{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:16:58Z","timestamp":1778696218010,"version":"3.51.4"},"reference-count":26,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Ovarian Hyperstimulation Syndrome (OHSS) is an uncommon but serious complication occurring in patients undergoing ovarian stimulation. It is characterized by ovarian enlargement, nausea, vomiting, abdominal pain\/distension, and reduction in urine output. However, OHSS may rarely evolve into a life-threatening condition with ascites, hemoconcentration and hypercoagulability. Prevention of OHSS consists of an integrated approach that associates behavioral aspects with administration of pharmacological compounds. Among drugs used to manage OHSS, Letrozole has recently been proposed as an effective option for prevention of the syndrome. However, despite the promising findings reported by several studies, to date Letrozole is not yet officially mentioned in the guidelines for \u201cPrevention and Treatment of moderate and severe ovarian hyperstimulation syndrome\u201d. In this scenario, the current study discusses Letrozole approaches scientifically available to prevent OHSS.<\/jats:p>","DOI":"10.3390\/jcm12020614","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T04:29:38Z","timestamp":1673497778000},"page":"614","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Letrozole and Ovarian Hyperstimulation Syndrome (OHSS): A Promising Prevention Strategy"],"prefix":"10.3390","volume":"12","author":[{"given":"Federica","family":"Di Guardo","sequence":"first","affiliation":[{"name":"Department of General Surgery and Medical Surgical Specialties, University of Catania, Via Santa Sofia 78, 95125 Catania, Italy"},{"name":"Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan, 101-1090 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Lello","sequence":"additional","affiliation":[{"name":"Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-0105","authenticated-orcid":false,"given":"Giosu\u00e8 Giordano","family":"Incognito","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical Surgical Specialties, University of Catania, Via Santa Sofia 78, 95125 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical Surgical Specialties, University of Catania, Via Santa Sofia 78, 95125 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical Surgical Specialties, University of Catania, Via Santa Sofia 78, 95125 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/humupd\/dmr008","article-title":"GnRH agonist for triggering of final oocyte maturation: Time for a change of practice?","volume":"17","author":"Humaidan","year":"2011","journal-title":"Hum. Reprod. Update"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s10815-015-0498-y","article-title":"Ovarian hyperstimulation syndrome after gonadotropin-releasing hormone agonist triggering and \u201cfreeze-all\u201d: In-depth analysis of genetic predisposition","volume":"32","author":"Polyzos","year":"2015","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_3","first-page":"153","article-title":"VEGF and follicle development","volume":"18","author":"Palumbo","year":"2004","journal-title":"Gynecol. Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1006\/cyto.1998.0363","article-title":"Macrophage-derived cytokines in the follicular fluids of women with infertility due to immunological causes. Elevated levels of interleukin 6 and low levels of granulocyte-macrophage colony-stimulating factor","volume":"10","author":"Calogero","year":"1998","journal-title":"Cytokine"},{"key":"ref_5","first-page":"15","article-title":"Renal and Hepatic Functions after A Week of Controlled Ovarian Hyperstimulation during In Vitro Fertilization Cycles","volume":"11","author":"Romito","year":"2017","journal-title":"Int. J. Fertil. Steril."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.fertnstert.2016.08.048","article-title":"Prevention and treatment of moderate and severe ovarian hyperstimulation syndrome: A guideline","volume":"106","author":"Pfeifer","year":"2016","journal-title":"Fertil. Steril."},{"key":"ref_7","first-page":"hoaa009","article-title":"ESHRE guideline: Ovarian stimulation for IVF\/ICSI\u2020","volume":"2","author":"Bosch","year":"2020","journal-title":"Hum. Reprod. Open"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0015-0282(00)00492-1","article-title":"Distinction between early and late ovarian hyperstimulation syndrome","volume":"73","author":"Mathur","year":"2000","journal-title":"Fertil. Steril."