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III","award":["B03_20R"],"award-info":[{"award-number":["B03_20R"]}]},{"name":"Instituto de Salud Carlos III","award":["\u201cConstruyendo Europa desde Arag\u00f3n\u201d"],"award-info":[{"award-number":["\u201cConstruyendo Europa desde Arag\u00f3n\u201d"]}]},{"name":"Instituto de Salud Carlos III","award":["Rio-Hortega fellowship"],"award-info":[{"award-number":["Rio-Hortega fellowship"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Branched-chain amino acids (BCAA) supplementation is used to promote protein synthesis in different clinical conditions in which proteolysis is increased. In addition, lower plasma BCAA levels have been related to an increased risk of hepatic encephalopathy in liver cirrhosis. In this article we will review the role of supplementation with BCAAs and BCAA derivative \u03b2-hydroxy-\u03b2-methylbutyrate (HMB) in liver cirrhosis, focusing on nutritional and clinical effects. Evidence shows that BCAA supplementation slightly increases muscle mass and body mass index, with an upward trend in muscular strength and no change in fat mass. Moreover, BCAA supplementation improves symptoms of hepatic encephalopathy, and is indicated as second-line therapy. The evidence is more limited for BCAA derivatives. HMB supplementation appears to increase muscle mass in chronic diseases associated with cachexia, although this effect has not yet been clearly demonstrated in liver cirrhosis studies. To date, HMB supplementation has no clinical indication in liver cirrhosis.<\/jats:p>","DOI":"10.3390\/jcm11247337","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T04:34:20Z","timestamp":1670819660000},"page":"7337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Role of Branched-Chain Amino Acids and Their Derivative \u03b2-Hydroxy-\u03b2-Methylbutyrate in Liver Cirrhosis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-9903","authenticated-orcid":false,"given":"Silvia","family":"Espina","sequence":"first","affiliation":[{"name":"Gastroenterology Department, General Hospital of Defense, 50009 Zaragoza, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria (IIS) Aragon, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7758-3588","authenticated-orcid":false,"given":"Alejandro","family":"Sanz-Paris","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria (IIS) Aragon, 50009 Zaragoza, Spain"},{"name":"Nutrition Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4016-2165","authenticated-orcid":false,"given":"Vanesa","family":"Bernal-Monterde","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria (IIS) Aragon, 50009 Zaragoza, Spain"},{"name":"Gastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-8940","authenticated-orcid":false,"given":"Diego","family":"Casas-Deza","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria (IIS) Aragon, 50009 Zaragoza, Spain"},{"name":"Gastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8982-3737","authenticated-orcid":false,"given":"Jose Miguel","family":"Arbon\u00e9s-Mainar","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria (IIS) Aragon, 50009 Zaragoza, Spain"},{"name":"Translational Research Unit, Instituto Aragon\u00e9s de Ciencias de la Salud (IACS), Miguel Servet University Hospital, 50009 Zaragoza, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda Obesidad y Nutrici\u00f3n (CIBERObn), Instituto Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nie, C., He, T., Zhang, W., Zhang, G., and Ma, X. 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