{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:47:28Z","timestamp":1788540448947,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Scientific Foundation","award":["20-14-00305"],"award-info":[{"award-number":["20-14-00305"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: There are no reliable and widely available markers of functional iron deficiency (FID) in cancer. The aim of the study was to evaluate the role of transferrin (Tf) as a marker of cancer of the ovary (CrO) and related FID. (2) Methods: The study groups consisted of 118 patients with CrO and 69 control females. Blood serum iron status was determined on a Beckman Coulter AU (USA) analyzer. Tf quantification was performed by immunoturbidimetry. The relative contents of apo- and holo-Tf (iron-free and iron-saturated Tf, respectively) were determined in eight patients and a control female by immunochromatographic analysis based on the use of monoclonal single-domain antibodies (nanobodies). (3) Results: Four groups of patients with different iron statuses were selected according to ferritin and transferrin saturation values: absolute iron deficiency (AID) (n = 42), FID (n = 70), iron overload (n = 4), normal iron status (n = 2). The groups differed significantly in Tf values (p &lt; 0.0001). Lower values of Tf were associated with FID. Furthermore, FID is already found in the initial stages of CrO (26%). Immunosorbents based on nanobodies revealed the accumulation of apo-Tf and the decrease in holo-Tf in patients with CrO. (4) Conclusions: Tf may be a promising tool for diagnosing both CrO and associated FID.<\/jats:p>","DOI":"10.3390\/jcm11247377","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T03:32:32Z","timestamp":1670902352000},"page":"7377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Prognostic Value of Serum Transferrin Analysis in Patients with Ovarian Cancer and Cancer-Related Functional Iron Deficiency: A Retrospective Case\u2013Control Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Tatiana I.","family":"Ivanova","sequence":"first","affiliation":[{"name":"A. Tsyb Medical Radiological Research Center\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Zhukova Str. 10, 249030 Obninsk, Russia"},{"name":"Institute of Gene Biology of the Russian Academy of Sciences, Vavilova Str. 34\/5, 119334 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2888-7999","authenticated-orcid":false,"given":"Ilya D.","family":"Klabukov","sequence":"additional","affiliation":[{"name":"National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Koroleva Str. 4, 249036 Obninsk, Russia"},{"name":"Department of Urology and Operative Nephrology, Peoples\u2019 Friendship University of Russia (RUDN University), Miklukho-Maklaya Str. 6, 117198 Moscow, Russia"},{"name":"Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University MEPhI, Studgorodok 1, 249039 Obninsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila I.","family":"Krikunova","sequence":"additional","affiliation":[{"name":"A. Tsyb Medical Radiological Research Center\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Zhukova Str. 10, 249030 Obninsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina V.","family":"Poluektova","sequence":"additional","affiliation":[{"name":"A. Tsyb Medical Radiological Research Center\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Zhukova Str. 10, 249030 Obninsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia I.","family":"Sychenkova","sequence":"additional","affiliation":[{"name":"A. Tsyb Medical Radiological Research Center\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Zhukova Str. 10, 249030 Obninsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-9557","authenticated-orcid":false,"given":"Vera A.","family":"Khorokhorina","sequence":"additional","affiliation":[{"name":"A. Tsyb Medical Radiological Research Center\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Zhukova Str. 10, 249030 Obninsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay V.","family":"Vorobyev","sequence":"additional","affiliation":[{"name":"Department of Oncology, Radiotherapy and Plastic Surgery, Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya str. 8-2, 119991 Moscow, Russia"},{"name":"P.A. Hertsen Moscow Oncology Research Institute\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 2nd Botkinsky Proezd 3, 125284 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita Ya.","family":"Gaas","sequence":"additional","affiliation":[{"name":"Department of Urology and Operative Nephrology, Peoples\u2019 Friendship University of Russia (RUDN University), Miklukho-Maklaya Str. 6, 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis S.","family":"Baranovskii","sequence":"additional","affiliation":[{"name":"A. Tsyb Medical Radiological Research Center\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Zhukova Str. 10, 249030 Obninsk, Russia"},{"name":"Department of Urology and Operative Nephrology, Peoples\u2019 Friendship University of Russia (RUDN University), Miklukho-Maklaya Str. 6, 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-9729","authenticated-orcid":false,"given":"Oksana S.","family":"Goryainova","sequence":"additional","affiliation":[{"name":"Institute of Gene Biology of the Russian Academy of Sciences, Vavilova Str. 34\/5, 119334 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiya M.","family":"Sachko","sequence":"additional","affiliation":[{"name":"Institute of Gene Biology of the Russian Academy of Sciences, Vavilova Str. 34\/5, 119334 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter V.","family":"Shegay","sequence":"additional","affiliation":[{"name":"National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Koroleva Str. 4, 249036 Obninsk, Russia"},{"name":"Department of Urology and Operative Nephrology, Peoples\u2019 Friendship University of Russia (RUDN University), Miklukho-Maklaya Str. 6, 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey D.","family":"Kaprin","sequence":"additional","affiliation":[{"name":"National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Koroleva Str. 4, 249036 Obninsk, Russia"},{"name":"Department of Urology and Operative Nephrology, Peoples\u2019 Friendship University of Russia (RUDN University), Miklukho-Maklaya Str. 6, 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7172-8731","authenticated-orcid":false,"given":"Sergei V.","family":"Tillib","sequence":"additional","affiliation":[{"name":"Institute of Gene Biology of the Russian Academy of Sciences, Vavilova Str. 34\/5, 119334 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Huang, J., Chan, W.C., Ngai, C.H., Lok, V., Zhang, L., Lucero-Prisno, D.E., Xu, W., Zheng, Z.-J., Elcarte, E., and Withers, M. 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