{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:43:54Z","timestamp":1771055034549,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Buddhist Tzu Chi Medical Foundation","award":["TCMF-MP-110-03-01"],"award-info":[{"award-number":["TCMF-MP-110-03-01"]}]},{"name":"Buddhist Tzu Chi Medical Foundation","award":["TCMF-SP-108-01"],"award-info":[{"award-number":["TCMF-SP-108-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: To investigate the long-term clinical and urodynamic outcomes of a small cohort of children who received short-term urotherapy for confirmed dysfunctional voiding (DV) and lower urinary tract symptoms (LUTS). Materials and Methods: This study included 26 children with confirmed LUTS and DV via video urodynamic study (VUDS) and received standard urological therapy, pelvic floor muscle training, or surgical intervention in childhood. Their current lower urinary tract conditions were assessed by chart review and direct and telephone interviews. Charts of 14 patients who underwent follow-up VUDS were reviewed to investigate their bladder and voiding dysfunction or follow-up on previous treatment results. The satisfaction of lower urinary tract status was assessed using the global response assessment (GRA) scale. Results: At initial enrolment, the mean age was 9.54 \u00b1 3.88 years, and urological treatment was performed during the first 1\u20135 years thereafter. Most patients were not regularly followed in the urology clinic. Among the 14 children available for follow-up, a GRA score of 3 was reported by 10 (71.4%) after a mean follow-up period of 10.3 \u00b1 6.74 (range, 2\u201320) years, indicating satisfactory bladder and voiding conditions. Four children with less favorable outcomes (GRA score of &lt;3) had significantly more post-void residual urine volume at baseline, and 75% of these patients had central nervous system diseases. Daytime incontinence and enuresis rates were significantly decreased at follow-up compared with the baseline. Significantly increased bladder capacity and sensation and significantly decreased voiding detrusor pressure were found on follow-up VUDS. Conclusions: Children with DV who received standard urotherapy upon diagnosis exhibited improved LUTS at a 10-year follow-up. Of the 14 children available for follow-up, 10 (71.4%) reported satisfactory bladder and voiding status without further medication or urotherapy, with significantly decreased voiding detrusor pressure.<\/jats:p>","DOI":"10.3390\/jcm11247395","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T02:54:21Z","timestamp":1670986461000},"page":"7395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long-Term Follow-Up of Lower Urinary Tract Outcome in Children with Dysfunctional Voiding"],"prefix":"10.3390","volume":"11","author":[{"given":"Chung-Hsin","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Urology, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City 242062, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-1185","authenticated-orcid":false,"given":"Sheng-Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 970473, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-4771","authenticated-orcid":false,"given":"Hann-Chorng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 970473, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/nau.24886","article-title":"The effect of biofeedback treatment for children with non-neurogenic voiding dysfunction: A systematic review and meta-analysis","volume":"41","author":"Qi","year":"2022","journal-title":"Neurourol. Urodyn."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/j.juro.2010.07.011","article-title":"Nonneurogenic voiding disorders in children and adolescents: Clinical and videourodynamic findings in 4 specific conditions","volume":"184","author":"Glassberg","year":"2010","journal-title":"J. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000089739","article-title":"Investigation of dysfunctional voiding in children with urgency frequency syndrome and urinary incontinence","volume":"76","author":"Kuo","year":"2006","journal-title":"Urol. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s11934-010-0166-9","article-title":"Biofeedback therapy for dysfunctional voiding in children","volume":"12","author":"Koenig","year":"2011","journal-title":"Curr. Urol. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00467-017-3679-3","article-title":"Dysfunctional voiding: The importance of non-invasive urodynamics in diagnosis and treatment","volume":"33","author":"Clothier","year":"2018","journal-title":"Pediatr. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/luts.12123","article-title":"Pathophysiological and therapeutic considerations for non-neurogenic lower urinary tract dysfunction in children","volume":"8","author":"Kakizaki","year":"2016","journal-title":"Low. Urin. Tract Symptoms"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.urology.2009.09.008","article-title":"Management of abnormal postvoid residual urine in children with dysfunctional voiding","volume":"75","author":"Kibar","year":"2010","journal-title":"Urology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/nau.10052","article-title":"The standardisation of terminology of lower urinary tract function: Report from the Standardisation Sub-Committee of the International Continence Society","volume":"21","author":"Abrams","year":"2002","journal-title":"Neurourol. Urodyn."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1464-410X.2000.tb16944.x","article-title":"Classification and treatment of functional incontinence in children","volume":"85","author":"Nijman","year":"2000","journal-title":"BJU Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.juro.2008.01.010","article-title":"The male urethral sphincter complex revisited: An anatomical concept and its physiological correlate","volume":"179","author":"Koraitim","year":"2008","journal-title":"J. Urol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/S0022-5347(05)64392-3","article-title":"Biofeedback therapy expedites the resolution of reflux in older children","volume":"168","author":"Palmer","year":"2002","journal-title":"J. Urol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"94.e1","DOI":"10.1016\/j.jpurol.2015.06.019","article-title":"Ten years of experience with intravesical and intrasphincteric onabotulinumtoxinA in children","volume":"12","author":"Greer","year":"2016","journal-title":"J. Pediatr. Urol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1464-410x.2000.00664.x","article-title":"Pelvic-floor therapy and toilet training in young children with dysfunctional voiding and obstipation","volume":"85","author":"Renson","year":"2000","journal-title":"BJU Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/MOU.0000000000000074","article-title":"Dysfunctional voiding","volume":"24","author":"Artibani","year":"2014","journal-title":"Curr. Opin. Urol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s00467-003-1210-5","article-title":"Natural history of voiding dysfunction","volume":"18","author":"Saedi","year":"2003","journal-title":"Pediatr. Nephrol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/nau.22751","article-title":"The standardization of terminology of lower urinary tract function in children and adolescents: Update report from the standardization committee of the International Children\u2019s Continence Society","volume":"35","author":"Austin","year":"2016","journal-title":"Neurourol. Urodyn."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1016\/S0022-5347(05)64225-5","article-title":"Spontaneous resolution of vesicoureteral reflux: A 15-year perspective","volume":"168","author":"Schwab","year":"2002","journal-title":"J. Urol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"24.e1","DOI":"10.1016\/j.jpurol.2021.11.013","article-title":"Comparison and characteristics of children successfully treated for daytime urinary incontinence","volume":"18","author":"Jessen","year":"2022","journal-title":"J. Pediatr. Urol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/nau.23842","article-title":"Pelvic floor biofeedback therapy in children: Assessment of symptom scores in responders and non-responders","volume":"38","author":"Taylor","year":"2019","journal-title":"Neurourol. Urodyn."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/iju.14740","article-title":"Which children are at risk of developing overactive bladder in early adulthood even if lower urinary tract symptoms improve during childhood?","volume":"29","author":"Selvi","year":"2022","journal-title":"Int. J. Urol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/01.ju.0000152183.91888.f6","article-title":"Dysfunctional voiding and incontinence scoring system: Quantitative evaluation of incontinence symptoms in pediatric population","volume":"173","author":"Akbal","year":"2005","journal-title":"J. Urol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1464-410X.2003.04734.x","article-title":"The role of video-urodynamic studies in managing non-neurogenic voiding dysfunction in children","volume":"93","author":"Arikan","year":"2004","journal-title":"BJU Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/UROS.UROS_46_21","article-title":"Videourodynamic precision diagnosis and treatment of lower urinary tract symptoms in women","volume":"32","author":"Kuo","year":"2021","journal-title":"Urol. Sci."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/24\/7395\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:40:47Z","timestamp":1760146847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/24\/7395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":23,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["jcm11247395"],"URL":"https:\/\/doi.org\/10.3390\/jcm11247395","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]}}}