{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:39:28Z","timestamp":1779187168770,"version":"3.51.4"},"reference-count":16,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The aims of this study were to evaluate the clinical outcomes and their predictive factors in locally advanced hypopharyngeal cancer (HC) patients included in a docetaxel-cisplatin-fluorouracil induction chemotherapy (ICT)-based larynx preservation (LP) program. Methods: Between 2005 and 2021, 82 patients with a locally advanced resectable HC who received ICT in an LP program were included in this retrospective study. The predictors of oncologic and swallowing outcomes were determined in univariate and multivariate analyses. Results: The three- and five-year overall survival (OS) rates were 67 and 54%, respectively. The T4 tumor stage was the only predictive factor of poor response to ICT (p = 0.03). In multivariate analysis, a T stage = 4 (p = 0.02), an ICT cycle number &lt; 3 (p = 0.003) and the absence of a response to ICT (p = 0.03) were significantly associated with worse OS. A low body mass index before therapy (p = 0.003) and enteral nutrition during therapy (p = 0.005) were significantly associated with severity of dysphagia 6 months after treatment. Conclusions: The T stage, number of ICT cycles performed and response to ICT are the main predictors of oncologic outcomes. Patients with T4 HC are poor candidates for LP and should be referred to immediate radical surgery.<\/jats:p>","DOI":"10.3390\/jcm12031131","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T01:36:59Z","timestamp":1675215419000},"page":"1131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2302-9992","authenticated-orcid":false,"given":"Pierre","family":"Mattei","sequence":"first","affiliation":[{"name":"Institut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-118X","authenticated-orcid":false,"given":"Jocelyn","family":"Gal","sequence":"additional","affiliation":[{"name":"Department of Statistics, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6841-4571","authenticated-orcid":false,"given":"Emmanuel","family":"Chamorey","sequence":"additional","affiliation":[{"name":"Department of Statistics, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Dassonville","sequence":"additional","affiliation":[{"name":"Institut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Poissonnet","sequence":"additional","affiliation":[{"name":"Institut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9borah","family":"Aloi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9d\u00e9ric","family":"Barret","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga","family":"Safta","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esma","family":"Saada","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Sudaka","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorian","family":"Culi\u00e9","sequence":"additional","affiliation":[{"name":"Institut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8576-3052","authenticated-orcid":false,"given":"Alexandre","family":"Bozec","sequence":"additional","affiliation":[{"name":"Institut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France"},{"name":"Faculty of Medecine, C\u00f4te d\u2019Azur University, 06107 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1017\/S0022215118000555","article-title":"Management of advanced hypopharyngeal carcinoma: Systematic review of survival following surgical and non-surgical treatments","volume":"132","author":"Habib","year":"2018","journal-title":"J. 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