{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:53:38Z","timestamp":1791420818574,"version":"4.3.3"},"reference-count":85,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Liposarcoma (LPS) is one of the most common soft-tissue sarcomas. However, intrathoracic LPS is rare, as only 1% of all LPS cases are found in the thorax. Methods: A systematic literature review through PubMed and Embase databases was performed. Only eligible case reports and case series reporting intrathoracic LPS in adult patients were included. Kaplan\u2013Meier curves were calculated to evaluate the survival rate of included patients based on the histological subtype of LPS. Results: 123 studies reporting 197 patients were included. We added a case of a 69-year-old female patient with recurrent giant intrathoracic LPS. The primary tumor measured 15.1cm \u00d7 22.9 cm \u00d7 21.9 cm and weighed 3100 g. Six months later, the patient was admitted to the hospital with another intrathoracic tumor measuring 9.5 cm \u00d7 9 cm\u00d7 1.4 cm. The immunohistochemical studies showed expression of murine double minute 2 (MDM2) antigen in both primary and recurrent tumor cells. Conclusions: Dyspnea, chest pain, and cough were the most common symptoms reported in included studies. Overall, the 5-year survival rate was 62%. The highest survival was observed in well-differentiated LPS patients (80%) and the lowest in myxoid LPS (31%).<\/jats:p>","DOI":"10.3390\/jcm11247353","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T04:34:20Z","timestamp":1670819660000},"page":"7353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinicopathological Features of Intrathoracic Liposarcoma\u2014A Systematic Review with an Illustrative Case"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-6753","authenticated-orcid":false,"given":"Kajetan","family":"Kie\u0142bowski","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery and Transplantation, Pomeranian Medical University in Szczecin, Alfreda Soko\u0142owskiego 11, 70-891 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Ruszel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Hypertension with Subdepartment of Cardiology, Independent Public Provincial Hospital in Szczecin, Alfreda Soko\u0142owskiego 11, 70-891 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seweryn Adam","family":"Skrzyniarz","sequence":"additional","affiliation":[{"name":"Dietrich-Bonhoeffer-Klinikum, 17036 Neubrandenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0817-1018","authenticated-orcid":false,"given":"Ma\u0142gorzata Edyta","family":"Wojty\u015b","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Transplantation, Pomeranian Medical University in Szczecin, Alfreda Soko\u0142owskiego 11, 70-891 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4820-0629","authenticated-orcid":false,"given":"Rafa\u0142","family":"Becht","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Chemotherapy and Cancer Immunotherapy, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Ptaszy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2488-427X","authenticated-orcid":false,"given":"Darko","family":"Gaji\u0107","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Transplantation, Pomeranian Medical University in Szczecin, Alfreda Soko\u0142owskiego 11, 70-891 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5836-8498","authenticated-orcid":false,"given":"Janusz","family":"W\u00f3jcik","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Transplantation, Pomeranian Medical University in Szczecin, Alfreda Soko\u0142owskiego 11, 70-891 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1053\/j.semdp.2019.02.006","article-title":"Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma: An Updated Review","volume":"36","author":"Thway","year":"2019","journal-title":"Semin. Diagn. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/his.12771","article-title":"Updates in the Approach to Intrathoracic Sarcomas","volume":"67","author":"Thway","year":"2015","journal-title":"Histopathology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.7453\/gahmj.2013.008","article-title":"The CARE Guidelines: Consensus-Based Clinical Case Reporting Guideline Development","volume":"2","author":"Gagnier","year":"2013","journal-title":"Glob. Adv. Health Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jclinepi.2009.06.006","article-title":"The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration","volume":"62","author":"Liberati","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.15171\/jcvtr.2018.28","article-title":"ECMO-Assisted Resection of Huge Thoracic Mass","volume":"10","author":"Jahangirifard","year":"2018","journal-title":"J. Cardiovasc. Thorac. