{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:35:41Z","timestamp":1771637741540,"version":"3.50.1"},"reference-count":125,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2018YFA0108700"],"award-info":[{"award-number":["2018YFA0108700"]}]},{"name":"National Key Research and Development Program of China","award":["2017YFA0105602"],"award-info":[{"award-number":["2017YFA0105602"]}]},{"name":"NSFC Projects of International Cooperation and Exchanges","award":["81720108004"],"award-info":[{"award-number":["81720108004"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81974019"],"award-info":[{"award-number":["81974019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong Provincial Special Support Program for Prominent Talents","award":["2021JC06Y656"],"award-info":[{"award-number":["2021JC06Y656"]}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["2020B1111170011"],"award-info":[{"award-number":["2020B1111170011"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["2022B1212010010"],"award-info":[{"award-number":["2022B1212010010"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong special funds for science and technology innovation strategy, China","award":["GDCI 2021"],"award-info":[{"award-number":["GDCI 2021"]}]},{"name":"Guangzhou Science and Technology Plan Project","award":["202201000006"],"award-info":[{"award-number":["202201000006"]}]},{"name":"The Special Project of the Dengfeng Program of Guangdong Provincial People\u2019s Hospital","award":["DFJH201812"],"award-info":[{"award-number":["DFJH201812"]}]},{"name":"The Special Project of the Dengfeng Program of Guangdong Provincial People\u2019s Hospital","award":["KJ012019119"],"award-info":[{"award-number":["KJ012019119"]}]},{"name":"The Special Project of the Dengfeng Program of Guangdong Provincial People\u2019s Hospital","award":["KJ012019423"],"award-info":[{"award-number":["KJ012019423"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["JCM"],"abstract":"<jats:p>Inactivity is a significant risk factor for cardiovascular disease. Exercise may greatly enhance the metabolism and function of the cardiovascular system, lower several risk factors, and prevent the development and treatment of cardiovascular disease while delivering easy, physical, and emotional enjoyment. Exercise regulates the cardiovascular system by reducing oxidative stress and chronic inflammation, regulating cardiovascular insulin sensitivity and the body\u2019s metabolism, promoting stem cell mobilization, strengthening autophagy and myocardial mitochondrial function, and enhancing cardiovascular damage resistance, among other effects. Appropriate exercise intervention has become an essential adjuvant therapy in clinical practice for treating and rehabilitating various cardiovascular diseases. However, the prescription of exercise for preventing and treating cardiovascular diseases, particularly the precise selection of individual exercise techniques and their volume, remains controversial. Using multiomics to explain further the molecular process underlying the positive effects of exercise on cardiovascular health will not only improve our understanding of the effects of exercise on health but also establish a scientific basis and supply new ideas for preventing and treating cardiovascular diseases by activating the endogenous protective mechanisms of the body and suggesting more specific exercise prescriptions for cardiovascular rehabilitation.<\/jats:p>","DOI":"10.3390\/jcm11247511","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T08:41:41Z","timestamp":1671439301000},"page":"7511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["RETRACTED: Cardiovascular Disease and Exercise: From Molecular Mechanisms to Clinical Applications"],"prefix":"10.3390","volume":"11","author":[{"given":"Bo","family":"Wang","sequence":"first","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China"},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7674-2858","authenticated-orcid":false,"given":"Lin","family":"Gan","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China"},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhi","family":"Deng","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China"},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuoji","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China"},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China"},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3685-748X","authenticated-orcid":false,"given":"Moussa","family":"Nasser","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China"},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China"},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China"},{"name":"Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1161\/CIRCRESAHA.118.312669","article-title":"Sedentary Behavior, Exercise, and Cardiovascular Health","volume":"124","author":"Lavie","year":"2019","journal-title":"Circ. