{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:28:44Z","timestamp":1778509724260,"version":"3.51.4"},"reference-count":25,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"General Project of the Zhejiang Provincial Health Science and Technology Plan","award":["2021KY546"],"award-info":[{"award-number":["2021KY546"]}]},{"name":"General Project of the Zhejiang Provincial Health Science and Technology Plan","award":["2021KY548"],"award-info":[{"award-number":["2021KY548"]}]},{"name":"General Project of the Zhejiang Provincial Health Science and Technology Plan","award":["2022RC015"],"award-info":[{"award-number":["2022RC015"]}]},{"name":"Zhejiang Provincial Health Science and Technology Program Young Innovative Talents Project","award":["2021KY546"],"award-info":[{"award-number":["2021KY546"]}]},{"name":"Zhejiang Provincial Health Science and Technology Program Young Innovative Talents Project","award":["2021KY548"],"award-info":[{"award-number":["2021KY548"]}]},{"name":"Zhejiang Provincial Health Science and Technology Program Young Innovative Talents Project","award":["2022RC015"],"award-info":[{"award-number":["2022RC015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Remimazolam is a novel ultrashort-acting intravenous benzodiazepine sedative\u2013hypnotic that significantly reduces the times to sedation onset and recovery. This trial was conducted to confirm the recovery time from anesthesia of remimazolam-flumazenil versus propofol in patients undergoing endotracheal surgery under rigid bronchoscopy. Methods: Patients undergoing endotracheal tumor resection or stent implantation were randomly allocated into a remimazolam group (Group R) or a propofol group (Group P). The primary outcome was the recovery time from general anesthesia. The secondary outcomes were the time to loss of consciousness (LoC), hemodynamic fluctuations, and adverse events. Results: A total of 34 patients were screened, and 30 patients were enrolled in the study. The recovery time was significantly shorter for Group R (140 \u00b1 52 s) than for Group P (374 \u00b1 195 s) (p &lt; 0.001). The times to LoC were 76 \u00b1 40 s in Group R and 75 \u00b1 25 s in Group P and were not significantly different. There were also no significant differences in hemodynamic fluctuations or adverse events between the two groups. Conclusions: The recovery time from general anesthesia in rigid bronchoscopy patients was shorter using remimazolam-flumazenil than with propofol, with no dramatic hemodynamic fluctuations and adverse events or differences between the agents. Remimazolam-flumazenil allows for faster recovery from anesthesia than propofol.<\/jats:p>","DOI":"10.3390\/jcm12010257","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:54:42Z","timestamp":1672282482000},"page":"257","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Comparison of Remimazolam-Flumazenil versus Propofol for Rigid Bronchoscopy: A Prospective Randomized Controlled Trial"],"prefix":"10.3390","volume":"12","author":[{"given":"Yafei","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Zhejiang Cancer Hospital, Research Center for Neuro-Oncology Interaction, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate School, Wannan Medical College, Wuhu 241000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulei","family":"Gu","sequence":"additional","affiliation":[{"name":"Graduate School, Wenzhou Medical University, Wenzhou 325035, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate School, Wenzhou Medical University, Wenzhou 325035, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhejiang Cancer Hospital, Research Center for Neuro-Oncology Interaction, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangxiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhejiang Cancer Hospital, Research Center for Neuro-Oncology Interaction, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dapeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhejiang Cancer Hospital, Research Center for Neuro-Oncology Interaction, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhejiang Cancer Hospital, Research Center for Neuro-Oncology Interaction, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China"},{"name":"Graduate School, Wenzhou Medical University, Wenzhou 325035, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangjie","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhejiang Cancer Hospital, Research Center for Neuro-Oncology Interaction, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/clpt.2008.100","article-title":"Contributions of PK\/PD modeling to intravenous anesthesia","volume":"84","author":"Minto","year":"2008","journal-title":"Clin. 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Anaesth."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/1\/257\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:54:53Z","timestamp":1760147693000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/1\/257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["jcm12010257"],"URL":"https:\/\/doi.org\/10.3390\/jcm12010257","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]}}}