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III","award":["CM20\/00138"],"award-info":[{"award-number":["CM20\/00138"]}]},{"name":"Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["COV20\/00491"],"award-info":[{"award-number":["COV20\/00491"]}]},{"name":"Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["PI18\/01238"],"award-info":[{"award-number":["PI18\/01238"]}]},{"name":"Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["CIBERINFEC CB21\/13\/00051"],"award-info":[{"award-number":["CIBERINFEC CB21\/13\/00051"]}]},{"name":"Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["VA321P18"],"award-info":[{"award-number":["VA321P18"]}]},{"name":"Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["GRS 1922\/A\/19"],"award-info":[{"award-number":["GRS 1922\/A\/19"]}]},{"name":"Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["GRS 2057\/A\/19"],"award-info":[{"award-number":["GRS 2057\/A\/19"]}]},{"name":"Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["VA256P20"],"award-info":[{"award-number":["VA256P20"]}]},{"name":"Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["CIVP19A5953"],"award-info":[{"award-number":["CIVP19A5953"]}]},{"name":"Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["CM20\/00138"],"award-info":[{"award-number":["CM20\/00138"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: procalcitonin is a valuable marker in the diagnosis of bacterial infections; however, the impairment of renal function can influence its diagnostic precision. The objective of this study is to evaluate the differential behaviour of procalcitonin, as well as its usefulness in the diagnosis of postoperative pulmonary infection after cardiac surgery, depending on the presence or absence of impaired renal function. Materials and methods: A total of 805 adult patients undergoing cardiac surgery with extracorporeal circulation (CBP) were prospectively recruited, comparing the behaviour of biomarkers between the groups with and without postoperative pneumonia and according to the presence or absence of renal dysfunction. Results: Pulmonary infection was diagnosed in 42 patients (5.21%). In total, 228 patients (28.32%) presented postoperative renal dysfunction. Procalcitonin was significantly higher in infected patients, even in the presence of renal dysfunction. The optimal procalcitonin threshold differed markedly in patients with renal dysfunction compared to patients without renal dysfunction (1 vs. 0.78 ng\/mL p &lt; 0.05). The diagnostic accuracy of procalcitonin increased significantly when the procalcitonin threshold was adapted to renal function. Conclusions: Procalcitonin is an accurate marker of postoperative infection in cardiac surgery, even in the presence of renal dysfunction. Renal function is an important determinant of procalcitonin levels and, therefore, its diagnostic thresholds must be adapted in the presence of renal dysfunction.<\/jats:p>","DOI":"10.3390\/jcm11247274","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T02:51:56Z","timestamp":1670467916000},"page":"7274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4428-2631","authenticated-orcid":false,"given":"Olga","family":"de la Varga-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Infanta Leonor University Hospital, Gran Via del Este 80, 28031 Madrid, Spain"},{"name":"BioCritic, Group for Biomedical Research in Critical Care Medicine, Ramon y Cajal Ave. 7, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2714-8120","authenticated-orcid":false,"given":"Marta","family":"Mart\u00edn-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"BioCritic, Group for Biomedical Research in Critical Care Medicine, Ramon y Cajal Ave. 7, 47005 Valladolid, Spain"},{"name":"Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Carlos III Health Institute, 28029 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Universidad de Valladolid, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3691-0252","authenticated-orcid":false,"given":"Mar\u00eda","family":"Heredia-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"BioCritic, Group for Biomedical Research in Critical Care Medicine, Ramon y Cajal Ave. 7, 47005 Valladolid, Spain"},{"name":"Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Carlos III Health Institute, 28029 Madrid, Spain"},{"name":"Department of Anaesthesiology, Clinical University Hospital of Salamanca, P.\u00b0 de San Vicente, 58, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Ceballos","sequence":"additional","affiliation":[{"name":"Viral Infection and Immunity Unit, National Center for Microbiology, Carlos III Health Institute, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9740-827X","authenticated-orcid":false,"given":"Hector","family":"Cubero-Gallego","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Cardiology Department, Hospital del Mar, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Priede-Vimbela","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Clinic University Hospital of Valladolid, Ramon y Cajal Ave. 3, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Bardaj\u00ed-Carrillo","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Clinic University Hospital of Valladolid, Ramon y Cajal Ave. 3, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"S\u00e1nchez-de Prada","sequence":"additional","affiliation":[{"name":"BioCritic, Group for Biomedical Research in Critical Care Medicine, Ramon y Cajal Ave. 7, 47005 Valladolid, Spain"},{"name":"Microbiology and Immunology Department, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0295-7071","authenticated-orcid":false,"given":"Roc\u00edo","family":"L\u00f3pez-Herrero","sequence":"additional","affiliation":[{"name":"BioCritic, Group for Biomedical Research in Critical Care Medicine, Ramon y Cajal Ave. 7, 47005 Valladolid, Spain"},{"name":"Department of Anaesthesiology, Clinic University Hospital of Valladolid, Ramon y Cajal Ave. 3, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Jorge-Monjas","sequence":"additional","affiliation":[{"name":"BioCritic, Group for Biomedical Research in Critical Care Medicine, Ramon y Cajal Ave. 7, 47005 Valladolid, Spain"},{"name":"Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Carlos III Health Institute, 28029 Madrid, Spain"},{"name":"Department of Anaesthesiology, Clinic University Hospital of Valladolid, Ramon y Cajal Ave. 3, 47003 Valladolid, Spain"},{"name":"Department of Surgery, Faculty of Medicine, Universidad de Valladolid, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8900-0944","authenticated-orcid":false,"given":"Eduardo","family":"Tamayo","sequence":"additional","affiliation":[{"name":"BioCritic, Group for Biomedical Research in Critical Care Medicine, Ramon y Cajal Ave. 7, 47005 Valladolid, Spain"},{"name":"Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Carlos III Health Institute, 28029 Madrid, Spain"},{"name":"Department of Anaesthesiology, Clinic University Hospital of Valladolid, Ramon y Cajal Ave. 3, 47003 Valladolid, Spain"},{"name":"Department of Surgery, Faculty of Medicine, Universidad de Valladolid, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9457-1394","authenticated-orcid":false,"given":"Esther","family":"G\u00f3mez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"BioCritic, Group for Biomedical Research in Critical Care Medicine, Ramon y Cajal Ave. 7, 47005 Valladolid, Spain"},{"name":"Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Carlos III Health Institute, 28029 Madrid, Spain"},{"name":"Department of Anaesthesiology, Clinic University Hospital of Valladolid, Ramon y Cajal Ave. 3, 47003 Valladolid, Spain"},{"name":"Department of Surgery, Faculty of Medicine, Universidad de Valladolid, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000479337","article-title":"Relevance of Endothelial 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