{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:44:36Z","timestamp":1760147076031,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences (CIFMS)","award":["2021-I2M-1-061","2021-I2M-1-013","2021-I2M-1-015","2022-I2M-C&T-B-054","SZSM201911008","CRF2020-2-4025","LC2021A03"],"award-info":[{"award-number":["2021-I2M-1-061","2021-I2M-1-013","2021-I2M-1-015","2022-I2M-C&T-B-054","SZSM201911008","CRF2020-2-4025","LC2021A03"]}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["2021-I2M-1-061","2021-I2M-1-013","2021-I2M-1-015","2022-I2M-C&T-B-054","SZSM201911008","CRF2020-2-4025","LC2021A03"],"award-info":[{"award-number":["2021-I2M-1-061","2021-I2M-1-013","2021-I2M-1-015","2022-I2M-C&T-B-054","SZSM201911008","CRF2020-2-4025","LC2021A03"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2021-I2M-1-061","2021-I2M-1-013","2021-I2M-1-015","2022-I2M-C&T-B-054","SZSM201911008","CRF2020-2-4025","LC2021A03"],"award-info":[{"award-number":["2021-I2M-1-061","2021-I2M-1-013","2021-I2M-1-015","2022-I2M-C&T-B-054","SZSM201911008","CRF2020-2-4025","LC2021A03"]}]},{"name":"Beijing Hope Run Special Fund of Cancer Foundation of China","award":["2021-I2M-1-061","2021-I2M-1-013","2021-I2M-1-015","2022-I2M-C&T-B-054","SZSM201911008","CRF2020-2-4025","LC2021A03"],"award-info":[{"award-number":["2021-I2M-1-061","2021-I2M-1-013","2021-I2M-1-015","2022-I2M-C&T-B-054","SZSM201911008","CRF2020-2-4025","LC2021A03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background It remains controversial whether endoscopic submucosal dissection (ESD) is still appropriate for circumferential superficial esophageal squamous cell neoplasms (SESCN), and few studies compared the short-term and long-term outcomes of ESD with radical surgery. Methods A total of 140 patients with SESCN who underwent ESD or surgery between February 2014 and October 2021 were retrospectively reviewed. The characteristics of patients, operative time, postoperative complications, overall survival (OS), recurrence-free survival (RFS), and quality of life (QOL) were compared between the ESD and surgery groups. The effect of different methods to prevent esophageal stenosis after ESD were analysed. Results Drinking, family history of cancer, macroscopic type, and intrapapillary capillary loop (IPCL) type were independent risk factors for deep submucosal invasion (SM \u2265 200 \u03bcm). Smoking and IPCL type were independent predictive factors for angiolymphatic invasion. The average operative time of ESD was significantly shorter than that of surgery (174.5 \u00b1 51.16 min vs. 255.9 \u00b1 88.18 min, p &lt; 0.001). The incidence of perioperative complications in ESD group was significantly lower than that in surgery group (5.5% vs. 19.4%, p = 0.015). The ESD group had significantly better functional scale scores for emotional functioning, cognitive functioning, and global health status, and lower rates of pain, dyspnoea, insomnia, appetite loss, diarrhoea, reflux, and trouble with taste than the surgery group. No significant difference in OS and RFS between ESD and surgery group. Conclusions ESD can significantly shorten the operative time and reduce perioperative complications. Additionally, on the premise of using appropriate measures to prevent postoperative stenosis, ESD can be the first choice for the treatment of SESCN, which could provide better QOL, and the long-term prognosis of ESD is no less than that of surgery.<\/jats:p>","DOI":"10.3390\/jcm12020471","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T03:31:28Z","timestamp":1672975888000},"page":"471","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Feasibility and Safety of Endoscopic Submucosal Dissection for Circumferential Superficial Esophageal Squamous Cell Neoplasms"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4552-3302","authenticated-orcid":false,"given":"Yi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Endoscopy, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhou","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jncc.2022.02.002","article-title":"Cancer incidence and mortality in China, 2016","volume":"2","author":"Zheng","year":"2022","journal-title":"J. Natl. Cancer Cent."},{"key":"ref_2","first-page":"73","article-title":"Chinese consensus: Screening, diagnosis and treatment of early esophageal squamous cell carcinoma and precancerous lesions","volume":"55","author":"Li","year":"2016","journal-title":"Chin. J. Intern. Med."},{"key":"ref_3","first-page":"427","article-title":"The five-year survival rate after endoscopic submucosal dissection for superficial esophageal squamous cell neoplasia","volume":"49","author":"Nagami","year":"2017","journal-title":"Dig. Liver Dis. Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver"},{"key":"ref_4","first-page":"452","article-title":"Endoscopic submucosal dissection\/endoscopic mucosal resection guidelines for esophageal cancer","volume":"32","author":"Ishihara","year":"2020","journal-title":"Dig. Endosc. Off. J. Jpn. Gastroenterol. Endosc. Soc."