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-981-15-1792-1_1","article-title":"An Overview of the Beneficial Effects of Exercise on Health and Performance","volume":"1228","author":"Kramer","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrcardio.2017.70","article-title":"Physical function and exercise training in older patients with heart failure","volume":"14","author":"Coats","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"729364","DOI":"10.3389\/fphys.2021.729364","article-title":"Exercise-Induced Adult Cardiomyocyte Proliferation in Mammals","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e12339","DOI":"10.14814\/phy2.12339","article-title":"Exercise training reduces insulin resistance in postmyocardial infarction rats","volume":"3","author":"Wang","year":"2015","journal-title":"Physiol. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"23705","DOI":"10.1002\/jcp.28939","article-title":"Postinfarction exercise training alleviates cardiac dysfunction and adverse remodeling via mitochondrial biogenesis and SIRT1\/PGC-1alpha\/PI3K\/Akt signaling","volume":"234","author":"Jia","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1161\/hh2301.100982","article-title":"Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes","volume":"89","author":"Boddi","year":"2001","journal-title":"Circ. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/CIRCRESAHA.117.305205","article-title":"Exercise and the cardiovascular system: Clinical science and cardiovascular outcomes","volume":"117","author":"Lavie","year":"2015","journal-title":"Circ. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s11357-020-00179-z","article-title":"Accelerated cerebral vascular injury in diabetes is associated with vascular smooth muscle cell dysfunction","volume":"42","author":"Guo","year":"2020","journal-title":"Geroscience"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1210\/jc.2018-02698","article-title":"Effect of Obesity and Exercise Training on Plasma Amino Acids and Amino Metabolites in American Indian Adolescents","volume":"104","author":"Short","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1001\/jama.2011.576","article-title":"Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: A systematic review and meta-analysis","volume":"305","author":"Umpierre","year":"2011","journal-title":"JAMA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.7150\/thno.44836","article-title":"Branched chain amino acids exacerbate myocardial ischemia\/reperfusion vulnerability via enhancing GCN2\/ATF6\/PPAR-alpha pathway-dependent fatty acid oxidation","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1001\/jamacardio.2020.2686","article-title":"Molecular Signature of Multisystem Cardiometabolic Stress and Its Association with Prognosis","volume":"5","author":"Murthy","year":"2020","journal-title":"JAMA Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Shaw, E., Leung, G.K.W., Jong, J., Coates, A.M., Davis, R., Blair, M., Huggins, C.E., Dorrian, J., Banks, S., and Kellow, N.J. (2019). The Impact of Time of Day on Energy Expenditure: Implications for Long-Term Energy Balance. Nutrients, 11.","DOI":"10.3390\/nu11102383"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jshs.2020.04.001","article-title":"Exercise-induced oxidative stress: Friend or foe?","volume":"9","author":"Powers","year":"2020","journal-title":"J. Sport Health Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1089\/ars.2011.3976","article-title":"Control of reactive oxygen species production in contracting skeletal muscle","volume":"15","author":"Jackson","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Taherkhani, S., Suzuki, K., and Castell, L. (2020). A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation. Antioxidants, 9.","DOI":"10.3390\/antiox9090886"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"8665","DOI":"10.1073\/pnas.0903485106","article-title":"Antioxidants prevent health-promoting effects of physical exercise in humans","volume":"106","author":"Ristow","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.lfs.2018.10.035","article-title":"Mitochondrial dynamics as an underlying mechanism involved in aerobic exercise training-induced cardioprotection against ischemia-reperfusion injury","volume":"213","author":"Ghahremani","year":"2018","journal-title":"Life Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/10715762.2013.825371","article-title":"Exercise-induced improvements in myocardial antioxidant capacity: The antioxidant players and cardioprotection","volume":"48","author":"Powers","year":"2014","journal-title":"Free Radic. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.redox.2016.10.003","article-title":"Nrf2 mediates redox adaptations to exercise","volume":"10","author":"Done","year":"2016","journal-title":"Redox Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.jacc.2003.10.041","article-title":"Reduction in C-reactive protein through cardiac rehabilitation and exercise training","volume":"43","author":"Milani","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1096\/fj.02-0670fje","article-title":"Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans","volume":"17","author":"Starkie","year":"2003","journal-title":"FASEB J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"109502","DOI":"10.1155\/2008\/109502","article-title":"Exercise as a mean to control low-grade systemic inflammation","volume":"2008","author":"Mathur","year":"2008","journal-title":"Mediat. Inflamm."