{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:54:48Z","timestamp":1792482888769,"version":"4.5.0"},"reference-count":237,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Hemorrhagic shock (HS) management is based on a timely, rapid, definitive source control of bleeding\/s and on blood loss replacement. Stopping the hemorrhage from progressing from any named and visible vessel is the main stem fundamental praxis of efficacy and effectiveness and an essential, obligatory, life-saving step. Blood loss replacement serves the purpose of preventing ischemia\/reperfusion toxemia and optimizing tissue oxygenation and microcirculation dynamics. The \u201cphysiological classification of HS\u201d dictates the timely management and suits the \u2018titrated hypotensive resuscitation\u2019 tactics and the \u2018damage control surgery\u2019 strategy. In any hypotensive but not yet critical shock, the body\u2019s response to a fluid load test determines the cut-off point between compensation and progression between the time for adopting conservative treatment and preparing for surgery or rushing to the theater for rapid bleeding source control. Up to 20% of the total blood volume is given to refill the unstressed venous return volume. In any critical level of shock where, ab initio, the patient manifests signs indicating critical physiology and impending cardiac arrest or cardiovascular accident, the balance between the life-saving reflexes stretched to the maximum and the insufficient distal perfusion (blood, oxygen, and substrates) remains in a liable and delicate equilibrium, susceptible to any minimal change or interfering variable. In a cardiac arrest by exsanguination, the core of the physiological issue remains the rapid restoration of a sufficient venous return, allowing the heart to pump it back into systemic circulation either by open massage via sternotomy or anterolateral thoracotomy or spontaneously after aorta clamping in the chest or in the abdomen at the epigastrium under extracorporeal resuscitation and induced hypothermia. This is the only way to prevent ischemic damage to the brain and the heart. This is accomplishable rapidly and efficiently only by a direct approach, which is a crush laparotomy if the bleeding is coming from an abdominal +\/\u2212 lower limb site or rapid sternotomy\/anterolateral thoracotomy if the bleeding is coming from a chest +\/\u2212 upper limbs site. Without first stopping the bleeding and refilling the heart, any further exercise is doomed to failure. Direct source control via laparotomy\/thoracotomy, with the concomitant or soon following venous refilling, are the two essential, initial life-saving steps.<\/jats:p>","DOI":"10.3390\/jcm12010260","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:54:42Z","timestamp":1672282482000},"page":"260","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Management of Hemorrhagic Shock: Physiology Approach, Timing and Strategies"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-3173","authenticated-orcid":false,"given":"Fabrizio G.","family":"Bonanno","sequence":"first","affiliation":[{"name":"Department of Surgery, Polokwane Provincial Hospital, Cnr Hospital & Dorp Street, Polokwane 0700, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4103\/0974-2700.102357","article-title":"Hemorrhagic shock: The \u201cphysiology approach\u201d","volume":"5","author":"Bonanno","year":"2012","journal-title":"J. Emerg. Trauma Shock"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/JETS.JETS_153_19","article-title":"The need for a physiological classification of haemorrhagic shock","volume":"13","author":"Bonanno","year":"2020","journal-title":"J Emerg. Trauma Shock."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1097\/TA.0000000000003595","article-title":"Advanced medical monitoring for the battlefield: A review on clinical applicability of compensatory reserve measurements for early and accurate hemorrhage detection","volume":"93","author":"Convertino","year":"2022","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/SHK.0000000000001696","article-title":"Resonance Raman Spectroscopy Derived Tissue Hemoglobin Oxygen Saturation in Critically Ill and Injured Patients","volume":"56","author":"Tiba","year":"2020","journal-title":"Shock"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4103\/0974-2700.82210","article-title":"Physiopathology of shock","volume":"4","author":"Bonanno","year":"2011","journal-title":"J. Emerg. Trauma Shock"},{"key":"ref_6","first-page":"1","article-title":"From a cardio-vascular reserve hypothesis to a proposed measurable index: A pilot empirical validation","volume":"12","author":"Gabbay","year":"2015","journal-title":"Clin. Trials Regul. Sci. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/SHK.0000000000000559","article-title":"The compensatory reserve for early and accurate prediction of hemodynamic compromise: A review of the underlying physiology","volume":"45","author":"Convertino","year":"2015","journal-title":"Shock"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00134-013-2928-6","article-title":"Changes in the mean systemic filling pressure during a fluid challenge in postsurgical intensive care patients","volume":"39","author":"Cecconi","year":"2013","journal-title":"Intensiv. Care Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-018-1993-1","article-title":"Effects of Fluids on the Macro- and Microcirculations","volume":"22","author":"Bennett","year":"2018","journal-title":"Crit. Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/TA.0000000000002304","article-title":"Echo is a good, not perfect, measure of cardiac output in critically ill surgical patients","volume":"87","author":"Olivieri","year":"2019","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13054-019-2413-x","article-title":"What is the lowest change in cardiac output that transthoracic echocardiography can detect?","volume":"23","author":"Jozwiak","year":"2019","journal-title":"Crit. Care"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/CCM.0000000000001517","article-title":"Pharmacodynamic Analysis of a Fluid Challenge","volume":"44","author":"Aya","year":"2016","journal-title":"Crit. Care Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1097\/CCM.0000000000002067","article-title":"Hemodynamic effect of different doses of fluids for a fluid challenge: A quasi randomized controlled study","volume":"45","author":"Aya","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_14","first-page":"1207","article-title":"Goal-directed resuscitation in the prehospital setting: A propensity-adjusted analysis","volume":"74","author":"Brown","year":"2013","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00000658-198709000-00006","article-title":"3% NaCl and 7.5% NaCl\/Dextran 70 in the Resuscitation of Severely Injured Patients","volume":"206","author":"Holcroft","year":"1987","journal-title":"Ann. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0039-6060(97)90135-5","article-title":"Efficacy of hypertonic 7.5% saline and 6% dextran 70 in treating trauma: A meta-analysis of controlled clinical trials","volume":"122","author":"Wade","year":"1997","journal-title":"Surgery"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/bja\/aes377","article-title":"Balanced crystalloid compared with balanced colloid solution using a goal-directed haemodynamic algorithm","volume":"110","author":"Feldheiser","year":"2012","journal-title":"Br. J. Anaesth."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13613-014-0038-4","article-title":"Choices in fluid type and volume during resuscitation: Impact on patient outcomes","volume":"4","author":"Lira","year":"2014","journal-title":"Ann. Intensiv. Care"},{"key":"ref_19","first-page":"S35","article-title":"Indications for Early Red Blood Cell Transfusion","volume":"60","author":"Dutton","year":"2006","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s002689900067","article-title":"Pattern of organ failure following severe trauma","volume":"20","author":"Regel","year":"1996","journal-title":"World J. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/00005373-199604000-00001","article-title":"Post-injury multiple organ failure: A bi-modal phenomenon","volume":"40","author":"Moore","year":"1996","journal-title":"J. Trauma"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/00000658-199806000-00008","article-title":"Microvascular Changes Explain the \u201cTwo-Hit\u201d Theory of Multiple Organ Failure","volume":"227","author":"Garrison","year":"1998","journal-title":"Ann. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Douzinas, E.E., Andrianakis, I., Livaditi, O., Paneris, P., Tasoulis, M., Pelekanou, A., Betrosian, A., and Giamarellos-Bourboulis, E.J. (2008). The level of hypotension during hemorrhagic shock is a major determinant of the post-resuscitation systemic inflammatory response: An experimental study. BMC Physiol., 8.","DOI":"10.1186\/1472-6793-8-15"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4103\/0974-2700.82211","article-title":"Clinical pathology of the shock syndromes","volume":"4","author":"Bonanno","year":"2011","journal-title":"J. Emerg. Trauma Shock"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1097\/CCM.0b013e31823e9501","article-title":"Hemorrhagic shock resuscitation: A critical issue on the development of post-traumatic multiple organ failure","volume":"40","author":"Douzinas","year":"2012","journal-title":"Crit. Care Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s00268-005-0131-9","article-title":"Selective conservativism in trauma management: A South African contri-bution","volume":"29","author":"Clarke","year":"2005","journal-title":"World J. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/bjs.4991","article-title":"Selective non-operative management of liver gunshot injuries","volume":"92","author":"Nicol","year":"2005","journal-title":"Br. J. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.injury.2020.09.043","article-title":"Time to surgery: Is it truly crucial in initially stable patients with penetrating injury?","volume":"52","author":"Hershkovitz","year":"2020","journal-title":"Injury"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.injury.2020.10.013","article-title":"Early hospital discharge following non-operative management of blunt liver and splenic trauma: A pilot randomized controlled trial","volume":"52","author":"Kumar","year":"2020","journal-title":"Injury"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"The Brain Trauma foundation, The American Association of Neurological Surgeons, and The Joint Section on Neurotrauma and Critical Care (2000). Resuscitation of blood pressure and oxygenation. J. Neurotrauma, 17, 471\u2013482.","DOI":"10.1089\/neu.2000.17.471"},{"key":"ref_31","first-page":"291","article-title":"Hypotension begins at 110 mm Hg: Redefining \u201chypotension\u201d with data","volume":"63","author":"Eastridge","year":"2007","journal-title":"J. Trauma"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.injury.2011.08.014","article-title":"Redefining hypotension in traumatic brain injury","volume":"43","author":"Berry","year":"2012","journal-title":"Injury"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1097\/TA.0b013e31824af90b","article-title":"Traditional systolic blood pressure targets underestimate hypo-tension-induced secondary brain injury","volume":"72","author":"Brenner","year":"2012","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/SHK.0000000000001634","article-title":"Shock index and postpartum haemorrhage in vaginal deliveries: A multicenter retrospective study","volume":"55","author":"Ushida","year":"2021","journal-title":"Shock"},{"key":"ref_35","first-page":"618","article-title":"The preventive treatment of wound shock","volume":"70","author":"Cannon","year":"1918","journal-title":"J. Am. Med. Assoc."},{"key":"ref_36","first-page":"851","article-title":"Fundamentals of physiologic control of arterial hemorrhage","volume":"58","author":"Shaftan","year":"1965","journal-title":"Surgery"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0002-9610(69)90146-9","article-title":"Bleeding and blood pressure","volume":"118","author":"Wangensteen","year":"1969","journal-title":"Am. J. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/bjs.1800800228","article-title":"Resuscitation for haemorrhagic shock","volume":"80","author":"Assalia","year":"1993","journal-title":"Br. J. Surg."},{"key":"ref_39","first-page":"S39","article-title":"Fluid Resuscitation Strategies in the Israeli Army","volume":"54","author":"Krausz","year":"2003","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_40","first-page":"6","article-title":"Pre-hospital fluid resuscitation in trauma: The IDF-MC panel Summary [Abstract]","volume":"1","author":"Blumenfeld","year":"2004","journal-title":"J. Israeli Mil. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0741-5214(91)90228-M","article-title":"Ruptured abdominal aneurysms","volume":"13","author":"Crawford","year":"1991","journal-title":"J. Vasc. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/bjs.1800731007","article-title":"Effect of early blood transfusion on gastrointestinal haemorrhage","volume":"73","author":"Blair","year":"1986","journal-title":"Br. J. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40560-016-0202-z","article-title":"Permissive hypotension\/hypotensive resuscitation and restricted\/controlled resuscitation in patients with severe trauma","volume":"5","author":"Kudo","year":"2017","journal-title":"J. Intensiv. Care"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Ding, Y., Zheng, D., Huang, X., Zhang, J., Liang, W., Huang, Z., and Zhu, S.G. (Research Square, 2021). Comparison of Permissive Hypotension vs. Conventional Re-suscitation. Strategies in Adult Trauma Patients with Hemorrhagic Shock: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials, Research Square.","DOI":"10.21203\/rs.3.rs-407033\/v1"},{"key":"ref_45","first-page":"e16487","article-title":"Permissive Hypotension vs. Conventional Resuscitation in Patients with Trauma or Hemorrhagic Shock: A Review","volume":"13","author":"Woodward","year":"2021","journal-title":"Cureus"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bja.2021.03.015","article-title":"Perioperative hypotension 2021: A contrarian view","volume":"127","author":"Kappen","year":"2021","journal-title":"Br. J. Anaesth."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.resuscitation.2004.10.012","article-title":"Titrated hypertonic\/hyperoncotic solution for hypotensive fluid resuscitation during uncontrolled hemorrhagic shock in rats","volume":"65","author":"Kentner","year":"2005","journal-title":"Resuscitation"},{"key":"ref_48","first-page":"H1708","article-title":"Alginate plasma expander maintains perfusion and plasma viscosity during extreme he-modilution","volume":"288","author":"Cabrales","year":"2005","journal-title":"Am. J. