{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:57:23Z","timestamp":1779339443177,"version":"3.51.4"},"reference-count":26,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study aimed to investigate the safety and efficacy of rapid primary phacoemulsification in patients with acute primary angle closure (APAC) (n = 41), with or without preoperative IOP-lowering medication. The best-corrected visual acuity (BCVA), intraocular pressure (IOP), number of corneal endothelial cells (CECs), and number of IOP-lowering medications at the preoperative examination (Pre), postoperative day 1 (1d), week 1 (1w), and month 1 (1m) were used as indicators and compared. BCVA significantly improved at 1d, 1w, and 1m compared with Pre (p &lt; 0.05) and significantly improved at 1m compared to 1d (p &lt; 0.05) for all eyes. IOP significantly decreased at 1d, 1w, and 1m compared with Pre (p &lt; 0.05). CECs were not significantly different between Pre and 1m; the number of IOP-lowering medications decreased significantly from Pre to 1m (p &lt; 0.05). BCVA and IOP were not significantly different between the two groups for all periods. CECs were not significantly different between the two groups at Pre and 1m. Rapid primary phacoemulsification improved visual acuity due to improvement of corneal edema without central visual field defects and good IOP control without reoperation or IOP-lowering medication and maintained the number of corneal endothelial cells with or without preoperative IOP-lowering medication in patients with APAC.<\/jats:p>","DOI":"10.3390\/jcm12020660","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T04:31:32Z","timestamp":1673843492000},"page":"660","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety and Efficacy of Rapid Primary Phacoemulsification on Acute Primary Angle Closure with and without Preoperative IOP-Lowering Medication"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7385-415X","authenticated-orcid":false,"given":"Takafumi","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shinseikai Toyama Hospital, Toyama 939-0243, Japan"},{"name":"Department of Ophthalmology, The University of Tokyo Hospital, Tokyo 113-8655, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The University of Tokyo Hospital, Tokyo 113-8655, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Tachi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shinseikai Toyama Hospital, Toyama 939-0243, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0115-3311","authenticated-orcid":false,"given":"Yoshiki","family":"Ueta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shinseikai Toyama Hospital, Toyama 939-0243, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Fukutome","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shinseikai Toyama Hospital, Toyama 939-0243, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shinseikai Toyama Hospital, Toyama 939-0243, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2256-8217","authenticated-orcid":false,"given":"Hirofumi","family":"Sasajima","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shinseikai Toyama Hospital, Toyama 939-0243, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Aihara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The University of Tokyo Hospital, Tokyo 113-8655, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e489","DOI":"10.1016\/S2214-109X(20)30488-5","article-title":"The Lancet Global Health Commission on Global Eye Health: Vision beyond 2020","volume":"9","author":"Burton","year":"2021","journal-title":"Lancet Glob. Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0161-6420(02)01123-5","article-title":"Primary phacoemulsification and intraocular lens implantation for acute angle-closure glaucoma","volume":"109","author":"Jacobi","year":"2002","journal-title":"Ophthalmology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1016\/j.ophtha.2012.06.015","article-title":"Initial management of acute primary angle closure: A randomized trial comparing phacoemulsification with laser peripheral iridotomy","volume":"119","author":"Husain","year":"2012","journal-title":"Ophthalmology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.ophtha.2007.10.033","article-title":"Randomized trial of early phacoemulsification versus peripheral iridotomy to prevent intraocular pressure rise after acute primary angle closure","volume":"115","author":"Lam","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jcrs.2005.11.014","article-title":"Phacoemulsification and intraocular lens implantation for acute angle closure not treated or previously treated by laser iridotomy","volume":"32","author":"Imaizumi","year":"2006","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(16)30956-4","article-title":"Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): A randomised controlled trial","volume":"388","author":"Burr","year":"2016","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0161-6420(02)01158-2","article-title":"Argon laser peripheral iridoplasty versus conventional systemic medical therapy in treatment of acute primary angle-closure glaucoma: A prospective, randomized, controlled trial","volume":"109","author":"Lam","year":"2002","journal-title":"Ophthalmology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/sj.eye.6701867","article-title":"To compare argon laser peripheral iridoplasty (ALPI) against systemic medications in treatment of acute primary angle-closure: Mid-term results","volume":"20","author":"Lai","year":"2006","journal-title":"Eye"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41433-018-0278-x","article-title":"Acute primary angle closure-treatment strategies, evidences and economical considerations","volume":"33","author":"Chan","year":"2019","journal-title":"Eye"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.joco.2015.12.001","article-title":"Early phacoemulsification in patients with acute primary angle closure","volume":"27","author":"Moghimi","year":"2015","journal-title":"J. Curr. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/ICO.0b013e31802c9e19","article-title":"National survey on bullous keratopathy in Japan","volume":"26","author":"Shimazaki","year":"2007","journal-title":"Cornea"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0002-9394(00)00621-8","article-title":"Acute primary angle-closure: Long-term intraocular pressure outcome in Asian eyes","volume":"131","author":"Aung","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.ophtha.2004.01.036","article-title":"Acute primary angle closure: Configuration of the drainage angle in the first year after laser peripheral iridotomy","volume":"111","author":"Lim","year":"2004","journal-title":"Ophthalmology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/eye.1999.168","article-title":"Acute angle closure glaucoma: An evaluation of a protocol for acute treatment","volume":"13","author":"Choong","year":"1999","journal-title":"Eye"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.ophtha.2003.12.061","article-title":"Long-term outcomes in Asians after acute primary angle closure","volume":"111","author":"Aung","year":"2004","journal-title":"Ophthalmology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1097\/IJG.0b013e31825c10c4","article-title":"Clear lens extraction in plateau iris with bilateral acute angle closure in young","volume":"22","author":"Rao","year":"2013","journal-title":"J. Glaucoma."},{"key":"ref_18","first-page":"742","article-title":"Angle parameter changes of phacoemulsification and combined phacotrabeculectomy for acute primary angle closure","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8849","DOI":"10.1167\/iovs.11-7591","article-title":"Histopathology of the trabecular meshwork and Schlemm\u2019s canal in primary angle-closure glaucoma","volume":"52","author":"Hamanaka","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ajo.2017.08.020","article-title":"Cataract surgery from 1918 to the present and future-just imagine!","volume":"185","author":"Olson","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.preteyeres.2016.12.003","article-title":"Primary angle closure glaucoma: What we know and what we don\u2019t know","volume":"57","author":"Sun","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_22","first-page":"122","article-title":"Plateau iris syndrome","volume":"83","author":"Wand","year":"1977","journal-title":"Trans. Sect. Ophthalmol. Am. Acad. Ophthalmol. Otolaryngol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1016\/S0161-6420(03)00563-3","article-title":"Angle closure in younger patients","volume":"110","author":"Ritch","year":"2003","journal-title":"Ophthalmology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1167\/iovs.62.2.37","article-title":"Posture-related changes of intraocular pressure in patients with acute primary angle closure","volume":"62","author":"Hsia","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1159\/000520176","article-title":"Aphakic pupillary block by an intact anterior vitreous membrane after total lens extraction by phacoemulsification","volume":"12","author":"Kono","year":"2021","journal-title":"Case Rep. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/IJG.0000000000000669","article-title":"Evaluation of angle closure as a risk factor for reduced corneal endothelial cell density","volume":"26","author":"Varadaraj","year":"2017","journal-title":"J. Glaucoma."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/2\/660\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:05:40Z","timestamp":1760119540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/2\/660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,13]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["jcm12020660"],"URL":"https:\/\/doi.org\/10.3390\/jcm12020660","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,13]]}}}