{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:59:30Z","timestamp":1778605170157,"version":"3.51.4"},"reference-count":19,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Intraoperative auditory brainstem response (ioABR) testing following tympanostomy tube (TT) placement may be biased due to temporary threshold shifts (TTS). The purpose of the study was to assess the evidence for TTS in children who have undergone ioABR using prolonged latencies of wave I (males &gt; 1.95 ms, females &gt; 1.88 ms) as a marker of a persisting air\u2013bone gap. Eighty-three children underwent ioABR following surgical procedures at University Hospital Bonn, Germany. The primary outcome measure was the latency of wave I at 80-dB SPL. The total sample consisted of 66 males (79.5%) and 17 females (20.5%) with a mean (SD) age of 46.4 (26.6) months. Of 163 operated ears (83 children), 72 (44.2%) had no middle ear fluid, 19 (11.6%) serous fluid, and 72 (44.2%) mucoid fluid. The risk of having a prolonged latency of wave I at 80-dB SPL was OR 4.61 (95% CI 2.01\u201310.59; p &lt; 0.001) in those with mucoid fluid as compared to those without mucoid fluid. Intraoperative ABR results should account for sex differences and be interpreted with caution and be verified. Ultimately, parents should be engaged in a preoperative discussion to decide if an ioABR should be postponed if mucoid fluid was found.<\/jats:p>","DOI":"10.3390\/jcm12030830","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T02:52:21Z","timestamp":1674183141000},"page":"830","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Decision Making for Intraoperative Auditory Brainstem Response Testing in Children following Tympanostomy Tube Placement"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2547-5371","authenticated-orcid":false,"given":"Maria","family":"Dietrich","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Schade","sequence":"additional","affiliation":[{"name":"Private Practice Kleinow, Pfarrer-Kenntemich-Platz 11, 53840 Troisdorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Nadal","sequence":"additional","affiliation":[{"name":"Department of Medical Biometrics, Informatics and Epidemiology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Keiner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6tz","family":"Schade","sequence":"additional","affiliation":[{"name":"Division of Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1055\/s-0031-1291330","article-title":"Fr\u00fche akustisch evozierte Potenziale: Low-Chirp-BERA versus Notched-Noise-BERA","volume":"91","author":"Schade","year":"2012","journal-title":"Laryngo-Rhino-Otologie"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1055\/s-2007-998761","article-title":"Die Kategorisierung von H\u00f6rst\u00f6rungen anhand der Latenzabweichung in der BERA","volume":"66","author":"Hoth","year":"1987","journal-title":"Laryngo-Rhino-Otologie"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s001060050720","article-title":"Fr\u00fcherkennung kindlicher H\u00f6rsch\u00e4den. Visuelle und automatische Verfahren im Vergleich","volume":"49","author":"Baumann","year":"2001","journal-title":"HNO"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s12070-012-0558-x","article-title":"The role of current audiological tests in the early diagnosis of hearing impairment in infant","volume":"65","author":"Kuki","year":"2013","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1055\/s-2004-814471","article-title":"Melatonin als Alternative zur Sedierung bei Durchf\u00fchrung einer Hirnstammaudiometrie bei Kindern","volume":"83","author":"Schmidt","year":"2004","journal-title":"Laryngo-Rhino-Otologie"},{"key":"ref_6","first-page":"240","article-title":"A pilot study of the relationship between Down`s syndrome and hearing loss","volume":"5","author":"Kattan","year":"2000","journal-title":"Neurosciences"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"350437","DOI":"10.1155\/2012\/350437","article-title":"Clinical experience of auditory brainstem response testing on pediatric patients in the operating room","volume":"2012","author":"Zhou","year":"2012","journal-title":"Int. J. Otolaryngol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.otohns.2009.09.009","article-title":"The role of intraoperative auditory brainstem response testing for infants and difficult-to-test children","volume":"142","author":"Yorgason","year":"2010","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1017\/S0022215100131159","article-title":"Raised ABR threshold after suction aspiration of glue from the middle ear: Three case studies","volume":"109","author":"Mason","year":"1995","journal-title":"J. Laryngol. Otol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1017\/S0022215106005226","article-title":"Hearing threshold assessment post grommet insertion. Is it reliable?","volume":"121","author":"Griffiths","year":"2007","journal-title":"J. Laryngol. Otol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ijporl.2011.04.010","article-title":"Pediatric hearing assessment by auditory brainstem response in the operating room","volume":"75","author":"Dornan","year":"2011","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1055\/s-0040-1718933","article-title":"Effect of tympanostomy tube placement on intraoperative auditory brainstem response","volume":"32","author":"Martinovic","year":"2021","journal-title":"J. Am. Acad. Audiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1046\/j.1365-2273.1996.00824.x","article-title":"The feasibility of recording transiently evoked otoacoustic emissions immediately following grommet insertion","volume":"21","author":"Richardson","year":"1996","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/MAO.0b013e31821b0d07","article-title":"Otitis media with effusion: An underestimated cause of hearing loss in infants","volume":"32","author":"Boudewijns","year":"2011","journal-title":"Otol. Neurotol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/00034894800890S346","article-title":"Auditory brainstem responses in children with otitis media with effusion","volume":"89","author":"Fria","year":"1980","journal-title":"Ann. Otol. Rhinol. Laryngol. Suppl."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1055\/s-0034-1385868","article-title":"Akustisch evozierte Potenziale: Grundlagen und klinische Anwendung","volume":"93","author":"Radeloff","year":"2014","journal-title":"Laryngo-Rhino-Otologie"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s00106-004-1082-4","article-title":"Verz\u00f6gerung in der H\u00f6rbahnreifung. Differenzialdiagnose bei H\u00f6rst\u00f6rungen im S\u00e4uglingsalter","volume":"52","author":"Massinger","year":"2004","journal-title":"HNO"},{"key":"ref_18","first-page":"109","article-title":"Age and sex differences in latencies of waves I, III and V in auditory brainstem response of normal hearing subjects","volume":"53","author":"Salguero","year":"1999","journal-title":"Acta Oto-Rhino-Laryngol. Belg."},{"key":"ref_19","first-page":"S1","article-title":"Clinical practice guideline: Tympanostomy tubes in children (Update)","volume":"166","author":"Rosenfeld","year":"2022","journal-title":"Otolaryngol. Head Neck Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/3\/830\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:11:51Z","timestamp":1760119911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/3\/830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["jcm12030830"],"URL":"https:\/\/doi.org\/10.3390\/jcm12030830","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]}}}