{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:19:57Z","timestamp":1792804797383,"version":"4.5.0"},"reference-count":37,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Changsha Natural Science Foundation","award":["kq2202382"],"award-info":[{"award-number":["kq2202382"]}]},{"name":"Changsha Natural Science Foundation","award":["2022JJ40802"],"award-info":[{"award-number":["2022JJ40802"]}]},{"name":"Changsha Natural Science Foundation","award":["2022JJ30928"],"award-info":[{"award-number":["2022JJ30928"]}]},{"name":"Changsha Natural Science Foundation","award":["2021JJ31085"],"award-info":[{"award-number":["2021JJ31085"]}]},{"name":"Changsha Natural Science Foundation","award":["2022M713525"],"award-info":[{"award-number":["2022M713525"]}]},{"name":"Natural Science Foundation of Hunan","award":["kq2202382"],"award-info":[{"award-number":["kq2202382"]}]},{"name":"Natural Science Foundation of Hunan","award":["2022JJ40802"],"award-info":[{"award-number":["2022JJ40802"]}]},{"name":"Natural Science Foundation of Hunan","award":["2022JJ30928"],"award-info":[{"award-number":["2022JJ30928"]}]},{"name":"Natural Science Foundation of Hunan","award":["2021JJ31085"],"award-info":[{"award-number":["2021JJ31085"]}]},{"name":"Natural Science Foundation of Hunan","award":["2022M713525"],"award-info":[{"award-number":["2022M713525"]}]},{"name":"China Postdoctoral Science Foundation","award":["kq2202382"],"award-info":[{"award-number":["kq2202382"]}],"id":[{"id":"https:\/\/ror.org\/0426zh255","id-type":"ROR","asserted-by":"crossref"}]},{"name":"China Postdoctoral Science Foundation","award":["2022JJ40802"],"award-info":[{"award-number":["2022JJ40802"]}],"id":[{"id":"https:\/\/ror.org\/0426zh255","id-type":"ROR","asserted-by":"crossref"}]},{"name":"China Postdoctoral Science Foundation","award":["2022JJ30928"],"award-info":[{"award-number":["2022JJ30928"]}],"id":[{"id":"https:\/\/ror.org\/0426zh255","id-type":"ROR","asserted-by":"crossref"}]},{"name":"China Postdoctoral Science Foundation","award":["2021JJ31085"],"award-info":[{"award-number":["2021JJ31085"]}],"id":[{"id":"https:\/\/ror.org\/0426zh255","id-type":"ROR","asserted-by":"crossref"}]},{"name":"China Postdoctoral Science Foundation","award":["2022M713525"],"award-info":[{"award-number":["2022M713525"]}],"id":[{"id":"https:\/\/ror.org\/0426zh255","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The diagnosis of phosphaturic mesenchymal tumors (PMT) is easily delayed clinically, and their surgical treatment is unstandardized. This study aimed to evaluate our experience in the diagnosis and treatment of PMT and provide a research basis for the accurate and standardized treatment of PMT. Materials and Methods: Twelve patients diagnosed with PMT in our department and who underwent surgical treatment were included in this study. Preoperative demographic and clinical information were recorded. CT, MRI, and technetium-99m (Tc99m)-octreotide PET\/CT imaging techniques were used to evaluate the general conditions and lesion boundaries of the tumors. Surgical treatment was performed using radical resection and microwave ablation-assisted extended curettage according to the lesion location and size. Patients were strictly followed up with and evaluated for oncological prognosis, radiological results, bone healing, serum ion levels, limb function, and pain level; the occurrence of complications was also recorded. Results: Three patients underwent radical resection, and nine underwent microwave ablation-assisted extended curettage. The average duration of symptoms in this group was 1.5 years (9\u201335 months) before diagnosis. Serum phosphate and AKP levels returned to normal one and two weeks postoperatively, respectively. There was no apparent specificity in the pathological findings; however, the immunohistochemistry of FGF-23 was positive, and the original fracture sites were effectively healed during the follow-up. The limb function and pain scores were significantly improved. The MSTS score increased from 15.3 to 29.0, and the VAS score decreased from 5.3 to 0.4. All patients recovered, and 90% resumed their original jobs. Conclusions: Accurate diagnosis and standardized surgical treatment are crucial to achieving a clinical cure for PMT. Combining clinical manifestations, biochemical examinations, imaging characteristics, and pathological findings is an effective way to diagnose PMT accurately. Radical resection and microwave ablation-assisted extended curettage are reliable surgical treatment methods for PMT.<\/jats:p>","DOI":"10.3390\/jcm12010252","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:54:42Z","timestamp":1672282482000},"page":"252","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Phosphaturic Mesenchymal Tumors: Rethinking the Clinical Diagnosis and Surgical Treatment"],"prefix":"10.3390","volume":"12","author":[{"given":"Yupeng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital, Central South University, 87th Xiangya Road, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital, Central South University, 87th Xiangya Road, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital, Central South University, 87th Xiangya Road, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital, Central South University, 87th Xiangya Road, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital, Central South University, 87th Xiangya Road, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1098-5475","authenticated-orcid":false,"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital, Central South University, 87th Xiangya Road, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e10661","DOI":"10.1002\/jbm4.10661","article-title":"Infigratinib reduces fibroblast growth factor 23 (fgf23) and increases blood phosphate in tumor-induced osteomalacia","volume":"6","author":"Hartley","year":"2022","journal-title":"JBMR Plus"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/jbmr.4620","article-title":"Clinical challenges in diagnosis, tumor localization and treatment of tumor-induced osteomalacia: Outcome of a retrospective surveillance","volume":"37","author":"Hidaka","year":"2022","journal-title":"J. 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