{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:28:36Z","timestamp":1790843316904,"version":"4.1.0"},"reference-count":20,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Dermoscopic features of actinic keratosis (AK) have been widely studied, but there is still little evidence for their diagnostic accuracy. Our study investigates whether established dermoscopic criteria are reliable predictors in differentiating non-pigmented actinic keratosis (NPAK) from pigmented actinic keratosis (PAK). For this purpose, dermoscopic images of 83 clinically diagnosed AK (45 NPAK, 38PAK) were examined, and the sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) were assessed. Features with statistical significance were the red pseudo-network (p = 0.02) for NPAK and the pigmented pseudo-network (p &lt; 0.001) with a pigment intensity value even less than 10% for PAK (p = 0.001). Pigmented pseudo-network (Se: 89%, Sp: 77%, PPV: 77%, NPV: 89%) with a pigment intensity value of more than 10% (Se: 90%, Sp: 86%, PPV: 79%, NPV: 93%) had excellent diagnostic accuracy for PAK. Scale and widened follicular openings with yellowish dots surrounded by white circles were equally represented in both variants of AK. Linear wavy vessels and shiny streaks were more prominently observed in NPAK, as were rosettes in PAK, but these results failed to meet statistical significance. The red starburst pattern was near statistical significance for PAK. Therefore, pigmentation is the strongest dermoscopic predictor for the differentiation between NPAK and PAK.<\/jats:p>","DOI":"10.3390\/jcm12031063","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T01:33:37Z","timestamp":1675042417000},"page":"1063","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Dermoscopy of Actinic Keratosis: Is There a True Differentiation between Non-Pigmented and Pigmented Lesions?"],"prefix":"10.3390","volume":"12","author":[{"given":"Dimitrios","family":"Sgouros","sequence":"first","affiliation":[{"name":"2nd Department of Dermatology and Venereology, \u201cAttikon\u201d General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melpomeni","family":"Theofili","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology, \u201cAttikon\u201d General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Zafeiropoulou","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology and Venereology, \u201cAndreas Sygros\u201d Hospital, Medical School, National and Kapodistrian University of Athens, 16121 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7193-0964","authenticated-orcid":false,"given":"Aimilios","family":"Lallas","sequence":"additional","affiliation":[{"name":"1st Dermatology Department, School of Health Sciences, Aristotle University of Thessaloniki, 54643 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Apalla","sequence":"additional","affiliation":[{"name":"2nd Dermatology Department, School of Health Sciences, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexios","family":"Zaras","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology and Venereology, \u201cAndreas Sygros\u201d Hospital, Medical School, National and Kapodistrian University of Athens, 16121 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Liopyris","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology and Venereology, \u201cAndreas Sygros\u201d Hospital, Medical School, National and Kapodistrian University of Athens, 16121 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6932-1441","authenticated-orcid":false,"given":"Georgia","family":"Pappa","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology, \u201cAttikon\u201d General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Polychronaki","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology and Venereology, \u201cAndreas Sygros\u201d Hospital, Medical School, National and Kapodistrian University of Athens, 16121 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiori","family":"Kousta","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology and Venereology, \u201cAndreas Sygros\u201d Hospital, Medical School, National and Kapodistrian University of Athens, 16121 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Panagiotopoulos","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology and Venereology, \u201cAndreas Sygros\u201d Hospital, Medical School, National and Kapodistrian University of Athens, 16121 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Stratigos","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology and Venereology, \u201cAndreas Sygros\u201d Hospital, Medical School, National and Kapodistrian University of Athens, 16121 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Rigopoulos","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology and Venereology, \u201cAndreas Sygros\u201d Hospital, Medical School, National and Kapodistrian University of Athens, 16121 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"Katoulis","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology, \u201cAttikon\u201d General University Hospital, Medical School, National and Kapodistrian 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