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"R54","DOI":"10.1186\/cc6874","article-title":"Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130\/0.4: A microvascular perspective","volume":"12","author":"Martini","year":"2008","journal-title":"Crit. Care"},{"key":"ref_50","first-page":"418","article-title":"Improved Resuscitation From Hemorrhagic Shock With Ringer\u2019s Lactate With Increased Viscosity in the Hamster Window Chamber Model","volume":"71","author":"Villela","year":"2011","journal-title":"J. Trauma"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1097\/01.shk.0000239782.71516.ba","article-title":"IS resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity?","volume":"27","author":"Cabrales","year":"2007","journal-title":"Shock"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.resuscitation.2007.03.010","article-title":"Transfusion restores blood viscosity and reinstates microvascular conditions from hemor-rhagic shock independent of oxygen carrying capacity","volume":"75","author":"Cabrales","year":"2007","journal-title":"Resuscitation"},{"key":"ref_53","first-page":"1421","article-title":"Microvascular experimental evidence on the relative significance of restoring oxygen carrying capacity vs blood viscosity in shock resuscitation","volume":"1784","author":"Wettstein","year":"2008","journal-title":"Biochem. Biophys. Acta"},{"key":"ref_54","first-page":"51","article-title":"Vasopressin during cardiopulmonary resuscitation and different shock states: A review of the literature","volume":"6","author":"Krismer","year":"2006","journal-title":"Biochem. Biophys. Acta"},{"key":"ref_55","first-page":"S69","article-title":"Vasopressin for Hemorrhagic Shock Management: Revisiting the Potential Value in Civilian and Combat Casualty Care","volume":"69","author":"Voelckel","year":"2010","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/01.TA.0000044357.25191.1B","article-title":"Successful Resuscitation of a Traumatic Cardiac Arrest Victim in Hemorrhagic Shock with Vasopressin: A Case Report and Brief Review of the Literature","volume":"57","author":"Haas","year":"2004","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1213\/01.ANE.0000175209.61051.7F","article-title":"Vasopressin in haemorrhagic shock","volume":"101","author":"Sharma","year":"2005","journal-title":"Anesth. Analg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1213\/01.ANE.0000175217.55775.1C","article-title":"Vasopressin During Uncontrolled Hemorrhagic Shock: Less Bleeding Below the Diaphragm, More Perfusion Above","volume":"101","author":"Stadlbauer","year":"2005","journal-title":"Anesthesia Analg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00540-004-0299-4","article-title":"Low dose vasopressin infusion in patients with severe vasodilatory hypo-tension after prolonged hemorrhage during general anesthesia","volume":"19","author":"Tsuneyoshi","year":"2005","journal-title":"J. Anest."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1213\/01.ANE.0000215135.44887.7E","article-title":"Bolus vasopressin during hemorrhagic shock?","volume":"102","author":"Roth","year":"2006","journal-title":"Anesth. Analg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"S474","DOI":"10.1097\/CCM.0b013e31818a8d7e","article-title":"Preventing cardiac arrest during hemorrhagic shock with vasopressin","volume":"36","author":"Raab","year":"2008","journal-title":"Crit. Care Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jcrc.2009.10.005","article-title":"Discontinuation of vasopressin before norepinephrine increases the incidence of hypotension in patients recovering from septic shock: A retrospective cohort study","volume":"25","author":"Bauer","year":"2010","journal-title":"J. Crit. Care"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1001\/jamasurg.2019.2884","article-title":"Effect of Low-Dose Supplementation of Arginine Vasopressin on Need for Blood Product Transfusions in Patients With Trauma and Hemorrhagic Shock: A Randomized Clinical Trial","volume":"154","author":"Sims","year":"2019","journal-title":"JAMA Surg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"421291","DOI":"10.1155\/2014\/421291","article-title":"Vasopressin in Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Randomized Animal Trials","volume":"2014","author":"Cossu","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1056\/NEJM199410273311701","article-title":"Immediate versus Delayed Fluid Resuscitation for Hypotensive Patients with Penetrating Torso Injuries","volume":"331","author":"Bickell","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/0974-2700.106320","article-title":"Pre-hospital transport times and survival for Hypotensive patients with penetrating thoracic trauma","volume":"6","author":"Swaroop","year":"2013","journal-title":"J. Emerg. Trauma Shock"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/TA.0000000000003380","article-title":"Pre-hospital Trauma Triage Re-search Collaborative (PTTRC). The impact of prehospital time intervals on mortality in moderately and severely injured pa-tients","volume":"92","author":"Waalwijk","year":"2022","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Bernard, C. (1878). Lecons sur les Phenomenes de la vie Communs aux Animaux and aux Vegetaux, Bailliere.","DOI":"10.5962\/bhl.title.44802"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1152\/physrev.1929.9.3.399","article-title":"Organization for physiological homeostasis","volume":"9","author":"Cannon","year":"1929","journal-title":"Physiol. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1097\/00005373-197508000-00008","article-title":"The use of fresh blood in the treatment of critically injured patients","volume":"15","author":"Sheldon","year":"1975","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/advan.00107.2015","article-title":"A physiologist\u2019s view of homeostasis","volume":"39","author":"Modell","year":"2015","journal-title":"Adv. Physiol. Educ."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/MOH.0000000000000284","article-title":"Whole blood: Back to the future","volume":"23","author":"Spinella","year":"2016","journal-title":"Curr. Opin. Hematol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.transci.2010.05.011","article-title":"Perfusion vs. oxygen delivery in transfusion with \u201cfresh\u201d and \u201cold\u201d red blood cells: The experimental evidence","volume":"43","author":"Tsai","year":"2010","journal-title":"Transfus. Apher. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/10731190601188257","article-title":"Comparison of treatment modalities for hemorrhagic shock","volume":"35","author":"Perlman","year":"2007","journal-title":"Artif. Cells Blood Substit. Immobil. Biotechnol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s13054-016-1485-0","article-title":"Regulation of blood flow and volume exchange across the microcirculation","volume":"20","author":"Jacob","year":"2016","journal-title":"Crit. Care"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/SHK.0000000000001578","article-title":"Early Sequential Microcirculation Assessment in Shocked Patients as a Predictor of Outcome: A Prospective Observational Cohort Study","volume":"55","author":"Holley","year":"2021","journal-title":"Shock"},{"key":"ref_77","first-page":"H2155","article-title":"The erithrocyte as a regulator of vascular tone","volume":"269","author":"Ellsworth","year":"1995","journal-title":"Am. J. Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"H1294","DOI":"10.1152\/ajpheart.2000.278.4.H1294","article-title":"Red blood cell regulation of microvascular tone through adenosine triphosphate","volume":"278","author":"Dietrich","year":"2000","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"H2833","DOI":"10.1152\/ajpheart.2001.280.6.H2833","article-title":"Role of erythrocyte in regulating local O2 delivery mediated by haemoglobin oxygenation","volume":"280","author":"Jagger","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1152\/physiol.00038.2008","article-title":"Erythrocytes: Oxygen Sensors and Modulators of Vascular Tone","volume":"24","author":"Ellsworth","year":"2009","journal-title":"Physiology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13054-017-1621-5","article-title":"Blood components are essential to regulate microcirculatory blood flow","volume":"21","author":"Morel","year":"2017","journal-title":"Crit. Care"},{"key":"ref_82","first-page":"1054","article-title":"Red Blood Cells Accelerate the Onset of Clot Formation in Polytrauma and Hemorrhagic Shock","volume":"69","author":"Spoerke","year":"2010","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/TA.0000000000002340","article-title":"Cold-stored whole blood platelet function is preserved in injured children with hemorrhagic shock","volume":"87","author":"Leeper","year":"2019","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/TA.0000000000002687","article-title":"Large Volume Transfusion with Whole Blood is Safe Compared to Component Therapy","volume":"89","author":"Gallaher","year":"2020","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/emp2.12089","article-title":"Whole blood transfusion versus component therapy in trauma resuscitation: A systematic review and meta-analysis","volume":"4","author":"Crowe","year":"2020","journal-title":"J. Am. Coll. Emerg. Physicians Open."