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This study investigates the effect of amiodarone on ablation outcomes in ARVC. (2) Methods: The study enrolled patients with ARVC undergoing CA of sustained VT. In all patients, substrate modification was performed to achieve non-inducible VT. The patients were categorized into two groups according to whether they had used amiodarone before CA. Baseline and electrophysiological characteristics, substrate, and outcomes were compared. (3) Results: A total of 72 ARVC patients were studied, including 29 (40.3%) \u201coff\u201d amiodarone and 43 (56.7%) \u201con\u201d amiodarone. The scar area was similar between the two groups. Patients \u201coff\u201d amiodarone had smaller endocardial and epicardial areas with abnormal electrograms. Twenty of 43 patients (47.5%) \u201con\u201d amiodarone discontinued it within 3 months after CA. During a mean follow-up period of 43.2 \u00b1 29.5 months, higher VT recurrence was observed in patients \u201con\u201d amiodarone. Patients \u201con\u201d amiodarone who discontinued amiodarone after CA had a lower recurrence than those without. (4) Conclusions: Patients with ARVC \u201con\u201d amiodarone before CA had distinct substrate characteristics and worse ablation outcomes than patients \u201coff\u201d amiodarone, especially in those who had used amiodarone continuously.<\/jats:p>","DOI":"10.3390\/jcm11247265","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T02:51:56Z","timestamp":1670467916000},"page":"7265","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3282-7523","authenticated-orcid":false,"given":"Chin-Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8960-1301","authenticated-orcid":false,"given":"Fa-Po","family":"Chung","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nwe","family":"Nwe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yangon General Hospital, Yangon Q4HX+MH5, Myanmar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Cheng","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"},{"name":"Cardiovascular Center, Taichung Veterans General Hospital, No. 1650, Taiwan Boulevard Sect. 4, Taichung City 40705, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hung","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"},{"name":"Cardiovascular Center, Taichung Veterans General Hospital, No. 1650, Taiwan Boulevard Sect. 4, Taichung City 40705, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yenn-Jiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7030-8471","authenticated-orcid":false,"given":"Shih-Lin","family":"Chang","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-227X","authenticated-orcid":false,"given":"Li-Wei","family":"Lo","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-2070","authenticated-orcid":false,"given":"Yu-Feng","family":"Hu","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta-Chuan","family":"Tuan","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze-Fan","family":"Chao","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8033-127X","authenticated-orcid":false,"given":"Jo-Nan","family":"Liao","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Yung","family":"Chang","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Kuo","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-I","family":"Wu","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Huei","family":"Liu","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Han","family":"Cheng","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan"},{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Ann","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Yang-Ming Chiao-Tung University, No. 155, Sec. 2, Linong St., Taipei 112, Taiwan"},{"name":"Cardiovascular Center, Taichung Veterans General Hospital, 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Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1161\/CIRCULATIONAHA.105.542266","article-title":"Arrhythmogenic right ventricular dysplasia: A United States experience","volume":"112","author":"Dalal","year":"2005","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1016\/j.hrthm.2019.05.007","article-title":"2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy","volume":"16","author":"Towbin","year":"2019","journal-title":"Heart Rhythm"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1001\/jama.298.11.1312","article-title":"Prescribing amiodarone: An evidence-based review of clinical indications","volume":"298","author":"Vassallo","year":"2007","journal-title":"JAMA"},{"key":"ref_5","first-page":"552","article-title":"Adverse reactions of Amiodarone","volume":"16","author":"Congedo","year":"2019","journal-title":"J. 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Electrophysiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1093\/europace\/euab060","article-title":"Clinical significance of J waves with respect to substrate characteristics and ablation outcomes in patients with arrhythmogenic right ventricular cardiomyopathy","volume":"23","author":"Lin","year":"2021","journal-title":"Europace"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1161\/01.CIR.101.11.1288","article-title":"Linear ablation lesions for control of unmappable ventricular tachycardia in patients with ischemic and nonischemic cardiomyopathy","volume":"101","author":"Marchlinski","year":"2000","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.hrthm.2009.04.030","article-title":"EHRA\/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias: Developed in a partnership with the European Heart Rhythm Association (EHRA), a Registered Branch of the European Society of Cardiology (ESC), and the Heart Rhythm Society (HRS); in collaboration with the American College of Cardiology (ACC) and the American Heart Association (AHA)","volume":"6","author":"Aliot","year":"2009","journal-title":"Heart Rhythm"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.hrthm.2013.09.069","article-title":"Seasonal variation in the frequency of sudden cardiac death and ventricular tachyarrhythmia in patients with arrhythmogenic right ventricular dysplasia\/cardiomyopathy: The effect of meteorological factors","volume":"10","author":"Chung","year":"2013","journal-title":"Heart Rhythm"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0167-5273(02)00011-6","article-title":"Absence of change of signal-averaged electrocardiogram identifies patients with ventricular arrhythmias who are non-responders to amiodarone","volume":"83","author":"Claudon","year":"2002","journal-title":"Int. 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