{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:30:22Z","timestamp":1781523022347,"version":"3.54.1"},"reference-count":14,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Slow continuous ultrafiltration (SCUF) is an extracorporeal therapy able to reduce fluid overload in chronic or acute heart failure resistant to diuretics. An in-vitro study demonstrated the SCUF feasibility using a standard fluid infusion central venous catheter (CVC). We describe the clinical application of this SCUF in regional citrate anticoagulation (SCUF-RCA) in a patient admitted to the Intensive Care Unit for acute decompensate heart failure with severe systemic fluid overload resistant to diuretics. To avoid risks deriving from a new catheterization, we used a pre-existing multi-lumen CVC for drug administration to provide 10 h of SCUF-RCA with a blood flow of 35 mL\/min and 100 mL\/h of ultrafiltration with a final weight loss of 1 Kilogram without technical and clinical complications. The patient had a hemodynamics improvement with the diuresis recovery from the previous oliguria after the SCUF-RCA. This clinical case can open the use of the SCUF-RCA in the clinical practice to treat the fluid overload unresponsive to maximal diuretic therapy not exposing the patient to the risks and complications related to the use of SCUF with CVC for dialysis and systemic anticoagulation with heparin. Accordingly, this technique may be useful in the treatment of fluid overload in outpatients.<\/jats:p>","DOI":"10.3390\/jcm12030988","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T11:19:53Z","timestamp":1675077593000},"page":"988","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Slow Continuous Ultrafiltration in Regional Citrate Anticoagulation Performed with a Standard Fluid Infusion Central Venous Catheter in Intensive Care Unit for Fluid Overload in Acute on Chronic Heart Failure: A Case Report"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1167-2764","authenticated-orcid":false,"given":"Federico","family":"Nalesso","sequence":"first","affiliation":[{"name":"Nephrology Unit, Department of Medicine, University of Padua, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Stefanelli","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Department of Medicine, University of Padua, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leda","family":"Cattarin","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Department of Medicine, University of Padua, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariaelena","family":"Billo","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Department of Medicine, University of Padua, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Gnappi","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Department of Medicine, University of Padua, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Partesano","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Department of Medicine, University of Padua, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Cacciapuoti","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Department of Medicine, University of Padua, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Babuin","sequence":"additional","affiliation":[{"name":"Cardiologic Intensive Care Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo A.","family":"Cal\u00f2","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Department of Medicine, University of Padua, Via Giustiniani 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000451054","article-title":"Extracorporeal Ultrafiltration for Acute Heart Failure: Lost Battle or Lasting Opportunity?","volume":"43","author":"Koratala","year":"2017","journal-title":"Blood Purif."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/MCC.0b013e328309a481","article-title":"Ultrafiltration in the management of heart failure","volume":"14","author":"Costanzo","year":"2008","journal-title":"Curr. 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Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.iccn.2017.05.006","article-title":"Prevention of central venous line associated bloodstream infections in adult intensive care units: A systematic review","volume":"43","author":"Reyes","year":"2017","journal-title":"Intensive Crit. Care Nurs."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1001\/jama.299.20.2413","article-title":"Femoral vs jugular venous catheterization and risk of nosocomial events in adults requiring acute renal replacement therapy: A randomized controlled trial","volume":"299","author":"Parienti","year":"2008","journal-title":"JAMA"},{"key":"ref_8","first-page":"97","article-title":"Effectiveness of sodium hypochlorite in the prevention of catheter related infections","volume":"154","author":"Cruz","year":"2007","journal-title":"Contrib. 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[3rd ed.]."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1111\/aor.14253","article-title":"In vitro use of standard fluid infusion central venous catheter for slow continuous ultrafiltration feasibility assessment","volume":"46","author":"Nalesso","year":"2022","journal-title":"Artif. Organs"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"714","DOI":"10.5301\/ijao.5000661","article-title":"Routine adoption of TIMP2 and IGFBP7 biomarkers in cardiac surgery for early identification of acute kidney injury","volume":"40","author":"Levante","year":"2017","journal-title":"Int. J. Artif. Organs"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000485591","article-title":"Predicting Acute Kidney Injury in Intensive Care Unit Patients: The Role of Tissue Inhibitor of Metalloproteinases-2 and Insulin-Like Growth Factor-Binding Protein-7 Biomarkers","volume":"45","author":"Nalesso","year":"2018","journal-title":"Blood Purif."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/3\/988\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:17:31Z","timestamp":1760120251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/3\/988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["jcm12030988"],"URL":"https:\/\/doi.org\/10.3390\/jcm12030988","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,27]]}}}