{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:44:13Z","timestamp":1784198653934,"version":"3.55.0"},"reference-count":31,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: This study evaluated the characteristics of patients with head and neck (H&amp;N) melanoma who underwent sentinel lymph node biopsy (SNLB) and assessed the clinical course of patients categorizing subjects according to SLNB status and melanoma location (scalp area vs. non-scalp areas). Methods: Patients undergoing SLNB for melanoma of H&amp;N from 2015 to 2021 were prospectively characterized according to sentinel lymph node (SLN) status. SPECT\/CT had been previously performed. Patients were followed until the first adverse event to evaluate progression-free survival. Results: 93 patients were enrolled. SLNB was negative in 75 patients. The median Breslow index was higher for patients with positive SLNB compared with patients with negative SLNB. In addition, the Breslow index was higher for melanoma of the scalp compared with non-scalp melanoma. The median follow-up was 24.8 months. Progression occurred at the systemic level in the 62.5% of cases. There was a significant association between positive SLNB and progression (p-value &lt; 0.01) of disease, with lower progression-free survival for patients with melanoma of the scalp compared with those with melanoma at other anatomic sites (p-value: 0.15). Conclusions: Scalp melanomas are more aggressive than other types of H&amp;N melanomas. Sentinel lymph node status is the strongest prognostic criterion for recurrence.<\/jats:p>","DOI":"10.3390\/jcm12020553","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T01:57:48Z","timestamp":1673315868000},"page":"553","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sentinel Lymph Node Biopsy in Malignant Melanoma of the Head and Neck: A Single Center Experience"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-656X","authenticated-orcid":false,"given":"Marco","family":"Rubatto","sequence":"first","affiliation":[{"name":"Section of Dermatology, Department of Medical Sciences, University of Turin, Via Cherasco 23, 10121 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Picciotto","sequence":"additional","affiliation":[{"name":"Dermatologic Surgery Section, Department of Surgery, Azienda Ospedaliera Universitaria (AOU) Citt\u00e0 della Salute e della Scienza, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovenale","family":"Moirano","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, 10121 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Fruttero","sequence":"additional","affiliation":[{"name":"Dermatologic Surgery Section, Department of Surgery, Azienda Ospedaliera Universitaria (AOU) Citt\u00e0 della Salute e della Scienza, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Caliendo","sequence":"additional","affiliation":[{"name":"Dermatologic Surgery Section, Department of Surgery, Azienda Ospedaliera Universitaria (AOU) Citt\u00e0 della Salute e della Scienza, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Borriello","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medical Sciences, University of Turin, Via Cherasco 23, 10121 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Sciamarrelli","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medical Sciences, University of Turin, Via Cherasco 23, 10121 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-7458","authenticated-orcid":false,"given":"Paolo","family":"Fava","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medical Sciences, University of Turin, Via Cherasco 23, 10121 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Senetta","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Oncology, University of Turin, 10121 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Lesca","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Division of Nuclear Medicine, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3542-9571","authenticated-orcid":false,"given":"Anna","family":"Sapino","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, 10121 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3817-6648","authenticated-orcid":false,"given":"D\u00e9sir\u00e9e","family":"Deandreis","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Division of Nuclear Medicine, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-1406","authenticated-orcid":false,"given":"Simone","family":"Ribero","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medical Sciences, University of Turin, Via Cherasco 23, 10121 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Quaglino","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medical Sciences, University of Turin, Via Cherasco 23, 10121 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cps.2021.06.003","article-title":"Extirpative Considerations of Melanoma of the Head and Neck","volume":"48","author":"Olla","year":"2021","journal-title":"Clin. Plast. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.5858\/arpa.2013-0157-RA","article-title":"Molecular pathology of cutaneous neoplasms of the head and neck","volume":"138","author":"Kraft","year":"2014","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_3","first-page":"37","article-title":"Assessment of melanoma histotypes and patient-associated factors: Basis for a predictive statistical model","volume":"13","author":"Haenssle","year":"2015","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"624","DOI":"10.2340\/00015555-2944","article-title":"Effect of Age on Melanoma Risk, Prognosis and Treatment Response","volume":"98","author":"Ribero","year":"2018","journal-title":"Acta Derm. Venereol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.amjsurg.2011.06.048","article-title":"Prognostic implications of anatomic location of primary cutaneous melanoma of 1 mm or thicker","volume":"202","author":"Callender","year":"2011","journal-title":"Am. J. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1245\/s10434-013-2977-7","article-title":"Is head and neck melanoma different from trunk and extremity melanomas with respect to sentinel lymph node status and clinical outcome?","volume":"20","author":"Fadaki","year":"2013","journal-title":"Ann. Surg. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2147\/CCID.S293115","article-title":"Diagnosis and Management of Melanoma of the Scalp: A Review of the Literature","volume":"14","author":"Licata","year":"2021","journal-title":"Clin. Cosmet Investig. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/jso.1091","article-title":"Management of primary cutaneous melanoma of the head and neck: The University of Colorado experience and a review of the literature","volume":"77","author":"Gibbs","year":"2001","journal-title":"J. Surg. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e252","DOI":"10.1016\/j.jcms.2013.09.007","article-title":"Value of anatomic site, histology and clinicopathological parameters for prediction of lymph node metastasis and overall survival in head and neck melanomas","volume":"42","author":"Ettl","year":"2014","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/ijc.31078","article-title":"Sentinel lymph node biopsy versus observation in thick melanoma: A multicenter propensity score matching study","volume":"142","author":"Boada","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.suronc.2010.11.001","article-title":"Clinico-pathologic features of primary melanoma and sentinel lymph node predictive for non-sentinel lymph node involvement and overall survival in melanoma patients: A single centre observational cohort study","volume":"20","author":"Quaglino","year":"2011","journal-title":"Surg. Oncol."},{"key":"ref_12","unstructured":"(2023, January 05). Aiom Melanoma Guidelines 2021. Available online: https:\/\/www.aiom.it\/linee-guida-aiom-2021-melanoma\/."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.6004\/jnccn.2019.0018","article-title":"Cutaneous melanoma, version 2.2019, NCCN clinical practice guidelines in oncology","volume":"17","author":"Coit","year":"2019","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/jso.26119","article-title":"Completion lymph node dissection in patients with sentinel lymph node positive cutaneous head and neck melanoma","volume":"122","author":"Huang","year":"2020","journal-title":"J. Surg. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1470-2045(16)00141-8","article-title":"Complete lymph node dissection versus no dissection in patients with sentinel lymph node biopsy positive melanoma (DeCOG-SLT): A multicentre, randomised, phase 3 trial","volume":"17","author":"Leiter","year":"2016","journal-title":"Lancet Oncol."},{"key":"ref_16","first-page":"22","article-title":"Role of SPECT-CT in sentinel lymph node biopsy in patients diagnosed with head and neck melanoma","volume":"35","year":"2016","journal-title":"Rev. Esp. Med. Nucl. Imagen Mol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.ejso.2019.12.021","article-title":"Patterns of failure in patients with cutaneous head and neck melanoma","volume":"46","author":"Bachar","year":"2020","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e13795","DOI":"10.1111\/dth.13795","article-title":"A brief synopsis on scalp melanoma","volume":"33","author":"Saaiq","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jaad.2016.08.066","article-title":"Italian Melanoma Intergroup. Mitotic rate correlates with sentinel lymph node status and outcome in cutaneous melanoma greater than 1 millimeter in thickness: A multi-institutional study of 1524 cases","volume":"76","author":"Galli","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/ans.13286","article-title":"Review of the role of sentinel node biopsy in cutaneous head and neck melanoma","volume":"86","author":"Roy","year":"2016","journal-title":"ANZ J. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1245\/ASO.2006.03.058","article-title":"Melanoma patients with positive sentinel lymph nodes who did not undergo completion lymphadenectomy: A multi-institutional study","volume":"13","author":"Huang","year":"2006","journal-title":"Ann. Surg. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1056\/NEJMoa1613210","article-title":"Completion dissection or observation for sentinel lymph node metastasis in melanoma","volume":"376","author":"Faries","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s40257-019-00456-4","article-title":"Adjuvant Treatment of Melanoma: Recent Developments and Future Perspectives","volume":"20","author":"Testori","year":"2019","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s10434-999-0150-0","article-title":"Parotid region lymphatic mapping and sentinel lymphadenectomy for cutaneous melanoma","volume":"6","author":"Ollila","year":"1999","journal-title":"Ann. Surg. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/hed.20328","article-title":"Lymphatic drainage patterns of head and neck cutaneous melanoma observed on lymphoscintigraphy and sentinel lymph node biopsy","volume":"28","author":"Lin","year":"2006","journal-title":"Head Neck."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/jso.21848","article-title":"Can lymphatic drainage of head and neck melanoma be predicted?","volume":"103","author":"Jensen","year":"2011","journal-title":"J. Surg. Oncol."},{"key":"ref_27","first-page":"584","article-title":"Melanoma of the head and neck in Auckland","volume":"100","author":"Douglas","year":"1987","journal-title":"N. Z. Med. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/ijd.15283","article-title":"Melanomas of the scalp: Is hair coverage preventing early diagnosis?","volume":"60","author":"Pereira","year":"2021","journal-title":"Int. J. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1245\/s10434-016-5175-6","article-title":"SPECT\/CT Improves Detection of Metastatic Sentinel Lymph Nodes in Patients with Head and Neck Melanoma","volume":"23","author":"Chapman","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Quartuccio, N., Garau, L.M., Arnone, A., Pappalardo, M., Rubello, D., Arnone, G., and Manca, G. (2020). Comparison of 99mTc-Labeled Colloid SPECT\/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061680"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hed.21392","article-title":"SPECT\/CT for sentinel lymph node mapping in head and neck melanoma","volume":"33","author":"Vermeeren","year":"2011","journal-title":"Head Neck."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/2\/553\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:05:09Z","timestamp":1760119509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/2\/553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,10]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["jcm12020553"],"URL":"https:\/\/doi.org\/10.3390\/jcm12020553","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,10]]}}}