{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:53:34Z","timestamp":1762080814163,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wonkwang University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study evaluated the impact of pre-existing gout on the occurrence of benign paroxysmal positional vertigo (BPPV), Meniere\u2019s disease, and vestibular neuronitis, with the goal of identifying novel associations of gout with other comorbid diseases. The 2002\u20132019 Korean National Health Insurance Service Health Screening Cohort data were retrospectively analyzed. 23,827 patients with gout were matched to 95,268 controls without gout for age, sex, income, region of residence, and index date. The occurrence of BPPV, Meniere\u2019s disease, and vestibular neuronitis was evaluated in both groups. The hazard ratios (HRs) of gout for BPPV, Meniere\u2019s disease, and vestibular neuronitis were calculated using a stratified Cox proportional hazard model. Participants with gout demonstrated a 1.13-fold higher risk of BPPV (95% CI, 1.06\u20131.21, p &lt; 0.001) and a 1.15-fold higher risk of Meniere\u2019s disease (95% CI, 1.15\u20131.37, p &lt; 0.001) than the matched control group. However, the HR for vestibular neuronitis was not significantly higher in the gout group (adjusted HR = 1.06, 95% CI, 0.93\u20131.21, p = 0.391). A previous history of gout was related to a higher risk of BPPV and Meniere\u2019s disease. Additional studies are necessary to elucidate the mechanism underlying the relationship between gout and comorbid diseases such as BPPV and Meniere\u2019s disease.<\/jats:p>","DOI":"10.3390\/jcm12010185","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T02:55:07Z","timestamp":1672109707000},"page":"185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Risk of BPPV, Meniere\u2019s Disease, and Vestibular Neuronitis in Patients with Gout: A Longitudinal Follow-Up Study Using a National Health Screening Cohort"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-9549","authenticated-orcid":false,"given":"Hyo Geun","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2449-9945","authenticated-orcid":false,"given":"So Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13488, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5099-5243","authenticated-orcid":false,"given":"Juyong","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Wonkwang University School of Medicine, 895 Muwang-ro, Iksan 54538, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1002\/art.30520","article-title":"Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007\u20132008","volume":"63","author":"Zhu","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41584-020-0441-1","article-title":"Global epidemiology of gout: Prevalence, incidence, treatment patterns and risk factors","volume":"16","author":"Dehlin","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s00296-017-3768-4","article-title":"Prevalence and incidence of gout in Korea: Data from the national health claims database 2007\u20132015","volume":"37","author":"Kim","year":"2017","journal-title":"Rheumatol. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1136\/annrheumdis-2014-206410","article-title":"Comorbidities in patients with gout prior to and following diagnosis: Case-control study","volume":"75","author":"Kuo","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3904\/kjim.2016.062","article-title":"Metabolic syndrome: Prevalence and risk factors in Korean gout patients","volume":"33","author":"Jung","year":"2018","journal-title":"Korean J. Intern. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/art.22466","article-title":"Prevalence of the metabolic syndrome in patients with gout: The Third National Health and Nutrition Examination Survey","volume":"57","author":"Choi","year":"2007","journal-title":"Arthritis Rheum."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13075-017-1322-0","article-title":"Gout and subsequent erectile dysfunction: A population-based cohort study from England","volume":"19","author":"Mallen","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.3899\/jrheum.141105","article-title":"Gout and a subsequent increased risk of erectile dysfunction in men aged 64 and under: A nationwide cohort study in Taiwan","volume":"42","author":"Chen","year":"2015","journal-title":"J. Rheumatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ejim.2015.06.001","article-title":"Gout is associated with organic and psychogenic erectile dysfunction","volume":"26","author":"Hsu","year":"2015","journal-title":"Eur. J. Intern. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e000712","DOI":"10.1136\/rmdopen-2018-000712","article-title":"Gout and the risk of incident atrial fibrillation in older adults: A study of US Medicare data","volume":"4","author":"Singh","year":"2018","journal-title":"RMD Open"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"32220","DOI":"10.1038\/srep32220","article-title":"The risk of atrial fibrillation in patients with gout: A nationwide population-based study","volume":"6","author":"Kuo","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/rheumatology\/kev418","article-title":"Impact of gout on the risk of atrial fibrillation","volume":"55","author":"Kuo","year":"2016","journal-title":"Rheumatology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1136\/annrheumdis-2015-208161","article-title":"Risk of incident atrial fibrillation in gout: A cohort study","volume":"75","author":"Kim","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1002\/art.39330","article-title":"Sleep apnea and the risk of incident gout: A population-based, body mass index\u2013matched cohort study","volume":"67","author":"Zhang","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/art.40662","article-title":"The risk of gout among patients with sleep apnea: A matched cohort study","volume":"71","author":"Mallen","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s00198-018-4375-2","article-title":"Gout as a risk factor for osteoporosis: Epidemiologic evidence from a population-based longitudinal study involving 108,060 individuals","volume":"29","author":"Kok","year":"2018","journal-title":"Osteoporos. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"26541","DOI":"10.1038\/srep26541","article-title":"Association between previous history of gout attack and risk of deep vein thrombosis\u2014A nationwide population-based cohort study","volume":"6","author":"Chiu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1093\/rheumatology\/kez398","article-title":"Trends of venous thromboembolism risk before and after diagnosis of gout: A general population-based study","volume":"59","author":"Li","year":"2020","journal-title":"Rheumatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E597","DOI":"10.1503\/cmaj.180717","article-title":"Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy","volume":"191","author":"Sultan","year":"2019","journal-title":"CMAJ"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.thromres.2016.06.020","article-title":"Serum uric acid, gout, and venous thromboembolism: The atherosclerosis risk in communities study","volume":"144","author":"Kubota","year":"2016","journal-title":"Thromb. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1212\/01.wnl.0000175987.59991.3d","article-title":"Epidemiology of vestibular vertigo: A neurotologic survey of the general population","volume":"65","author":"Neuhauser","year":"2005","journal-title":"Neurology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00415-009-0149-2","article-title":"Epidemiology of vertigo, migraine and vestibular migraine","volume":"256","author":"Lempert","year":"2009","journal-title":"J. Neurol."},{"key":"ref_23","first-page":"40","article-title":"Epidemiology of vertigo","volume":"20","author":"Neuhauser","year":"2007","journal-title":"Hand. Clin. Neurol."},{"key":"ref_24","first-page":"S1","article-title":"Clinical practice guideline: Benign paroxysmal positional vertigo (update)","volume":"156","author":"Bhattacharyya","year":"2017","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1056\/NEJM199911183412107","article-title":"Benign paroxysmal positional vertigo","volume":"341","author":"Furman","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3389\/fneur.2018.00486","article-title":"Efficacy of repositioning therapy in patients with benign paroxysmal positional vertigo and preexisting central neurologic disorders","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0140-6736(08)61161-7","article-title":"Meniere\u2019s disease","volume":"372","author":"Sajjadi","year":"2008","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3109\/00016489509121906","article-title":"Epidemiological and clinical characteristics of Meniere\u2019s disease in Japan","volume":"115","author":"Watanabe","year":"1995","journal-title":"Acta Otolaryngol."},{"key":"ref_29","first-page":"87","article-title":"Vestibular neuritis: Recent advances in etiology, diagnostic evaluation, and treatment","volume":"82","author":"Le","year":"2019","journal-title":"Adv. Otorhinolaryngol."},{"key":"ref_30","first-page":"222","article-title":"Benign positional vertigo as a clinical manifestation of hyperuricemia\u2013a recent discovery","volume":"187","author":"Adam","year":"2001","journal-title":"J. Neurol. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/ene.12248","article-title":"Serum uric acid levels correlate with benign paroxysmal positional vertigo","volume":"21","author":"Celikbilek","year":"2014","journal-title":"Eur. J. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fneur.2019.00091","article-title":"Association between serum uric acid levels and benign paroxysmal positional vertigo: A systematic review and meta-analysis of observational studies","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jocn.2012.05.036","article-title":"Association between gout and vertigo in a Taiwanese population","volume":"20","author":"Lin","year":"2013","journal-title":"J. Clin. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"412","DOI":"10.21053\/ceo.2018.01774","article-title":"Tobacco smoking and alcohol consumption are related to benign parotid tumor: A nested case-control study using a national health screening cohort","volume":"12","author":"Kim","year":"2019","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"ref_35","unstructured":"World Health Organization Western Pacific Region, and IASO, International Association for the Study of Obesity (2000). The Asia-Pacific perspective: Redefining obesity and its treatment. Int. Obes. Taskforce, 2, 15\u201321."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/aje\/kwq433","article-title":"Practice of epidemiology: Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries","volume":"173","author":"Quan","year":"2011","journal-title":"Am. J. Epidemiol."