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and Technological Talents Applied Technology Research Program of Shenyang","award":["18-014-4-56"],"award-info":[{"award-number":["18-014-4-56"]}]},{"name":"Scientific and Technological Talents Applied Technology Research Program of Shenyang","award":["19-110-4-23"],"award-info":[{"award-number":["19-110-4-23"]}]},{"name":"Science and Technology Innovation Environment Creation Program of Shenyang","award":["81671423"],"award-info":[{"award-number":["81671423"]}]},{"name":"Science and Technology Innovation Environment Creation Program of Shenyang","award":["2016YFC1000603"],"award-info":[{"award-number":["2016YFC1000603"]}]},{"name":"Science and Technology Innovation Environment Creation Program of Shenyang","award":["20-205-4-006"],"award-info":[{"award-number":["20-205-4-006"]}]},{"name":"Science and Technology Innovation Environment Creation Program of Shenyang","award":["18-014-4-56"],"award-info":[{"award-number":["18-014-4-56"]}]},{"name":"Science and Technology Innovation Environment Creation Program of Shenyang","award":["19-110-4-23"],"award-info":[{"award-number":["19-110-4-23"]}]},{"name":"345 Talent Project of Shengjing Hospital","award":["81671423"],"award-info":[{"award-number":["81671423"]}]},{"name":"345 Talent Project of Shengjing Hospital","award":["2016YFC1000603"],"award-info":[{"award-number":["2016YFC1000603"]}]},{"name":"345 Talent Project of Shengjing Hospital","award":["20-205-4-006"],"award-info":[{"award-number":["20-205-4-006"]}]},{"name":"345 Talent Project of Shengjing Hospital","award":["18-014-4-56"],"award-info":[{"award-number":["18-014-4-56"]}]},{"name":"345 Talent Project of Shengjing Hospital","award":["19-110-4-23"],"award-info":[{"award-number":["19-110-4-23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study aimed to assess the effects of GH adjuvant therapy on the cumulative live birth rate in patients with poor embryo quality and to determine the characteristics of patients who are more responsive to GH. A retrospective cohort study was carried out in patients who have suffered from previous IVF failure due to poor embryonic development and underwent IVF with or without a 6-week pretreatment with GH in the subsequent cycle from January 2018 to December 2020. Clinical parameters including the cumulative live birth rate between the (\u2212) GH and (+) GH groups were compared. Multivariate analysis was performed to ascertain associations between clinical parameters and cumulative live birth rate. Upon analysis of the clinical data from 236 IVF cycles, 84 patients received GH and 152 did not receive GH. In frozen embryo transfer cycles, compared with the (\u2212) GH group, the implantation rate and live birth rate were significantly higher in the (+) GH group (p &lt; 0.05). After adjusting for possible confounding factors, GH improved cumulative live birth per oocyte retrieval cycle by 1.96 folds (p = 0.032). Furthermore, when patients were subdivided based on age and BMI, a significant increase in the cumulative live birth rate was found in the (+) GH group of patients between 35 and 42 years old and BMI \u2265 24 kg\/m2, respectively (p &lt; 0.05). GH may increase the live birth rate in women who experienced IVF failure because of poor embryonic development, particularly in obese patients and women with advanced age.<\/jats:p>","DOI":"10.3390\/jcm12030955","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T02:30:38Z","timestamp":1674786638000},"page":"955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Advantage of Growth Hormone Alone as an Adjuvant Therapy in Advanced Age and BMI \u2265 24 kg\/m2 with In Vitro Fertilization Failure Due to Poor Embryo Quality"],"prefix":"10.3390","volume":"12","author":[{"given":"Shuyi","family":"Jiang","sequence":"first","affiliation":[{"name":"Center of Reproductive Medicine, Shengjing Hospital of China Medical University, 36 SanHao Street, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjie","family":"Fu","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Shengjing Hospital of China Medical University, 36 SanHao Street, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Shengjing Hospital of China Medical University, 36 SanHao Street, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zuo","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Shengjing Hospital of China Medical University, 36 SanHao Street, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzheng","family":"Guan","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Shengjing Hospital of China Medical University, 36 SanHao Street, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-7820","authenticated-orcid":false,"given":"Hao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Evidence-Based Medicine, the First Hospital of China Medical University, 155 Nanjing North Street, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Shengjing Hospital of China Medical University, 36 SanHao Street, Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1093\/oxfordjournals.humrep.a136312","article-title":"Embryo score to predict implantation after in-vitro fertilization: Based on 957 single embryo transfers","volume":"10","author":"Giorgetti","year":"1995","journal-title":"Hum. 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