{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:34:08Z","timestamp":1791894848115,"version":"4.3.4"},"reference-count":80,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: There is clinical interest in determining the effects of low-load blood flow restriction (LL-BFR) resistance training on muscle strength and hypertrophy compared with traditional high- and low-load (HL and LL) resistance training in healthy older adults and the influence of LL-BFR training cuff-pressure on these outcomes. Methods: A search was performed on the MEDLINE, PEDro, CINHAL, Web of Science, Science Direct, Scopus, and CENTRAL databases. Results: The analysis included 14 studies. HL resistance training produces a small increase in muscle strength (eight studies; SMD, \u22120.23 [\u22120.41; \u22120.05]) but not in muscle hypertrophy (six studies; (SMD, 0.08 [\u22120.22; 0.38]) when compared with LL-BFR resistance training. Compared with traditional LL resistance training, LL-BFR resistance training produces small\u2013moderate increases in muscle strength (seven studies; SMD, 0.44 [0.28; 0.60]) and hypertrophy (two studies; SMD, 0.51 [0.06; 0.96]). There were greater improvements in muscle strength when higher cuff pressures were applied versus traditional LL resistance training but not versus HL resistance training. Conclusions: LL-BFR resistance training results in lower muscle strength gains than HL resistance training and greater than traditional LL resistance training in healthy adults older than 60 years. LL-BFR resistance training promotes a similar muscle hypertrophy to HL resistance training but is greater than that of traditional LL resistance training. Applying cuff pressures above the limb occlusion pressure could enhance the increases in muscle strength compared with traditional LL resistance training.<\/jats:p>","DOI":"10.3390\/jcm11247389","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T03:32:32Z","timestamp":1670902352000},"page":"7389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of Low-Load Blood Flow Restriction Resistance Training on Muscle Strength and Hypertrophy Compared with Traditional Resistance Training in Healthy Adults Older Than 60 Years: Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6565-4967","authenticated-orcid":false,"given":"Ra\u00fal","family":"Fabero-Garrido","sequence":"first","affiliation":[{"name":"Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, Physiotherapy and Podiatry, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Gragera-Vela","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, Physiotherapy and Podiatry, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3144-5411","authenticated-orcid":false,"given":"Tamara","family":"del Corral","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, Physiotherapy and Podiatry, Complutense University of Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7234-641X","authenticated-orcid":false,"given":"Juan","family":"Izquierdo-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, Physiotherapy and Podiatry, Complutense University of Madrid, 28040 Madrid, Spain"},{"name":"Multidisciplinary Cardiac Rehabilitation Unit, University Hospital 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-5027","authenticated-orcid":false,"given":"Gustavo","family":"Plaza-Manzano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, Physiotherapy and Podiatry, Complutense University of Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibai","family":"L\u00f3pez-de-Uralde-Villanueva","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, Physiotherapy and Podiatry, Complutense University of Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021). Ageing and Health."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1532-5415.2002.50216.x","article-title":"Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability","volume":"50","author":"Janssen","year":"2002","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Sayer","year":"2019","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10522-016-9641-0","article-title":"Physical activity in older age: Perspectives for healthy ageing and frailty","volume":"17","author":"McPhee","year":"2016","journal-title":"Biogerontology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11357-015-9832-7","article-title":"The emergence of sedentary behaviour physiology and its effects on the cardiometabolic profile in young and older adults","volume":"37","author":"Ryan","year":"2015","journal-title":"Age"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1007\/s40279-020-01331-7","article-title":"Effects of Resistance Training on Muscle Size and Strength in Very Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"50","author":"Grgic","year":"2020","journal-title":"Sport Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1519\/JSC.0000000000003230","article-title":"Resistance Training for Older Adults: Position Statement From the National Strength and Conditioning Association","volume":"33","author":"Fragala","year":"2019","journal-title":"J. Strength Cond. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2147\/CIA.S104674","article-title":"Resistance training for activity limitations in older adults with skeletal muscle function deficits: A systematic review","volume":"12","author":"Papa","year":"2017","journal-title":"Clin. Interv. Aging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/sms.12536","article-title":"Effects of resistance training with moderate vs heavy loads on muscle mass and strength in the elderly: A meta-analysis","volume":"26","author":"Csapo","year":"2016","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1007\/s40279-015-0385-9","article-title":"Dose-Response Relationships of Resistance Training in Healthy Old Adults: A Systematic Review and Meta-Analysis","volume":"45","author":"Borde","year":"2015","journal-title":"Sports Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1249\/MSS.0b013e3181c34465","article-title":"Dose-response relationship of resistance training in older adults: A meta-analysis","volume":"42","author":"Steib","year":"2010","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jamda.2011.11.001","article-title":"Efficacy of progressive resistance training interventions in older adults in nursing homes: A systematic review","volume":"13","author":"Valenzuela","year":"2012","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1113\/jphysiol.2008.164483","article-title":"Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men","volume":"587","author":"Kumar","year":"2009","journal-title":"J. