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The human cochlea is very small and deeply embedded within the densest skull bone, making nondestructive visualization of its internal microstructures extremely challenging. Current imaging techniques used in clinical practice, such as MRI and CT, fall short in their resolution to visualize important intracochlear landmarks, and histological analysis of the cochlea cannot be performed on living patients without compromising their hearing. Recently, optical coherence tomography (OCT) has been shown to be a promising tool for nondestructive micrometer resolution imaging of the mammalian inner ear. Various studies performed on human cadaveric tissue and living animals demonstrated the ability of OCT to visualize important cochlear microstructures (scalae, organ of Corti, spiral ligament, and osseous spiral lamina) at micrometer resolution. However, the interpretation of human intracochlear OCT images is non-trivial for researchers and clinicians who are not yet familiar with this novel technology. In this study, we present an atlas of intracochlear OCT images, which were acquired in a series of 7 fresh and 10 fresh-frozen human cadaveric cochleae through the round window membrane and describe the qualitative characteristics of visualized intracochlear structures. Likewise, we describe several intracochlear abnormalities, which could be detected with OCT and are relevant for clinical practice.<\/jats:p>","DOI":"10.3390\/jcm12010238","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:54:42Z","timestamp":1672282482000},"page":"238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Optical Coherence Tomography-Based Atlas of the Human Cochlear Hook Region"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-3995","authenticated-orcid":false,"given":"Lore","family":"Kerkhofs","sequence":"first","affiliation":[{"name":"Research Group Experimental Oto-Rhino-Laryngology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium"},{"name":"Department of Neurosciences, Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiya","family":"Starovoyt","sequence":"additional","affiliation":[{"name":"Research Group Experimental Oto-Rhino-Laryngology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium"},{"name":"Department of Neurosciences, Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wouters","sequence":"additional","affiliation":[{"name":"Research Group Experimental Oto-Rhino-Laryngology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium"},{"name":"Department of Neurosciences, Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0690-3636","authenticated-orcid":false,"given":"Tristan","family":"Putzeys","sequence":"additional","affiliation":[{"name":"Research Group Experimental Oto-Rhino-Laryngology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium"},{"name":"Department of Neurosciences, Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium"},{"name":"Laboratory for Soft Matter and Biophysics, Department of Physics and Astronomy, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3512-1334","authenticated-orcid":false,"given":"Nicolas","family":"Verhaert","sequence":"additional","affiliation":[{"name":"Research Group Experimental Oto-Rhino-Laryngology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium"},{"name":"Department of Neurosciences, Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals of Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2021, August 01). 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