{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:27:14Z","timestamp":1784118434090,"version":"3.55.0"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Eulji University","award":["EJRG-22-02"],"award-info":[{"award-number":["EJRG-22-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: To compare optic nerve sheath diameter (ONSD) in normal-tension glaucoma (NTG) and healthy eyes and to investigate the association between ONSD and lamina cribrosa (LC) morphology. (2) Methods: This cross-sectional study included 69 NTG eyes and 69 healthy eyes matched for age, axial length, and intraocular pressure. The LC curvature index (LCCI) was measured from horizontal Cirrus HD-OCT B-scan images from five uniformly divided positions vertically of the optic nerve. The average LCCI was defined as the mean of the measurements at these five locations. ONSD was measured as the width of the optic nerve sheath at the site perpendicular 3 mm behind the posterior globe. LCCI and ONSD were compared in eyes with NTG and healthy eyes. The clinical factors that could affect LCCI were analyzed. (3) Results: NTG eyes had significantly smaller mean ONSD (4.55 \u00b1 0.69 mm vs. 4.97 \u00b1 0.58 mm, p &lt; 0.001) and larger average LCCI (11.61 \u00b1 1.43 vs. 7.58 \u00b1 0.90, p &lt; 0.001) than matched healthy control eyes. LCCI was significantly correlated with smaller ONSD, higher intraocular pressure, thinner global retinal nerve fiber thickness, and worse visual field loss in all subjects (all Ps \u2264 0.022). (4) Conclusions: NTG eyes had smaller ONSD and greater LCCI than healthy control eyes. In addition, a negative correlation was observed between ONSD and LCCI. These findings suggest that cerebrospinal fluid pressure, which ONSD indirectly predicts, may affect LC configuration. Changes in the retrolaminar compartment may play a role in glaucoma pathogenesis.<\/jats:p>","DOI":"10.3390\/jcm12010360","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T02:05:53Z","timestamp":1672711553000},"page":"360","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between Optic Nerve Sheath Diameter and Lamina Cribrosa Morphology in Normal-Tension Glaucoma"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2189-2821","authenticated-orcid":false,"given":"Seung Hyen","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Nowon Eulji Medical Center, Eulji University College of Medicine, Seoul 01830, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunkyung","family":"Kil","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bundang Jesaeng General Hospital, Seongnam 13590, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1001\/archopht.1995.01100070092031","article-title":"Risk factors for open-angle glaucoma. The Barbados Eye Study","volume":"113","author":"Leske","year":"1995","journal-title":"Arch. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: A new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"Burgoyne","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1001\/archopht.1981.03930021035010","article-title":"Anatomy of the lamina cribrosa in human eyes","volume":"99","author":"Radius","year":"1981","journal-title":"Arch. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1167\/iovs.01-1282","article-title":"Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma","volume":"44","author":"Bellezza","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1167\/iovs.15-18982","article-title":"Reduction of the Lamina Cribrosa Curvature After Trabeculectomy in Glaucoma","volume":"57","author":"Lee","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1167\/iovs.16-21393","article-title":"Deformation of the Lamina Cribrosa and Optic Nerve Due to Changes in Cerebrospinal Fluid Pressure","volume":"58","author":"Feola","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_7","first-page":"3236","article-title":"Optic disc movement with variations in intraocular and cerebrospinal fluid pressure","volume":"43","author":"Morgan","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/s41598-018-19321-1","article-title":"Ocular and Clinical Characteristics Associated with the Extent of Posterior Lamina Cribrosa Curve in Normal Tension Glaucoma","volume":"8","author":"Lee","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1167\/iovs.61.4.4","article-title":"Comparison of lamina cribrosa morphology in eyes with ocular hypertension and normal-tension glaucoma","volume":"61","author":"Kim","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_10","first-page":"1419","article-title":"The correlation between cerebrospinal fluid pressure and retrolaminar tissue pressure","volume":"39","author":"Morgan","year":"1998","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/emj.2008.058453","article-title":"Optic nerve sonography: A new window for the non-invasive evaluation of intracranial pressure in brain injury","volume":"26","author":"Soldatos","year":"2009","journal-title":"Emerg. Med. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3171\/jns.1997.87.1.0034","article-title":"Validation of the optic nerve sheath response to changing cerebrospinal fluid pressure: Ultrasound findings during intrathecal infusion tests","volume":"87","author":"Hansen","year":"1997","journal-title":"J. Neurosurg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ajo.2017.11.024","article-title":"Measurement and Associations of the Optic Nerve Subarachnoid Space in Normal Tension and Primary Open-Angle Glaucoma","volume":"186","author":"Liu","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.ophtha.2012.03.054","article-title":"Orbital cerebrospinal fluid space in glaucoma: The Beijing intracranial and intraocular pressure (iCOP) study","volume":"119","author":"Wang","year":"2012","journal-title":"Ophthalmology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1167\/iovs.16-20802","article-title":"Diagnostic Power of Lamina Cribrosa Depth and Curvature in Glaucoma","volume":"58","author":"Lee","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1007\/BF02343067","article-title":"Optic disc shape in glaucoma","volume":"234","author":"Jonas","year":"1996","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0002-9394(02)01339-9","article-title":"Population prevalence of tilted optic disks and the relationship of this sign to refractive error","volume":"133","author":"Vongphanit","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.ophtha.2011.02.040","article-title":"Myopia-related optic disc and retinal changes in adolescent children