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Rysz, J., Franczyk, B., Rysz-Gorzynska, M., and Gluba-Brzozka, A. (2021). Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010183"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/5584_2017_3","article-title":"Exercise Strategies to Counteract Brain Aging Effects","volume":"1020","author":"Szalewska","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000445158","article-title":"Impact of Physical Exercise on Endocrine Aging","volume":"47","author":"Janssen","year":"2016","journal-title":"Front. Horm. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3389\/fphys.2013.00348","article-title":"Effects of exercise training on cardiovascular adrenergic system","volume":"4","author":"Leosco","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s12012-019-09514-z","article-title":"High Intensity Interval Training Ameliorates Mitochondrial Dysfunction in the Left Ventricle of Mice with Type 2 Diabetes","volume":"19","author":"Baekkerud","year":"2019","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCRESAHA.115.305250","article-title":"The Role of Exercise in Cardiac Aging: From Physiology to Molecular Mechanisms","volume":"118","author":"Roh","year":"2016","journal-title":"Circ. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.freeradbiomed.2016.03.037","article-title":"Effects of exercise training and resveratrol on vascular health in aging","volume":"98","author":"Gliemann","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.freeradbiomed.2018.10.444","article-title":"Exercise effects on physiological function during aging","volume":"132","author":"Radak","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1136\/bjsports-2018-099921","article-title":"How does exercise treatment compare with antihypertensive medications? A network meta-analysis of 391 randomised controlled trials assessing exercise and medication effects on systolic blood pressure","volume":"53","author":"Naci","year":"2019","journal-title":"Br. J. Sports Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1007\/s40279-018-0944-y","article-title":"Effects of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training on Blood Pressure in Adults with Pre- to Established Hypertension: A Systematic Review and Meta-Analysis of Randomized Trials","volume":"48","author":"Costa","year":"2018","journal-title":"Sports Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/hr.2010.72","article-title":"Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension","volume":"33","author":"Ciolac","year":"2010","journal-title":"Hypertens. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Feraco, A., Gorini, S., Armani, A., Camajani, E., Rizzo, M., and Caprio, M. (2021). Exploring the Role of Skeletal Muscle in Insulin Resistance: Lessons from Cultured Cells to Animal Models. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179327"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2016.02.021","article-title":"Redox control of skeletal muscle atrophy","volume":"98","author":"Powers","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/eurjpc\/zwaa139","article-title":"Sarcopenia in heart failure: \u2018waste\u2019 the appropriate time and resources, not the muscles","volume":"28","author":"Kokkinidis","year":"2021","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1093\/eurjpc\/zwaa117","article-title":"Impact of sarcopenia on prognosis in patients with heart failure with reduced and preserved ejection fraction","volume":"28","author":"Konishi","year":"2021","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Son, J., Jang, L.G., Kim, B.Y., Lee, S., and Park, H. (2020). The Effect of Athletes\u2019 Probiotic Intake May Depend on Protein and Dietary Fiber Intake. Nutrients, 12.","DOI":"10.3390\/nu12102947"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1249\/MSS.0000000000001495","article-title":"Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans","volume":"50","author":"Allen","year":"2018","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_42","first-page":"625","article-title":"The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level","volume":"67","author":"Barton","year":"2018","journal-title":"Gut"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cmet.2019.11.001","article-title":"Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention","volume":"31","author":"Liu","year":"2020","journal-title":"Cell Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.amjcard.2003.10.015","article-title":"Prevalence of anxiety in coronary patients with improvement following cardiac rehabilitation and exercise training","volume":"93","author":"Lavie","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/01.CIR.0000121360.31954.1F","article-title":"Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: A randomized trial","volume":"109","author":"Hambrecht","year":"2004","journal-title":"Circulation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/CS20110469","article-title":"Impact of exercise training on arterial wall thickness in humans","volume":"122","author":"Thijssen","year":"2012","journal-title":"Clin. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ijcard.2010.05.057","article-title":"Atherosclerotic plaques induced by marble-burying behavior are stabilized by exercise training in experimental atherosclerosis","volume":"151","author":"Shimada","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1152\/japplphysiol.90553.2008","article-title":"Habitual exercise and arterial aging","volume":"105","author":"Seals","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Schuttler, D., Clauss, S., Weckbach, L.T., and Brunner, S. (2019). Molecular Mechanisms of Cardiac Remodeling and Regeneration in Physical Exercise. Cells, 8.","DOI":"10.3390\/cells8101128"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"972807","DOI":"10.4061\/2011\/972807","article-title":"Molecular mechanisms in exercise-induced cardioprotection","volume":"2011","author":"Golbidi","year":"2011","journal-title":"Cardiol. Res. Pract."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Gu, J.W., Gadonski, G., Wang, J., Makey, I., and Adair, T.H. (2004). Exercise increases endostatin in circulation of healthy volunteers. BMC Physiol., 4.","DOI":"10.1186\/1472-6793-4-2"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/micc.12116","article-title":"Exercise training-induced adaptations in mediators of sustained endothelium-dependent coronary artery relaxation in a porcine model of ischemic heart disease","volume":"21","author":"Heaps","year":"2014","journal-title":"Microcirculation"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1152\/japplphysiol.01028.2007","article-title":"Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?","volume":"105","author":"Green","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1161\/01.CIR.0000074229.93804.5C","article-title":"Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase","volume":"107","author":"Hambrecht","year":"2003","journal-title":"Circulation"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1161\/CIRCRESAHA.118.314635","article-title":"Longterm Exercise-Derived Exosomal miR-342-5p: A Novel Exerkine for Cardioprotection","volume":"124","author":"Hou","year":"2019","journal-title":"Circ. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1123\/jpah.2020-0365","article-title":"Stretching is Superior to Brisk Walking for Reducing Blood Pressure in People with High-Normal Blood Pressure or Stage I Hypertension","volume":"18","author":"Ko","year":"2021","journal-title":"J. Phys. Act. Health"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1161\/ATVBAHA.119.313348","article-title":"Force Sensing by Piezo Channels in Cardiovascular Health and Disease","volume":"39","author":"Beech","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/dvdy.401","article-title":"Emerging role of Piezo ion channels in cardiovascular development","volume":"251","author":"Shah","year":"2022","journal-title":"Dev. Dyn."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"210852","DOI":"10.1155\/2012\/210852","article-title":"Exercise and the cardiovascular system","volume":"2012","author":"Golbidi","year":"2012","journal-title":"Cardiol. Res. Pract."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"H1683","DOI":"10.1152\/ajpheart.00136.2004","article-title":"Differential effects of exercise on aortic mitochondria","volume":"288","author":"Young","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3389\/fcvm.2018.00127","article-title":"Metabolic Mechanisms of Exercise-Induced Cardiac Remodeling","volume":"5","author":"Fulghum","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1161\/CIRCULATIONAHA.117.028274","article-title":"Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth","volume":"136","author":"Gibb","year":"2017","journal-title":"Circulation"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1249\/MSS.0b013e318231c037","article-title":"Exercise protects cardiac mitochondria against ischemia-reperfusion injury","volume":"44","author":"Lee","year":"2012","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.freeradbiomed.2020.04.005","article-title":"Exercise training protects the heart against ischemia-reperfusion injury: A central role for mitochondria?","volume":"152","author":"Boulghobra","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"H1895","DOI":"10.1152\/ajpheart.00486.2004","article-title":"Collateral damage: Cardiovascular consequences of chronic sympathetic activation with human aging","volume":"287","author":"Seals","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.pcad.2014.09.008","article-title":"Physical activity versus cardiorespiratory fitness: Two (partly) distinct components of cardiovascular health?","volume":"57","author":"DeFina","year":"2015","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pcad.2014.09.011","article-title":"Physical activity and cardiorespiratory fitness as