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1097\/TA.0000000000002840","article-title":"Fresh whole blood from walking blood banks for patients with traumatic hemorrhagic shock: A systematic review and meta-analysis","volume":"89","author":"Naumann","year":"2020","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/TA.0000000000003334","article-title":"A pilot study of stored low titer group O whole blood + component therapy versus component therapy only for civilian trauma patients","volume":"91","author":"Siletz","year":"2021","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_88","first-page":"880","article-title":"Whole Blood Versus Conventional Blood Component Massive Transfusion Protocol Therapy in Civilian Trauma Patients","volume":"5","author":"Lee","year":"2021","journal-title":"Am. Surg."},{"key":"ref_89","first-page":"42","article-title":"Complications of Hemorrhagic Shock and Massive Transfusion\u2014A Comparison before and after the Damage Control Resuscitation ERA","volume":"56","author":"Guyette","year":"2020","journal-title":"Shock"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.injury.2020.10.095","article-title":"Effectiveness and safety of whole blood compared to balanced blood components in resuscitation of hemorrhaging trauma patients\u2014A systematic review","volume":"52","author":"Malkin","year":"2020","journal-title":"Injury"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1097\/TA.0000000000002488","article-title":"Prehospital resuscitation in adult patients following injury: A Western Trauma Association critical decisions algorithm","volume":"87","author":"Sperry","year":"2019","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Fecher, A., Stimpson, A., Ferrigno, L., and Pohlman, T.H. (2021). The pathophysiology and management of hemorrhagic shock in the poly-trauma patient. J. Clin. Med., 10.","DOI":"10.3390\/jcm10204793"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/TA.0000000000002799","article-title":"Hemostatic potential of cold-stored non-leukoreduced whole blood over time: An assessment of platelet function and thrombin generation for optimal shelf life","volume":"89","author":"Assen","year":"2020","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/TA.0000000000003058","article-title":"The prehospital use of younger age whole blood is as-sociated with an improved arrival coagulation profile","volume":"90","author":"Clements","year":"2021","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.injury.2018.11.049","article-title":"What is the impact of prehospital blood product administration for patients with cata-strophic haemorrhage: An integrative review","volume":"50","author":"Shand","year":"2019","journal-title":"Injury"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.injury.2019.03.033","article-title":"Is prehospital blood transfusion effective and safe in haemorrhagic trauma patients? A systematic review and meta-analysis","volume":"50","author":"Rijnhout","year":"2019","journal-title":"Injury"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1111\/trf.16528","article-title":"Prehospital whole blood reduces early mortality in patients with hemorrhagic shock","volume":"61","author":"Braverman","year":"2021","journal-title":"Transfusion"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00068-015-0612-y","article-title":"Protocols for massive blood transfusion: When and why, and potential complications","volume":"42","author":"Guerado","year":"2015","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/TA.0000000000002657","article-title":"Early and pre-hospital trauma deaths: Who might benefit from advanced resuscitative care?","volume":"88","author":"Carroll","year":"2020","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1097\/TA.0000000000002833","article-title":"Bleeding to death in a big city: An analysis of all trauma deaths from hemorrhage in a metropolitan area during 1 year","volume":"89","author":"Kalkwarf","year":"2020","journal-title":"J. Trauma Inj. Infect. Crit. Care"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/SHK.0000000000000788","article-title":"Earlier Endpoints are Required for Haemorrhagic Shock Trials Among Severely Injured Patients","volume":"47","author":"Fox","year":"2017","journal-title":"Shock"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.injury.2008.10.007","article-title":"Exsanguination in trauma: A review of diagnostics and treatment options","volume":"40","author":"Geeraedts","year":"2009","journal-title":"Injury"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(18)31553-8","article-title":"Plasma-first resuscitation to treat haemor-rhagic shock during emergency ground transportation in an urban area: A randomised trial","volume":"392","author":"Moore","year":"2018","journal-title":"Lancet"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1056\/NEJMoa1802345","article-title":"Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock","volume":"379","author":"Sperry","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/TA.0000000000002406","article-title":"PAMPer study group. Implementation of a pre-hospital air medical thawed plasma program: Is it even feasible?","volume":"87","author":"Adams","year":"2019","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s13054-019-2524-4","article-title":"Pre-hospital plasma transfusion: A valuable coagulation support or an expensive fluid therapy?","volume":"23","author":"Fries","year":"2019","journal-title":"Crit. Care"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/TA.0000000000002822","article-title":"Liquid plasma: A solution to optimizing early and balanced plasma resuscitation in massive transfusion","volume":"89","author":"Beattie","year":"2020","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1097\/CCM.0b013e31828a3214","article-title":"Effect of plasma-to-RBC ratios in trauma patients: A cohort study with time-dependent data","volume":"41","author":"Halmin","year":"2013","journal-title":"Crit. Care Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jss.2015.06.022","article-title":"Liquidplasma use during \u201csuper\u201d massive transfusion protocol","volume":"199","author":"Allen","year":"2015","journal-title":"J. Surg. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/TA.0000000000001569","article-title":"Prehospital administration of freeze-dried plasma, is it the solution for trauma casualties?","volume":"83","author":"Shlaifer","year":"2017","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/trf.15035","article-title":"Single-donor spray-dried plasma","volume":"59","author":"Liu","year":"2019","journal-title":"Transfusion"},{"key":"ref_112","first-page":"975","article-title":"Development and testing of freeze-dried plasma for the treatment of trauma-associated coagulopathy","volume":"65","author":"Shuja","year":"2008","journal-title":"J. Trauma"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/SHK.0000000000000047","article-title":"Freeze-dried plasma at the point of injury: From concept to doctrine","volume":"40","author":"Glassberg","year":"2013","journal-title":"Shock"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1111\/trf.14149","article-title":"Freeze-dried plasma enhances clot formation and inhibits fibrinolysis in the presence of tissue plasminogen activator similar to pooled liquid plasma","volume":"57","author":"Huebner","year":"2017","journal-title":"Transfusion"},{"key":"ref_115","first-page":"664","article-title":"Development and Testing of Low-Volume Hyperoncotic, Hyperosmotic Spray-Dried Plasma for the Treatment of Trauma-Associated Coagulopathy","volume":"70","author":"Shuja","year":"2011","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/TA.0000000000002485","article-title":"Prehospital plasma in injured patients is associated with survival principally in blunt injury: Results from two randomized prehospital plasma trials","volume":"88","author":"Reitz","year":"2020","journal-title":"Acute Care Surg."