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"937","DOI":"10.4085\/418-20","article-title":"Blood Flow Restriction Training","volume":"56","author":"Lorenz","year":"2021","journal-title":"J. Athl. Train."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3806\/ijktr.1.6","article-title":"Skeletal muscle size and circulating IGF-1 are increased after two weeks of twice daily \u201cKAATSU\u201d resistance training","volume":"1","author":"Abe","year":"2005","journal-title":"Int. J. KAATSU Train. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2170\/jjphysiol.54.585","article-title":"Cooperative effects of exercise and occlusive stimuli on muscular function in low-intensity resistance exercise with moderate vascular occlusion","volume":"54","author":"Takarada","year":"2004","journal-title":"Jpn. J. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s40279-018-0994-1","article-title":"Effects of Blood Flow Restriction Training on Muscular Strength and Hypertrophy in Older Individuals: A Systematic Review and Meta-Analysis","volume":"49","author":"Centner","year":"2019","journal-title":"Sports Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111827","DOI":"10.1016\/j.exger.2022.111827","article-title":"Effect of blood flow restriction combined with low-intensity training on the lower limbs muscle strength and function in older adults: A meta-analysis","volume":"164","author":"Zhang","year":"2022","journal-title":"Exp. Gerontol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Rodrigo-Mallorca, D., Loaiza-Betancur, A.F., Monteagudo, P., Blasco-Lafarga, C., and Chulvi-Medrano, I. (2021). Resistance Training with Blood Flow Restriction Compared to Traditional Resistance Training on Strength and Muscle Mass in Non-Active Older Adults: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Heal., 18.","DOI":"10.3390\/ijerph182111441"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1080\/02640414.2014.992036","article-title":"The effects of resistance exercise with and without different degrees of blood-flow restriction on perceptual responses","volume":"33","author":"Loenneke","year":"2015","journal-title":"J. Sports Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.metabol.2010.01.016","article-title":"Venous blood gas and metabolite response to low-intensity muscle contractions with external limb compression","volume":"59","author":"Yasuda","year":"2010","journal-title":"Metabolism"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1556\/036.102.2015.4.10","article-title":"The acute muscular effects of cycling with and without different degrees of blood flow restriction","volume":"102","author":"Kim","year":"2015","journal-title":"Acta Physiol. Hung."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., Altman, D., and PRISMA Group (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med., 6.","DOI":"10.2427\/5768"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Methley, A.M., Campbell, S., Chew-Graham, C., McNally, R., and Cheraghi-Sohi, S. (2014). PICO, PICOS and SPIDER: A comparison study of specificity and sensitivity in three search tools for qualitative systematic reviews. BMC Health Serv. Res., 14.","DOI":"10.1186\/s12913-014-0579-0"},{"key":"ref_25","unstructured":"Scherbov, S., and Sanderson, W. (2020). New Measures of Population Ageing, United Nations."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s00421-021-04627-2","article-title":"Patterns of responses and time-course of changes in muscle size and strength during low-load blood flow restriction resistance training in women","volume":"121","author":"Hill","year":"2021","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/07303084.1993.10606684","article-title":"Strength Testing\u2014Predicting a One-Rep Max from Reps-to-Fatigue","volume":"64","author":"Brzycki","year":"1993","journal-title":"J. Phys. Educ. Recreat. Dance"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.exger.2018.10.017","article-title":"Effect of 16 weeks of resistance exercise and detraining comparing two methods of blood flow restriction in muscle strength of healthy older women: A randomized controlled trial","volume":"114","author":"Letieri","year":"2018","journal-title":"Exp. Gerontol."},{"key":"ref_29","first-page":"169","article-title":"Reliability of isokinetic knee extension and flexion strength testing in elderly women","volume":"38","author":"Capranica","year":"1998","journal-title":"J. Sports Med. Phys. Fit."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1589\/jpts.26.1855","article-title":"Reliability of Isometric Knee Extension Muscle Strength Measurements of Healthy Elderly Subjects Made with a Hand-held Dynamometer and a Belt","volume":"26","author":"Katoh","year":"2014","journal-title":"J. Phys. Ther. Sci."