major markers of cardiovascular risk: Their independent and interwoven importance to health status","volume":"57","author":"Myers","year":"2015","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nrendo.2016.76","article-title":"The potential of endurance exercise-derived exosomes to treat metabolic diseases","volume":"12","author":"Safdar","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1161\/CIRCULATIONAHA.109.882068","article-title":"Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure","volume":"121","author":"Heineke","year":"2010","journal-title":"Circulation"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/CIRCRESAHA.115.304185","article-title":"Myostatin regulates energy homeostasis in the heart and prevents heart failure","volume":"115","author":"Biesemann","year":"2014","journal-title":"Circ. Res."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Nara, H., and Watanabe, R. (2021). Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189889"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1161\/CIRCULATIONAHA.113.007469","article-title":"Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle-like cells in pulmonary hypertension","volume":"129","author":"Ricard","year":"2014","journal-title":"Circulation"},{"key":"ref_73","first-page":"131","article-title":"The problem of fatigue in patients suffering from neoplastic disease","volume":"21","author":"Kolak","year":"2017","journal-title":"Contemp. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13578-019-0294-y","article-title":"Exercise-induced myokine FNDC5\/irisin functions in cardiovascular protection and intracerebral retrieval of synaptic plasticity","volume":"9","author":"Zhou","year":"2019","journal-title":"Cell Biosci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.cell.2014.03.065","article-title":"Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis","volume":"157","author":"Rao","year":"2014","journal-title":"Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.bbadis.2016.11.007","article-title":"Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases","volume":"1863","author":"Zhong","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"32802","DOI":"10.1074\/jbc.M803440200","article-title":"Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism","volume":"283","author":"Ouchi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41467-020-20790-0","article-title":"MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis","volume":"12","author":"Reynolds","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cmet.2013.12.003","article-title":"beta-Aminoisobutyric acid induces browning of white fat and hepatic beta-oxidation and is inversely correlated with cardiometabolic risk factors","volume":"19","author":"Roberts","year":"2014","journal-title":"Cell Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.2174\/092986712803833254","article-title":"Adiponectin: Key player in the adipose tissue-liver crosstalk","volume":"19","author":"Moschen","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tcm.2006.03.001","article-title":"Cardioprotection by adiponectin","volume":"16","author":"Ouchi","year":"2006","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Aljafary, M.A., and Al-Suhaimi, E.A. (2022). Adiponectin System (Rescue Hormone): The Missing Link between Metabolic and Cardiovascular Diseases. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14071430"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"T17","DOI":"10.1530\/JOE-12-0232","article-title":"Role of adipokines in cardiovascular disease","volume":"216","author":"Mattu","year":"2013","journal-title":"J. Endocrinol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.ebiom.2019.07.051","article-title":"Noncoding RNAs in exercise-induced cardio-protection for chronic heart failure","volume":"46","author":"Ma","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.jshs.2020.12.003","article-title":"The epigenetic landscape of exercise in cardiac health and disease","volume":"10","author":"Wu","year":"2021","journal-title":"J. Sport Health Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1113\/jphysiol.2010.189860","article-title":"Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle","volume":"588","author":"Nielsen","year":"2010","journal-title":"J. Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1152\/japplphysiol.01291.2009","article-title":"Evidence for microRNA involvement in exercise-associated neutrophil gene expression changes","volume":"109","author":"Zaldivar","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1007\/s00421-013-2685-9","article-title":"Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K\/AKT\/mTOR signaling pathway","volume":"113","author":"Ma","year":"2013","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1249\/MSS.0b013e31824e8a36","article-title":"Swimming training in rats increases cardiac MicroRNA-126 expression and angiogenesis","volume":"44","author":"Fernandes","year":"2012","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Melo, S.F., Barauna, V.G., Neves, V.J., Fernandes, T., Lara