{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:29:42Z","timestamp":1788395382762,"version":"build-2803163510"},"reference-count":150,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The pressure exerted on the heart and blood vessels because of blood flow is considered an essential parameter for cardiovascular function. It determines sufficient blood perfusion, and transportation of nutrition, oxygen, and other essential factors to every organ. Pressure in the primary arteries near the heart and the brain is known as central blood pressure (CBP), while that in the peripheral arteries is known as peripheral blood pressure (PBP). Usually, CBP and PBP are correlated; however, various types of shocks and cardiovascular disorders interfere with their regulation and differently affect the blood flow in vital and accessory organs. Therefore, understanding blood pressure in normal and disease conditions is essential for managing shock-related cardiovascular implications and improving treatment outcomes. In this review, we have described the control systems (neural, hormonal, osmotic, and cellular) of blood pressure and their regulation in hemorrhagic\/hypovolemic shock using centhaquine (Lyfaquin\u00ae) as a resuscitative agent.<\/jats:p>","DOI":"10.3390\/jcm12031108","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T01:36:59Z","timestamp":1675215419000},"page":"1108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Controls of Central and Peripheral Blood Pressure and Hemorrhagic\/Hypovolemic Shock"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7529-7409","authenticated-orcid":false,"given":"Amaresh K.","family":"Ranjan","sequence":"first","affiliation":[{"name":"Chicago College of Pharmacy, Midwestern University, Downers Grove, IL 60515, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7420-4554","authenticated-orcid":false,"given":"Anil","family":"Gulati","sequence":"additional","affiliation":[{"name":"Chicago College of Pharmacy, Midwestern University, Downers Grove, IL 60515, USA"},{"name":"Pharmazz Inc., Research and Development, Willowbrook, IL 60527, USA"},{"name":"Department of Bioengineering, The University of Illinois at Chicago, Chicago, IL 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","unstructured":"Rogers, M.E., Oliver, M.F., and Matthews, B.E. (2022, October 30). \u201cCirculatory System\u201d. Encyclopedia Britannica, 20 October 2022. Available online: https:\/\/www.britannica.com\/science\/circulatory-system."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bpobgyn.2015.08.008","article-title":"Human fetal cardiac progenitors: The role of stem cells and progenitors in the fetal and adult heart","volume":"31","author":"Bulatovic","year":"2016","journal-title":"Best Pract. Res. Clin. Obs. Gynaecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nrg1710","article-title":"Building the mammalian heart from two sources of myocardial cells","volume":"6","author":"Buckingham","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000501906","article-title":"The Transitional Heart: From Early Embryonic and Fetal Development to Neonatal Life","volume":"47","author":"Tan","year":"2020","journal-title":"Fetal Diagn. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1161\/01.CIR.21.5.744","article-title":"Regulation of the heart\u2019s functions","volume":"21","author":"Rushmer","year":"1960","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"726895","DOI":"10.3389\/fphys.2021.726895","article-title":"Neurohumoral Cardiac Regulation: Optogenetics Gets into the Groove","volume":"12","author":"Scalco","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0006-3495(62)86849-0","article-title":"The physics of blood flood in capillaries. II. The capillary resistance to flow","volume":"2","author":"Prothero","year":"1962","journal-title":"Biophys. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0006-3495(61)86909-9","article-title":"The physics of blood flow in capillaries. I. The nature of the motion","volume":"1","author":"Prothero","year":"1961","journal-title":"Biophys. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0010-4825(95)98881-D","article-title":"Finite element analysis of nonlinear pulsatile suspension flow dynamics in blood vessels with aneurysm","volume":"25","author":"Kumar","year":"1995","journal-title":"Comput. Biol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1161\/01.RES.2.2.127","article-title":"The dynamics of pulsatile blood flow","volume":"2","author":"Peterson","year":"1954","journal-title":"Circ. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1152\/advan.00114.2010","article-title":"Neural control of the circulation","volume":"35","author":"Thomas","year":"2011","journal-title":"Adv. Physiol. Educ."