"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.joen.2013.02.004","article-title":"The critical apical diameter to obtain regeneration of the pulp tissue after tooth transplantation, replantation, or regenerative endodontic treatment","volume":"39","author":"Laureys","year":"2013","journal-title":"J. Endod."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/jcpe.12228","article-title":"Outcomes of autotransplanted teeth with complete root formation: A systematic review and meta-analysis","volume":"41","author":"Chung","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.oooo.2011.09.037","article-title":"Prognostic factors for autotransplantation of teeth with complete root formation","volume":"114","author":"Aoyama","year":"2012","journal-title":"Oral Surg. Oral. Med. Oral Pathol. Oral Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.ajodo.2003.12.002","article-title":"Autotransplantation of premolars to premolar sites. A long-term follow-up study of 40 consecutive patients","volume":"125","author":"Jonsson","year":"2004","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-9657.1998.tb00815.x","article-title":"Periodontal ligament vitality and histologic healing of teeth stored for extended periods before transplantation","volume":"14","author":"Hupp","year":"1998","journal-title":"Endod. Dent. Traumatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.5395\/rde.2012.37.3.136","article-title":"Minimizing the extra-oral time in autogeneous tooth transplantation: Use of computer-aided rapid prototyping (CARP) as a duplicate model tooth","volume":"37","author":"Lee","year":"2012","journal-title":"Restor. Dent. Endod."},{"key":"ref_30","first-page":"321","article-title":"Accuracy assessment of 3D-printed tooth replicas","volume":"22","author":"Sokolowski","year":"2019","journal-title":"Int. J. Comput. Dent."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.joen.2011.08.025","article-title":"Immunohistological characterization of newly formed tissues after regenerative procedure in immature dog teeth","volume":"37","author":"Yamauchi","year":"2011","journal-title":"J. Endod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.joen.2009.09.039","article-title":"Histologic characterization of regenerated tissues in canal space after the revitalization\/revascularization procedure of immature dog teeth with apical periodontitis","volume":"36","author":"Wang","year":"2010","journal-title":"J. Endod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.joms.2017.03.049","article-title":"Do autotransplanted teeth require elective root canal therapy? A long-term follow-up case series","volume":"75","author":"Murtadha","year":"2017","journal-title":"J. Oral. Maxillofac. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"132","DOI":"10.12998\/wjcc.v3.i2.132","article-title":"Role of third molars in orthodontics","volume":"3","author":"Almpani","year":"2015","journal-title":"World J. Clin. 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