Lda, S., Mazzotti, D.R., and Oliveira, E.M. (2015). Exercise training restores the cardiac microRNA-1 and -214 levels regulating Ca2+ handling after myocardial infarction. BMC Cardiovasc. Disord., 15.","DOI":"10.1186\/s12872-015-0156-4"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1159\/000358642","article-title":"Expression of MicroRNA-29 and Collagen in Cardiac Muscle after Swimming Training in Myocardial-Infarcted Rats","volume":"33","author":"Melo","year":"2014","journal-title":"Cell Physiol. Biochem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.omtn.2019.08.002","article-title":"Exercise Reduces Insulin Resistance in Type 2 Diabetes Mellitus via Mediating the lncRNA MALAT1\/MicroRNA-382-3p\/Resistin Axis","volume":"18","author":"Liu","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2015.216","article-title":"Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy","volume":"12","author":"Jia","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.dsx.2019.02.023","article-title":"Insulin resistance is a cardiovascular risk factor in humans","volume":"13","year":"2019","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s12265-020-10057-w","article-title":"Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention","volume":"14","author":"Iaccarino","year":"2021","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2459\/JCM.0000000000000855","article-title":"The role of physical activity in individuals with cardiovascular risk factors: An opinion paper from Italian Society of Cardiology-Emilia Romagna-Marche and SIC-Sport","volume":"20","author":"Nasi","year":"2019","journal-title":"J. Cardiovasc. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1748-1716.2007.01783.x","article-title":"Exercise training-induced improvements in insulin action","volume":"192","author":"Hawley","year":"2008","journal-title":"Acta Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2000-8847","article-title":"Exercise and insulin sensitivity: A review","volume":"21","author":"Borghouts","year":"2000","journal-title":"Int. J. Sports Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1161\/HYPERTENSIONAHA.120.15262","article-title":"TRAF3IP2 (TRAF3 Interacting Protein 2) Mediates Obesity-Associated Vascular Insulin Resistance and Dysfunction in Male Mice","volume":"76","author":"Grunewald","year":"2020","journal-title":"Hypertension"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Saotome, M., Ikoma, T., Hasan, P., and Maekawa, Y. (2019). Cardiac Insulin Resistance in Heart Failure: The Role of Mitochondrial Dynamics. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143552"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"17927","DOI":"10.1038\/srep17927","article-title":"Direct Evidence that Myocardial Insulin Resistance following Myocardial Ischemia Contributes to Post-Ischemic Heart Failure","volume":"5","author":"Fu","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1161\/HYPERTENSIONAHA.111.00728","article-title":"A novel mechanism for vascular insulin resistance in normotensive young SHRs: Hypoadiponectinemia and resultant APPL1 downregulation","volume":"61","author":"Xing","year":"2013","journal-title":"Hypertension"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s10495-007-0090-8","article-title":"Long-term aerobic exercise protects the heart against ischemia\/reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism","volume":"12","author":"Zhang","year":"2007","journal-title":"Apoptosis"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cardiores.2007.04.015","article-title":"Swim training sensitizes myocardial response to insulin: Role of Akt-dependent eNOS activation","volume":"75","author":"Zhang","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/japplphysiol.00004.2011","article-title":"Exercise-induced cardiac preconditioning: How exercise protects your achy-breaky heart","volume":"111","author":"Frasier","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/j.jacc.2019.01.072","article-title":"Exercise Intolerance in Patients with Heart Failure: JACC State-of-the-Art Review","volume":"73","author":"Arena","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1161\/CIRCULATIONAHA.117.029058","article-title":"Exercise Intolerance in Heart Failure with Preserved Ejection Fraction: Diagnosing and Ranking Its Causes Using Personalized O2 Pathway Analysis","volume":"137","author":"Houstis","year":"2018","journal-title":"Circulation"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/CIRCHEARTFAILURE.114.001825","article-title":"Mechanisms of exercise intolerance in heart failure with preserved ejection fraction: The role of abnormal peripheral oxygen extraction","volume":"8","author":"Dhakal","year":"2015","journal-title":"Circ. Heart Fail."