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e195085","DOI":"10.1001\/jamasurg.2019.5085","article-title":"Association of Prehospital Plasma Transfusion with Survival in Trauma Patients with Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials","volume":"155","author":"Pusateri","year":"2020","journal-title":"JAMA Surg."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1159\/000519627","article-title":"Prehospital plasma transfusion: What does literature show?","volume":"48","author":"Jackson","year":"2021","journal-title":"Transf. Med. Hemother."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13054-019-2369-x","article-title":"Resuscitation Fluid Choices to Preserve the Endothelial Glycocalyx","volume":"23","author":"Milford","year":"2019","journal-title":"Crit. Care"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/TA.0000000000001695","article-title":"Poor microcirculatory flow dynamics are associated with endothelial cell damage and glycocalyx shedding after traumatic hemorrhagic shock","volume":"84","author":"Naumann","year":"2018","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.injury.2004.12.037","article-title":"Pathophysiology of polytrauma","volume":"36","author":"Keel","year":"2005","journal-title":"Injury"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"278","DOI":"10.7205\/MILMED.171.4.278","article-title":"Traumatic shock","volume":"171","author":"Hardaway","year":"2006","journal-title":"Mil. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4103\/0974-2700.96487","article-title":"Shock\u2014A reappraisal: The holistic approach","volume":"5","author":"Bonanno","year":"2012","journal-title":"J. Emerg. Trauma Shock"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bpa.2009.09.007","article-title":"Perioperative coagulation management--fresh frozen plasma","volume":"24","author":"Kor","year":"2010","journal-title":"Best Pract Res Clin Anaesthesiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jamcollsurg.2010.01.031","article-title":"Impact of Plasma Transfusion in Trauma Patients Who Do Not Require Massive Transfusion","volume":"210","author":"Inaba","year":"2010","journal-title":"J. Am. Coll. Surg."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tmrv.2017.06.003","article-title":"Optimal Dose, Timing and Ratio of Blood Products in Massive Transfusion: Results from a Systematic Review","volume":"32","author":"McQuilten","year":"2018","journal-title":"Transfus. Med. Rev."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1097\/CCM.0b013e31829a6ecb","article-title":"The use of higher platelet: RBC transfusion ratio in the acute phase of trauma resuscitation: A systematic review","volume":"41","author":"Hallet","year":"2013","journal-title":"Crit. Care Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/anae.13067","article-title":"Haemostatic profile of reconstituted blood in a proposed 1:1:1 ratio of packed red blood cells, platelet concentrate and four different plasma preparations","volume":"70","author":"Ponschab","year":"2015","journal-title":"Anaesthesia"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13054-019-2347-3","article-title":"The European guideline on management of major bleeding and coagulopathy following trauma: Fifth edition","volume":"23","author":"Spahn","year":"2019","journal-title":"Crit. Care"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/bjs.10052","article-title":"Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice","volume":"103","author":"Stanworth","year":"2016","journal-title":"Br. J. Surg."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1537-2995.2012.03828.x","article-title":"The clinical significance of platelet counts in the first 24 h after severe injury","volume":"53","author":"Stansbury","year":"2012","journal-title":"Transfusion"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4103\/2229-5151.195448","article-title":"Early high ratio platelet transfusion in trauma resusci-tation and its outcomes","volume":"6","author":"Peralta","year":"2016","journal-title":"Int J Crit Illn Inj Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/TA.0000000000001520","article-title":"Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma hemorrhage","volume":"83","author":"Vulliamy","year":"2017","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1016\/j.injury.2021.05.025","article-title":"Aspirin does not increase the need for haemostatic interventions in blunt liver and spleen injuries","volume":"52","author":"Huang","year":"2021","journal-title":"Injury"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1016\/j.injury.2020.05.002","article-title":"The effect of anticoagulation on outcomes after liver and spleen injuries: A research consortium of New England centers for trauma (ReCONECT) study","volume":"51","author":"Bhattacharya","year":"2020","journal-title":"Injury"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1016\/j.injury.2020.07.063","article-title":"Comparison of outcomes in non-head injured trauma patients using pre-injury warfarin or direct oral anticoagulant therapy","volume":"51","author":"Mokhtari","year":"2020","journal-title":"Injury"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/1460408621993752","article-title":"Early coagulopathy in trauma and major bleeding: Is it time to challenge the dogma?","volume":"23","author":"Bonanno","year":"2021","journal-title":"Trauma"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13054-019-2492-8","article-title":"Reversal of oral anticoagulation in patients with acute intracerebral haemorrhage","volume":"23","author":"Kuramatsu","year":"2019","journal-title":"Crit. Care."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(10)60835-5","article-title":"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial","volume":"376","author":"Collaborators","year":"2010","journal-title":"Lancet"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta17100","article-title":"The CRASH-2 trial: A randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients","volume":"17","author":"Roberts","year":"2013","journal-title":"Health Technol. Assess."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.wneu.2018.11.214","article-title":"Effect of Tranexamic Acid in Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis","volume":"123","author":"Weng","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/1460408619842736","article-title":"Efficacy of tranexamic acid in traumatic brain injury: Updated systematic review and meta-analysis","volume":"21","author":"Alhelaly","year":"2018","journal-title":"Trauma"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/TA.0000000000000960","article-title":"Damage-control resuscitation and emergency lap-arotomy: Findings from the PROPPR study","volume":"80","author":"Leroux","year":"2016","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/00005373-199809000-00022","article-title":"Outcome after Hemorrhagic Shock in Trauma Patients","volume":"45","author":"Heckbert","year":"1998","journal-title":"J. Trauma"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.shk.0000209564.84822.f2","article-title":"The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies","volume":"26","author":"Cotton","year":"2006","journal-title":"Shock"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4103\/0974-2700.86630","article-title":"Influence of pre-hospital fluid resuscitation on patients with multiple injuries in hemorrhagic shock, in patients from the DGU trauma registry","volume":"4","author":"Lefering","year":"2011","journal-title":"J. Emerg. Trauma & Shock"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"ATLS Subcommittee, American College of Surgeons\u2019 Committee on Trauma, and International ATLS Working Group (2013). Advanced trauma life support (ATLS): The ninth edition. J. Trauma Acute Care Surg., 74, 1363\u20131366.","DOI":"10.1097\/TA.0b013e31828b82f5"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijsu.2016.12.073","article-title":"10-Year trend in crystalloid resuscitation: Reduced volume and lower mortality","volume":"38","author":"Harada","year":"2016","journal-title":"Int. J. Surg."