},{"key":"ref_37","first-page":"344","article-title":"Relationship between serum level of uric acid and benign paroxysmal positional vertigo","volume":"95","author":"Yuan","year":"2015","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_38","first-page":"21","article-title":"The correlation between serum uric acid level and benign paroxysmal position vertigo","volume":"20","author":"Dong","year":"2017","journal-title":"Chin. J. Pract Nervous Dis."},{"key":"ref_39","first-page":"11","article-title":"Study on the correlation between uric acid level and benign paroxysmal positional vertigo","volume":"17","author":"Xu","year":"2015","journal-title":"J. Xiangnan Univ."},{"key":"ref_40","first-page":"126","article-title":"Plasma homocysteine and uric acid levels in young patients with benign paroxysmal positional vertigo and their correlations","volume":"17","author":"Wei","year":"2017","journal-title":"Chin. J. Ophthalmol. Otorhinolaryngol."},{"key":"ref_41","first-page":"54","article-title":"Analysis of serum uric acid level in patients with benign paroxysmal positional vertigo","volume":"46","author":"Si","year":"2016","journal-title":"Qinghai Med. J."},{"key":"ref_42","first-page":"696","article-title":"Relationship between benign paroxysmal positional vertigo and serum uric acid level in elderly patients","volume":"23","author":"Zhu","year":"2016","journal-title":"Chin. Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00415-004-0277-7","article-title":"Is uric acid implicated in benign paroxysmal positional vertigo?","volume":"251","author":"Ziavra","year":"2004","journal-title":"J. Neurol."},{"key":"ref_44","first-page":"442","article-title":"Risk factors associated with benign paroxysmal positional vertigo\u2014A case-control study","volume":"37","author":"Lu","year":"2017","journal-title":"J. Nantong Univ."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.12659\/MSM.905716","article-title":"Factors associated with benign paroxysmal positional vertigo: A Chinese case-control study","volume":"23","author":"Yuan","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref_46","first-page":"27","article-title":"The effect of serum uric acid in generating idiopathic benign paroxysmal positional vertigo","volume":"9","author":"Jeong","year":"2010","journal-title":"Res. Vestib. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/jsbi.2000.4260","article-title":"The otoconia of the guinea pig utricle: Internal structure, surface exposure, and interactions with the filament matrix","volume":"131","author":"Lins","year":"2000","journal-title":"J. Struct. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/cmi.2011.35","article-title":"Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis","volume":"8","author":"Chen","year":"2011","journal-title":"Cell. Mol. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/j.1745-7254.2008.00877.x","article-title":"Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells","volume":"29","author":"Chao","year":"2008","journal-title":"Acta pharmacol. Sin."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1111\/j.1523-1755.2005.00273.x","article-title":"Hyperuricemia induces endothelial dysfunction","volume":"67","author":"Khosla","year":"2005","journal-title":"Kidney Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/MAO.0b013e3181b4ec89","article-title":"Vascular findings in the stria vascularis of patients with unilateral or bilateral M\u00e9ni\u00e8re\u2019s disease: A histopathologic temporal bone study","volume":"30","author":"Kariya","year":"2009","journal-title":"Otol. Neurotol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"53","DOI":"10.7874\/jao.2020.00115","article-title":"Experimental animal models for meniere\u2019s disease: A mini-review","volume":"24","author":"Seo","year":"2020","journal-title":"J. Audiol. Otol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.mehy.2013.10.015","article-title":"The Meniere attack: An ischemia\/reperfusion disorder of inner ear sensory tissues","volume":"81","author":"Foster","year":"2013","journal-title":"Med. Hypotheses"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s13075-018-1612-1","article-title":"Obesity, hypertension and diuretic use as risk factors for incident gout: A systematic review and meta-analysis of cohort studies","volume":"20","author":"Evans","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/WNR.0000000000000908","article-title":"Low serum uric acid levels in patients with acute central nervous system viral infections","volume":"28","author":"Li","year":"2017","journal-title":"Neuroreport"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.semnephrol.2011.08.004","article-title":"The epidemiology of uric acid and fructose","volume":"31","author":"Rho","year":"2011","journal-title":"Semin. Nephrol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1136\/ard.2009.109884","article-title":"Menopause, postmenopausal hormone use and risk of incident gout","volume":"69","author":"Hak","year":"2010","journal-title":"Ann. Rheum. Dis."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/1\/185\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:51:55Z","timestamp":1760147515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/1\/185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["jcm12010185"],"URL":"https:\/\/doi.org\/10.3390\/jcm12010185","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2022,12,26]]}}}