{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:48:01Z","timestamp":1787168881130,"version":"build-2736575974"},"reference-count":23,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study aimed to validate the association between the grades of severity of diabetic foot ulcers (DFUs) identified by the fast-tack model and specific outcomes. Three hundred and sixty-seven patients with new DFUs who were referred to a tertiary level diabetic foot service serving Rome, Italy, were included. The fast-track model identifies three levels of DFUs\u2019 severity: uncomplicated DFUs, including superficial wounds, not-infected wounds, and not-ischemic wounds; complicated DFUs, including ischemic wounds, infected wounds, and deep ulcers involving the muscles, tendons, or bones, and any kind of ulcers in patients on dialysis and\/or with heart failure; and severely complicated DFUs, including abscesses, wet gangrene, necrotizing fasciitis, fever, or clinical signs of sepsis. Healing, minor and major amputation, hospitalization, and survival after 24 weeks of follow-up were considered. Among the included patients, 35 (9.6%) had uncomplicated DFUs, 210 (57.2%) had complicated DFUs, and 122 (33.2%) had severely complicated DFUs. The outcomes for patients with uncomplicated, complicated, and severely complicated DFUs were as follows, respectively: healing, 97.1%, 86.2%, and 69.8%; minor amputation, 2.9%, 20%, and 66.4%; major amputation, 0%, 2.9%, and 16.4%; hospitalization, 14.3%, 55.7%, and 89.3%; survival, 100%, 96.7%, and 89.3%. DFU severity was an independent predictor of healing, amputation, hospitalization, and survival. The current study shows an association between the grade of severity of DFUs identified by the fast-track model and the considered outcomes. The fast-track model may be a useful tool for assessing the severity and prognosis of DFUs.<\/jats:p>","DOI":"10.3390\/jcm12030761","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T03:04:44Z","timestamp":1674011084000},"page":"761","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Validation of the Fast-Track Model: A Simple Tool to Assess the Severity of Diabetic Foot Ulcers"],"prefix":"10.3390","volume":"12","author":[{"given":"Marco","family":"Meloni","sequence":"first","affiliation":[{"name":"Diabetic Foot Unit, Department of System Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4317-6714","authenticated-orcid":false,"given":"Benjamin","family":"Bouillet","sequence":"additional","affiliation":[{"name":"Endocrinology Department, University Hospital Center, 21000 Dijon, France"},{"name":"INSERM-University of Bourgogne Franche-Comt\u00e9, LNC UMR1231, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-7649","authenticated-orcid":false,"given":"Raju","family":"Ahluwalia","sequence":"additional","affiliation":[{"name":"Department of Trauma and Ortophaedic, King\u2019s College Hospital, London SE5 9RS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7907-611X","authenticated-orcid":false,"given":"Juan Pedro","family":"Sanchez-Rios","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit, Vascular Surgery Department, Hospital Fundaci\u00f3n Alcorcon, 28922 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Iacopi","sequence":"additional","affiliation":[{"name":"Diabetic Foot Section, University of Pisa, Ospedale di Cisanello, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Izzo","sequence":"additional","affiliation":[{"name":"UniCamillus-Saint Camillus International, University of Health Science, 00131 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1703-7059","authenticated-orcid":false,"given":"Chris","family":"Manu","sequence":"additional","affiliation":[{"name":"Diabetic Foot Clinic, King\u2019s College Hospital, Denmark Hill, London SE5 9RS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vouillarmet","family":"Julien","sequence":"additional","affiliation":[{"name":"Endocrinology Department, University Hospital Center, 69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claas","family":"Luedmann","sequence":"additional","affiliation":[{"name":"Franziskus Krankenhaus Berlin, 10787 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Garcia-Klepzig","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Clinico San Carlos De Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9rome","family":"Guillaumat","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Hospital of Caen, 14033 Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-0265","authenticated-orcid":false,"given":"Jose Luis","family":"Lazaro-Martinez","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.numecd.2020.10.010","article-title":"Barriers to diabetic foot management in Italy: A multicentre survey in diabetic foot centres of the Diabetic Foot Study Group of the Italian Society of Diabetes (SID) and Association of Medical Diabetologists (AMD)","volume":"31","author":"Meloni","year":"2020","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"804","DOI":"10.12968\/jowc.2021.30.10.804","article-title":"Characteristics of new patient referrals to specialised diabetic foot units across Europe and factors influencing delays","volume":"30","author":"Bouillet","year":"2021","journal-title":"J. Wound Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.12968\/jowc.2018.27.3.186","article-title":"Delayed referral of patients with diabetic foot ulcers across Europe: Patterns between primary care and specialised units","volume":"27","author":"Manu","year":"2018","journal-title":"J. Wound Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.12968\/jowc.2018.27.5.310","article-title":"Perception of diabetic foot ulcers among general practitioners in four