},{"key":"ref_12","first-page":"109","article-title":"[Neural control of the peripheral circulation and blood pressure]","volume":"79","author":"Estanol","year":"2009","journal-title":"Arch. Cardiol. Mex."},{"key":"ref_13","first-page":"83","article-title":"[Neural control of the coronary circulation]","volume":"4","year":"1951","journal-title":"Bol. Sanid. Mil."},{"key":"ref_14","first-page":"205","article-title":"Capillary Circulation and Blood-Pressure and the Conditions that Control them","volume":"89","author":"Haig","year":"1906","journal-title":"Med. Chir. Trans."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0733-8651(02)00004-8","article-title":"The heart, kidney, and brain as target organs in hypertension","volume":"20","author":"Mensah","year":"2002","journal-title":"Cardiol. Clin."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1007\/s00415-012-6736-7","article-title":"Neurogenic orthostatic hypotension: Pathophysiology, evaluation, and management","volume":"260","author":"Metzler","year":"2013","journal-title":"J. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Marazzato, J., Blasi, F., Golino, M., Verdecchia, P., Angeli, F., and De Ponti, R. (2022). Hypertension and Arrhythmias: A Clinical Overview of the Pathophysiology-Driven Management of Cardiac Arrhythmias in Hypertensive Patients. J. Cardiovasc. Dev. Dis., 9.","DOI":"10.3390\/jcdd9040110"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1111\/jch.14561","article-title":"Central hypertension is a non-negligible cardiovascular risk factor","volume":"24","author":"Cheng","year":"2022","journal-title":"J. Clin. Hypertens."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/emj.2003.012450","article-title":"Critical care in the emergency department: Shock and circulatory support","volume":"22","author":"Graham","year":"2005","journal-title":"Emerg. Med. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1161\/HYPERTENSIONAHA.114.03361","article-title":"Association of central and peripheral blood pressures with intermediate cardiovascular phenotypes","volume":"63","author":"Roman","year":"2014","journal-title":"Hypertension"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"294","DOI":"10.5847\/wjem.j.issn.1920-8642.2013.04.010","article-title":"Discrepancy of blood pressure between the brachial artery and radial artery","volume":"4","author":"Li","year":"2013","journal-title":"World J. Emerg. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/s41371-020-00472-6","article-title":"Features and implications of higher systolic central than peripheral blood pressure in patients at very high risk of atherosclerotic cardiovascular disease","volume":"35","author":"Kim","year":"2021","journal-title":"J. Hum. Hypertens."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.hlc.2021.07.019","article-title":"Central Over Peripheral Blood Pressure: An Emerging Issue in Hypertension Research","volume":"30","author":"Gardikioti","year":"2021","journal-title":"Heart. Lung. Circ."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"608098","DOI":"10.3389\/fphys.2021.608098","article-title":"Estimating Central Pulse Pressure from Blood Flow by Identifying the Main Physical Determinants of Pulse Pressure Amplification","volume":"12","author":"Chowienczyk","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/oxfordjournals.eurheartj.a059669","article-title":"Nitroglycerin has more favourable effects on left ventricular afterload than apparent from measurement of pressure in a peripheral artery","volume":"11","author":"Kelly","year":"1990","journal-title":"Eur. Heart J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/HYPERTENSIONAHA.109.134379","article-title":"Role of pulse pressure amplification in arterial hypertension: Experts\u2019 opinion and review of the data","volume":"54","author":"Avolio","year":"2009","journal-title":"Hypertension"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"705558","DOI":"10.3389\/fphys.2021.705558","article-title":"SBP Is Superior to MAP to Reflect Tissue Perfusion and Hemodynamic Abnormality Perioperatively","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00002480-200303000-00129","article-title":"Relation between mean arterial pressure (MAP) and cardiac output (CO) in open chest pigs","volume":"49","author":"Curtis","year":"2003","journal-title":"ASAIO J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.resuscitation.2021.08.037","article-title":"Increasing mean arterial pressure or cardiac output in comatose out-of-hospital cardiac arrest patients undergoing targeted temperature management: Effects on cerebral tissue oxygenation and systemic hemodynamics","volume":"168","author":"Grand","year":"2021","journal-title":"Resuscitation"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0022-5223(19)35338-3","article-title":"Chronotropic and inotropic supports are both required to increase cardiac output early after corrective operations for tetralogy of Fallot","volume":"97","author":"Berner","year":"1989","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"H313","DOI":"10.1152\/ajpheart.2000.278.2.H313","article-title":"Mechanism of preserved positive lusitropy by cAMP-dependent drugs in heart failure","volume":"278","author":"Tanigawa","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/01.RES.48.6.813","article-title":"Volume loading slows left ventricular isovolumic relaxation rate. Evidence of load-dependent relaxation in the intact dog heart","volume":"48","author":"Raff","year":"1981","journal-title":"Circ. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/1753944715591450","article-title":"The systemic vascular resistance response: A cardiovascular response modulating blood viscosity with implications for primary hypertension and certain anemias","volume":"9","author":"Sloop","year":"2015","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"R819","DOI":"10.1152\/ajpregu.00813.2004","article-title":"Baroreceptors, baroreceptor unloading, and the long-term control of blood pressure","volume":"288","author":"Thrasher","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/expphysiol.2004.027441","article-title":"Baroreceptors and the long-term control of blood pressure","volume":"89","author":"Thrasher","year":"2004","journal-title":"Exp. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3988\/jcn.2015.11.3.220","article-title":"Orthostatic Hypotension: Mechanisms, Causes, Management","volume":"11","author":"Low","year":"2015","journal-title":"J. Clin. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1161\/01.CIR.98.23.2615","article-title":"Vagal cardiopulmonary reflexes after total cardiac deafferentation","volume":"98","author":"Minisi","year":"1998","journal-title":"Circulation"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fmed.2018.00082","article-title":"Role of the Sympathetic Nervous System and Its Modulation in Renal Hypertension","volume":"5","author":"Sata","year":"2018","journal-title":"Front. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Mahdi, A., Sturdy, J., Ottesen, J.T., and Olufsen, M.S. (2013). Modeling the afferent dynamics of the baroreflex control system. PLoS Comput. Biol., 9.","DOI":"10.1371\/journal.pcbi.1003384"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fnins.2017.00461","article-title":"Resetting of the Baroreflex Control of Sympathetic Vasomotor Activity during Natural Behaviors: Description and Conceptual Model of Central Mechanisms","volume":"11","author":"Dampney","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/cphy.c140004","article-title":"Regulation of breathing and autonomic outflows by chemoreceptors","volume":"4","author":"Guyenet","year":"2014","journal-title":"Compr. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/japplphysiol.00809.2003","article-title":"Peripheral chemoreceptors in health and disease","volume":"96","author":"Prabhakar","year":"2004","journal-title":"J. Appl. Physiol. (1985)"},{"key":"ref_43","first-page":"21","article-title":"Chemoreceptors and their reflexes with special reference to the fetus and newborn","volume":"3","author":"Purves","year":"1981","journal-title":"J. Dev. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fnins.2020.00524","article-title":"The Mammalian Diving Response: Inroads to Its Neural Control","volume":"14","author":"Panneton","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0034-5687(94)90104-X","article-title":"Nasal receptors responding to noxious chemical irritants","volume":"96","author":"Sekizawa","year":"1994","journal-title":"Respir. Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3389\/fphys.2012.00111","article-title":"Activation of brainstem neurons by underwater diving in the rat","volume":"3","author":"Panneton","year":"2012","journal-title":"Front. Physiol."},{"key":"ref_47","first-page":"124","article-title":"Cardiovascular sensory receptors and their regulatory mechanisms","volume":"47","author":"Fahim","year":"2003","journal-title":"Indian J. Physiol. Pharm."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4196\/kjpp.2018.22.4.363","article-title":"Role of peripheral vestibular receptors in the control of blood pressure following hypotension","volume":"22","author":"Jin","year":"2018","journal-title":"Korean J. Physiol. Pharm."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"H1191","DOI":"10.1152\/ajpheart.00208.2011","article-title":"Cardiovascular regulation by skeletal muscle reflexes in health and disease","volume":"301","author":"Murphy","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/jch.12145","article-title":"The relationship between blood pressure and pain","volume":"15","author":"Sacco","year":"2013","journal-title":"J. Clin. Hypertens."