{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:11:48Z","timestamp":1776723108052,"version":"3.51.2"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Female gender, degree of QT prolongation, and genetic susceptibility are known risk factors for developing torsades de pointes (TdP) during high-grade atrioventricular block (HG-AVB). Our objective was to analyze the prevalence and clinical characteristics of patients presenting with TdP and AVB (TdP [+]) in comparison with non-TdP patients with AVB (TdP [\u2212]). Methods: All the ECGs from patients prospectively admitted for AVB (2 to 1, HG, and complete) at the University Hospital of Nice were analyzed. Automated corrected QT (QTc), manual measurements of QT and JT intervals, and Tpeak-to-end were performed at the time of the most severe bradycardia. Results: From September 2020 to November 2021, 100 patients were admitted for HG-AVB. Among them, 17 patients with TdP were identified (8 men; 81 \u00b1 10 years). No differences could be identified concerning automated QTc, manual QTc (Bazett correction), baseline QRS width, or mean left ventricular ejection fraction between the two groups. Potassium serum level on admission and mean number of QT-prolonging drugs per patient were not significantly different between the two groups, respectively: 4.34 \u00b1 0.5 mmol\/L in TdP [+] versus 4.52 \u00b1 0.6 mmol\/L (p = 0.33); and 0.6 \u00b1 0.7 in TdP [+] versus 0.3 \u00b1 0.5 (p = 0.15). In contrast, manual QTcFR (Fridericia correction), JT (Fridericia correction), Tpeak-to-end, and Tpe\/QT ratio were significantly increased in the TdP [+] group, respectively: 486 \u00b1 70 ms versus 456 \u00b1 53 ms (p = 0.04); 433 \u00b1 98 ms versus 381 \u00b1 80 ms (p = 0.02); 153 \u00b1 57 ms versus 110 \u00b1 40 ms (p &lt; 0.001); and 0.27 \u00b1 0.08 versus 0.22 \u00b1 0.06 (p &lt; 0.001). Conclusions: The incidence of TdP complicating acquired AVB was 17%. Longer QTcFR, JT, and Tpeak-to-end were significantly increased in the case of TdP but also in the presence of permanent AVB during the hospitalization.<\/jats:p>","DOI":"10.3390\/jcm12031067","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T01:33:37Z","timestamp":1675042417000},"page":"1067","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and Clinical Characteristics of Patients with Torsades de Pointes Complicating Acquired Atrioventricular Block"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3016-9192","authenticated-orcid":false,"given":"Sok-Sithikun","family":"Bun","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Pasteur University Hospital, 06000 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8933-5226","authenticated-orcid":false,"given":"Nathan","family":"Heme","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pasteur University Hospital, 06000 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Asarisi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pasteur University Hospital, 06000 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Squara","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pasteur University Hospital, 06000 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Scarlatti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pasteur University Hospital, 06000 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Moceri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pasteur University Hospital, 06000 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emile","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pasteur University Hospital, 06000 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"ref_1","first-page":"263","article-title":"La tachycardie ventriculaire \u00e0 deux foyers oppos\u00e9s variables [Ventricular tachycardia with 2 variable opposing foci]","volume":"59","author":"Dessertenne","year":"1966","journal-title":"Arch. 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