{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:57:32Z","timestamp":1771675052551,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Key R&amp;D Program of China","award":["2022YFC2704200"],"award-info":[{"award-number":["2022YFC2704200"]}]},{"name":"the National Key R&amp;D Program of China","award":["82073647"],"award-info":[{"award-number":["82073647"]}]},{"name":"the National Key R&amp;D Program of China","award":["82103914"],"award-info":[{"award-number":["82103914"]}]},{"name":"the National Key R&amp;D Program of China","award":["XLYC1907102"],"award-info":[{"award-number":["XLYC1907102"]}]},{"name":"the National Key R&amp;D 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of Liaoning Province","award":["2022YFC2704200"],"award-info":[{"award-number":["2022YFC2704200"]}]},{"name":"the JieBangGuaShuai Project of Liaoning Province","award":["82073647"],"award-info":[{"award-number":["82073647"]}]},{"name":"the JieBangGuaShuai Project of Liaoning Province","award":["82103914"],"award-info":[{"award-number":["82103914"]}]},{"name":"the JieBangGuaShuai Project of Liaoning Province","award":["XLYC1907102"],"award-info":[{"award-number":["XLYC1907102"]}]},{"name":"the JieBangGuaShuai Project of Liaoning Province","award":["2021JH1\/1040050"],"award-info":[{"award-number":["2021JH1\/1040050"]}]},{"name":"the JieBangGuaShuai Project of Liaoning Province","award":["M0268"],"award-info":[{"award-number":["M0268"]}]},{"name":"the JieBangGuaShuai Project of Liaoning Province","award":["M0952"],"award-info":[{"award-number":["M0952"]}]},{"name":"345 Talent Project of Shengjing Hospital of China Medical 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University","award":["M0952"],"award-info":[{"award-number":["M0952"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The relationship between prediagnosis depression, anxiety symptoms, and ovarian cancer (OC) survival is unknown. We aimed to explore these associations to provide further epidemiological evidence. Methods: We investigated the relationship between prediagnosis depression, anxiety symptoms, and OC survival in a prospective cohort study of newly diagnosed OC patients aged 18\u201379 years. Depression and anxiety symptoms were assessed using the Patient Health Questionnaire 9 and Generalized Anxiety Disorder 7 at diagnosis, respectively. Deaths were ascertained until 31 March 2021 via medical records and active follow-up. Multivariable-adjusted Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with prediagnosis depression and anxiety symptoms and all-cause mortality of OC. Results: We found 56 (9.4%) and 235 (39.3%) OC patients with depression and anxiety symptoms, respectively. During a median follow-up of 37.2 months (interquartile range 24.7\u201350.2 months), 130 deaths were confirmed. Compared with non-depression symptoms, patients with prediagnosis depressive symptoms showed a significantly increased risk of OC mortality (HR = 2.10, 95% CI: 1.20\u20133.70). Of note, the association was still robust when focusing on the OC patients with severe depressive symptoms (HR = 2.10, 95% CI: 1.07\u20134.12). However, we observed no association between prediagnosis anxiety symptoms of different severity and OC mortality. Interestingly, OC patients with combined moderate depression and anxiety symptoms had a significantly increased risk of OC mortality (HR = 3.23, 95% CI: 1.14\u20139.11) compared to those with no symptoms of depression and anxiety. Notably, Wilms\u2019s tumor 1 was significantly associated with depression and anxiety symptoms (p &lt; 0.05). Conclusions: Prediagnosis depression increases the risk of OC mortality. Large multicenter studies are required to confirm this finding.<\/jats:p>","DOI":"10.3390\/jcm11247394","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T02:54:21Z","timestamp":1670986461000},"page":"7394","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prediagnosis Depression Rather Than Anxiety Symptoms Is Associated with Decreased Ovarian Cancer Survival: Findings from the Ovarian Cancer Follow-Up Study (OOPS)"],"prefix":"10.3390","volume":"11","author":[{"given":"Yi-Zi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine and Joint Surgery, The People\u2019s Hospital of Liaoning Province, Shenyang 110000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Fan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0806-4247","authenticated-orcid":false,"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shengjing Hospital of China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Ting","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-106X","authenticated-orcid":false,"given":"Qi-Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Key Laboratory of Reproductive and Genetic Medicine, National Health Commission, China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 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