from singapore","volume":"118","author":"Samarawickrama","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1038\/s41598-018-38331-7","article-title":"Lamina Cribrosa Curvature in Healthy Korean Eyes","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0002-9394(14)73195-2","article-title":"Measurement and relationship of subarachnoid pressure of the optic nerve to intracranial pressures in fresh cadavers","volume":"116","author":"Liu","year":"1993","journal-title":"Am. J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/BF01383383","article-title":"Fundamentals of transorbital sonographic evaluation of optic nerve sheath expansion under intracranial hypertension. I. Experimental study","volume":"26","author":"Helmke","year":"1996","journal-title":"Pediatr. Radiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1553-2712.2007.00031.x","article-title":"Correlation of optic nerve sheath diameter with direct measurement of intracranial pressure","volume":"15","author":"Kimberly","year":"2008","journal-title":"Acad. Emerg. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00134-011-2224-2","article-title":"Ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure: A systematic review and meta-analysis","volume":"37","author":"Dubourg","year":"2011","journal-title":"Intensive Care Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/brain\/awl324","article-title":"Cerebrospinal fluid dynamics between the intracranial and the subarachnoid space of the optic nerve. Is it always bidirectional?","volume":"130","author":"Killer","year":"2007","journal-title":"Brain"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1212\/01.wnl.0000250270.54587.71","article-title":"CSF pressure assessed by lumbar puncture agrees with intracranial pressure","volume":"68","author":"Lenfeldt","year":"2007","journal-title":"Neurology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1212\/WNL.0b013e3182574f50","article-title":"Clinical assessment of noninvasive intracranial pressure absolute value measurement method","volume":"78","author":"Ragauskas","year":"2012","journal-title":"Neurology"},{"key":"ref_27","first-page":"181","article-title":"Ultrastructure of the extracellular matrix of bovine dura mater, optic nerve sheath and sclera","volume":"181","author":"Raspanti","year":"1992","journal-title":"J. Anat."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3174\/ajnr.A1027","article-title":"Decreased diameter of the optic nerve sheath associated with CSF hypovolemia","volume":"29","author":"Watanabe","year":"2008","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.3174\/ajnr.A2120","article-title":"MR imaging of the optic nerve sheath in patients with craniospinal hypotension","volume":"31","author":"Rohr","year":"2010","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s00417-011-1878-3","article-title":"Intraocular pressure correlates with optic nerve sheath diameter in patients with normal tension glaucoma","volume":"250","author":"Vandewalle","year":"2012","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1136\/bjo.2010.199224","article-title":"Optic nerve sheath diameter in normal-tension glaucoma patients","volume":"96","author":"Jaggi","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ophtha.2017.09.022","article-title":"Normal-tension glaucoma has normal intracranial pressure: A prospective study of intracranial pressure and intraocular pressure in different body positions","volume":"125","author":"Qvarlander","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ophtha.2009.06.058","article-title":"Cerebrospinal fluid pressure in glaucoma: A prospective study","volume":"117","author":"Ren","year":"2010","journal-title":"Ophthalmology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.ophtha.2008.01.013","article-title":"Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma","volume":"115","author":"Berdahl","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1167\/iovs.08-2228","article-title":"Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: A case-control study","volume":"49","author":"Berdahl","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/bs.pbr.2015.06.002","article-title":"Cerebrospinal fluid pressure in the pathogenesis of glaucoma","volume":"221","author":"Jonas","year":"2015","journal-title":"Prog. Brain Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/bjo.84.3.318","article-title":"Age related compliance of the lamina cribrosa in human eyes","volume":"84","author":"Albon","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1167\/iovs.07-1429","article-title":"Lamina cribrosa and peripapillary sclera histomorphometry in normal and advanced glaucomatous Chinese eyes with various axial length","volume":"50","author":"Ren","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3389\/fneur.2020.00764","article-title":"Effects of age and sex on optic nerve sheath diameter in healthy volunteers and patients with traumatic brain injury","volume":"11","author":"Cardim","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1007\/s00134-018-5305-7","article-title":"Optic nerve sheath diameter measured sonographically as non-invasive estimator of intracranial pressure: A systematic review and meta-analysis","volume":"44","author":"Robba","year":"2018","journal-title":"Intensive Care Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1167\/iovs.04-0114","article-title":"Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes","volume":"46","author":"Downs","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/jon.12691","article-title":"Quantification of optic nerve and sheath diameter by transorbital sonography: A systematic review and metanalysis","volume":"30","author":"Schroeder","year":"2020","journal-title":"J. Neuroimaging"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/bjophthalmol-2018-312934","article-title":"Ultrasonic measurement of optic nerve sheath diameter: A non-invasive surrogate approach for dynamic, real-time evaluation of intracranial pressure","volume":"103","author":"Chen","year":"2019","journal-title":"Br. J. Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/1\/360\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:56:32Z","timestamp":1760118992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/1\/360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,2]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["jcm12010360"],"URL":"https:\/\/doi.org\/10.3390\/jcm12010360","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,2]]}}}