{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:14:13Z","timestamp":1792293253025,"version":"4.4.0"},"reference-count":137,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Breast cancer is still a lethal disease and the leading cause of death in women, undermining patients\u2019 survival and quality of life. Modern techniques of surgery and radiotherapy allow for the obtaining of good results in terms of survival, however they cause long-term side effects that persist over time, such as lymphedema and neuropathy. Similarly, the advent of new therapies such as endocrine therapy revolutionized breast cancer outcomes, but side effects are still present even in years of follow-up after cure. Besides the side effects of medical and surgical therapy, breast cancer is a real disruption in patients\u2019 lives considering quality of life-related aspects such as the distortion of body image, the psychological consequences of the diagnosis, and the impact on family dynamics. Therefore, the doctor-patient relationship is central to providing the best support both during treatment and afterwards. The aim of this review is to summarize the consequences of medical and surgical treatment on breast cancer patients and to emphasize the importance of early prevention of side effects to improve patients\u2019 quality of life.<\/jats:p>","DOI":"10.3390\/jcm11237239","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T04:00:37Z","timestamp":1670385637000},"page":"7239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Long-Term Effects of Breast Cancer Therapy and Care: Calm after the Storm?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9230-9288","authenticated-orcid":false,"given":"Chiara","family":"Tommasi","sequence":"first","affiliation":[{"name":"Medical Oncology and Breast Unit, University Hospital of Parma, 43126 Parma, Italy"},{"name":"Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy"},{"name":"GOIRC (Gruppo Oncologico Italiano di Ricerca Clinica), 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4368-6973","authenticated-orcid":false,"given":"Rita","family":"Balsano","sequence":"additional","affiliation":[{"name":"Medical Oncology and Breast Unit, University Hospital of Parma, 43126 Parma, Italy"},{"name":"Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy"},{"name":"GOIRC (Gruppo Oncologico Italiano di Ricerca Clinica), 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Corian\u00f2","sequence":"additional","affiliation":[{"name":"Medical Oncology and Breast Unit, University Hospital of Parma, 43126 Parma, Italy"},{"name":"Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy"},{"name":"GOIRC (Gruppo Oncologico Italiano di Ricerca Clinica), 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Medical Oncology and Breast Unit, University Hospital of Parma, 43126 Parma, Italy"},{"name":"Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy"},{"name":"GOIRC (Gruppo Oncologico Italiano di Ricerca Clinica), 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Saba","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, University of Cagliari, 09042 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Bardanzellu","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, University of Cagliari, 09042 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8605-4290","authenticated-orcid":false,"given":"Nerina","family":"Denaro","sequence":"additional","affiliation":[{"name":"Medical Oncology, Fondazione Ca\u2019 Grande Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Ramundo","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa di Oncologia, Azienda Ospedaliera Cardinale G. 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