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EU","award":["RD21\/0012\/0001"],"award-info":[{"award-number":["RD21\/0012\/0001"]}]},{"name":"European Union-Next Generation EU","award":["JR19\/00047"],"award-info":[{"award-number":["JR19\/00047"]}]},{"name":"Juan Rod\u00e9s","award":["PI19\/00702"],"award-info":[{"award-number":["PI19\/00702"]}]},{"name":"Juan Rod\u00e9s","award":["RD16\/0022\/0015"],"award-info":[{"award-number":["RD16\/0022\/0015"]}]},{"name":"Juan Rod\u00e9s","award":["PT13\/0002\/0028"],"award-info":[{"award-number":["PT13\/0002\/0028"]}]},{"name":"Juan Rod\u00e9s","award":["RD21\/0012\/0001"],"award-info":[{"award-number":["RD21\/0012\/0001"]}]},{"name":"Juan Rod\u00e9s","award":["JR19\/00047"],"award-info":[{"award-number":["JR19\/00047"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>N-terminal pro-brain natriuretic peptide (NT-proBNP) and uric acid are elevated in pregnancies with preeclampsia (PE). Short-term prediction of PE using angiogenic factors has many false-positive results. Our objective was to validate a machine-learning model (MLM) to predict PE in patients with clinical suspicion, and evaluate if the model performed better than the sFlt-1\/PlGF ratio alone. A multicentric cohort study of pregnancies with suspected PE between 24+0 and 36+6 weeks was used. The MLM included six predictors: gestational age, chronic hypertension, sFlt-1, PlGF, NT-proBNP, and uric acid. A total of 936 serum samples from 597 women were included. The PPV of the MLM for PE following 6 weeks was 83.1% (95% CI 78.5\u201388.2) compared to 72.8% (95% CI 67.4\u201378.4) for the sFlt-1\/PlGF ratio. The specificity of the model was better; 94.9% vs. 91%, respectively. The AUC was significantly improved compared to the ratio alone [0.941 (95% CI 0.926\u20130.956) vs. 0.901 (95% CI 0.880\u20130.921), p &lt; 0.05]. For prediction of preterm PE within 1 week, the AUC of the MLM was 0.954 (95% CI 0.937\u20130.968); significantly greater than the ratio alone [0.914 (95% CI 0.890\u20130.934), p &lt; 0.01]. To conclude, an MLM combining the sFlt-1\/PlGF ratio, NT-proBNP, and uric acid performs better to predict preterm PE compared to the sFlt-1\/PlGF ratio alone, potentially increasing clinical precision.<\/jats:p>","DOI":"10.3390\/jcm12020431","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T04:12:56Z","timestamp":1672891976000},"page":"431","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Predictive Model for Preeclampsia Combining sFlt-1, PlGF, NT-proBNP, and Uric Acid as Biomarkers"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2180-1715","authenticated-orcid":false,"given":"Carmen","family":"Garrido-Gim\u00e9nez","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Unit (Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret, 167), Universitat Aut\u00f2noma de Barcelona, 08025 Barcelona, Spain"},{"name":"Women and Perinatal Health Research Group, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU), Sant Quint\u00ed 77\u201379, 08041 Barcelona, Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Network (SAMID-RICORS, RD21\/0012) and Maternal and Child Health Development Network (SAMID, RD16\/0022), Instituto de Salud Carlos III, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-3578","authenticated-orcid":false,"given":"M\u00f3nica","family":"Cruz-Lemini","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Unit (Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret, 167), Universitat Aut\u00f2noma de Barcelona, 08025 Barcelona, Spain"},{"name":"Women and Perinatal Health Research Group, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU), Sant Quint\u00ed 77\u201379, 08041 Barcelona, Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Network (SAMID-RICORS, RD21\/0012) and Maternal and Child Health Development Network (SAMID, RD16\/0022), Instituto de Salud Carlos III, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco V.","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Laboratory Medicine, Hospital Universitario Central de Asturias and Department of Biochemistry and Molecular Biology, Universidad de Oviedo, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madalina Nicoleta","family":"Nan","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Carretero","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Laboratory Medicine, Hospital Universitario Central de Asturias and Department of Biochemistry and Molecular Biology, Universidad de Oviedo, 33011 Oviedo, Spain"},{"name":"C\u00e1tedra de Inteligencia Anal\u00edtica, Universidad de Oviedo, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Fern\u00e1ndez-Oliva","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Unit (Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret, 167), Universitat Aut\u00f2noma de Barcelona, 08025 Barcelona, Spain"},{"name":"Women and Perinatal Health Research Group, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU), Sant Quint\u00ed 77\u201379, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Mora","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"S\u00e1nchez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Women and Perinatal Health Research Group, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU), Sant Quint\u00ed 77\u201379, 08041 Barcelona, Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Network (SAMID-RICORS, RD21\/0012) and Maternal and Child Health Development Network (SAMID, RD16\/0022), Instituto de Salud Carlos III, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6682-0226","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Garc\u00eda-Osuna","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9212-3619","authenticated-orcid":false,"given":"Jaume","family":"Alijotas-Reig","sequence":"additional","affiliation":[{"name":"Systemic Autoimmune Disease Unit, Internal Medicine Department, Vall d\u2019Hebron University Hospital, Departament de Medicina de la Universitat Aut\u00f2noma de Barcelona, 08025 Barcelona, Spain"},{"name":"Systemic Autoimmune Diseases Research Group, Vall d\u2019Hebron Research Institute\/Vall d\u2019Hebron Hospital, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-6407","authenticated-orcid":false,"given":"Elisa","family":"Llurba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Unit (Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret, 167), Universitat Aut\u00f2noma de Barcelona, 08025 Barcelona, Spain"},{"name":"Women and Perinatal Health Research Group, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU), Sant Quint\u00ed 77\u201379, 08041 Barcelona, Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Network (SAMID-RICORS, RD21\/0012) and Maternal and Child Health Development Network (SAMID, RD16\/0022), Instituto de Salud Carlos III, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the EuroPE Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","article-title":"Global and regional estimates of preeclampsia and eclampsia: A systematic review","volume":"170","author":"Abalos","year":"2013","journal-title":"Eur. 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