{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:35:22Z","timestamp":1782797722659,"version":"3.54.5"},"reference-count":30,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T00:00:00Z","timestamp":1673740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Acute lymphocytic leukemia is one of the most common cancers in children. Multi-drug chemotherapy is used for treatment, and the representative drug is vincristine. Although various side effects may occur due to vincristine, the association with peripheral neuropathy is high compared to that of other drugs. This study focused on children under the age of 18 years of age with ALL who received chemotherapy containing vincristine. We retrospectively analyzed the results of a nerve conduction study and a cumulative dose of vincristine in 30 children diagnosed with peripheral neuropathy. The average cumulative dose until diagnosis of vincristine-induced peripheral neuropathy was 14.99 \u00b1 1.21 mg\/m2, and motor nerves were predominantly involved. Additionally, a marked decrease in average amplitude was also observed in motor nerves. In addition, when the relationship between the incidence of peripheral neuropathy and the cumulative dose was analyzed through the survival curve, about 50% of children developed peripheral neuropathy at a dose of 15.5 \u00b1 1.77 mg\/m2. Based on the electrophysiological characteristics of pediatric vincristine-induced peripheral neuropathy, as well as the relationship between the incidence rate and the cumulative dose, it is possible to observe more closely the vincristine-induced peripheral neuropathy occurrence in children with ALL at an appropriate time.<\/jats:p>","DOI":"10.3390\/jcm12020686","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T04:31:32Z","timestamp":1673843492000},"page":"686","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Electrophysiologic Patterns of Symptomatic Vincristine-Induced Peripheral Neuropathy in Children with Acute Lymphocytic Leukemia"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7552-8174","authenticated-orcid":false,"given":"Jae-Gyeong","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Kyungpook National University Hospital, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hwan","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Kyungpook National University Hospital, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0373-0538","authenticated-orcid":false,"given":"Yu-Sun","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea"},{"name":"Department of Rehabilitation Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea"},{"name":"Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5577-6629","authenticated-orcid":false,"given":"Ji Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea"},{"name":"Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1636-8665","authenticated-orcid":false,"given":"Tae-Du","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea"},{"name":"Department of Rehabilitation Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e577","DOI":"10.1038\/bcj.2017.53","article-title":"Acute lymphoblastic leukemia: A comprehensive review and 2017 update","volume":"7","author":"Terwilliger","year":"2017","journal-title":"Blood Cancer J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1056\/NEJMra1400972","article-title":"Acute Lymphoblastic Leukemia in Children","volume":"373","author":"Hunger","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1056\/NEJMra052603","article-title":"Treatment of acute lymphoblastic leukemia","volume":"354","author":"Pui","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.12688\/f1000research.8053.1","article-title":"Chemotherapy-induced peripheral neuropathy: An update on the current understanding","volume":"5","author":"Addington","year":"2016","journal-title":"F1000Research"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e26471","DOI":"10.1002\/pbc.26471","article-title":"Vincristine-induced peripheral neuropathy in survivors of childhood acute lymphoblastic leukaemia","volume":"64","author":"Tay","year":"2017","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_6","first-page":"2416","article-title":"Vincristine-induced peripheral neuropathy in pediatric cancer patients","volume":"6","author":"Mora","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"ref_7","first-page":"3798","article-title":"Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on microtubules in vitro","volume":"36","author":"Himes","year":"1976","journal-title":"Cancer Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1177\/0883073813491829","article-title":"Vincristine-induced neuropathy in childhood ALL (acute lymphoblastic leukemia) survivors: Prevalence and electrophysiological characteristics","volume":"29","author":"Jain","year":"2014","journal-title":"J. Child Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0022-510X(70)90013-4","article-title":"The neuromyopathy of vincristine in man. Clinical, electrophysiological and pathological studies","volume":"10","author":"Bradley","year":"1970","journal-title":"J. Neurol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/jns.12114","article-title":"Patterns and severity of vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia","volume":"20","author":"Li","year":"2015","journal-title":"J. Peripher. Nerv. Syst. JPNS"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12098-009-0254-3","article-title":"Vincristine