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40696-017-0030-2","article-title":"Fluid resuscitation in haemorrhagic shock in combat casualties","volume":"3","author":"Ravi","year":"2017","journal-title":"Disaster Mil. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/00003246-199602001-00003","article-title":"resuscitation from severe haemorrhage","volume":"24","author":"Schoemaker","year":"1996","journal-title":"Crit. Care Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1186\/s13054-014-0719-2","article-title":"The arterial blood pressure associated with terminal cardiovascular collapse in critically ill patients: A retrospective cohort study","volume":"18","author":"Brunauer","year":"2014","journal-title":"Crit. Care"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-016-1577-x","article-title":"Resuscitative endovascular balloon occlusion of the aorta versus aortic cross clamping among patients with critical trauma: A nationwide cohort study in Japan","volume":"20","author":"Abe","year":"2016","journal-title":"Crit. Care"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.injury.2018.12.030","article-title":"Examination of hemodynamics in patients in hemorrhagic shock undergoing Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)","volume":"50","author":"Wasicek","year":"2018","journal-title":"Injury"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/TA.0000000000002773","article-title":"Resuscitative endovascular balloon of the aorta is feasible in penetrating chest trauma with major hemorrhage: Proposal of a new institutional deployment algorithm","volume":"89","author":"Parra","year":"2020","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1097\/TA.0000000000002747","article-title":"Emerging hemorrhage control and resuscitation strategies in trauma: Endovascular to extracorporeal","volume":"89","author":"Manning","year":"2020","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1097\/TA.0000000000003166","article-title":"Resuscitative endovascular balloon occlusion of the aorta in combat casualties: The past, present, and future","volume":"91","author":"Stokes","year":"2021","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1097\/TA.0000000000003092","article-title":"A technique for open chest selective aortic arch perfusion","volume":"90","author":"Abdou","year":"2021","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s13054-019-2437-2","article-title":"Extracorporeal gas exchange: When to start and how to end?","volume":"23","author":"Gattinoni","year":"2019","journal-title":"Crit. Care."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/TA.0000000000001680","article-title":"Is extracorporeal cardiopulmonary resuscitation practical in severe chest trauma? A systematic review in single center of developing country","volume":"83","author":"Huh","year":"2017","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1016\/j.injury.2021.03.058","article-title":"ECMO (extra corporeal membrane oxygenation) in major trauma: A 10 year single centre experience","volume":"52","author":"Amos","year":"2021","journal-title":"Injury"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0003-4975(10)65812-2","article-title":"Recent advances in the operative management of massive chest trauma","volume":"16","author":"Reul","year":"1973","journal-title":"Ann. Thorac. Surg."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/00005373-199206000-00019","article-title":"Emergency center thoracotomy: Impact of prehospital re-suscitation","volume":"32","author":"Durham","year":"1992","journal-title":"J. Trauma"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S1072-7515(99)00233-1","article-title":"Survival after emergency department thoracotomy: Review of published data from the past 25 years","volume":"190","author":"Rhee","year":"2000","journal-title":"J. Am. Coll. Surg."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1007\/s00268-005-0463-5","article-title":"Penetrating Cardiac Injuries: Recent Experience in South Africa","volume":"30","author":"Degiannis","year":"2006","journal-title":"World J. Surg."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/TA.0000000000000648","article-title":"An evidence-based approach to patient selection for emergency department thoracotomy: A practice management guideline from the eastern association for the surgery of trauma","volume":"79","author":"Seamon","year":"2015","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1001\/jama.1956.02970150022005","article-title":"Four-minute limit for cardiac resuscitation","volume":"161","author":"Cole","year":"1956","journal-title":"J. Am. Med. Assoc."},{"key":"ref_167","first-page":"138","article-title":"Cerebral resuscitation after cardiac arrest: A review","volume":"74","author":"Safar","year":"1986","journal-title":"Circulation"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/00003246-198810000-00003","article-title":"Resuscitation from clinical death: Pathophysiologic limits and therapeutic potentials","volume":"16","author":"Safar","year":"1988","journal-title":"Crit. Care Med."},{"key":"ref_169","first-page":"147","article-title":"Is 30 min the golden period to perform emergency room thoracotomy (ERT) in penetrating chest injuries?","volume":"40","author":"Frezza","year":"1999","journal-title":"J. Cardiovasc. Surg."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1191\/1460408605ta334oa","article-title":"Emergency Department Thoracotomy (EDT)","volume":"7","author":"Doll","year":"2005","journal-title":"Trauma"},{"key":"ref_171","first-page":"26","article-title":"Trauma Resuscitation: An evidence-based review of prehospital traumatic cardiac arrest","volume":"42","author":"Chinn","year":"2017","journal-title":"JEMS J. Emerg. Med. Serv."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Boffard, K.D. (2019). The chest. Manual of Definitive Surgical Trauma Care, Taylor & Francis.","DOI":"10.1201\/9781351012874-8"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4103\/jets.jets_85_21","article-title":"Complete Maternal Recovery after Prolonged Cardiac Arrest Due to Atonic Postpartum Hemorrhaging","volume":"14","author":"Yanagawa","year":"2021","journal-title":"J. Emerg. Trauma Shock"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Boffard, K.D. (2019). Trauma anaesthesia. Manual of Definitive Surgical Trauma Care, V Ed, Boffard KD, Editor, Taylor & Francis Group.","DOI":"10.1201\/9781351012874-18"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13054-015-0975-9","article-title":"Incidence of and risk factors for severe cardiovascular collapse after endotracheal intubation in the ICU: A multicenter observational study","volume":"19","author":"Perbet","year":"2015","journal-title":"Crit. Care"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(09)60949-1","article-title":"Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: A multicentre randomised controlled trial","volume":"374","author":"Jabre","year":"2009","journal-title":"Lancet"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0020-1383(96)00140-4","article-title":"Ketamine in the field: The use of ketamine for induction of anaesthesia before intubation in injured patients in the field","volume":"28","author":"Gofrit","year":"1997","journal-title":"Injury"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2044.2008.05835.x","article-title":"Anaesthesia in haemodynamically compromised emergency patients: Does ketamine represent the best choice of induction agent?","volume":"64","author":"Morris","year":"2009","journal-title":"Anaesthesia"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0020-1383(01)00209-1","article-title":"Ketamine in war\/tropical surgery (a final tribute to the racemic mixture)","volume":"33","author":"Bonanno","year":"2002","journal-title":"Injury"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1007\/s00134-009-1603-4","article-title":"The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock","volume":"35","author":"Cuthbertson","year":"2009","journal-title":"Intensive Care Med."