{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:37:04Z","timestamp":1790840224815,"version":"4.1.0"},"reference-count":73,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Humans interfere with a variety of endocrine disruptors on a daily basis, which may result in adverse health effects. Among them, Bisphenol-A (BPA) is the most debated endocrine disruptor, despite being widely studied, regarding its effects on fertility. The aim of this review was to investigate the interrelation of BPA and female fertility. PubMed (Medline) was searched from 2013 until 2022 to identify epidemiological studies that report the association of BPA with fertility parameters, in vitro fertilization (IVF) outcomes, polycystic ovarian syndrome (PCOS) and endometriosis. Regarding general fertility, most studies report an inverse association between BPA and ovarian reserve markers, namely antral follicle count (AFC) and anti-M\u00fcllerian hormone (AMH). The BPA and estradiol (E2) levels did not correlate significantly in the majority of studies. No definite conclusions can be reached regarding BPA and IVF endpoints or endometriosis. Lastly, most studies report higher prevalence of PCOS in women with higher BPA concentrations, although no casualty has been proven. Although most studies fail to reach definite conclusion regarding the impact of BPA on fertility, there is accumulating evidence suggesting a negative role of BPA in female reproductive health.<\/jats:p>","DOI":"10.3390\/jcm11237227","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T08:10:57Z","timestamp":1670227857000},"page":"7227","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Bisphenol-A and Female Fertility: An Update of Existing Epidemiological Studies"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6921-0573","authenticated-orcid":false,"given":"Konstantinos","family":"Stavridis","sequence":"first","affiliation":[{"name":"2nd Department of Obstetrics and Gynaecology, Aretaieion Hospital, University of Athens, 11527 Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Triantafyllidou","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynaecology, Aretaieion Hospital, University of Athens, 11527 Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0913-5556","authenticated-orcid":false,"given":"Maria","family":"Pisimisi","sequence":"additional","affiliation":[{"name":"School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8479-6517","authenticated-orcid":false,"given":"Nikolaos","family":"Vlahos","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynaecology, Aretaieion Hospital, University of Athens, 11527 Attica, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12958-018-0433-z","article-title":"Air pollution and female fertility: A systematic review of literature","volume":"16","author":"Conforti","year":"2018","journal-title":"Reprod. 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