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"614636","DOI":"10.3389\/fneur.2021.614636","article-title":"All Central Nervous System Neuro- and Vascular-Communication Channels Are Surrounded with Cerebrospinal Fluid","volume":"12","author":"Fahmy","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5688\/aj710478","article-title":"Physiology of the autonomic nervous system","volume":"71","author":"McCorry","year":"2007","journal-title":"Am. J. Pharm. Educ."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/bjaed\/mkw011","article-title":"Autonomic nervous system: Anatomy, physiology, and relevance in anaesthesia and critical care medicine","volume":"16","author":"Bankenahally","year":"2016","journal-title":"BJA Educ."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"dev.162552","DOI":"10.1242\/dev.162552","article-title":"Neuropilins guide preganglionic sympathetic axons and chromaffin cell precursors to establish the adrenal medulla","volume":"145","author":"Lumb","year":"2018","journal-title":"Development"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00441-021-03548-y","article-title":"The sympathies of the body: Functional organization and neuronal differentiation in the peripheral sympathetic nervous system","volume":"386","author":"Ernsberger","year":"2021","journal-title":"Cell Tissue Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0950-351X(05)80177-6","article-title":"Essential organization of the sympathetic nervous system","volume":"7","author":"Gilbey","year":"1993","journal-title":"Baillieres Clin. Endocrinol. Metab."},{"key":"ref_57","first-page":"155","article-title":"Functional organization of the sympathetic nervous system","volume":"32","author":"Szulczyk","year":"1981","journal-title":"Acta Physiol. Pol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fpsyt.2018.00044","article-title":"Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders","volume":"9","author":"Breit","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1152\/advan.00027.2016","article-title":"Central neural control of the cardiovascular system: Current perspectives","volume":"40","author":"Dampney","year":"2016","journal-title":"Adv. Physiol. Educ."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1440-1681.1997.tb02125.x","article-title":"Central nervous system control of cardiovascular function: Neural mechanisms and novel modulators","volume":"24","author":"Spyer","year":"1997","journal-title":"Clin. Exp. Pharm. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"R321","DOI":"10.1152\/ajpregu.00451.2012","article-title":"Medullary GABAergic mechanisms contribute to electroacupuncture modulation of cardiovascular depressor responses during gastric distention in rats","volume":"304","author":"Tjen","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-925X-9-4","article-title":"Neural set point for the control of arterial pressure: Role of the nucleus tractus solitarius","volume":"9","author":"Zanutto","year":"2010","journal-title":"Biomed. Eng. Online"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00424-008-0498-1","article-title":"Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption","volume":"456","author":"Boone","year":"2008","journal-title":"Pfl\u00fcgers Arch. -Eur. J. Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10286-012-0168-4","article-title":"Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin","volume":"23","author":"Harlan","year":"2013","journal-title":"Clin. Auton. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1161\/HYPERTENSIONAHA.113.01404","article-title":"Subfornical organ mediates sympathetic and hemodynamic responses to blood-borne proinflammatory cytokines","volume":"62","author":"Wei","year":"2013","journal-title":"Hypertension"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molmet.2017.12.001","article-title":"The LepR-mediated leptin transport across brain barriers controls food reward","volume":"8","author":"Sandin","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"838175","DOI":"10.3389\/fphys.2022.838175","article-title":"Spinal Reflex Control of Arterial Blood Pressure: The Role of TRP Channels and Their Endogenous Eicosanoid Modulators","volume":"13","author":"Minic","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Spencer, N.J., Kyloh, M., and Duffield, M. (2014). Identification of different types of spinal afferent nerve endings that encode noxious and innocuous stimuli in the large intestine using a novel anterograde tracing technique. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0112466"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1152\/jn.00354.2017","article-title":"Afferent input and sensory function after human spinal cord injury","volume":"119","author":"Ozdemir","year":"2018","journal-title":"J. Neurophysiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/0192623313505929","article-title":"Effects of inflammation on the innervation of the colon","volume":"42","author":"Moynes","year":"2014","journal-title":"Toxicol. Pathol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10238-020-00639-y","article-title":"The risk of cardiovascular complications in inflammatory bowel disease","volume":"20","author":"Czubkowski","year":"2020","journal-title":"Clin. Exp. