{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:59:09Z","timestamp":1777553949208,"version":"3.51.4"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective(s): There is still limited data in the literature concerning the survival of patients with tumors of the thoracic spine. In this study, we analyzed clinical features, perioperative and long-term outcomes in patients who underwent vertebrectomy for cancer. Furthermore, we evaluated the survival and surgical complications. Methods: We retrospectively reviewed all cases of thoracic spinal tumors treated by the same team between 1998 and 2018. We divided them into three groups according to type of tumor (primary vertebral, primary lung and metastases) and compared outcomes. For each patient, Overall Survival (OS) and Cumulative Incidence of Relapse (CIR) were estimated. Complications and survival were analyzed using a logistic model. Results: Seventy-two patients underwent thoracic spine surgery (40 in group 1, 16 in each group 2 and 3). Thirty patients died at the end of the observation at a mean follow up time of 60 months (41%). The 5-year overall survival was 72% (95% CI: 0.52\u20130.84), 20% (95% CI: 0.05\u20130.43) and 27% (95% CI: 0.05\u20130.56) for each group, respectively. CIR of group 3 was higher (HR 2.57, 95% CI: 1.22\u20135.45, p = 0.013). The logistic model revealed that age was related to complications (p = 0.04), while surgery for a type 3 tumor was related to mortality (p = 0.02). Conclusions: Although the cohort size was limited, primary vertebral tumors displayed the best 5-y-OS with an acceptable complications rate. The indication of surgery should be advised by a multidisciplinary team and only for selected cases. Finally, the use of a combined approach does not increase the risk of complications.<\/jats:p>","DOI":"10.3390\/jcm12010031","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T02:31:33Z","timestamp":1671589893000},"page":"31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Surgical and Oncological Outcomes of En-Bloc Resection for Malignancies Invading the Thoracic Spine"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6087-3901","authenticated-orcid":false,"given":"Pierluigi","family":"Novellis","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8605-1746","authenticated-orcid":false,"given":"Luca","family":"Cannav\u00f2","sequence":"additional","affiliation":[{"name":"Division of Orthopedic Oncology and Spine Reconstructive Surgery (CCOORR), IRCCS Galeazzi Orthopedic Institute, 20161 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3944-2490","authenticated-orcid":false,"given":"Rosalba","family":"Lembo","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1901-2805","authenticated-orcid":false,"given":"Andrea","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Unit of Clinical Epidemiology, Citt\u00e0 della Salute e della Scienza di Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Dieci","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Giudici","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Humanitas Clinical and Research Center, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Veronesi","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"},{"name":"Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Luzzati","sequence":"additional","affiliation":[{"name":"Division of Orthopedic Oncology and Spine Reconstructive Surgery (CCOORR), IRCCS Galeazzi Orthopedic Institute, 20161 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Alloisio","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Humanitas Clinical and Research Center, 20089 Rozzano, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, 20090 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Cariboni","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Humanitas Clinical and Research Center, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.athoracsur.2008.07.087","article-title":"Technical challenges and utility of anterior exposure for thoracic spine pathology","volume":"86","author":"Pettiford","year":"2008","journal-title":"Ann. 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