},{"key":"ref_31","first-page":"843","article-title":"Measurement and evaluation of the quadriceps muscle mass in young men based on magnetic resonance imaging","volume":"53","author":"Wu","year":"2021","journal-title":"J. Peking Univ. Health Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00421-005-0061-0","article-title":"Prediction and validation of total and regional skeletal muscle mass by ultrasound in Japanese adults","volume":"96","author":"Sanada","year":"2006","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Meza-Valderrama, D., S\u00e1nchez- Rodr\u00edguez, D., Perkisas, S., Duran, X., Bastijns, S., D\u00e1valos-Yerovi, V., Da Costa, E., and Marco, E. (2022). The feasibility and reliability of measuring forearm muscle thickness by ultrasound in a geriatric inpatient setting: A cross-sectional pilot study. BMC Geriatr., 22.","DOI":"10.1186\/s12877-022-02811-3"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1249\/00005768-199010000-00027","article-title":"Anthropometric estimation of muscle mass in men","volume":"22","author":"Martin","year":"1990","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.2196\/medinform.7680","article-title":"Expert Search Strategies: The Information Retrieval Practices of Healthcare Information Professionals","volume":"5","author":"Chamberlain","year":"2017","journal-title":"JMIR Med. Inform."},{"key":"ref_36","unstructured":"Higgins, J., and Sally, G. (2012). Cochrane Handbook for Systematic Reviews of Interventions, Cochrane Collaboration. version 5.1.0."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/ptj\/83.8.713","article-title":"Reliability of the PEDro Scale for Rating Quality of Randomized Controlled Trials","volume":"83","author":"Maher","year":"2003","journal-title":"Phys. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jclinepi.2005.01.002","article-title":"The PEDro scale provides a more comprehensive measure of methodological quality than the Jadad scale in stroke rehabilitation literature","volume":"58","author":"Bhogal","year":"2005","journal-title":"J. Clin. Epidemiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"276","DOI":"10.11613\/BM.2012.031","article-title":"Interrater reliability: The kappa statistic","volume":"22","author":"McHugh","year":"2012","journal-title":"Biochem. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jclinepi.2012.03.013","article-title":"GRADE guidelines: 14. Going from evidence to recommendations: The significance and presentation of recommendations","volume":"66","author":"Andrews","year":"2013","journal-title":"J. Clin. Epidemiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1055\/a-1386-4846","article-title":"Resistance Training with Blood Flow Restriction on Vascular Function: A Meta-analysis","volume":"42","author":"Liu","year":"2021","journal-title":"Int. J. Sports Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/17461390500528527","article-title":"Meta-analysis in sport and exercise research: Review, recent developments, and recommendations","volume":"6","author":"Hagger","year":"2006","journal-title":"Eur. J. Sport Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol. Bull."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ejvs.2010.07.011","article-title":"Quality Control in Systematic Reviews and Meta-analyses","volume":"40","author":"Bown","year":"2010","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/jrsm.11","article-title":"Outlier and influence diagnostics for meta-analysis","volume":"1","author":"Viechtbauer","year":"2010","journal-title":"Res. Synth. Methods"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jclinepi.2004.01.018","article-title":"Sensitivity analyses allowed more appropriate and reliable meta-analysis conclusions for multiple outcomes when missing data was present","volume":"57","author":"Riley","year":"2004","journal-title":"J. Clin. Epidemiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0895-4356(01)00377-8","article-title":"Funnel plots for detecting bias in meta-analysis","volume":"54","author":"Sterne","year":"2001","journal-title":"J. Clin. Epidemiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"33595","DOI":"10.18632\/oncotarget.9564","article-title":"Thigh muscle size and vascular function after blood flow-restricted elastic band training in older women","volume":"7","author":"Yasuda","year":"2016","journal-title":"Oncotarget"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1519\/JSC.0000000000000703","article-title":"Comparisons between low-intensity resistance training with blood flow restriction and high-intensity resistance training on quadriceps muscle mass and strength in elderly","volume":"29","author":"Vechin","year":"2015","journal-title":"J. Strength Cond. Res."},{"key":"ref_52","first-page":"531","article-title":"Effects of strength training with and without blood flow restriction on quality of life in elderly women","volume":"19","author":"Ruaro","year":"2019","journal-title":"J. Phys. Educ. Sport"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.exger.2017.09.016","article-title":"Effects of blood flow restricted exercise training on muscular strength and blood flow in older adults","volume":"99","author":"Kim","year":"2017","journal-title":"Exp. Gerontol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.exger.2017.10.004","article-title":"Blood flow restricted resistance training in older adults at risk of mobility limitations","volume":"99","author":"Cook","year":"2017","journal-title":"Exp. Gerontol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3389\/fphys.2019.00738","article-title":"Progression of blood flow restricted resistance training in older adults at risk of mobility limitations","volume":"10","author":"Cook","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_56","first-page":"395","article-title":"Effect of concurrent training with blood flow restriction in the elderly","volume":"36","author":"Libardi","year":"2015","journal-title":"Front. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"104110","DOI":"10.1016\/j.archger.2020.104110","article-title":"Functional training with blood occlusion influences muscle quality indices in older adults","volume":"90","author":"Bigdeli","year":"2020","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1123\/japa.19.3.201","article-title":"Enhancing strength and postocclusive calf blood flow in older people with training with blood-flow restriction","volume":"19","author":"Patterson","year":"2011","journal-title":"J. Aging Phys. Act."