{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:28:35Z","timestamp":1789680515098,"version":"4.0.1"},"reference-count":53,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SEMERGEN Foundation"},{"name":"AstraZeneca"},{"name":"Menarini"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The role of uric acid levels in the cardiovascular continuum is not clear. Our objective is to analyze the prevalence of hyperuricemia (HU) and its association with cardiovascular risk factors (CVRF), subclinical target organ damage (sTOD), and cardiovascular diseases (CVD). We evaluated the prevalence of HU in 6.927 patients included in the baseline visit of the IBERICAN study. HU was defined as uric acid levels above 6 mg\/dL in women, and 7 mg\/dL in men. Using adjusted logistic regression models, the odds ratios were estimated according to CVRF, sTOD, and CVD. The prevalence of HU was 16.3%. The risk of HU was higher in patients with pathological glomerular filtration rate (aOR: 2.92), heart failure (HF) (aOR: 1.91), abdominal obesity (aOR: 1.80), hypertension (HTN) (aOR: 1.65), use of thiazides (aOR: 1.54), left ventricular hypertrophy (LVH) (aOR: 1.36), atrial fibrillation (AFIB) (aOR: 1.29), and albuminuria (aOR: 1.27). On the other hand, being female (aOR: 0.82) showed a reduced risk. The prevalence of HU was higher in men, in patients presenting CVRF such as HTN and abdominal obesity, and with co-existence of LVH, atrial fibrillation (AFIB), HF, and any form of kidney injury. These associations raise the possibility that HU forms part of the early stages of the cardiovascular continuum. This may influence its management in Primary Healthcare because the presence of HU could mean an increased CV risk in the patients.<\/jats:p>","DOI":"10.3390\/jcm12010050","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T02:31:11Z","timestamp":1671676271000},"page":"50","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prevalence of Hyperuricemia and Its Association with Cardiovascular Risk Factors and Subclinical Target Organ Damage"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7923-0292","authenticated-orcid":false,"given":"Paula","family":"Antelo-Pais","sequence":"first","affiliation":[{"name":"Santa Comba Health Centre, Health Area of Santiago de Compostela, 15970 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8079-6624","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Prieto-D\u00edaz","sequence":"additional","affiliation":[{"name":"Vallob\u00edn-La Florida Health Centre, 33012 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael M.","family":"Mic\u00f3-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Fontanars dels Alforins Health Centre, X\u00e0tiva\u2013Ontinyent Department of Health, 46635 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2985-6078","authenticated-orcid":false,"given":"Vicente","family":"Pallar\u00e9s-Carratal\u00e1","sequence":"additional","affiliation":[{"name":"Health Surveillance Unit, Mutual Insurance Union, 12004 Castellon, Spain"},{"name":"Department of Medicine, Jaume I University, 12071 Castellon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonsoles","family":"Velilla-Zancada","sequence":"additional","affiliation":[{"name":"Joaquin Elizalde Health Centre, 26004 Logro\u00f1o, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Polo-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Casar de C\u00e1ceres Health Centre, 10200 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7074-4951","authenticated-orcid":false,"given":"Alfonso","family":"Barquilla-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Trujillo Health Center, 10200 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8350-3524","authenticated-orcid":false,"given":"Leovigildo","family":"Ginel-Mendoza","sequence":"additional","affiliation":[{"name":"Ciudad Jard\u00edn Health Center, 29014 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-2242","authenticated-orcid":false,"given":"Antonio","family":"Segura-Fragoso","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Semergen Research Agency, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3118-3570","authenticated-orcid":false,"given":"Facundo","family":"Vitelli-Storelli","sequence":"additional","affiliation":[{"name":"Gene-Environment-Health Interaction Research Group (GIIGAS)\/Institute of Biomedicine (IBIOMED), University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0552-2804","authenticated-orcid":false,"given":"Vicente","family":"Mart\u00edn-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine (IBIOMED), Epidemiology and Public Health Networking Biomedical Research Centre (CIBERESP), University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3757-262X","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Hermida-Ameijerias","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital of Santiago de Compostela, 15706 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4486-2820","authenticated-orcid":false,"given":"Sergio","family":"Cinza-Sanjurjo","sequence":"additional","affiliation":[{"name":"Porto do Son Health Centre, Health Area of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS), Networking Biomedical Research Centre-Cardiovascular Diseases (CIBERCV), 15970 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"ref_1","unstructured":"Instituto Nacional de Estad\u00edstica (INE) (2020). 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