European countries: Knowledge, skills and urgency","volume":"27","author":"Manu","year":"2018","journal-title":"J. Wound Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e3272","DOI":"10.1002\/dmrr.3272","article-title":"Diabetic foot ulcer classifications: A critical review","volume":"36","author":"Boyko","year":"2020","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_6","first-page":"38","article-title":"Fast-track pathway: An easy-to-use tool to reduce delayed referral and amputations in diabetic patients with foot ulceration","volume":"22","author":"Meloni","year":"2019","journal-title":"Diabet. Foot J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s00592-021-01721-x","article-title":"Effectiveness of fast-track pathway for diabetic foot ulcerations","volume":"58","author":"Meloni","year":"2021","journal-title":"Acta Diabetol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e3266","DOI":"10.1002\/dmrr.3266","article-title":"Practical Guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update)","volume":"36","author":"Schaper","year":"2020","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_9","first-page":"1167","article-title":"2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure","volume":"69","author":"Ponikowski","year":"2016","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.numecd.2013.12.007","article-title":"Treatment of peripheral arterial disease in diabetes: A consensus of the Italian Societies of Diabetes (SID, AMD), Radiology (SIRM) and Vascular Endovascular Surgery (SICVE)","volume":"24","author":"Aiello","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_11","first-page":"31","article-title":"Impact of heart failure and dialysis in the prognosis of diabetic patients with ischemic foot ulcers","volume":"11","author":"Meloni","year":"2018","journal-title":"J. Clin. Transl. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"660","DOI":"10.12968\/jowc.2021.30.8.660","article-title":"Peripheral arterial disease in patients with renal-diabetic foot ulcers","volume":"30","author":"Meloni","year":"2021","journal-title":"J. Wound Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"822","DOI":"10.2337\/dc08-1223","article-title":"Long-term prognosis of diabetic patients with critical limb ischemia: A population-based cohort study","volume":"32","author":"Faglia","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.jvs.2011.02.006","article-title":"Factors related to outcome of neuroischemic\/ischemic foot ulcer in diabetic patients","volume":"53","author":"Apelqvist","year":"2011","journal-title":"J. Vasc. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00125-008-1226-2","article-title":"Complexity of factors related to outcome of neuropathic and neuroischaemic\/ischaemic diabetic foot ulcers: A cohort study","volume":"52","author":"Gershater","year":"2008","journal-title":"Diabetologia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.diabres.2016.04.030","article-title":"Long term outcomes of diabetic haemodialysis patients with critical limb ischemia and foot ulcer","volume":"116","author":"Meloni","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00125-008-0940-0","article-title":"Prediction of outcome in individuals with diabetic foot ulcers: Focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study","volume":"51","author":"Prompers","year":"2008","journal-title":"Diabetologia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3109\/00365548.2013.765589","article-title":"The implications of the presence of osteomyelitis on outcomes of infected diabetic foot wounds","volume":"45","author":"Mutluoglu","year":"2013","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1007\/s00125-008-1131-8","article-title":"Outcomes of surgical treatment of diabetic foot osteomyelitis: A series of 185 patients with histopathological confirmation of bone involvement","volume":"51","author":"Armstrong","year":"2008","journal-title":"Diabetologia"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Meloni, M., Izzo, V., Giurato, L., L\u00e1zaro-Mart\u00ednez, J.L., and Uccioli, L. (2020). Prevalence, Clinical Aspects and Outcomes in a Large Cohort of Persons with Diabetic Foot Disease: Comparison between Neuropathic and Ischemic Ulcers. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061780"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"i1820","DOI":"10.1136\/bmj.i1820","article-title":"Early referral for foot ulcers is vital, finds audit of diabetes care","volume":"352","author":"Wise","year":"2016","journal-title":"BMJ"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Smith-Str\u00f8m, H., Iversen, M., Igland, J., \u00d8stbye, T., Graue, M., Skeie, S., Wu, B., and Rokne, B. (2017). Severity and duration of diabetic foot ulcer (DFU) before seeking care as predictors of healing time: A retrospective cohort study. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0177176"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1053\/j.jfas.2006.04.002","article-title":"The Role of Early Surgical Debridement and Revascularization in Patients With Diabetes and Deep Foot Space Abscess: Retrospective Review of 106 Patients With Diabetes","volume":"45","author":"Faglia","year":"2006","journal-title":"J. Foot Ankle Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/3\/761\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:08:54Z","timestamp":1760119734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/3\/761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,18]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["jcm12030761"],"URL":"https:\/\/doi.org\/10.3390\/jcm12030761","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,18]]}}}