induced neurotoxicity in cancer patients","volume":"77","author":"Gomber","year":"2010","journal-title":"Indian J. Pediatr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/088307389701200102","article-title":"Study of nerve conduction and late responses in normal Chinese infants, children, and adults","volume":"12","author":"Cai","year":"1997","journal-title":"J. Child Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1021\/bi953037i","article-title":"Interaction of vinca alkaloids with tubulin: A comparison of vinblastine, vincristine, and vinorelbine","volume":"35","author":"Lobert","year":"1996","journal-title":"Biochemistry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neuro.2013.05.008","article-title":"Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: Implications for chemotherapy-induced peripheral neuropathy","volume":"37","author":"LaPointe","year":"2013","journal-title":"Neurotoxicology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0074-7742(09)85014-9","article-title":"Involvement of inflammatory mediators in neuropathic pain caused by vincristine","volume":"85","author":"Kiguchi","year":"2009","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00221-006-0499-2","article-title":"Vincristine-induced neuropathy in rat: Electrophysiological and histological study","volume":"173","author":"Hamdan","year":"2006","journal-title":"Exp. Brain Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.critrevonc.2011.04.012","article-title":"Chemotherapy-induced peripheral neurotoxicity (CIPN): An update","volume":"82","author":"Argyriou","year":"2012","journal-title":"Crit Rev. Oncol. Hematol."},{"key":"ref_18","first-page":"1258","article-title":"Vincristine treatment of advanced cancer: A cooperative study of 392 cases","volume":"33","author":"Holland","year":"1973","journal-title":"Cancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/mus.24647","article-title":"Vincristine-Induced Neuropathy: Atypical Electrophysiological Patterns in Children","volume":"52","author":"Courtemanche","year":"2015","journal-title":"Muscle Nerve"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s00018-016-2364-1","article-title":"Schwann cell mitochondria as key regulators in the development and maintenance of peripheral nerve axons","volume":"74","author":"Ino","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.neuron.2007.05.023","article-title":"Hierarchical control of sensory neuron development by neurotrophic factors","volume":"54","author":"Ibanez","year":"2007","journal-title":"Neuron"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/MPH.0000000000000825","article-title":"Electrophysiological Studies to Detect Peripheral Neuropathy in Children Treated With Vincristine","volume":"39","author":"Kavcic","year":"2017","journal-title":"J. Pediatr. Hematol.\/Oncol."},{"key":"ref_23","first-page":"225","article-title":"Mild axonal neuropathy of children during treatment for acute lymphoblastic leukaemia","volume":"4","author":"Fock","year":"2000","journal-title":"Eur. J. Paediatr. Neurol. EJPN Off. J. Eur. Paediatr. Neurol. Soc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"E49","DOI":"10.1097\/NCC.0b013e318299ad23","article-title":"Measuring vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia","volume":"36","author":"Li","year":"2013","journal-title":"Cancer Nurs."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1001\/jama.2015.0894","article-title":"Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia","volume":"313","author":"Diouf","year":"2015","journal-title":"Jama"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s00280-011-1745-2","article-title":"Impact of plasma and intracellular exposure and CYP3A4, CYP3A5, and ABCB1 genetic polymorphisms on vincristine-induced neurotoxicity","volume":"68","author":"Guilhaumou","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fnmol.2017.00174","article-title":"Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy","volume":"10","author":"Starobova","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Triarico, S., Romano, A., Attina, G., Capozza, M.A., Maurizi, P., Mastrangelo, S., and Ruggiero, A. (2021). Vincristine-Induced Peripheral Neuropathy (VIPN) in Pediatric Tumors: Mechanisms, Risk Factors, Strategies of Prevention and Treatment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084112"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.REO.0000000000000111","article-title":"Physical Therapy-Based Interventions Improve Balance, Function, Symptoms, and Quality of Life in Patients With Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review","volume":"36","author":"Brayall","year":"2018","journal-title":"Rehabil. Oncol."},{"key":"ref_30","first-page":"73","article-title":"Nerve conduction studies in polyneuropathy: Practical physiology and patterns of abnormality","volume":"106","author":"Franssen","year":"2006","journal-title":"Acta Neurol. Belg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/2\/686\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:06:33Z","timestamp":1760119593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/2\/686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,15]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["jcm12020686"],"URL":"https:\/\/doi.org\/10.3390\/jcm12020686","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,15]]}}}