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e008702","DOI":"10.1136\/bmjopen-2015-008702","article-title":"Long-term risk of cardiovascular and cerebrovascular disease after removal of the colonic microbiota by colectomy: A cohort study based on the Danish National Patient Register from 1996 to 2014","volume":"5","author":"Jensen","year":"2015","journal-title":"BMJ Open"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"S281","DOI":"10.4103\/2230-8210.86860","article-title":"Neuro-endocrine regulation of blood pressure","volume":"15","author":"Chopra","year":"2011","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Emamian, M., Hasanian, S.M., Tayefi, M., Bijari, M., Movahedian Far, F., Shafiee, M., Avan, A., Heidari-Bakavoli, A., Moohebati, M., and Ebrahimi, M. (2017). Association of hematocrit with blood pressure and hypertension. J. Clin. Lab. Anal., 31.","DOI":"10.1002\/jcla.22124"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1056\/NEJM196509162731205","article-title":"Catecholamines","volume":"273","author":"Wurtman","year":"1965","journal-title":"N. Engl. J. Med."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Gootman, P.M. (1986). Developmental Neurobiology of the Autonomic Nervous System, Humana Press.","DOI":"10.1385\/0896030806"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/01.RES.78.5.737","article-title":"alpha 1-adrenergic receptor subtypes. Molecular structure, function, and signaling","volume":"78","author":"Graham","year":"1996","journal-title":"Circ. Res."},{"key":"ref_78","unstructured":"Paravati, S.R.A., and Warrington, S.J. (2022, May 20). Physiology, Catecholamines, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507716\/."},{"key":"ref_79","first-page":"463","article-title":"Glucose counterregulatory responses to hypoglycemia","volume":"9","author":"Sprague","year":"2011","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1038\/emm.2016.4","article-title":"Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism","volume":"48","author":"Roh","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"91","DOI":"10.18773\/austprescr.2021.016","article-title":"Updated anaphylaxis guidelines: Management in infants and children","volume":"44","author":"Frith","year":"2021","journal-title":"Aust. Prescr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1161\/01.HYP.17.4.469","article-title":"Human prorenin","volume":"17","author":"Hsueh","year":"1991","journal-title":"Hypertension"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/hr.2009.201","article-title":"Biochemical properties of renin and prorenin binding to the (pro)renin receptor","volume":"33","author":"Nabi","year":"2010","journal-title":"Hypertens. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1161\/HYPERTENSIONAHA.110.167130","article-title":"Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6","volume":"57","author":"Aldehni","year":"2011","journal-title":"Hypertension"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fendo.2013.00201","article-title":"Update on the Angiotensin converting enzyme 2-Angiotensin (1-7)-MAS receptor axis: Fetal programing, sex differences, and intracellular pathways","volume":"4","author":"Chappell","year":"2014","journal-title":"Front. Endocrinol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"770375","DOI":"10.3389\/fphys.2022.770375","article-title":"Aldosterone-Regulated Sodium Transport and Blood Pressure","volume":"13","author":"Tsilosani","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1210\/en.2010-1070","article-title":"Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor","volume":"152","author":"Yatabe","year":"2011","journal-title":"Endocrinology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1152\/physrev.00006.2018","article-title":"Lower Body Negative Pressure: Physiological Effects, Applications, and Implementation","volume":"99","author":"Goswami","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_90","first-page":"97","article-title":"Aldosterone: Refreshing a slow hormone by swift action","volume":"19","author":"Boldyreff","year":"2004","journal-title":"News Physiol. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"F991","DOI":"10.1152\/ajprenal.00432.2014","article-title":"Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2)","volume":"307","author":"Castrop","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/j.bbamcr.2013.05.009","article-title":"Aldosterone regulates Na(+), K(+) ATPase activity in human renal proximal tubule cells through mineralocorticoid receptor","volume":"1833","author":"Salyer","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fped.2017.00213","article-title":"Pathophysiology of Hyponatremia in Children","volume":"5","author":"Zieg","year":"2017","journal-title":"Front. Pediatr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"F1143","DOI":"10.1152\/ajprenal.00396.2011","article-title":"Molecular regulation of NKCC2 in the thick ascending limb","volume":"301","author":"Ares","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0092-8674(01)00241-0","article-title":"Molecular mechanisms of human hypertension","volume":"104","author":"Lifton","year":"2001","journal-title":"Cell"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/jhh.2010.95","article-title":"Characteristics of resistant hypertension: Ageing, body mass index, hyperaldosteronism, cardiac hypertrophy and vascular stiffness","volume":"25","author":"Martins","year":"2011","journal-title":"J. Hum. Hypertens."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ccl.2010.04.001","article-title":"The role of aldosteronism in causing obesity-related cardiovascular risk","volume":"28","author":"Calhoun","year":"2010","journal-title":"Cardiol. Clin."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1001\/archinte.1956.00250200011001","article-title":"Aldosterone in clinical medicine; past, present, and future","volume":"97","author":"Conn","year":"1956","journal-title":"AMA Arch. Intern. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators","volume":"341","author":"Pitt","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.jacc.2011.04.049","article-title":"Eplerenone survival benefits in heart failure patients post-myocardial infarction are independent from its diuretic and potassium-sparing effects. Insights from an EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) substudy","volume":"58","author":"Rossignol","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1001\/jama.1996.03530430051039","article-title":"Reversal of left ventricular hypertrophy in essential hypertension. A meta-analysis of randomized double-blind studies","volume":"275","author":"Schmieder","year":"1996","journal-title":"JAMA"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1161\/01.CIR.0000024416.33113.0A","article-title":"Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: A blood pressure-independent effect","volume":"106","author":"Viberti","year":"2002","journal-title":"Circulation"},{"key":"ref_104","first-page":"24S","article-title":"Interaction between atrial natriuretic peptide and the renin angiotensin aldosterone system. Endogenous antagonists","volume":"87","author":"Johnston","year":"1989","journal-title":"Am. J. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"14","DOI":"10.15420\/cfr.2016:4:2","article-title":"Current Understanding of the Compensatory Actions of Cardiac Natriuretic Peptides in Cardiac Failure: A Clinical Perspective","volume":"2","author":"Lee","year":"2016","journal-title":"Card. Fail. Rev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1161\/HYPERTENSIONAHA.112.193565","article-title":"Hemoglobin level is positively associated with blood pressure in a large cohort of healthy individuals","volume":"60","author":"Atsma","year":"2012","journal-title":"Hypertension"},{"key":"ref_107","unstructured":"Schoener, B., and Borger, J. (2022). Erythropoietin Stimulating Agents, StatPearls."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.3389\/fphys.2019.01534","article-title":"The Many Facets of Erythropoietin Physiologic and Metabolic Response","volume":"10","author":"Suresh","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2174\/1874192401004010302","article-title":"The endothelium and its role in regulating vascular tone","volume":"4","author":"Sandoo","year":"2010","journal-title":"Open Cardiovasc. Med. J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1161\/CIRCRESAHA.113.301577","article-title":"The identification of nitric oxide as endothelium-derived relaxing factor","volume":"113","author":"Loscalzo","year":"2013","journal-title":"Circ. Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1524-6175.2006.06025.x","article-title":"Nitric oxide in the pathogenesis of cardiac disease","volume":"8","author":"Raij","year":"2006","journal-title":"J. Clin. Hypertens."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.tips.2012.05.005","article-title":"Vascular effects of prostacyclin: Does activation of PPARdelta play a role?","volume":"33","author":"Katusic","year":"2012","journal-title":"Trends Pharm. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/0165-6147(89)90011-4","article-title":"Molecular biology and biochemistry of the endothelins","volume":"10","author":"Yanagisawa","year":"1989","journal-title":"Trends Pharm. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/3-540-32967-6_9","article-title":"Endothelin","volume":"176\/I","author":"Davenport","year":"2006","journal-title":"Handb. Exp. Pharm."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2147\/VHRM.S1905","article-title":"The renin-angiotensin system and diabetes: An update","volume":"4","author":"Nogueira","year":"2008","journal-title":"Vasc. Health. Risk. Manag."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1210\/endo.140.10.7023","article-title":"Endothelin-mediated vascular growth requires p42\/p44 mitogen-activated protein kinase and p70 S6 kinase cascades via transactivation of epidermal growth factor receptor","volume":"140","author":"Iwasaki","year":"1999","journal-title":"Endocrinology"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"C251","DOI":"10.1152\/ajpcell.00601.2001","article-title":"ET-1 stimulates ERK signaling pathway through sequential activation of PKC and Src in rat myometrial cells","volume":"283","author":"Robin","year":"2002","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1186\/cc2851","article-title":"Clinical review: Hemorrhagic shock","volume":"8","author":"Gutierrez","year":"2004","journal-title":"Crit. Care"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/cc968","article-title":"Pathophysiology of fluid imbalance","volume":"4","author":"Kreimeier","year":"2000","journal-title":"Crit. Care"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e4149","DOI":"10.1097\/MD.0000000000004149","article-title":"Effect of postural changes on cardiovascular parameters across gender","volume":"95","author":"Patel","year":"2016","journal-title":"Medicine"},{"key":"ref_121","first-page":"246","article-title":"Adrenal adrenoceptors in heart failure","volume":"5","author":"Femminella","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"R238","DOI":"10.1152\/ajpregu.00486.2014","article-title":"Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: Importance of the subfornical organ","volume":"308","author":"Coble","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_123","first-page":"1","article-title":"Brain neuropeptide Y mechanisms. Basic aspects and involvement in cardiovascular and neuroendocrine regulation","volume":"565","author":"Harfstrand","year":"1987","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000125010","article-title":"Localization of neuropeptide Y binding sites in the zona glomerulosa of the bovine adrenal gland","volume":"48","author":"Torda","year":"1988","journal-title":"Neuroendocrinology"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"R408","DOI":"10.1152\/ajpregu.00361.2017","article-title":"Time course of compensatory physiological responses to central hypovolemia in high- and low-tolerant human subjects","volume":"315","author":"Xiang","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2110-5820-3-12","article-title":"Clinical use of lactate monitoring in critically ill patients","volume":"3","author":"Bakker","year":"2013","journal-title":"Ann. Intensive Care."},{"key":"ref_127","first-page":"757","article-title":"The Nomenclature, Definition and Distinction of Types of Shock","volume":"115","author":"Standl","year":"2018","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/21691401.2016.1185728","article-title":"Effects of resuscitation with polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and oxygen delivery in a rat model of hemorrhagic shock","volume":"45","author":"Wang","year":"2017","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"124S","DOI":"10.1111\/trf.12046","article-title":"Blood Far Forward\u2014A whole blood research and training program for austere environments","volume":"53","author":"Strandenes","year":"2013","journal-title":"Transfusion."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"661660","DOI":"10.3389\/fvets.2021.661660","article-title":"The Effects of Resuscitative Fluid Therapy on the Endothelial Surface Layer","volume":"8","author":"Smart","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.15190\/d.2020.1","article-title":"Artificial Blood: The History and Current Perspectives of Blood Substitutes","volume":"8","author":"Khan","year":"2020","journal-title":"Discoveries"},{"key":"ref_132","first-page":"s59","article-title":"Haemoglobin-based oxygen carriers: Research and reality towards an alternative to blood transfusions","volume":"8","author":"Mozzarelli","year":"2010","journal-title":"Blood. Transfus."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"760215","DOI":"10.3389\/fphar.2021.760215","article-title":"Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation","volume":"12","author":"Cao","year":"2021","journal-title":"Front. Pharm."