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1007\/s001010050503","article-title":"Vom Razemat zum Eutomer: (S)-Ketamin\u2014Renaissance einer Substanz?","volume":"46","author":"Adams","year":"1997","journal-title":"Anaesthesist"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1007\/PL00002462","article-title":"Endokrine Reaktionen nach S-( + )-Ketamin","volume":"46","author":"Adams","year":"1997","journal-title":"Der Anaesthesist"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/00000542-200102000-00014","article-title":"( + )-Ketamine Increases Muscle Sympathetic Activity and Maintains the Neural Response to Hypotensive Challenges in Humans","volume":"94","author":"Kienbaum","year":"2001","journal-title":"Anesthesiology"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00508-017-1299-3","article-title":"S ( + )-ketamine: Current trends in emergency and intensive care medicine","volume":"130","author":"Trimmel","year":"2018","journal-title":"Wien Klin Wochensch"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/00000658-199205000-00010","article-title":"Abbreviated laparotomy and planned reoperation for critically injured patients","volume":"215","author":"Burch","year":"1992","journal-title":"Ann. Surg."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00005373-199309000-00008","article-title":"\u2018Damage control\u2019: An approach for improved survival in exsanguinating penetrating abdominal injury","volume":"35","author":"Rotondo","year":"1993","journal-title":"J. Trauma"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0002-9610(96)00216-4","article-title":"\u2018Thomas G. Orr Memorial Lecture\u2019: Staged laparotomy for the hypothermia, acidosis, and coagulopathy syndrome","volume":"172","author":"Moore","year":"1996","journal-title":"Am. J. Surg."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1445-2197.2008.04601.x","article-title":"Extending damage control philosophy to non-haemorrhagic situations: Implications for a reclassification of SHOCK states","volume":"78","author":"Bonanno","year":"2008","journal-title":"ANZ J. Surg."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S1072-7515(98)00202-6","article-title":"Elevated Arterial Base Deficit in Trauma Patients: A Marker of Impaired Oxygen Utilization","volume":"187","author":"Kincaid","year":"1998","journal-title":"J. Am. Coll. Surg."},{"key":"ref_190","first-page":"1580","article-title":"Base Deficit: A Better Indicator for Diagnosis and Treatment of Shock in Trauma Patients","volume":"70","author":"Paydar","year":"2011","journal-title":"J. Trauma Inj. Infect. Crit. Care"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"R42","DOI":"10.1186\/cc12555","article-title":"Trauma Register DGU? Renaissance of base deficit for the initial assessment of trauma patients: A base deficit-based classification for hypovolemic shock developed on data from 16,305 patients derived from the Trauma Register DGU?","volume":"17","author":"Mutschler","year":"2013","journal-title":"Crit. Care."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1007\/s001340050470","article-title":"The association between blood lactate concentration on admission, duration of cardiac arrest, and functional neurological recovery in patients resuscitated from ventricular fibril-lation","volume":"23","author":"Mullner","year":"1997","journal-title":"Intensive Care Med."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/00005373-200011000-00033","article-title":"Damage Control: Collective Review","volume":"49","author":"Shapiro","year":"2000","journal-title":"J. Trauma Inj. Infect. Crit. Care"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1097\/TA.0b013e31826fc780","article-title":"Damage control resuscitation: Early decision strategies in abdominal gunshot wounds using an easy \u201cABCD\u201d mnemonic","volume":"73","author":"Badiel","year":"2012","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/SLA.0000000000001347","article-title":"Indications for Use of Damage Control Surgery in Civilian Trauma Patients: A Content Analysis and Expert Appropriateness Rating Study","volume":"263","author":"Roberts","year":"2016","journal-title":"Ann. Surg."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"e1474","DOI":"10.1590\/0100-6991e-20181474","article-title":"Damage control surgery: Are we losing control over indications?","volume":"45","author":"Pimentel","year":"2018","journal-title":"Rev Col Bras Cir."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/jramc-2018-000950","article-title":"Lessons learnt from the Pietermaritzburg experience with damage control laparotomy for trauma","volume":"164","author":"Weale","year":"2018","journal-title":"J. R. Army Med. Corps"},{"key":"ref_198","first-page":"420","article-title":"Time to laparotomy for intra-abdominal bleeding from trauma does affect survival for delays up to 90 min","volume":"52","author":"Clarke","year":"2002","journal-title":"J. Trauma"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1097\/01.ta.0000196434.88182.77","article-title":"Pre-Hospital Endotracheal Intubation and Positive Pressure Ventilation Is Associated with Hypotension and Decreased Survival in Hypovolemic Trauma Patients: An Analysis of the National Trauma Data Bank","volume":"59","author":"Shafi","year":"2005","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_200","first-page":"1038","article-title":"Prehospital Hypotension in Blunt Trauma: Identifying the \u201cCrump Factor\u201d","volume":"70","author":"Bilello","year":"2011","journal-title":"J. Trauma"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"e000013","DOI":"10.1136\/tsaco-2016-000013","article-title":"Isolated prehospital hypotension correlates with injury severity and outcomes in patients with trauma","volume":"1","author":"Damme","year":"2016","journal-title":"Trauma Surg. Acute Care Open"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s00595-016-1451-0","article-title":"Impact of urgent resuscitative surgery for life-threatening torso trauma","volume":"47","author":"Matsumoto","year":"2016","journal-title":"Surg. Today"},{"key":"ref_203","first-page":"312","article-title":"Hemoglobin drops within minutes of injuries and predicts need for an intervention to stop haemorrhage","volume":"63","author":"Bruns","year":"2007","journal-title":"J. Trauma"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0002-9610(01)00809-1","article-title":"Reliable variables in the exsanguinated patient which indicate damage control and predict outcome","volume":"182","author":"Asensio","year":"2001","journal-title":"Am. J. Surg."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/TA.0000000000001561","article-title":"Increased mortality in trauma patients who develop post-intubation hypotension","volume":"83","author":"Green","year":"2017","journal-title":"J. Trauma"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/archsurg.136.5.513","article-title":"Timing of urgent thoracotomy for hem-orrhage after trauma: A multicentre study","volume":"136","author":"Jurkovich","year":"2001","journal-title":"Arch. Surg."