{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:46:21Z","timestamp":1763988381399,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>A healthy vaginal microbiota is Lactobacillus-dominated. Several factors can interfere with the state of balance leading to dysbiosis, such as vaginal infections caused by bacteria and Candida species. The present single-arm, uncontrolled open-label study aimed to evaluate the ability of the SYNBIO\u00ae probiotic combination, taken as an oral formulation, to contribute to vaginal health. Thirty pre-menopausal participants were included in the study. Participants were instructed for daily oral intake of SYNBIO\u00ae probiotic capsules for 15 days. Vaginal swabs were collected at baseline (T0), 15 days after the start of the treatment (T1), and 7 days after the end of the treatment (T2). Amsel criteria, Nugent score, and vaginal pH were evaluated at each sampling time. In addition, the participants\u2019 quality of life was assessed by the WHOQOL-BREF questionnaire. The administration of SYNBIO\u00ae once daily for 15 days resulted in a substantial improvement in the vaginal flora in terms of an increase in lactobacilli and a decrease in enterococci, staphylococci, Gardnerella spp., and Candida spp. According to the results, statistically significant changes in leucorrhoea, itching, and vulvo-vaginal erythema\/edema as well as a decrease in all the Amsel criteria were recorded. The oral consumption of SYNBIO\u00ae demonstrated enhanced benefits for vaginal health.<\/jats:p>","DOI":"10.3390\/jcm12010027","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T02:04:21Z","timestamp":1671588261000},"page":"27","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Oral Intake of the Commercial Probiotic Blend Synbio\u00ae for the Management of Vaginal Dysbiosis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8246-106X","authenticated-orcid":false,"given":"Alessandra","family":"Pino","sequence":"first","affiliation":[{"name":"Department of Agricultural, Food and Environment, University of Catania, Santa Sofia Street 100, 95123 Catania, Italy"},{"name":"ProBioEtna S.r.l., Spin Off of the University of Catania, Santa Sofia Street 100, 95123 Catania, Italy"},{"name":"CERNUT, Interdepartmental Research Centre in Nutraceuticals and Health Products, University of Catania, A. Doria Street 6, 95125 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnese Maria Chiara","family":"Rapisarda","sequence":"additional","affiliation":[{"name":"ProBioEtna S.r.l., Spin Off of the University of Catania, Santa Sofia Street 100, 95123 Catania, Italy"},{"name":"Department of General Surgery and Medical Surgical Specialties, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4902-1799","authenticated-orcid":false,"given":"Amanda","family":"Vaccalluzzo","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Environment, University of Catania, Santa Sofia Street 100, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosamaria Roberta","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Environment, University of Catania, Santa Sofia Street 100, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1594-4613","authenticated-orcid":false,"given":"Maria Magdalena","family":"Coman","sequence":"additional","affiliation":[{"name":"Synbiotec S.r.l., Gentile III da Varano Street, 62032 Camerino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5668-2467","authenticated-orcid":false,"given":"Raffaela Luisa","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical Surgical Specialties, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Caggia","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Environment, University of Catania, Santa Sofia Street 100, 95123 Catania, Italy"},{"name":"ProBioEtna S.r.l., Spin Off of the University of Catania, Santa Sofia Street 100, 95123 Catania, Italy"},{"name":"CERNUT, Interdepartmental Research Centre in Nutraceuticals and Health Products, University of Catania, A. Doria Street 6, 95125 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1243-5357","authenticated-orcid":false,"given":"Cinzia Lucia","family":"Randazzo","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Environment, University of Catania, Santa Sofia Street 100, 95123 Catania, Italy"},{"name":"ProBioEtna S.r.l., Spin Off of the University of Catania, Santa Sofia Street 100, 95123 Catania, Italy"},{"name":"CERNUT, Interdepartmental Research Centre in Nutraceuticals and Health Products, University of Catania, A. Doria Street 6, 95125 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2304-7859","authenticated-orcid":false,"given":"Nunziatina","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Environment, University of Catania, Santa Sofia Street 100, 95123 Catania, Italy"},{"name":"ProBioEtna S.r.l., Spin Off of the University of Catania, Santa Sofia Street 100, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Marzio","family":"Panella","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical Surgical Specialties, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Cianci","sequence":"additional","affiliation":[{"name":"ProBioEtna S.r.l., Spin Off of the University of Catania, Santa Sofia Street 100, 95123 Catania, Italy"},{"name":"Department of General Surgery and Medical Surgical Specialties, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5441-0361","authenticated-orcid":false,"given":"Maria Cristina","family":"Verdenelli","sequence":"additional","affiliation":[{"name":"Synbiotec S.r.l., Gentile III da Varano Street, 62032 Camerino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1111\/j.1753-4887.2012.00493.x","article-title":"Defining the human microbiome","volume":"70","author":"Ursell","year":"2012","journal-title":"Nutr. 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