{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:22:10Z","timestamp":1785363730656,"version":"3.55.0"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III and FEDER Founds","doi-asserted-by":"publisher","award":["JR\/21\/00041"],"award-info":[{"award-number":["JR\/21\/00041"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III and FEDER Founds","doi-asserted-by":"publisher","award":["16\/11\/00420 CIBER-CV"],"award-info":[{"award-number":["16\/11\/00420 CIBER-CV"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III and FEDER Founds","doi-asserted-by":"publisher","award":["CM21\/00175"],"award-info":[{"award-number":["CM21\/00175"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Instituto de Salud Carlos III","award":["JR\/21\/00041"],"award-info":[{"award-number":["JR\/21\/00041"]}]},{"name":"the Instituto de Salud Carlos III","award":["16\/11\/00420 CIBER-CV"],"award-info":[{"award-number":["16\/11\/00420 CIBER-CV"]}]},{"name":"the Instituto de Salud Carlos III","award":["CM21\/00175"],"award-info":[{"award-number":["CM21\/00175"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>A non-neglectable percentage of patients with non-ST elevation myocardial infarction (NSTEMI) show non-obstructive coronary arteries (MINOCA). Specific data in older patients are scarce. We aimed to identify the clinical predictors of MINOCA in older patients admitted for NSTEMI and to explore the long-term prognosis of MINOCA. This was a single-center, observational, consecutive cohort study of older (\u226570 years) patients admitted for NSTEMI between 2010 and 2014 who underwent coronary angiography. Univariate and multivariate Cox regression were performed to analyze the association of variables with MINOCA and all-cause mortality and with major adverse cardiac events (MACE), defined as a combined endpoint of all-cause mortality and nonfatal myocardial infarction and a combined endpoint of cardiovascular mortality, nonfatal myocardial infarction, and unplanned revascularization. The registry included 324 patients (mean age 78.8 \u00b1 5.4 years), of which 71 (21.9%) were diagnosed with MINOCA. Predictors of MINOCA were female sex, left bundle branch block, pacemaker rhythm, chest pain at rest, peak troponin level, previous MI, Killip \u22652, and ST segment depression. Regarding prognosis, patients with obstructive coronary arteries (stenosis \u226550%) and the subgroup of MINOCA patients with plaques &lt;50% had a similar prognosis; while MINOCA patients with angiographically smooth coronary arteries had a reduced risk of MACE. We conclude that the following: (1) in elderly patients admitted for NSTEMI, certain universally available clinical, electrocardiographic, and analytical variables are associated with the diagnosis of MINOCA; (2) elderly patients with MINOCA have a better prognosis than those with obstructive coronary arteries; however, only those with angiographically smooth coronary arteries have a reduced risk of all-cause mortality and MACE.<\/jats:p>","DOI":"10.3390\/jcm12031181","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T01:53:54Z","timestamp":1675302834000},"page":"1181","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical Predictors and Prognosis of Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) without ST-Segment Elevation in Older Adults"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2475-0282","authenticated-orcid":false,"given":"Ana","family":"Gabaldon-Perez","sequence":"first","affiliation":[{"name":"Cardiology Department, University Hospital Clinic of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-7107","authenticated-orcid":false,"given":"Clara","family":"Bonanad","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Clinic of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Department of Medicine, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1998-3735","authenticated-orcid":false,"given":"Sergio","family":"Garcia-Blas","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Clinic of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2014Cardiovascular (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5565-5547","authenticated-orcid":false,"given":"V\u00edctor","family":"Marcos-Garc\u00e9s","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Clinic of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessika Gonzalez","family":"D\u2019Gregorio","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Clinic of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2014Cardiovascular (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Fernandez-Cisnal","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Clinic of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2014Cardiovascular (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Valero","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Clinic of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2014Cardiovascular (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8777-2588","authenticated-orcid":false,"given":"Gema","family":"Minana","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Clinic of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Department of Medicine, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2014Cardiovascular (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Merenciano-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Clinic of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mollar","sequence":"additional","affiliation":[{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2014Cardiovascular (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Bodi","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Clinic of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Department of Medicine, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2014Cardiovascular (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-7119","authenticated-orcid":false,"given":"Julio","family":"Nunez","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Clinic of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Department of Medicine, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2014Cardiovascular (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0797-8709","authenticated-orcid":false,"given":"Juan","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Clinic of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Department of 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