{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:32:42Z","timestamp":1783636362165,"version":"3.55.0"},"reference-count":45,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Diabetic ketoacidosis (DKA) is an acute life-threatening complication occurring mainly at the onset of type 1 diabetes mellitus. The neutrophil-to-lymphocyte ratio (NLR), a marker for systemic inflammation, has recently generated increasing interest in many chronic diseases. The aim of this cross-sectional study was to determine the value of the neutrophil-to-lymphocyte ratio (NLR) in association with DKA severity across these cases. A total of 155 children with new-onset type 1 DM from one large center were included in the study. Total and differential leukocyte counts were measured upon admission and calculation of the NLR was performed. Patients were classified into four groups: without DKA, mild, moderate, and severe DKA at disease onset. Total WBCs, neutrophils, and monocytes increased with DKA severity (p-value &lt; 0.005), while eosinophiles displayed an inverse relationship (p-value &lt; 0.001). Median NLR scores increased from those without ketoacidosis (1.11) to mild (1.58), moderate (3.71), and severe (5.77) ketoacidosis groups. The statistical threshold value of the NLR in predicting DKA was 1.84, with a sensitivity of 80.2% and a specificity of 80%. Study findings indicate that a higher NLR score adds valuable information regarding the presence of DKA in children with new-onset T1DM.<\/jats:p>","DOI":"10.3390\/jcm12010221","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T05:31:54Z","timestamp":1672205514000},"page":"221","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Neutrophil-to-Lymphocyte Ratio Adds Valuable Information Regarding the Presence of DKA in Children with New-Onset T1DM"],"prefix":"10.3390","volume":"12","author":[{"given":"Alexandra-Cristina","family":"Scutca","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300040 Timisoara, Romania"},{"name":"Department of Pediatrics I, Children\u2019s Emergency Hospital \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia-Maria","family":"Nicoar\u0103","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300040 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"M\u0103r\u0103zan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics I, Children\u2019s Emergency Hospital \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgiana-Flavia","family":"Brad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300040 Timisoara, Romania"},{"name":"Department of Pediatrics I, Children\u2019s Emergency Hospital \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-7643","authenticated-orcid":false,"given":"Otilia","family":"M\u0103rginean","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300040 Timisoara, Romania"},{"name":"Department of Pediatrics I, Children\u2019s Emergency Hospital \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"},{"name":"Department XI Pediatrics, Discipline I Pediatrics, Disturbances of Growth and Development in Children\u2013BELIVE, 300011 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"856958","DOI":"10.3389\/fendo.2022.856958","article-title":"Incidence of Diabetic Ketoacidosis Among Pediatrics with Type 1 Diabetes Prior to and During COVID-19 Pandemic: A Meta-Analysis of Observational Studies","volume":"13","author":"Alfayez","year":"2022","journal-title":"Front. 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