{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T08:53:54Z","timestamp":1784364834855,"version":"3.55.0"},"reference-count":18,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Twin anemia-polycythemia sequence (TAPS) is a complication in monochorionic-diamniotic (MCDA) twin pregnancies. This study analyzes whether the prenatal diagnosis using delta middle cerebral artery-peak systolic velocity (MCA-PSV) &gt; 0.5 multiples of the median (MoM) (delta group) detects more TAPS cases than the guideline-based diagnosis using the MCA-PSV cut off levels of &gt;1.5 and &lt;1.0 MoM (cut-off group), in a heterogenous group of MCDA twins. Methods: A retrospective analysis of 348 live-born MCDA twin pregnancies from 2010 to 2021 with available information on MCA-PSV within one week before delivery and hemoglobin-values within 24 h postnatally were considered eligible. Results: Among postnatal confirmed twin pairs with TAPS, the cut-off group showed lower sensitivity than the delta group (33% vs. 82%). Specificity proved higher in the cut-off group with 97% than in the delta group at 86%. The risk that a TAPS is mistakenly not recognized prenatally is higher in the cut-off group than in the delta group (52% vs. 18%). Conclusions: Our data shows that delta MCA-PSV &gt; 0.5 MoM detects more cases of TAPS, which would not have been diagnosed prenatally according to the current guidelines. In the collective examined in the present study, TAPS diagnostics using delta MCA-PSV proved to be a more robust method.<\/jats:p>","DOI":"10.3390\/jcm11247541","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T02:05:02Z","timestamp":1671501902000},"page":"7541","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Value of Delta Middle Cerebral Artery Peak Systolic Velocity for the Prediction of Twin Anemia-Polycythemia Sequence\u2014Analysis of a Heterogenous Cohort of Monochorionic Twins"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8168-6697","authenticated-orcid":false,"given":"Anthea","family":"de Sainte Fare","sequence":"first","affiliation":[{"name":"Department of Prenatal Medicine and Fetal Therapy, University Hospital Giessen, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7688-5357","authenticated-orcid":false,"given":"Ivonne","family":"Bedei","sequence":"additional","affiliation":[{"name":"Department of Prenatal Medicine and Fetal Therapy, University Hospital Giessen, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Wolter","sequence":"additional","affiliation":[{"name":"Department of Prenatal Medicine and Fetal Therapy, University Hospital Giessen, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Schenk","sequence":"additional","affiliation":[{"name":"Department of Prenatal Medicine and Fetal Therapy, University Hospital Giessen, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellydda","family":"Widriani","sequence":"additional","affiliation":[{"name":"Department of Prenatal Medicine and Fetal Therapy, University Hospital Giessen, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1455-1319","authenticated-orcid":false,"given":"Corinna","family":"Keil","sequence":"additional","affiliation":[{"name":"Department of Prenatal Medicine and Fetal Therapy, University Hospital Marburg, 35041 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegmund","family":"Koehler","sequence":"additional","affiliation":[{"name":"Department of Prenatal Medicine and Fetal Therapy, University Hospital Marburg, 35041 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Bahlmann","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Diagnostics and Prenatal Medicine, Buergerhospital Frankfurt, 60318 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3625-7097","authenticated-orcid":false,"given":"Brigitte","family":"Strizek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-4669","authenticated-orcid":false,"given":"Ulrich","family":"Gembruch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, 53127 Bonn, Germany"},{"name":"Department of Prenatal Medicine and Gynaecological Ultrasound, University Hospital Cologne, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Axt-Fliedner","sequence":"additional","affiliation":[{"name":"Department of Prenatal Medicine and Fetal Therapy, University Hospital Giessen, 35392 Giessen, Germany"},{"name":"Department of Prenatal Medicine and Fetal Therapy, University Hospital Marburg, 35041 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Krampl-Bettelheim, E. 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