{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:45:19Z","timestamp":1784756719416,"version":"3.55.0"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>There are no clear guidelines for diuretic administration in heart failure (HF), and reliable markers are needed to tailor treatment. Continuous monitoring of multiple advanced physiological parameters during diuresis may allow better differentiation of patients into subgroups according to their responses. In this study, 29 HF patients were monitored during outpatient intravenous diuresis, using a noninvasive wearable multi-parameter monitor. Analysis of changes in these parameters during the course of diuresis aimed to recognize subgroups with different response patterns. Parameters did not change significantly, however, subgroup analysis of the last quartile of treatment showed significant differences in cardiac output, cardiac index, stroke volume, pulse rate, and systemic vascular resistance according to gender, and in systolic blood pressure according to habitus. Changes in the last quartile could be differentiated using k-means, a technique of unsupervised machine learning. Moreover, patients\u2019 responses could be best clustered into four groups. Analysis of baseline parameters showed that two of the clusters differed by baseline parameters, body mass index, and diabetes status. To conclude, we show that physiological changes during diuresis in HF patients can be categorized into subgroups sharing similar response trends, making noninvasive monitoring a potential key to personalized treatment in HF.<\/jats:p>","DOI":"10.3390\/jcm12010045","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T02:31:11Z","timestamp":1671676271000},"page":"45","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Advanced Hemodynamic Monitoring Allows Recognition of Early Response Patterns to Diuresis in Congestive Heart Failure Patients"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-7158","authenticated-orcid":false,"given":"Maya","family":"Dagan","sequence":"first","affiliation":[{"name":"Heart Institute, Hadassah Medical Center, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yotam","family":"Kolben","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hadassah University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Biobeat Technologies Ltd., Petah Tikva 4951126, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arik","family":"Ben Ishay","sequence":"additional","affiliation":[{"name":"Biobeat Technologies Ltd., Petah Tikva 4951126, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5008-4722","authenticated-orcid":false,"given":"Meir","family":"Fons","sequence":"additional","affiliation":[{"name":"Biobeat Technologies Ltd., Petah Tikva 4951126, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roei","family":"Merin","sequence":"additional","affiliation":[{"name":"Biobeat Technologies Ltd., Petah Tikva 4951126, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9368-3490","authenticated-orcid":false,"given":"Arik","family":"Eisenkraft","sequence":"additional","affiliation":[{"name":"Biobeat Technologies Ltd., Petah Tikva 4951126, Israel"},{"name":"Institute for Research in Military Medicine, Faculty of Medicine, the Hebrew University of Jerusalem, the Israel Defense Force Medical Corps, Jerusalem 9112102, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Offer","family":"Amir","sequence":"additional","affiliation":[{"name":"Heart Institute, Hadassah Medical Center, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel"},{"name":"Azrieli Faculty of Medicine, Bar-Ilan University, Zfat 1311502, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0258-7402","authenticated-orcid":false,"given":"Rabea","family":"Asleh","sequence":"additional","affiliation":[{"name":"Heart Institute, Hadassah Medical Center, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"Ben-Yehuda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hadassah University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-284X","authenticated-orcid":false,"given":"Dean","family":"Nachman","sequence":"additional","affiliation":[{"name":"Heart Institute, Hadassah Medical Center, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel"},{"name":"Institute for Research in Military Medicine, Faculty of Medicine, the Hebrew University of Jerusalem, the Israel Defense Force Medical Corps, Jerusalem 9112102, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. 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