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijscr.2018.07.037","article-title":"An Unusual Case of Recurrent Huge Primary Mediastinal Dedifferentiated Liposarcoma","volume":"50","author":"Soeroso","year":"2018","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_7","first-page":"281","article-title":"Recurrent Intrathoracic Dedifferentiated Liposarcoma: A Case Report and Literature Review","volume":"26","author":"Ashraf","year":"2019","journal-title":"Respir. Med. Case Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.32074\/1591-951X-213","article-title":"The 2020 WHO Classification of Soft Tissue Tumours: News and Perspectives","volume":"113","author":"Sbaraglia","year":"2020","journal-title":"Pathologica"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/PAS.0000000000001552","article-title":"The 2020 WHO Classification: What\u2019s New in Soft Tissue Tumor Pathology?","volume":"45","author":"Kallen","year":"2020","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.suronc.2019.04.004","article-title":"Natural History of Well-Differentiated Liposarcoma of the Extremity Compared to Patients Treated with Surgery","volume":"29","author":"Vos","year":"2019","journal-title":"Surg. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1067\/j.cpradiol.2009.02.001","article-title":"Cross-Sectional Imaging of Primary Thoracic Sarcomas with Histopathologic Correlation: A Review for the Radiologist","volume":"39","author":"Dillman","year":"2010","journal-title":"Curr. Probl. Diagn. Radiol."},{"key":"ref_12","first-page":"100842","article-title":"Pulmonary Artery Sarcoma: A Differential Diagnosis of Persistent Pulmonary Embolism","volume":"80","author":"Roeser","year":"2021","journal-title":"Respir. Med. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.clinimag.2015.04.004","article-title":"Imaging Features of Primary and Recurrent Intrathoracic Synovial Sarcoma: A Single-Institute Experience","volume":"39","author":"Baheti","year":"2015","journal-title":"Clin. Imaging"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7594027","DOI":"10.1155\/2021\/7594027","article-title":"Diagnosis and Prognosis of Retroperitoneal Liposarcoma: A Single Asian Center Cohort of 57 Cases","volume":"2021","author":"Xiao","year":"2021","journal-title":"J. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.rmed.2017.02.013","article-title":"State-of-the-Art: Radiological Investigation of Pleural Disease","volume":"124","author":"Hallifax","year":"2017","journal-title":"Respir. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e11806","DOI":"10.1097\/MD.0000000000011806","article-title":"Successful Removal of Giant Mediastinal Lipoma and Liposarcoma Involving Both Chest Cavities","volume":"97","author":"Chen","year":"2018","journal-title":"Medicine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.5603\/OCP.2018.0047","article-title":"Liposarcoma\u2014Spectrum of Disease","volume":"14","year":"2019","journal-title":"Oncol. Clin. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.21037\/tcr-20-1270","article-title":"Giant Mediastinal Liposarcoma Resected by Median Sternotomy: A Case Report","volume":"9","author":"Zhang","year":"2020","journal-title":"Transl. Cancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3348\/kjr.2019.0897","article-title":"Pictorial Review of Mediastinal Masses with an Emphasis on Magnetic Resonance Imaging","volume":"22","author":"Park","year":"2021","journal-title":"Korean J. Radiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12055-019-00871-6","article-title":"A Rare Case of a Giant Anterior Mediastinal Liposarcoma","volume":"36","author":"Gaikwad","year":"2019","journal-title":"Indian J. Thorac. Cardiovasc. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e12873","DOI":"10.1097\/MD.0000000000012873","article-title":"Giant Primary Liposarcoma of the Anterior Mediastinum","volume":"97","author":"Yang","year":"2018","journal-title":"Medicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"bcr0620114341","DOI":"10.1136\/bcr.06.2011.4341","article-title":"Giant Liposarcoma of the Posterior Mediastinum and Retroperitoneum","volume":"2011","author":"Taki","year":"2011","journal-title":"BMJ Case Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/jso.26118","article-title":"Single Centre 30-year Experience in Treating Retroperitoneal Liposarcomas","volume":"122","author":"Homsy","year":"2020","journal-title":"J. Surg. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3857\/roj.2016.01858","article-title":"Retroperitoneal Liposarcoma: The Role of Adjuvant Radiation Therapy and the Prognostic Factors","volume":"34","author":"Lee","year":"2016","journal-title":"Radiat. Oncol. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/S1470-2045(20)30446-0","article-title":"Preoperative Radiotherapy plus Surgery versus Surgery Alone for Patients with Primary Retroperitoneal Sarcoma (EORTC-62092: STRASS): A Multicentre, Open-Label, Randomised, Phase 3 Trial","volume":"21","author":"Bonvalot","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1002\/cncr.24375","article-title":"Radiosensitivity Translates into Excellent Local Control in Extremity Myxoid Liposarcoma","volume":"115","author":"Chung","year":"2009","journal-title":"Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.tranon.2014.09.007","article-title":"Pazopanib, a Receptor Tyrosine Kinase Inhibitor, Suppresses Tumor Growth through Angiogenesis in Dedifferentiated Liposarcoma Xenograft Models","volume":"7","author":"Li","year":"2014","journal-title":"Transl. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/17512433.2017.1289086","article-title":"Pharmacological Therapies for Liposarcoma","volume":"10","author":"Saponara","year":"2017","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1159\/000524939","article-title":"Established and Experimental Systemic Treatment Options for Advanced Liposarcoma","volume":"45","year":"2022","journal-title":"Oncol. Res. Treat."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1080\/14737140.2017.1344098","article-title":"Eribulin in Advanced Liposarcoma and Leiomyosarcoma","volume":"17","author":"Setola","year":"2017","journal-title":"Expert Rev. Anticancer Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/S0140-6736(15)01283-0","article-title":"Eribulin versus Dacarbazine in Previously Treated Patients with Advanced Liposarcoma or Leiomyosarcoma: A Randomised, Open-Label, Multicentre, Phase 3 Trial","volume":"387","author":"Chawla","year":"2016","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1200\/JCO.2015.62.4734","article-title":"Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial","volume":"34","author":"Demetri","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1016\/j.ejca.2012.05.012","article-title":"A Retrospective Analysis of Antitumour Activity with Trabectedin in Translocation-Related Sarcomas","volume":"48","author":"Cesne","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S1470-2045(07)70175-4","article-title":"Efficacy of Trabectedin (Ecteinascidin-743) in Advanced Pretreated Myxoid Liposarcomas: A Retrospective Study","volume":"8","author":"Grosso","year":"2007","journal-title":"Lancet Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"579","DOI":"10.4143\/crt.2021.496","article-title":"Clinicopathologic Characteristics and Clinical Outcome of Localized Liposarcoma: A Single-Center Experience over 25 Years and Evaluation of PD-L1 Expression","volume":"54","author":"Chae","year":"2022","journal-title":"Cancer Res. Treat."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Resag, A., Toffanin, G., Bene\u0161ov\u00e1, I., M\u00fcller, L., Potkrajcic, V., Ozaniak, A., Lischke, R., Bartunkova, J., Rosato, A., and J\u00f6hrens, K. (2022). The Immune Contexture of Liposarcoma and Its Clinical Implications. Cancers, 14.","DOI":"10.3390\/cancers14194578"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12703\/r\/10-1","article-title":"Recent Advances in the Understanding and Management of Liposarcoma","volume":"10","author":"Haddox","year":"2021","journal-title":"Fac. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/dc.24928","article-title":"Differential Diagnosis of Lipoma and Atypical Lipomatous Tumor\/Well-differentiated Liposarcoma by Cytological Analysis","volume":"50","author":"Sugiyama","year":"2022","journal-title":"Diagn. Cytopathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s12094-019-02158-z","article-title":"Anti-Tumor Activity of the MDM2-TP53 Inhibitor BI-907828 in Dedifferentiated Liposarcoma Patient-Derived Xenograft Models Harboring MDM2 Amplification","volume":"22","author":"Cornillie","year":"2019","journal-title":"Clin. Transl. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Nishio, J., Nakayama, S., Nabeshima, K., and Yamamoto, T. (2021). Biology and Management of Dedifferentiated Liposarcoma: State of the Art and Perspectives. J. Clin. Med., 10.","DOI":"10.3390\/jcm10153230"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.5152\/j.aott.2020.01.445","article-title":"Diagnostic Importance of Clinicopathologic Features and P16, CD34, MDM2 Expression in Differential Diagnosis of Adipocytic Tumors","volume":"54","author":"Altun","year":"2020","journal-title":"Acta Orthop. Traumatol. Turc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/PAS.0000000000001564","article-title":"DDIT3 Immunohistochemistry Is a Useful Tool for the Diagnosis of Myxoid Liposarcoma","volume":"45","author":"Scapa","year":"2020","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wong, G.S., Bass, D., Chen, I.Y., Thomas, R., Velez, M.J., and Hobbs, S.K. (2022). Imaging and Clinical Findings in a Series of Six Cases of Rare Primary Mediastinal Liposarcoma. Radiol. Cardiothorac. Imaging, 4.","DOI":"10.1148\/ryct.210259"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1200\/JCO.2017.74.9598","article-title":"Clinical and Molecular Spectrum of Liposarcoma","volume":"36","author":"Lee","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/01.sla.0000108670.31446.54","article-title":"Operative Management of Primary Retroperitoneal Sarcomas","volume":"239","author":"Hassan","year":"2004","journal-title":"Ann. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1016\/j.ejso.2019.08.026","article-title":"Impact of Primary Tumor Location on Outcome of Liposarcoma Patients, a Retrospective Cohort Study","volume":"45","author":"Vos","year":"2019","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jscr\/2010.8.1","article-title":"Successful Resection of a Large Incidentally Found Primary Mediastinal Liposarcoma","volume":"2010","author":"Chughtai","year":"2010","journal-title":"J. Surg. Case Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/ejcts\/ezt149","article-title":"Giant Liposarcoma Elongating Mediastinal Vessels with Intrathoracic Inferior Vena Cava Replacement","volume":"44","author":"Garofalo","year":"2013","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/modpathol.2014.152","article-title":"Liposarcomas of the Posterior Mediastinum: Clinicopathologic Study of 18 Cases","volume":"28","author":"Ortega","year":"2014","journal-title":"Mod. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.3892\/ol.2015.3103","article-title":"Primary Mediastinal Giant Liposarcoma with Smooth Muscle and Neural Differentiation: A Case Report","volume":"9","author":"Ma","year":"2015","journal-title":"Oncol. Lett."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"rjv126","DOI":"10.1093\/jscr\/rjv126","article-title":"Surgical Resection of a Giant Primary Liposarcoma of the Anterior Mediastinum","volume":"2015","author":"Mani","year":"2015","journal-title":"J. Surg. Case Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ijscr.2017.10.055","article-title":"A Giant Mediastinal Liposarcoma Weighing 3500 g Resected with Clam Shell Approach, a Case Report with Review of Literature","volume":"41","author":"Sugiura","year":"2017","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"E689","DOI":"10.21037\/jtd.2017.07.90","article-title":"Surgical Resection of a Well-Differentiated Inflammatory Liposarcoma of the Middle Mediastinum: A Case Report","volume":"9","author":"Edagawa","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"ref_54","first-page":"2763","article-title":"A Huge Mediastinal, Well-Differentiated Liposarcoma with Heterogenous Smooth Muscle Differentiation: A Case Report","volume":"12","author":"Mei","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1017\/S1460396919000372","article-title":"Liposarcoma of the Left Hemithorax and Implications of MDM2","volume":"18","author":"Stolten","year":"2019","journal-title":"J. Radiother. Pract."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13019-019-0965-0","article-title":"Resection of a Huge Mediastinal Well-Differentiated Liposarcoma Involving Left Thoracic Cavity","volume":"14","author":"Zhang","year":"2019","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1111\/1759-7714.13495","article-title":"Primary Pleural Liposarcoma Combined Spindle Cell Lipoma of the Lung","volume":"11","author":"Kang","year":"2020","journal-title":"Thorac. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s40792-020-00928-4","article-title":"An Extremely Rare Case of Rapidly Growing Mediastinal Well-Differentiated Liposarcoma with a Sclerosing Variant: A Case Report","volume":"6","author":"Iwamoto","year":"2020","journal-title":"Surg. Case Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"104517","DOI":"10.1016\/j.yexmp.2020.104517","article-title":"Well-Differentiated Liposarcoma Primary from Thymic Stroma: Case Report and Literature Review","volume":"116","author":"Furlan","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e203","DOI":"10.1016\/j.athoracsur.2021.05.021","article-title":"A Liposarcoma Arising in a Pulmonary Hamartoma, Coexisting with Benign Metastasizing Leiomyoma","volume":"113","author":"Siblani","year":"2022","journal-title":"Ann. Thorac. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00428-014-1556-z","article-title":"Lipomatous Tumors of the Anterior Mediastinum with Muscle Differentiation: A Clinicopathological and Immunohistochemical Study of Three Cases","volume":"464","author":"Weissferdt","year":"2014","journal-title":"Virchows Arch."},{"key":"ref_62","first-page":"59","article-title":"Primary Mediastinal Liposarcoma","volume":"12","author":"Ouadnouni","year":"2015","journal-title":"Ann. Afr. Surg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00595-004-2940-0","article-title":"Dedifferentiated Liposarcoma of the Pleura: Report of a Case","volume":"35","author":"Takanami","year":"2005","journal-title":"Surg. Today"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cancergencyto.2007.09.006","article-title":"Dedifferentiated Liposarcoma of the Pleura Mimicking a Malignant Solitary Fibrous Tumor and Associated with Dedifferentiated Liposarcoma of the Mediastinum: Usefulness of Cytogenetic and Molecular Genetic Analyses","volume":"179","author":"Benchetritt","year":"2007","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s10147-008-0819-6","article-title":"A Dedifferentiated Liposarcoma of the Anterior Mediastinum","volume":"14","author":"Fukai","year":"2009","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1510\/icvts.2009.209494","article-title":"Recurrent Dedifferentiated Liposarcoma of Mediastinum Involving Lung and Pleura","volume":"9","author":"Coulibaly","year":"2009","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2739\/kurumemedj.58.63","article-title":"Giant Liposarcoma Occupying Most of The Hemi-Thorax and Resected in the Supine Position: Report of a Rare Case","volume":"58","author":"Matsuo","year":"2011","journal-title":"Kurume Med. J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1055\/s-0033-1358605","article-title":"A Mediastinal Liposarcoma Resected Using a Double Approach with a Thoracoscope","volume":"2","author":"Asaka","year":"2013","journal-title":"Thorac. Cardiovasc. Surg. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1055\/s-0035-1553367","article-title":"Dedifferentiated Liposarcoma of the Anterior Mediastinum: A Rare Case","volume":"188","author":"Harth","year":"2015","journal-title":"RoFo"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"rjv163","DOI":"10.1093\/jscr\/rjv163","article-title":"Primary Mediastinal Dedifferentiated Liposarcoma Resected by Lateral Thoracotomy with Video-Assisted Thoracoscopic Surgery","volume":"2016","author":"Hamanaka","year":"2016","journal-title":"J. Surg. Case Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/00015385.2017.1335460","article-title":"Mediastinal Dedifferentiated Liposarcoma","volume":"72","author":"Sbrana","year":"2017","journal-title":"Acta Cardiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1111\/1759-7714.12888","article-title":"Primary Mediastinal Dedifferentiated Liposarcoma: Five Case Reports and a Review","volume":"9","author":"Miura","year":"2018","journal-title":"Thorac. Cancer"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/1759-7714.12930","article-title":"Rapidly Growing Pleural Liposarcoma Masquerading as Extrapleural Hematoma","volume":"10","author":"Lin","year":"2019","journal-title":"Thorac. Cancer"},{"key":"ref_74","first-page":"132","article-title":"Pleural Dedifferentiated Liposarcoma: A Case Report","volume":"10","author":"Matsukuma","year":"2019","journal-title":"Mol. Clin. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/ans.14697","article-title":"Inflammatory Calcified De-differentiated Liposarcoma of the Anterior Mediastinum","volume":"89","author":"Kim","year":"2019","journal-title":"ANZ J. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.clinimag.2019.08.004","article-title":"Incidental Dedifferentiated Mediastinal Liposarcoma on F-18-Fluciclovine PET\/CT","volume":"59","author":"Boatright","year":"2020","journal-title":"Clin. Imaging"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"939","DOI":"10.12998\/wjcc.v8.i5.939","article-title":"Combining Surgery with 125I Brachytherapy for Recurrent Mediastinal Dedifferentiated Liposarcoma: A Case Report and Review of Literature","volume":"8","author":"Chen","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s11748-021-01735-w","article-title":"A Successful Trimodality Therapy for Difficult-to-Diagnose Primary Mediastinal Dedifferentiated Liposarcoma, Which Originated from the Perihilar Fat and Invaded the Right Lungs","volume":"70","author":"Ochi","year":"2021","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1200\/JCO.2005.05.056","article-title":"Conditions Suggesting Lymphoma: Case 2. Mediastinal Liposarcoma in a Patient with Previous Testicular Cancer","volume":"23","author":"Caraglia","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1159\/000325185","article-title":"Pleural Liposarcoma Mimicking Carcinoma in Pleural Effusion Cytology","volume":"54","author":"Dagli","year":"2010","journal-title":"Acta Cytol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.3760\/cma.j.issn.0366-6999.2010.13.041","article-title":"A Giant Primary Myxoid Liposarcoma of the Posterior Mediastinum","volume":"123","author":"Liu","year":"2010","journal-title":"Chin. Med. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1749-8090-9-119","article-title":"Primary Intrathoracic Liposarcoma: A Clinicopathologic Study and Prognostic Analysis of 23 Cases","volume":"9","author":"Chen","year":"2014","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1177\/0218492315589201","article-title":"Giant Primary Mediastinal Liposarcoma: A Rare Cause of Atrial Flutter","volume":"23","year":"2015","journal-title":"Asian Cardiovasc. Thorac. Ann."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s11748-005-0082-y","article-title":"Pulmonary Pleomorphic Liposarcoma","volume":"53","author":"Ibe","year":"2005","journal-title":"Jpn. J. Thorac. Cardiovasc. Surg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1159\/000325763","article-title":"Mediastinal Pleomorphic Liposarcoma Diagnosed by Fine Needle Aspiration Biopsy","volume":"51","year":"2007","journal-title":"Acta Cytol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/24\/7353\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:37:59Z","timestamp":1760146679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/24\/7353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,10]]},"references-count":85,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["jcm11247353"],"URL":"https:\/\/doi.org\/10.3390\/jcm11247353","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,10]]}}}