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"794561","DOI":"10.3389\/fmed.2021.794561","article-title":"New Applications of HBOC-201: A 25-Year Review of the Literature","volume":"8","author":"Cao","year":"2021","journal-title":"Front. Med."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Edgworth, E., Ernst, L., Czigany, Z., Saritas, T., Zarnitz, L.S., Wiartalla, M., Boor, P., Buhl, E.M., Rossaint, R., and Tolba, R.H. (2022). HBOC-301 in Porcine Kidney Normothermic Machine Perfusion and the Effect of Vitamin C on Methemoglobin Formation. Antioxidants, 11.","DOI":"10.3390\/antiox11071329"},{"key":"ref_136","first-page":"S55","article-title":"Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw","volume":"69","author":"Pati","year":"2010","journal-title":"J. Trauma"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13054-020-2799-5","article-title":"Effect of therapeutic plasma exchange on endothelial activation and coagulation-related parameters in septic shock","volume":"24","author":"Stahl","year":"2020","journal-title":"Crit. Care"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2110-5820-3-1","article-title":"Resuscitative strategies in traumatic hemorrhagic shock","volume":"3","author":"Harrois","year":"2013","journal-title":"Ann. Intensive Care"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e195085","DOI":"10.1001\/jamasurg.2019.5085","article-title":"Association of Prehospital Plasma Transfusion with Survival in Trauma Patients With Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials","volume":"155","author":"Pusateri","year":"2020","journal-title":"JAMA Surg."},{"key":"ref_140","first-page":"693","article-title":"Effect of centhaquine on spontaneous and evoked norepinephrine release from isolated perfused rabbit heart","volume":"35","author":"Bhatnagar","year":"1985","journal-title":"Arzneimittelforschung"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1358\/dof.2020.45.3.3098155","article-title":"Centhaquine citrate","volume":"45","author":"Gulati","year":"2020","journal-title":"Drug Future"},{"key":"ref_142","first-page":"A16250","article-title":"Evaluation of Centhaquine, a Novel Resuscitative Agent, in Hemorrhagic Shock Patients","volume":"140","author":"Gulati","year":"2019","journal-title":"Circulation"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1097\/01.ccm.0000649224.29144.8f","article-title":"A phase II multicentric randomized controlled study of centhaquine in hemorrhagic shock patients","volume":"48","author":"Gulati","year":"2020","journal-title":"Crit. Care Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s40265-021-01547-5","article-title":"A Multicentric, Randomized, Controlled Phase III Study of Centhaquine (Lyfaquin((R))) as a Resuscitative Agent in Hypovolemic Shock Patients","volume":"81","author":"Gulati","year":"2021","journal-title":"Drugs"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1007\/s12325-021-01760-4","article-title":"Resuscitative Effect of Centhaquine (Lyfaquin((R))) in Hypovolemic Shock Patients: A Randomized, Multicentric, Controlled Trial","volume":"38","author":"Gulati","year":"2021","journal-title":"Adv. Ther."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s13054-018-2265-9","article-title":"Prevalence and risk factors for acute kidney injury among trauma patients: A multicenter cohort study","volume":"22","author":"Harrois","year":"2018","journal-title":"Crit. Care"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/ALN.0b013e3181c4a5e2","article-title":"Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats","volume":"112","author":"Legrand","year":"2010","journal-title":"Anesthesiology"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/cphy.c110041","article-title":"Pathophysiology of acute kidney injury","volume":"2","author":"Basile","year":"2012","journal-title":"Compr. Physiol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"616253","DOI":"10.3389\/fphar.2021.616253","article-title":"Centhaquine Restores Renal Blood Flow and Protects Tissue Damage After Hemorrhagic Shock and Renal Ischemia","volume":"12","author":"Ranjan","year":"2021","journal-title":"Front. Pharm."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/01.ccm.0000645620.40050.9f","article-title":"Centhaquine Upregulates Hif1-a and Protects Hemorrhage-Induced Acute Kidney Injury","volume":"48","author":"Ranjan","year":"2020","journal-title":"Crit. Care Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/3\/1108\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:19:26Z","timestamp":1760120366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/3\/1108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":150,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["jcm12031108"],"URL":"https:\/\/doi.org\/10.3390\/jcm12031108","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202212.0030.v1","asserted-by":"object"}]},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,31]]}}}