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00421-016-3328-8","article-title":"Low-intensity resistance training with blood flow restriction improves vascular endothelial function and peripheral blood circulation in healthy elderly people","volume":"116","author":"Shimizu","year":"2016","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/s40064-015-1132-2","article-title":"Effects of detraining after blood flow-restricted low-load elastic band training on muscle size and arterial stiffness in older women","volume":"4","author":"Yasuda","year":"2015","journal-title":"Springerplus"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/gerona\/glu084","article-title":"Effects of Low-Load, Elastic Band Resistance Training Combined With Blood Flow Restriction on Muscle Size and Arterial Stiffness in Older Adults","volume":"70","author":"Yasuda","year":"2015","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_62","first-page":"117","article-title":"Effects of low-intensity resistance exercise with vascular occlusion on physical function in healthy elderly people","volume":"2","author":"Yokokawa","year":"2008","journal-title":"PubMed Biosci. Trends"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jclinepi.2019.05.012","article-title":"Risk of bias assessments for blinding of participants and personnel in Cochrane reviews were frequently inadequate","volume":"113","author":"Barcot","year":"2019","journal-title":"J. Clin. Epidemiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/mus.25420","article-title":"The problem Of muscle hypertrophy: Revisited","volume":"54","author":"Buckner","year":"2016","journal-title":"Muscle Nerve"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s40279-017-0795-y","article-title":"Magnitude of Muscle Strength and Mass Adaptations Between High-Load Resistance Training Versus Low-Load Resistance Training Associated with Blood-Flow Restriction: A Systematic Review and Meta-Analysis","volume":"48","author":"Ugrinowitsch","year":"2018","journal-title":"Sports Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s40279-014-0264-9","article-title":"A Review on the Mechanisms of Blood-Flow Restriction Resistance Training-Induced Muscle Hypertrophy","volume":"45","author":"Pearson","year":"2015","journal-title":"Sports Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1152\/japplphysiol.01264.2001","article-title":"Invited Review: Autocrine\/paracrine IGF-I and skeletal muscle adaptation","volume":"93","author":"Adams","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1249\/MSS.0b013e31826c6fa8","article-title":"Neuromuscular Function after a Bout of Low-Load Blood Flow\u2013Restricted Exercise","volume":"45","author":"Cook","year":"2013","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/BF02388334","article-title":"Changes in force, cross-sectional area and neural activation during strength training and detraining of the human quadriceps","volume":"59","author":"Narici","year":"1989","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s004210000248","article-title":"Neuromuscular adaptation during prolonged strength training, detraining and re-strength-training in middle-aged and elderly people","volume":"83","author":"Alen","year":"2000","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ptsp.2021.02.005","article-title":"Comparison of blood flow restriction devices and their effect on quadriceps muscle activation","volume":"49","author":"Bordessa","year":"2021","journal-title":"Phys. Ther. Sport"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1136\/bjsports-2016-097071","article-title":"Blood flow restriction training in clinical musculoskeletal rehabilitation: A systematic review and meta-analysis","volume":"51","author":"Hughes","year":"2017","journal-title":"Br. J. Sports Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1152\/japplphysiol.01266.2009","article-title":"Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men","volume":"108","author":"Fry","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1152\/jappl.2000.88.1.61","article-title":"Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion","volume":"88","author":"Takarada","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.mehy.2011.10.014","article-title":"The anabolic benefits of venous blood flow restriction training may be induced by muscle cell swelling","volume":"78","author":"Loenneke","year":"2012","journal-title":"Med. Hypotheses"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1519\/JSC.0b013e31824f207e","article-title":"Does exercise-induced muscle damage play a role in skeletal muscle hypertrophy?","volume":"26","author":"Schoenfeld","year":"2012","journal-title":"J. Strength Cond. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s11033-018-4261-1","article-title":"Acute responses of hemodynamic and oxidative stress parameters to aerobic exercise with blood flow restriction in hypertensive elderly women","volume":"45","author":"Barili","year":"2018","journal-title":"Mol. Biol. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/2000656X.2020.1755297","article-title":"Use of a biopsy punch for end-to-side anastomosis in free-tissue transfer","volume":"54","author":"Chung","year":"2020","journal-title":"J. Plast. Surg. Hand Surg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/mus.24448","article-title":"Effects of exercise with and without different degrees of blood flow restriction on torque and muscle activation","volume":"51","author":"Loenneke","year":"2015","journal-title":"Muscle Nerve"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/cpf.12312","article-title":"Blood flow-restricted walking in older women: Does the acute hormonal response associate with muscle hypertrophy?","volume":"37","author":"Ozaki","year":"2017","journal-title":"Clin. Physiol. Funct. 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