},{"key":"ref_5","first-page":"134","article-title":"Prevention of esophageal stricture after endoscopic resection","volume":"31","author":"Ishihara","year":"2019","journal-title":"Dig. Endosc. Off. J. Jpn. Gastroenterol. Endosc. Soc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/ajg.2016.60","article-title":"Triamcinolone injection and shielding with polyglycolic acid sheets and fibrin glue for postoperative stricture prevention after esophageal endoscopic resection: A pilot study","volume":"111","author":"Sakaguchi","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3748\/wjg.v23.i6.931","article-title":"Prophylactic stenting for esophageal stricture prevention after endoscopic submucosal dissection","volume":"23","author":"Shi","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"822","DOI":"10.14309\/ajg.0000000000000169","article-title":"Autologous skin-grafting surgery to prevent esophageal stenosis after complete circular endoscopic submucosal tunnel dissection for superficial esophageal neoplasms","volume":"114","author":"Chai","year":"2019","journal-title":"Am. J. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1007\/s00268-015-3193-3","article-title":"Prevention of esophageal stricture after endoscopic submucosal dissection: A systematic review","volume":"39","author":"Yu","year":"2015","journal-title":"World J. Surg."},{"key":"ref_10","first-page":"282","article-title":"Stricture after endoscopic submucosal dissection for early gastric cancers and adenomas","volume":"22","author":"Iizuka","year":"2010","journal-title":"Dig. Endosc. Off. J. Jpn. Gastroenterol. Endosc. Soc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1440-1746.2011.07039.x","article-title":"Risk factors for perforation and delayed bleeding associated with endoscopic submucosal dissection for early gastric neoplasms: Analysis of 1123 lesions","volume":"27","author":"Toyokawa","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3797615","DOI":"10.1155\/2016\/3797615","article-title":"Analysis of predictors for lymph node metastasis in patients with superficial esophageal carcinoma","volume":"2016","author":"Jia","year":"2016","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1007\/s10620-018-5029-0","article-title":"Curative criteria after endoscopic resection for superficial esophageal squamous cell carcinomas","volume":"63","author":"Mizumoto","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1055\/s-2005-861352","article-title":"Update on the paris classification of superficial neoplastic lesions in the digestive tract","volume":"37","author":"Axon","year":"2005","journal-title":"Endoscopy"},{"key":"ref_15","first-page":"41","article-title":"Magnification endoscopy in esophageal squamous cell carcinoma: A review of the intrapapillary capillary loop classification","volume":"28","author":"Inoue","year":"2015","journal-title":"Ann. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"AB456","DOI":"10.1016\/j.gie.2012.03.1234","article-title":"Usefulness of Japan esophageal society classification of magnified endoscopy for the diagnosis of superficial esophageal squamous cell carcinoma","volume":"75","author":"Oyama","year":"2012","journal-title":"Gastrointest. Endosc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-018-0960-y","article-title":"Additional radiotherapy following endoscopic submucosal dissection for T1a-MM\/T1b-SM esophageal squamous cell carcinoma improves locoregional control","volume":"13","author":"Hisano","year":"2018","journal-title":"Radiat. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1442-2050.2012.01370.x","article-title":"Clinical outcome of endoscopic mucosal resection for esophageal squamous cell cancer invading muscularis mucosa and submucosal layer","volume":"26","author":"Yoshii","year":"2013","journal-title":"Dis. Esophagus Off. J. Int. Soc. Dis. Esophagus"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s00535-014-0983-6","article-title":"Esophagectomy for superficial esophageal cancer after non-curative endoscopic resection","volume":"50","author":"Saeki","year":"2015","journal-title":"J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/ajg.2013.8","article-title":"Long-term outcome and metastatic risk after endoscopic resection of superficial esophageal squamous cell carcinoma","volume":"108","author":"Yamashina","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1055\/s-0043-124433","article-title":"Management decision based on lymphovascular involvement leads to favorable outcomes after endoscopic treatment of esophageal squamous cell carcinoma","volume":"50","author":"Takahashi","year":"2018","journal-title":"Endoscopy"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.3748\/wjg.v20.i20.6322","article-title":"Clinicopathologic