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/eurheartj\/ehaa605","article-title":"2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease","volume":"42","author":"Pelliccia","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e694","DOI":"10.1161\/CIR.0000000000000406","article-title":"2016 Focused Update: Clinical Recommendations for Cardiopulmonary Exercise Testing Data Assessment in Specific Patient Populations","volume":"133","author":"Guazzi","year":"2016","journal-title":"Circulation"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jchf.2013.08.006","article-title":"Clinical outcomes and cardiovascular responses to different exercise training intensities in patients with heart failure: A systematic review and meta-analysis","volume":"1","author":"Ismail","year":"2013","journal-title":"JACC Heart Fail."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ijcard.2018.02.076","article-title":"High intensity interval training versus moderate intensity continuous training on exercise capacity and quality of life in patients with heart failure with reduced ejection fraction: A systematic review and meta-analysis","volume":"261","author":"Duraes","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jchf.2013.01.005","article-title":"Exercise training and implantable cardioverter-defibrillator shocks in patients with heart failure: Results from HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing)","volume":"1","author":"Piccini","year":"2013","journal-title":"JACC Heart Fail."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11897-019-00428-z","article-title":"Exercise in Heart Failure-What Is the Optimal Dose to Improve Pathophysiology and Exercise Capacity?","volume":"16","author":"Schindler","year":"2019","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1002\/ehf2.13498","article-title":"A systematic review of rehabilitation in chronic heart failure: Evaluating the reporting of exercise interventions","volume":"8","author":"Harwood","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s10741-020-09969-1","article-title":"Effect of renin-angiotensin system inhibition on cardiac structure and function and exercise capacity in heart failure with preserved ejection fraction: A meta-analysis of randomized controlled trials","volume":"26","author":"Fukuta","year":"2021","journal-title":"Heart Fail. Rev."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s40279-019-01148-z","article-title":"The Impact of Different Types of Exercise Training on Peripheral Blood Brain-Derived Neurotrophic Factor Concentrations in Older Adults: A Meta-Analysis","volume":"49","author":"Marinus","year":"2019","journal-title":"Sports Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1161\/CIRCULATIONAHA.108.821736","article-title":"Effects of different types of exercise training followed by detraining on endothelium-dependent dilation in patients with recent myocardial infarction","volume":"119","author":"Vona","year":"2009","journal-title":"Circulation"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1136\/bjsports-2016-096822","article-title":"Associations of specific types of sports and exercise with all-cause and cardiovascular-disease mortality: A cohort study of 80 306 British adults","volume":"51","author":"Oja","year":"2017","journal-title":"Br. J. Sports Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/s41591-020-1012-3","article-title":"Wearable-device-measured physical activity and future health risk","volume":"26","author":"Strain","year":"2020","journal-title":"Nat. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00125-018-4767-z","article-title":"Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: A randomised crossover trial","volume":"62","author":"Savikj","year":"2019","journal-title":"Diabetologia"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/hr.2010.106","article-title":"Early physical activity promotes lower prevalence of chronic diseases in adulthood","volume":"33","author":"Fernandes","year":"2010","journal-title":"Hypertens. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tem.2018.01.003","article-title":"Maternal Exercise Improves the Metabolic Health of Adult Offspring","volume":"29","author":"Harris","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.2337\/db17-0098","article-title":"Maternal Exercise Improves Glucose Tolerance in Female Offspring","volume":"66","author":"Stanford","year":"2017","journal-title":"Diabetes"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.2337\/db18-0667","article-title":"Paternal Exercise Improves Glucose Metabolism in Adult Offspring","volume":"67","author":"Stanford","year":"2018","journal-title":"Diabetes"}],"updated-by":[{"DOI":"10.3390\/jcm12062143","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"record-id":"44088"},{"DOI":"10.3390\/jcm12062143","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000}}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/24\/7511\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:41:47Z","timestamp":1754260907000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/24\/7511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,19]]},"references-count":125,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["jcm11247511"],"URL":"https:\/\/doi.org\/10.3390\/jcm11247511","relation":{"retraction":[{"id-type":"doi","id":"10.3390\/jcm12062143","asserted-by":"object"}]},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,19]]}}}