{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:36:55Z","timestamp":1777430215122,"version":"3.51.4"},"reference-count":69,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Norwegian Women\u2019s Public Health Association","award":["14902"],"award-info":[{"award-number":["14902"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Spondyloarthropathies (SpA) are associated with increased cardiovascular risk. Among possible mechanisms is the dysfunction of serum lipoproteins in regulating cell cholesterol homeostasis. Cholesterol efflux capacity (CEC)\u2014the atheroprotective ability of HDL (high density lipoproteins) to accept cholesterol from macrophages\u2014might predict cardiovascular disease independently of HDL-cholesterol levels. We aimed at evaluating modifications of CEC and of the atherogenic cholesterol loading capacity (CLC) of serum lipoproteins in psoriatic arthritis (PsA) and ankylosing spondylitis (AS) following anti-rheumatic treatment. A total of 62 SpA patients (37 PsA and 25 AS) were evaluated before and after treatment with tumor necrosis factor inhibitor and\/or methotrexate. CEC and CLC were measured by radioisotopic and fluorometric techniques, respectively. Endothelial function was assessed by finger plethysmography (Endopat). In the whole SpA group, total and HDL-cholesterol increased after treatment, while lipoprotein(a) decreased and CLC was unchanged. Treatment was associated with increased Scavenger Receptor class B type I (SR-BI)-mediated CEC in the AS group. SR-BI- and ABCG1-mediated CEC were negatively associated with inflammatory parameters and positively related to coffee consumption. SR-BI CEC and CLC were positively and negatively associated with endothelial function, respectively. Our pilot study suggests that anti-rheumatic treatment is associated with favorable modulation of lipoprotein quality and function in SpA, particularly in AS, in spite of the induced increase in total cholesterol levels. If confirmed in a larger population, this might represent an atheroprotective benefit beyond what is reflected by conventional serum lipid profile.<\/jats:p>","DOI":"10.3390\/jcm11247330","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T04:34:20Z","timestamp":1670819660000},"page":"7330","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Antirheumatic Treatment on Cell Cholesterol Efflux and Loading Capacity of Serum Lipoproteins in Spondylarthropathies"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8009-4670","authenticated-orcid":false,"given":"Ingrid","family":"Hokstad","sequence":"first","affiliation":[{"name":"Lillehammer Hospital for Rheumatic Diseases, 2609 Lillehammer, Norway"},{"name":"Institute of Clinical Sciences, University of Oslo, 0318 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Food and Drug, University of Parma, 43124 Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gia","family":"Deyab","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Vestre Viken Trust, 3004 Drammen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten Wang","family":"Fagerland","sequence":"additional","affiliation":[{"name":"Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, 0424 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Agewall","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, University of Oslo, 0318 Oslo, Norway"},{"name":"Department of Medicine, Oslo University Hospital Ullev\u00e5l, 0424 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnbj\u00f8rg","family":"Hjeltnes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Innlandet Hospital Trust, 2819 Lillehammer, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6665-263X","authenticated-orcid":false,"given":"Francesca","family":"Zimetti","sequence":"additional","affiliation":[{"name":"Department of Food and Drug, University of Parma, 43124 Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Bernini","sequence":"additional","affiliation":[{"name":"Department of Food and Drug, University of Parma, 43124 Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Ronda","sequence":"additional","affiliation":[{"name":"Department of Food and Drug, University of Parma, 43124 Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Hollan","sequence":"additional","affiliation":[{"name":"Beitost\u00f8len Health and Sport Centre, 2953 Beitost\u00f8len, Norway"},{"name":"Institute for Health Sciences, The Norwegian University of Science and Technology, 7034 Gj\u00f8vik, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.berh.2019.01.002","article-title":"Cardiovascular morbidity and mortality in ankylosing spondylitis and psoriatic arthritis","volume":"32","author":"Liew","year":"2018","journal-title":"Best Pract. 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