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ams2.148","article-title":"Thoracotomy for blunt chest trauma: Is chest tube output a useful criterion?","volume":"3","author":"Mizushima","year":"2016","journal-title":"Acute Med. Surg."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"336","DOI":"10.2106\/00004623-198971030-00004","article-title":"Early versus delayed stabilization of femoral fractures: A prospective randomized study","volume":"71","author":"Bone","year":"1989","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1046\/j.1365-2168.1998.00770.x","article-title":"Stimulation of inflammatory markers after blunt trauma","volume":"85","author":"Giannoudis","year":"1998","journal-title":"Br. J. Surg."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/01.TA.0000153942.28015.77","article-title":"Alterations in the Systemic Inflammatory Response after Early Total Care and Damage Control Procedures for Femoral Shaft Fracture in Severely Injured Patients","volume":"58","author":"Harwood","year":"2005","journal-title":"J. Trauma Inj. Infect. Crit. Care"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0020-1383(07)70005-0","article-title":"Surgical stress response","volume":"37","author":"Giannoudis","year":"2006","journal-title":"Injury"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.injury.2011.02.011","article-title":"Second hit phenomenon: Existing evidence of clinical implications","volume":"42","author":"Lasanianos","year":"2011","journal-title":"Injury"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.amjsurg.2017.10.044","article-title":"The effect of damage control laparotomy on major abdominal complications: A matched analysis","volume":"216","author":"George","year":"2017","journal-title":"Am. J. Surg."},{"key":"ref_214","unstructured":"Hunt, T.K., and Dunphy, J.E. (1979). Disorders of repair and their management. Fundamentals of Wound Management, Appleton Century Crofts."},{"key":"ref_215","unstructured":"Hunt, T.K., and Dunphy, J.E. (1979). Normal repair. Fundamentals of Wound Management, Appleton Century Crofts."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF02554084","article-title":"The experimental basis of intestinal suturing. Effect of surgical technique, inflammation and infection on enteric wound healing","volume":"27","author":"Ballantyne","year":"1984","journal-title":"Dis. Colon Rectum"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1001\/archsurg.1994.01420350077010","article-title":"Loss of colonic structural collagen impairs healing during intra-abdominal sepsis","volume":"129","author":"Ahrendt","year":"1994","journal-title":"Arch. Surg."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/BF00309502","article-title":"The lower limit of tissue blood flow for safe colonic anastomosis: An experimental study using laser doppler velocimetry","volume":"23","author":"Kashiwagi","year":"1993","journal-title":"Surg. Today"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1097\/00000542-200405000-00022","article-title":"Effects of Dopamine, Dobutamine, and Dopexamine on Microcirculatory Blood Flow in the Gastrointestinal Tract during Sepsis and Anesthesia","volume":"100","author":"Hiltebrand","year":"2004","journal-title":"Anesthesiology"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1097\/01.CCM.0000215834.48023.57","article-title":"Effects of epinephrine, norepinephrine, and phenylephrine on microcirculatory blood flow in the gastrointestinal tract in sepsis*","volume":"34","author":"Krejci","year":"2006","journal-title":"Crit. Care Med."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/08941939809032201","article-title":"Colonic anastomosis in the presence of fecal peritonitis using a disposable skin stapler","volume":"11","author":"Edwards","year":"1998","journal-title":"J. Investig. Surg."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/01.TA.0000101067.52018.42","article-title":"Changing Patterns in the Management of Penetrating Abdominal Trauma: The More Things Change, the More They Stay the Same","volume":"55","author":"Nicholas","year":"2003","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1001\/archsurg.139.2.209","article-title":"Has evolution in awareness of guidelines for institution of damage control improved outcome in the management of the posttraumatic open abdomen?","volume":"139","author":"Asensio","year":"2004","journal-title":"Arch. Surg."},{"key":"ref_224","first-page":"53","article-title":"Damage Control Laparotomy: A Vital Tool Once Overused","volume":"69","author":"Higa","year":"2010","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.surg.2016.05.044","article-title":"Delayed interventions and mortality in trauma damage control laparotomy","volume":"160","author":"Lauerman","year":"2016","journal-title":"Surgery"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.amjsurg.2015.10.014","article-title":"Control the damage: Morbidity and mortality after emergent trauma laparotomy","volume":"212","author":"Harvin","year":"2015","journal-title":"Am. J. Surg."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/TA.0000000000001619","article-title":"Mortality after emergent trauma laparotomy: A multicenter, retrospective study","volume":"83","author":"Harvin","year":"2017","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"e000235","DOI":"10.1136\/tsaco-2018-000235","article-title":"Damage control or definitive repair? A retrospective review of abdominal trauma at a major trauma center in South Africa","volume":"4","author":"Weale","year":"2019","journal-title":"Trauma Surg. Acute Care Open"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/TA.0000000000002167","article-title":"Outcomes after single-look trauma laparotomy: A large population-based study","volume":"86","author":"Bowie","year":"2019","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"e000777","DOI":"10.1136\/tsaco-2021-000777","article-title":"Damage control laparotomy in trauma: A pilot randomized controlled trial. The DCL trial","volume":"6","author":"Harvin","year":"2021","journal-title":"Trauma Surg. Acute Care Open"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/cc2423","article-title":"Occult hypoperfusion is associated with increased mortality in hemodynamically stable, high-risk, surgical patients","volume":"8","author":"Meregalli","year":"2004","journal-title":"Crit. Care"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1056\/NEJMon1211064","article-title":"Chocolate consumption, cognitive function, and Nobel laureates","volume":"367","author":"Messerli","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Ioannidis, J.P.A. (2005). Why most published research findings are false. PLoS Med., 2.","DOI":"10.1371\/journal.pmed.0020124"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/00000542-194611000-00008","article-title":"Resuscitation and anesthesia","volume":"7","author":"Beecher","year":"1946","journal-title":"Anesthesiology"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/00005373-199005000-00002","article-title":"Gross: Pioneer academic trauma surgeon of 19th century America","volume":"30","author":"Mullins","year":"1990","journal-title":"J. Trauma"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/TA.0b013e3182a686ed","article-title":"Hemorrhagic shock","volume":"75","author":"Gann","year":"2013","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1097\/TA.0000000000002826","article-title":"\u201cA cold and drowsy humor\u201d: Theories of traumatic shock from Bernard to Laborit","volume":"89","author":"Helling","year":"2020","journal-title":"J. Trauma Acute Care Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/1\/260\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:54:54Z","timestamp":1760147694000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/1\/260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":237,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["jcm12010260"],"URL":"https:\/\/doi.org\/10.3390\/jcm12010260","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]}}}