factors influencing the accuracy of EUS for superficial esophageal carcinoma","volume":"20","author":"Jung","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0022-5223(19)36738-8","article-title":"Esophageal ultrasound and the preoperative staging of carcinoma of the esophagus","volume":"101","author":"Rice","year":"1991","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_24","first-page":"604","article-title":"Diagnostic yield of conventional endoscopy with endoscopic ultrasonography for submucosal invasion of superficial esophageal squamous cell carcinoma: A post hoc analysis of multicenter prospective confirmatory study (JCOG0508)","volume":"18","author":"Kadota","year":"2021","journal-title":"Esophagus Off. J. Jpn. Esophageal Soc."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ishihara, R., Matsuura, N., Hanaoka, N., Yamamoto, S., Akasaka, T., Takeuchi, Y., Higashino, K., Uedo, N., and Iishi, H. (2017). Endoscopic imaging modalities for diagnosing invasion depth of superficial esophageal squamous cell carcinoma: A systematic review and meta-analysis. BMC Gastroenterol., 17.","DOI":"10.1186\/s12876-017-0574-0"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1055\/s-0033-1344228","article-title":"Microvascular caliber changes in intramucosal and submucosally invasive esophageal cancer","volume":"45","author":"Santi","year":"2013","journal-title":"Endoscopy"},{"key":"ref_27","first-page":"105","article-title":"Prediction of the invasion depth of superficial squamous cell carcinoma based on microvessel morphology: Magnifying endoscopic classification of the Japan Esophageal Society","volume":"14","author":"Oyama","year":"2017","journal-title":"Esophagus Off. J. Jpn. Esophageal Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00464-017-5685-8","article-title":"Clinical implication of endoscopic gross appearance in superficial esophageal squamous carcinoma: Revisited","volume":"32","author":"Huh","year":"2018","journal-title":"Surg. Endosc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.gie.2014.11.015","article-title":"Multicenter, prospective trial of white-light imaging alone versus white-light imaging followed by magnifying endoscopy with narrow-band imaging for the real-time imaging and diagnosis of invasion depth in superficial esophageal squamous cell carcinoma","volume":"81","author":"Ebi","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jtcvs.2018.07.034","article-title":"Predicting lymph node metastasis for endoscopic resection of superficial esophageal squamous cell carcinoma","volume":"157","author":"Ma","year":"2019","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/jgh.14915","article-title":"Nomogram for prediction of lymph node metastasis in patients with superficial esophageal squamous cell carcinoma","volume":"35","author":"Min","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"doaa032","DOI":"10.1093\/dote\/doaa032","article-title":"Prediction of lymph node metastasis in superficial esophageal squamous cell carcinoma in Asia: A systematic review and meta-analysis","volume":"33","author":"Xu","year":"2020","journal-title":"Dis. Esophagus Off. J. Int. Soc. Dis. Esophagus"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"16544","DOI":"10.1038\/s41598-021-96088-y","article-title":"Retrospective analysis of predictive factors for lymph node metastasis in superficial esophageal squamous cell carcinoma","volume":"11","author":"Ruan","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_34","unstructured":"Zhou, Y., Luo, J.H., and Chen, L. (2016). An analysis of vascular tumor embolus: A risk factor for the esophageal carcinoma. Acta Univ. Med. Nanjing Nat. Sci., 36."},{"key":"ref_35","first-page":"doy021","article-title":"Endoscopic submucosal dissection for superficial esophageal cancer","volume":"31","author":"Aadam","year":"2018","journal-title":"Dis. Esophagus Off. J. Int. Soc. Dis. Esophagus"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.3748\/wjg.14.4289","article-title":"Perspective on the practical indications of endoscopic submucosal dissection of gastrointestinal neoplasms","volume":"14","author":"Fujishiro","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1696849","DOI":"10.1155\/2018\/1696849","article-title":"Progress on the prevention of esophageal stricture after endoscopic submucosal dissection","volume":"2018","author":"Shi","year":"2018","journal-title":"Gastroenterol. Res. Pract."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/2\/471\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:01:09Z","timestamp":1760119269000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/2\/471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,6]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["jcm12020471"],"URL":"https:\/\/doi.org\/10.3390\/jcm12020471","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2023,1,6]]}}}