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.fertnstert.2012.05.042","article-title":"Prediction of in vitro fertilization outcome at different antral follicle count thresholds in a prospective cohort of 1012 women","volume":"98","author":"Jayaprakasan","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.3109\/00016340903287482","article-title":"Prediction of ovarian hyperstimulation syndrome in women undergoing in vitro fertilization","volume":"88","author":"Kahnberg","year":"2009","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.fertnstert.2009.05.092","article-title":"Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome","volume":"94","author":"Luke","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.fertnstert.2005.07.1292","article-title":"Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles","volume":"85","author":"Papanikolaou","year":"2006","journal-title":"Fertil. Steril."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.fertnstert.2013.12.026","article-title":"Oocyte number as a predictor for ovarian hyperstimulation syndrome and live birth: An analysis of 256,381 in vitro fertilization cycles","volume":"101","author":"Steward","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1472-6483(10)60212-X","article-title":"Luteal phase oestradiol suppression by letrozole: A pilot study in oocyte donors","volume":"17","author":"Fatemi","year":"2008","journal-title":"Reprod. Biomed. Online"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.fertnstert.2008.04.042","article-title":"Letrozole administration during the luteal phase after ovarian stimulation impacts corpus luteum function: A randomized, placebo-controlled trial","volume":"92","author":"Quea","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/humrep\/deg208","article-title":"Prediction of ovarian hyperstimulation syndrome (OHSS). Estradiol level has an important role in the prediction of OHSS","volume":"18","author":"Aboulghar","year":"2003","journal-title":"Hum. Reprod."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.fertnstert.2005.01.117","article-title":"The aromatase inhibitor letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: A pilot study","volume":"84","author":"Moreno","year":"2005","journal-title":"Fertil. Steril."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejogrb.2010.09.003","article-title":"Comparison of aromatase inhibitor (letrozole) and immunomodulators (infliximab and etanercept) on the regression of endometriotic implants in a rat model","volume":"154","author":"Ceyhan","year":"2011","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_19","first-page":"869","article-title":"Luteal letrozole administration decreases serum estrogen level but not the risk of ovarian hyperstimulation syndrome","volume":"45","author":"Wang","year":"2013","journal-title":"Beijing Da Xue Xue Bao. Yi Xue Ban=J. Peking University. Health Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13048-015-0190-y","article-title":"Can steroidal ovarian suppression during the luteal phase after oocyte retrieval reduce the risk of severe OHSS?","volume":"8","author":"Wang","year":"2015","journal-title":"J. Ovarian Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3109\/19396368.2014.957879","article-title":"Effects of different doses of letrozole on the incidence of early-onset ovarian hyperstimulation syndrome after oocyte retrieval","volume":"60","author":"He","year":"2014","journal-title":"Syst. Biol. Reprod. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"42.e1","DOI":"10.1016\/j.ajog.2016.08.018","article-title":"Effect of letrozole on moderate and severe early-onset ovarian hyperstimulation syndrome in high-risk women: A prospective randomized trial","volume":"216","author":"Mai","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_23","first-page":"263","article-title":"A Prospective Randomised Comparative Clinical Trial Study of Luteal Phase Letrozole versus Ganirelix Acetate Administration to Prevent Severity of Early Onset OHSS in ARTs","volume":"15","author":"Choudhary","year":"2021","journal-title":"Int. J. Fertil. Steril."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12978-020-01042-2","article-title":"Whether Letrozole could reduce the incidence of early ovary hyperstimulation syndrome after assisted reproductive technology? A systematic review and meta-analysis","volume":"17","author":"Zhao","year":"2020","journal-title":"Reprod. Health"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.rbmo.2020.10.006","article-title":"Effect of GnRH-antagonist, mifepristone and letrozole on preventing ovarian hyperstimulation syndrome in rat model","volume":"42","author":"Luo","year":"2021","journal-title":"Reprod. Biomed. Online"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"101643","DOI":"10.1016\/j.jogoh.2019.101643","article-title":"The role of Letrozole (LE) in controlled ovarian stimulation (COS) in patients at high risk to develop ovarian hyper stimulation syndrome (OHSS). 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