{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:08:08Z","timestamp":1778317688884,"version":"3.51.4"},"reference-count":39,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>With the advent of new viscoelastometric hemostatic assay (VHA) devices, with ready-to-use cartridge reagents allowing for their use by people without special laboratory skills, the appreciation of the actual clinical value of VHAs in settings such as severe trauma, post-partum hemorrhage, cardiac surgery and liver transplantation still needs to be fully validated. While two of the newest versions remain based on a \u2018cup and pin\u2019 system (ROTEM\u00ae sigma, ClotPro\u00ae), two other new devices (TEG\u00ae 6s, Quantra\u00ae) rely on very different technologies: clotting blood is no longer in contact with the probe and challenged by oscillation of one of the components but explored with ultrasound exposure. A systematic literature search (including Sonoclot\u00ae) retrieved 20 observational studies (19 prospective). Most studies pointed to imperfect agreements, highlighting the non-interchangeability of devices. Only a few studies, often with a limited number of patients enrolled, used a clinical outcome. No study compared VHA results with conventional laboratory assays obtained through a rapid tests panel. Clinical evidence of the utility of the new VHAs largely remains to be proven through randomized clinical trials, with clinically relevant outcomes, and compared to rapid panel hemostasis testing. The availability of new, improved VHA devices provides an impetus and an opportunity to do so.<\/jats:p>","DOI":"10.3390\/jcm12020477","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T04:47:08Z","timestamp":1673239628000},"page":"477","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Are Viscoelastometric Assays of Old Generation Ready for Disposal? Comment on Volod et al. Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices. J. Clin. Med. 2022, 11, 860"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3589-4804","authenticated-orcid":false,"given":"Marion","family":"Bareille","sequence":"first","affiliation":[{"name":"CHU UCL Namur, Namur Thrombosis and Hemostasis Center (NTHC), Universit\u00e9 Catholique de Louvain, 5530 Yvoir, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lecompte","sequence":"additional","affiliation":[{"name":"Pharmacy Department, University of Namur, 5000 Namur, Belgium"},{"name":"Universit\u00e9 de Lorraine, 54000 Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6947-6099","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Mullier","sequence":"additional","affiliation":[{"name":"CHU UCL Namur, Namur Thrombosis and Hemostasis Center (NTHC), Universit\u00e9 Catholique de Louvain, 5530 Yvoir, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-0621","authenticated-orcid":false,"given":"St\u00e9phanie","family":"Roullet","sequence":"additional","affiliation":[{"name":"Laboratory for Hemostasis, Inflammation & Thrombosis (HITh), Unit\u00e9 Mixte de Recherche (UMR)-1176, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm), Universit\u00e9 Paris-Saclay, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Volod, O., Bunch, C.M., Zackariya, N., Moore, E.E., Moore, H.B., Kwaan, H.C., Neal, M.D., Al-Fadhl, M.D., Patel, S.S., and Wiarda, G. 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